JP2015512612A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015512612A5 JP2015512612A5 JP2014552348A JP2014552348A JP2015512612A5 JP 2015512612 A5 JP2015512612 A5 JP 2015512612A5 JP 2014552348 A JP2014552348 A JP 2014552348A JP 2014552348 A JP2014552348 A JP 2014552348A JP 2015512612 A5 JP2015512612 A5 JP 2015512612A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- expression
- gene
- level
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261586660P | 2012-01-13 | 2012-01-13 | |
| US61/586,660 | 2012-01-13 | ||
| PCT/US2013/021306 WO2013106765A1 (en) | 2012-01-13 | 2013-01-11 | Biological markers for identifying patients for treatment with vegf antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017237944A Division JP2018082705A (ja) | 2012-01-13 | 2017-12-12 | Vegfアンタゴニストで治療するための患者を同定するための生物学的マーカー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015512612A JP2015512612A (ja) | 2015-04-30 |
| JP2015512612A5 true JP2015512612A5 (https=) | 2016-03-03 |
| JP6529261B2 JP6529261B2 (ja) | 2019-06-12 |
Family
ID=48781962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552348A Expired - Fee Related JP6529261B2 (ja) | 2012-01-13 | 2013-01-11 | Vegfアンタゴニストで治療するための患者を同定するための生物学的マーカー |
| JP2017237944A Pending JP2018082705A (ja) | 2012-01-13 | 2017-12-12 | Vegfアンタゴニストで治療するための患者を同定するための生物学的マーカー |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017237944A Pending JP2018082705A (ja) | 2012-01-13 | 2017-12-12 | Vegfアンタゴニストで治療するための患者を同定するための生物学的マーカー |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20130216533A1 (https=) |
| EP (1) | EP2802346B1 (https=) |
| JP (2) | JP6529261B2 (https=) |
| KR (1) | KR20140114415A (https=) |
| CN (1) | CN104203268A (https=) |
| AU (2) | AU2013207778B2 (https=) |
| BR (1) | BR112014017320A2 (https=) |
| CA (1) | CA2862835A1 (https=) |
| HK (1) | HK1204933A1 (https=) |
| IL (2) | IL233467B (https=) |
| MX (1) | MX356802B (https=) |
| NZ (1) | NZ627443A (https=) |
| RU (1) | RU2659173C2 (https=) |
| SG (1) | SG11201403927XA (https=) |
| WO (1) | WO2013106765A1 (https=) |
| ZA (1) | ZA201405305B (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013031019A2 (pt) | 2011-06-02 | 2017-03-21 | Almac Diagnostics Ltd | teste diagnóstico molecular para câncer |
| MX2015006955A (es) | 2012-12-03 | 2016-01-25 | Almac Diagnostics Ltd | Prueba de diagnostico molecular para cancer. |
| ES2859645T3 (es) | 2013-03-14 | 2021-10-04 | Mayo Found Medical Education & Res | Detección de neoplasia |
| US10617755B2 (en) | 2013-08-30 | 2020-04-14 | Genentech, Inc. | Combination therapy for the treatment of glioblastoma |
| US10456470B2 (en) * | 2013-08-30 | 2019-10-29 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| GB201409479D0 (en) | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular diagnostic test for cancer |
| CN109207580B (zh) | 2014-03-12 | 2022-03-11 | 西奈山伊坎医学院 | 鉴定处于慢性损伤风险的肾异体移植物接受者的方法 |
| US20170184602A1 (en) * | 2014-04-24 | 2017-06-29 | Pfizer Inc. | Cancer treatment |
| GB201409478D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Pro-angiogenic signature |
| GB201409476D0 (en) * | 2014-05-28 | 2014-07-09 | Almac Diagnostics Ltd | Molecular subtype for use in prognosis |
| WO2015200887A2 (en) | 2014-06-26 | 2015-12-30 | Icahn School Of Medicine At Mount Sinai | Method for diagnosing subclinical and clinical acute rejection by analysis of predictive gene sets |
