JP2015516806A5 - - Google Patents

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JP2015516806A5
JP2015516806A5 JP2015503315A JP2015503315A JP2015516806A5 JP 2015516806 A5 JP2015516806 A5 JP 2015516806A5 JP 2015503315 A JP2015503315 A JP 2015503315A JP 2015503315 A JP2015503315 A JP 2015503315A JP 2015516806 A5 JP2015516806 A5 JP 2015516806A5
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Japan
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patient
expression
vegf antagonist
gene
level
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JP2015503315A
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Japanese (ja)
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JP6335875B2 (ja
JP2015516806A (ja
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Priority claimed from PCT/US2013/031760 external-priority patent/WO2013148288A1/en
Publication of JP2015516806A publication Critical patent/JP2015516806A/ja
Publication of JP2015516806A5 publication Critical patent/JP2015516806A5/ja
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Publication of JP6335875B2 publication Critical patent/JP6335875B2/ja
Expired - Fee Related legal-status Critical Current
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JP2015503315A 2012-03-30 2013-03-14 癌の治療のための診断法及び組成物 Expired - Fee Related JP6335875B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261618199P 2012-03-30 2012-03-30
US61/618,199 2012-03-30
PCT/US2013/031760 WO2013148288A1 (en) 2012-03-30 2013-03-14 Diagnostic methods and compositions for treatment of cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017229130A Division JP2018075015A (ja) 2012-03-30 2017-11-29 癌の治療のための診断法及び組成物

Publications (3)

Publication Number Publication Date
JP2015516806A JP2015516806A (ja) 2015-06-18
JP2015516806A5 true JP2015516806A5 (https=) 2016-05-12
JP6335875B2 JP6335875B2 (ja) 2018-05-30

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ID=49261061

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015503315A Expired - Fee Related JP6335875B2 (ja) 2012-03-30 2013-03-14 癌の治療のための診断法及び組成物
JP2017229130A Pending JP2018075015A (ja) 2012-03-30 2017-11-29 癌の治療のための診断法及び組成物

Family Applications After (1)

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JP2017229130A Pending JP2018075015A (ja) 2012-03-30 2017-11-29 癌の治療のための診断法及び組成物

Country Status (14)

