JP2017527533A5 - - Google Patents
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- JP2017527533A5 JP2017527533A5 JP2016575798A JP2016575798A JP2017527533A5 JP 2017527533 A5 JP2017527533 A5 JP 2017527533A5 JP 2016575798 A JP2016575798 A JP 2016575798A JP 2016575798 A JP2016575798 A JP 2016575798A JP 2017527533 A5 JP2017527533 A5 JP 2017527533A5
- Authority
- JP
- Japan
- Prior art keywords
- dkk2
- cancer
- antibody
- group
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462020684P | 2014-07-03 | 2014-07-03 | |
| US62/020,684 | 2014-07-03 | ||
| PCT/US2015/038581 WO2016004055A1 (en) | 2014-07-03 | 2015-06-30 | Dickkopf2 (Dkk2) Inhibition Suppresses Tumor Formation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020183427A Division JP2021038232A (ja) | 2014-07-03 | 2020-11-02 | 腫瘍形成を抑制するディコップ２（Ｄｉｃｋｋｏｐｆ２）（Ｄｋｋ２）阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017527533A JP2017527533A (ja) | 2017-09-21 |
| JP2017527533A5 true JP2017527533A5 (https=) | 2018-08-02 |
| JP6789124B2 JP6789124B2 (ja) | 2020-11-25 |
Family
ID=55019920
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016575798A Active JP6789124B2 (ja) | 2014-07-03 | 2015-06-30 | 腫瘍形成を抑制するディコップ２（Ｄｉｃｋｋｏｐｆ２）（Ｄｋｋ２）阻害 |
| JP2020183427A Withdrawn JP2021038232A (ja) | 2014-07-03 | 2020-11-02 | 腫瘍形成を抑制するディコップ２（Ｄｉｃｋｋｏｐｆ２）（Ｄｋｋ２）阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020183427A Withdrawn JP2021038232A (ja) | 2014-07-03 | 2020-11-02 | 腫瘍形成を抑制するディコップ２（Ｄｉｃｋｋｏｐｆ２）（Ｄｋｋ２）阻害 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10398765B2 (https=) |
| EP (2) | EP3978524A1 (https=) |
| JP (2) | JP6789124B2 (https=) |
| CN (2) | CN106659912B (https=) |
| CA (1) | CA2953149A1 (https=) |
| ES (1) | ES2903029T3 (https=) |
| WO (1) | WO2016004055A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3368567B1 (en) * | 2015-10-28 | 2025-10-01 | Yale University | Humanized anti-dkk2 antibody and uses thereof |
| US20200179510A1 (en) * | 2017-03-24 | 2020-06-11 | Yale University | Low density lipoprotein receptor related protein 5 inhibition suppresses tumor formation |
| TW202104258A (zh) * | 2019-03-29 | 2021-02-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗癌組合療法 |
| CN112180094A (zh) * | 2019-07-04 | 2021-01-05 | 上海东慈生物科技有限公司 | Dkk1抑制剂在预防和/或治疗肿瘤恶病质与糖尿病伴随疾病中的应用 |
| WO2021003687A1 (en) * | 2019-07-10 | 2021-01-14 | Yale University | Compositions and methods of using a humanized anti-dkk2 antibody |
| US20230340089A1 (en) * | 2020-05-14 | 2023-10-26 | City Of Hope | Smc1a antibodies and uses thereof |
| GB202008860D0 (en) * | 2020-06-11 | 2020-07-29 | Univ Oxford Innovation Ltd | BTLA antibodies |
| CN112592402B (zh) * | 2020-12-02 | 2022-04-26 | 杭州奕安济世生物药业有限公司 | 抗dkk2抗体、包含该抗dkk2抗体的组合物及其用途 |
| EP4359535A1 (en) * | 2021-06-21 | 2024-05-01 | Empirico Inc. | Treatment of dkk2 related diseases and disorders |
| WO2024137663A2 (en) * | 2022-12-20 | 2024-06-27 | Empirico Inc. | Treatment of dkk2 related diseases and disorders |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023243A (en) | 1981-10-23 | 1991-06-11 | Molecular Biosystems, Inc. | Oligonucleotide therapeutic agent and method of making same |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5190931A (en) | 1983-10-20 | 1993-03-02 | The Research Foundation Of State University Of New York | Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5168053A (en) | 1989-03-24 | 1992-12-01 | Yale University | Cleavage of targeted RNA by RNAase P |