| WO2016011052A1 (en) * | 2014-07-14 | 2016-01-21 | Genentech, Inc. | Diagnostic methods and compositions for treatment of glioblastoma |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| AU2015328411C1 (en) * | 2014-10-06 | 2022-03-03 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
| WO2016118670A1 (en) * | 2015-01-20 | 2016-07-28 | Memorial Sloan-Kettering Cancer Center | Multigene expression assay for patient stratification in resected colorectal liver metastases |
| EP3067698A1 (en) * | 2015-03-11 | 2016-09-14 | Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) | Pd-ecgf as biomarker of cancer |
| CN107532124B (zh) | 2015-03-27 | 2022-08-09 | 精密科学公司 | 检测食管疾病 |
| EP3091084A1 (en) * | 2015-05-08 | 2016-11-09 | Université Catholique De Louvain | Methods for assessing the purity of a mesenchymal stem cells preparation |
| CN108138235B (zh) | 2015-08-31 | 2022-04-15 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| PT3384049T (pt) * | 2015-12-03 | 2023-08-18 | Regeneron Pharma | Método de associação de variantes genéticas com um resultado clínico em doentes que sofrem de degeneração macular relacionada à idade tratados com anti-vegf |
| US9845505B2 (en) | 2016-01-29 | 2017-12-19 | BluePrint Bio, Inc. | Prediction of therapeutic response in inflammatory conditions |
| WO2017180581A1 (en) * | 2016-04-15 | 2017-10-19 | Genentech, Inc. | Diagnostic and therapeutic methods for cancer |
| AU2017248766A1 (en) * | 2016-04-15 | 2018-11-01 | Genentech, Inc. | Methods for monitoring and treating cancer |
| EP3523779B1 (en) * | 2016-10-07 | 2026-04-29 | Ventana Medical Systems, Inc. | Digital pathology system and associated workflow for providing visualized whole-slide image analysis |
| RU2019119858A (ru) * | 2016-12-01 | 2021-01-14 | Сантен Фармасьютикал Ко., Лтд. | Способ прогнозирования отвечаемости пациента с влажной amd на анти-vegf терапию |
| CN110546277B (zh) | 2017-03-01 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| US12070489B2 (en) | 2018-12-12 | 2024-08-27 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with a cancer therapy in combination with another therapeutic agent |
| CA3066053A1 (en) | 2017-06-04 | 2018-12-13 | Rappaport Family Institute For Research In The Medical Sciences | Method of predicting personalized response to cancer treatment with immune checkpoint inhibitors and kits therefor |
| US12016900B2 (en) | 2017-06-04 | 2024-06-25 | Rappaport Family Institute For Research In The Medical Sciences | Method of treating cancer with an immune checkpoint inhibitor in combination with another therapeutic agent |
| JP2018049015A (ja) * | 2017-09-26 | 2018-03-29 | マイクロ モーション インコーポレイテッド | 防炎性の電気フィードスルー |
| FI3743091T3 (fi) | 2018-01-26 | 2025-01-03 | Univ California | Menetelmät ja koostumukset verisuoniperäisten sairauksien hoitoon käyttämällä anti-vegf vaikuttavia aineita |
| CA3096222A1 (en) | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| ES3037279T3 (en) | 2018-04-16 | 2025-09-30 | Icahn School Med Mount Sinai | Method and kits for prediction of acute rejection and renal allograft loss using pre-transplant transcriptomic signatures in recipient blood |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| WO2021034091A1 (ko) * | 2019-08-19 | 2021-02-25 | 재단법인 아산사회복지재단 | 교모세포종의 진단 방법 |
| CN114746120B (zh) | 2019-10-03 | 2024-07-30 | Atyr医药公司 | 包含抗nrp2抗体的组合物和方法 |
| WO2021108255A1 (en) | 2019-11-25 | 2021-06-03 | The Regents Of The University Of California | Long-acting vegf inhibitors for intraocular neovascularization |
| US20240321393A1 (en) * | 2021-07-28 | 2024-09-26 | The Regents Of The University Of California | Cell-type optimization method and scanner |