Country Link
US (1) US20150056190A1 (https=)
EP (1) EP2830661A4 (https=)
JP (2) JP6335875B2 (https=)
KR (1) KR20140142719A (https=)
CN (1) CN104271157A (https=)
AU (2) AU2013240234B2 (https=)
BR (1) BR112014024219A8 (https=)
CA (1) CA2867588A1 (https=)
HK (1) HK1200739A1 (https=)
IL (1) IL234678A0 (https=)
MX (1) MX2014011582A (https=)
RU (1) RU2666627C2 (https=)
SG (2) SG10201509939PA (https=)
WO (1) WO2013148288A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10456470B2 (en) 2013-08-30 2019-10-29 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
US10617755B2 (en) 2013-08-30 2020-04-14 Genentech, Inc. Combination therapy for the treatment of glioblastoma
JP2015096049A (ja) * 2013-11-15 2015-05-21 凸版印刷株式会社 Vegf阻害剤長期奏功性予測方法
WO2015082880A1 (en) * 2013-12-02 2015-06-11 Astrazeneca Ab Methods of selecting treatment regimens
WO2016011052A1 (en) * 2014-07-14 2016-01-21 Genentech, Inc. Diagnostic methods and compositions for treatment of glioblastoma
EP3194972B1 (en) * 2014-09-17 2021-04-14 Merck Patent GmbH A method of treating bone metastasis diseases, medicaments therefore, and a method of predicting the clinical outcome of treating bone metastasis diseases
WO2016041614A1 (en) 2014-09-17 2016-03-24 Merck Patent Gmbh A method of treating solid cancers and/or metastases thereof, medicaments therefore, and a method of predicting the clinical outcome of treating solid cancers and/or metastases thereof
CA2963091A1 (en) * 2014-10-06 2016-04-14 Dana-Farber Cancer Institute, Inc. Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
KR20170094165A (ko) * 2014-12-23 2017-08-17 제넨테크, 인크. 화학요법-내성 암을 치료 및 진단하는 조성물 및 방법
EP3550305A4 (en) * 2016-12-01 2020-11-11 Santen Pharmaceutical Co., Ltd. METHOD OF PREDICTING THE EFFECTIVENESS OF AN ANTI-VEGF ACTIVE INGREDIENT FOR EXUDATIVE AGE-RELATED MACULAR DEGENERATION
KR20200005540A (ko) * 2017-04-14 2020-01-15 제넨테크, 인크. 암의 진단 및 치료 방법
US12016900B2 (en) 2017-06-04 2024-06-25 Rappaport Family Institute For Research In The Medical Sciences Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent
US12070489B2 (en) 2018-12-12 2024-08-27 Rappaport Family Institute For Research In The Medical Sciences Method of treating cancer with a cancer therapy in combination with another therapeutic agent
WO2018225063A1 (en) * 2017-06-04 2018-12-13 Rappaport Family Institute For Research In The Medical Sciences Method of predicting personalized response to cancer treatment with immune checkpoint inhibitors and kits therefor
RU2701356C1 (ru) * 2018-09-18 2019-09-25 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ онкологии им. Н.Н. Блохина" Минздрава России) Способ диагностики рака молочной железы с экспрессией рецептора Her2/neu на мембране опухолевых клеток
US11793889B2 (en) * 2018-09-24 2023-10-24 Kinase Pharma Inc. Methods for selective kinase inhibition by endogenously produced antagonists of one or more kinases
CN110714078B (zh) * 2019-09-29 2021-11-30 浙江大学 一种用于ii期结直肠癌复发预测的标记基因及应用
GB202007099D0 (en) * 2020-05-14 2020-07-01 Kymab Ltd Tumour biomarkers for immunotherapy
EP4099219A1 (en) * 2021-06-02 2022-12-07 Siemens Healthcare GmbH Method and device for determining presence of tumor
WO2023017525A1 (en) 2021-08-11 2023-02-16 OncoHost Ltd. Predicting patient response
CN115840046A (zh) * 2022-08-17 2023-03-24 中国药科大学 一种鉴别anti-VEGF抗体获得性耐药的蛋白聚糖ESM1生物学标记物及其应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4018653A (en) 1971-10-29 1977-04-19 U.S. Packaging Corporation Instrument for the detection of Neisseria gonorrhoeae without culture
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4424279A (en) 1982-08-12 1984-01-03 Quidel Rapid plunger immunoassay method and apparatus
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US4892538A (en) 1987-11-17 1990-01-09 Brown University Research Foundation In vivo delivery of neurotransmitters by implanted, encapsulated cells
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
WO1996033735A1 (en) 1995-04-27 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
GB9114948D0 (en) 1991-07-11 1991-08-28 Pfizer Ltd Process for preparing sertraline intermediates
EP0646178A1 (en) 1992-06-04 1995-04-05 The Regents Of The University Of California expression cassette with regularoty regions functional in the mammmlian host
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5910486A (en) 1994-09-06 1999-06-08 Uab Research Foundation Methods for modulating protein function in cells using, intracellular antibody homologues
WO1996034096A1 (en) 1995-04-28 1996-10-31 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6267958B1 (en) 1995-07-27 2001-07-31 Genentech, Inc. Protein formulation
CA2722378C (en) 1996-12-03 2015-02-03 Amgen Fremont Inc. Human antibodies that bind tnf.alpha.
KR100816621B1 (ko) 1997-04-07 2008-03-24 제넨테크, 인크. 항-vegf 항체
US6884879B1 (en) 1997-04-07 2005-04-26 Genentech, Inc. Anti-VEGF antibodies
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
DK1034298T3 (da) 1997-12-05 2012-01-30 Scripps Research Inst Humanisering af murint antistof
ATE375365T1 (de) 1998-04-02 2007-10-15 Genentech Inc Antikörper varianten und fragmente davon
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
EP1140137A2 (en) * 1998-12-18 2001-10-10 Scios Inc. Method for detection and use of differentially expressed genes in disease states
PL209392B1 (pl) 1999-01-15 2011-08-31 Genentech Inc Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
US6737056B1 (en) 1999-01-15 2004-05-18 Genentech, Inc. Polypeptide variants with altered effector function
US6949245B1 (en) 1999-06-25 2005-09-27 Genentech, Inc. Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies
WO2001075166A2 (en) 2000-03-31 2001-10-11 Genentech, Inc. Compositions and methods for detecting and quantifying gene expression
KR20030074693A (ko) 2000-12-28 2003-09-19 알투스 바이올로직스 인코포레이티드 전항체 및 이의 단편의 결정과 이의 제조 및 사용 방법
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US20060084064A1 (en) * 2003-01-22 2006-04-20 Aird William C Endocan compositions and methods for the treatment of neoplasms
US20050106667A1 (en) 2003-08-01 2005-05-19 Genentech, Inc Binding polypeptides with restricted diversity sequences
US7758859B2 (en) * 2003-08-01 2010-07-20 Genentech, Inc. Anti-VEGF antibodies
WO2005044853A2 (en) 2003-11-01 2005-05-19 Genentech, Inc. Anti-vegf antibodies
US20060008823A1 (en) 2004-05-12 2006-01-12 Kemp Jennifer T DNA profiling and SNP detection utilizing microarrays
WO2007047955A2 (en) * 2005-10-21 2007-04-26 Bayer Healthcare Llc Methods for prediction and prognosis of cancer, and monitoring cancer therapy
RU2415869C2 (ru) * 2006-06-06 2011-04-10 Дженентек, Инк. Антитела против dll4 и способы их применения
AU2008205543A1 (en) * 2007-01-18 2008-07-24 University Of Southern California Genetic markers for predicting responsiveness to combination therapy
CA2705152C (en) * 2007-11-09 2016-10-11 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
AU2010273585B2 (en) * 2009-07-13 2015-04-23 Genentech, Inc. Diagnostic methods and compositions for treatment of cancer
EP2464744A1 (en) * 2009-08-14 2012-06-20 F. Hoffmann-La Roche AG Biological markers for monitoring patient response to vegf antagonists

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