| JP3257675B2 (ja) | 1990-10-12 | 2002-02-18 | マックス−プランク−ゲゼルシャフト ツール フェルデルング デル ビッセンシャフテン エー．ファウ． | 修飾リボザイム |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| AU675929B2 (en) | 1992-02-06 | 1997-02-27 | Curis, Inc. | Biosynthetic binding protein for cancer marker |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6133232A (en) | 1996-06-20 | 2000-10-17 | The Regents Of The University Of California | Endoderm, cardiac and neural inducing factors |
| US5770380A (en) | 1996-09-13 | 1998-06-23 | University Of Pittsburgh | Synthetic antibody mimics--multiple peptide loops attached to a molecular scaffold |
| AU5233599A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | Ddkh-3 nucleic acids, polypeptides, vectors, host cells, methods and uses thereof |
| US6485972B1 (en) | 1998-10-15 | 2002-11-26 | President And Fellows Of Harvard College | WNT signalling in reproductive organs |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| DK1390535T3 (da) | 2001-04-26 | 2010-12-06 | Amgen Mountain View Inc | Kombinatoriske biblioteker af monomer-domæner |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| AU2002357932A1 (en) | 2001-12-18 | 2003-06-30 | Whitehead Institute For Biomedical Research | Fusion partner cells and uses thereof |
| US20060204496A1 (en) | 2003-11-28 | 2006-09-14 | Tetsuo Kojima | Agonist antibody against heteroreceptor |
| US8343922B2 (en) * | 2004-05-19 | 2013-01-01 | Enzo Biochem, Inc. | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells |
| RU2494107C2 (ru) * | 2005-05-09 | 2013-09-27 | Оно Фармасьютикал Ко., Лтд. | Моноклональные антитела человека к белку программируемой смерти 1 (pd-1) и способы лечения рака с использованием анти-pd-1-антител самостоятельно или в комбинации с другими иммунотерапевтическими средствами |
| AR060017A1 (es) * | 2006-01-13 | 2008-05-21 | Novartis Ag | Composiciones y metodos de uso para anticuerpos de dickkopf -1 |
| WO2007122815A1 (ja) * | 2006-04-14 | 2007-11-01 | Ono Pharmaceutical Co., Ltd. | Ｂｉｒ１に対する二価抗体 |
| US20100104577A1 (en) * | 2006-10-10 | 2010-04-29 | Golde Todd E | Methods and materials related to anti-a (beta) antibodies |
| PE20100092A1 (es) | 2008-06-03 | 2010-03-12 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
| BRPI0913366A8 (pt) * | 2008-06-03 | 2017-07-11 | Abbott Lab | Imunoglobulinas de domínio variável duplo e seus usos |
| CN113967253A (zh) * | 2012-05-15 | 2022-01-25 | 百时美施贵宝公司 | 通过破坏pd-1/pd-l1信号传输的免疫治疗 |
-
2015
- 2015-06-30 EP EP21208628.4A patent/EP3978524A1/en active Pending
- 2015-06-30 EP EP15816061.4A patent/EP3164194B1/en active Active
- 2015-06-30 US US15/322,595 patent/US10398765B2/en active Active
- 2015-06-30 CN CN201580036541.2A patent/CN106659912B/zh active Active
- 2015-06-30 ES ES15816061T patent/ES2903029T3/es active Active
- 2015-06-30 CN CN202111337246.4A patent/CN114306605A/zh active Pending
- 2015-06-30 CA CA2953149A patent/CA2953149A1/en not_active Abandoned
- 2015-06-30 WO PCT/US2015/038581 patent/WO2016004055A1/en not_active Ceased
- 2015-06-30 JP JP2016575798A patent/JP6789124B2/ja active Active
-
2019
- 2019-08-01 US US16/529,174 patent/US11497799B2/en active Active
-
2020
- 2020-11-02 JP JP2020183427A patent/JP2021038232A/ja not_active Withdrawn
-
2022
- 2022-10-06 US US17/938,549 patent/US20230190897A1/en not_active Abandoned
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