| CA3227993A1 (en) | 2021-08-11 | 2023-02-16 | OncoHost Ltd. | Predicting patient response |
| CN113834942B (zh) * | 2021-11-02 | 2024-02-02 | 河北特温特生物科技发展有限公司 | 一种胎盘生长因子质控品及其制备方法 |
| CN115840046A (zh) * | 2022-08-17 | 2023-03-24 | 中国药科大学 | 一种鉴别anti-VEGF抗体获得性耐药的蛋白聚糖ESM1生物学标记物及其应用 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
| US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
| US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US4892538A (en) | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5283187A (en) | 1987-11-17 | 1994-02-01 | Brown University Research Foundation | Cell culture-containing tubular capsule produced by co-extrusion |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP1690934A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
| EP0646178A1 (en) | 1992-06-04 | 1995-04-05 | The Regents Of The University Of California | expression cassette with regularoty regions functional in the mammmlian host |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5910486A (en) | 1994-09-06 | 1999-06-08 | Uab Research Foundation | Methods for modulating protein function in cells using, intracellular antibody homologues |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0823941A4 (en) | 1995-04-28 | 2001-09-19 | Abgenix Inc | HUMAN ANTIBODIES DERIVED FROM IMMUNIZED XENO MOUSES |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| EP1500329B1 (en) | 1996-12-03 | 2012-03-21 | Amgen Fremont Inc. | Human antibodies that specifically bind human TNF alpha |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| JP3957765B2 (ja) | 1997-04-07 | 2007-08-15 | ジェネンテク・インコーポレイテッド | 抗vegf抗体 |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| ES2375931T3 (es) | 1997-12-05 | 2012-03-07 | The Scripps Research Institute | Humanización de anticuerpo murino. |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| ES2292236T3 (es) | 1998-04-02 | 2008-03-01 | Genentech, Inc. | Variantes de anticuerpos y sus fragmentos. |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| HU230769B1 (hu) | 1999-01-15 | 2018-03-28 | Genentech Inc. | Módosított effektor-funkciójú polipeptid-változatok |
| US6949245B1 (en) | 1999-06-25 | 2005-09-27 | Genentech, Inc. | Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies |
| WO2001075166A2 (en) | 2000-03-31 | 2001-10-11 | Genentech, Inc. | Compositions and methods for detecting and quantifying gene expression |
| NZ526720A (en) | 2000-12-28 | 2007-11-30 | Altus Pharmaceuticals Inc | Crystallisation of whole antibodies or fragments thereof, on a large scale and a process allowing an alternative route for delivery of therapeutic antibodies |
| US7435419B2 (en) | 2002-07-19 | 2008-10-14 | Beth Israel Deaconess Medical Center | Methods of diagnosing and treating pre-eclampsia or eclampsia |
| US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| US20050106667A1 (en) | 2003-08-01 | 2005-05-19 | Genentech, Inc | Binding polypeptides with restricted diversity sequences |
| WO2005044853A2 (en) | 2003-11-01 | 2005-05-19 | Genentech, Inc. | Anti-vegf antibodies |
| AU2005236075A1 (en) * | 2004-04-26 | 2005-11-03 | Children's Medical Center Corporation | Platelet biomarkers for the detection of disease |
| US20060008823A1 (en) | 2004-05-12 | 2006-01-12 | Kemp Jennifer T | DNA profiling and SNP detection utilizing microarrays |
| DK2069798T3 (da) | 2006-10-04 | 2014-06-16 | Genentech Inc | Elisa til vegf |
| EP2109686A2 (en) | 2007-01-18 | 2009-10-21 | University Of Southern California | Genetic markers for predicting responsiveness to combination therapy |
| EP2065399A1 (en) | 2007-11-30 | 2009-06-03 | Siemens Healthcare Diagnostics GmbH | The present invention relates to methods for prediction of the therapeutic success of breast cancer therapy |
| CN101910416A (zh) * | 2007-11-09 | 2010-12-08 | 健泰科生物技术公司 | 在癌症患者中诊断性使用的方法和组合物 |
| US20100029491A1 (en) * | 2008-07-11 | 2010-02-04 | Maike Schmidt | Methods and compositions for diagnostic use for tumor treatment |
| AU2009329994B2 (en) | 2008-12-23 | 2014-04-03 | Genentech, Inc. | Methods and compositions for diagnostic use in cancer patients |
| KR101179843B1 (ko) | 2009-04-08 | 2012-09-04 | 경북대학교 산학협력단 | 뉴로필린 2의 위암 진단 및 치료용 용도 |
| CN102482715A (zh) | 2009-07-13 | 2012-05-30 | 霍夫曼-拉罗奇有限公司 | 用于癌症治疗的诊断方法和组合物 |
| MX2012001716A (es) * | 2009-08-14 | 2012-04-02 | Genentech Inc | Marcadores biologicos para monitorizar la respuesta del paciente a los antagonistas vegf. |
| AU2010297344A1 (en) * | 2009-09-17 | 2012-02-23 | F. Hoffmann-La Roche Ag | Methods and compositions for diagnostics use in cancer patients |
| CN102822676B (zh) * | 2010-01-12 | 2015-02-18 | 雀巢产品技术援助有限公司 | 用于预测三阴性乳腺癌对疗法的应答的方法 |
| AU2011208805A1 (en) | 2010-01-19 | 2012-06-21 | F. Hoffman-La Roche Ag | Tumor tissue based biomarkers for bevacizumab combination therapies |
-
2013
- 2013-01-11 KR KR1020147021823A patent/KR20140114415A/ko not_active Ceased
- 2013-01-11 AU AU2013207778A patent/AU2013207778B2/en not_active Ceased
- 2013-01-11 MX MX2014008463A patent/MX356802B/es active IP Right Grant
- 2013-01-11 JP JP2014552348A patent/JP6529261B2/ja not_active Expired - Fee Related
- 2013-01-11 RU RU2014133164A patent/RU2659173C2/ru not_active IP Right Cessation
- 2013-01-11 WO PCT/US2013/021306 patent/WO2013106765A1/en not_active Ceased
- 2013-01-11 CN CN201380013876.3A patent/CN104203268A/zh active Pending
- 2013-01-11 CA CA2862835A patent/CA2862835A1/en not_active Abandoned
- 2013-01-11 SG SG11201403927XA patent/SG11201403927XA/en unknown
- 2013-01-11 EP EP13736138.2A patent/EP2802346B1/en not_active Not-in-force
- 2013-01-11 NZ NZ627443A patent/NZ627443A/en not_active IP Right Cessation
- 2013-01-11 HK HK15105537.2A patent/HK1204933A1/xx unknown
- 2013-01-11 BR BR112014017320-6A patent/BR112014017320A2/en not_active IP Right Cessation
- 2013-03-15 US US13/837,343 patent/US20130216533A1/en not_active Abandoned
- 2013-03-15 US US13/836,535 patent/US10364466B2/en not_active Expired - Fee Related
-
2014
- 2014-06-30 IL IL233467A patent/IL233467B/en active IP Right Grant
- 2014-07-18 ZA ZA2014/05305A patent/ZA201405305B/en unknown
-
2017
- 2017-12-12 JP JP2017237944A patent/JP2018082705A/ja active Pending
-
2018
- 2018-01-12 AU AU2018200270A patent/AU2018200270A1/en not_active Abandoned
- 2018-01-24 IL IL257141A patent/IL257141A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2015512612A5 (https=) | ||
| RU2014133164A (ru) | Биологические маркеры для идентификации пациентов для лечения антагонистами vegf | |
| Wick et al. | Current status and future directions of anti-angiogenic therapy for gliomas | |
| Shen et al. | Tumor vasculature remolding by thalidomide increases delivery and efficacy of cisplatin | |
| Sun et al. | Treatment of metastatic renal cell carcinoma | |
| Torre et al. | New insights in lymphangioleiomyomatosis and pulmonary Langerhans cell histiocytosis | |
| Liebner et al. | Thyroid cancer: pathogenesis and targeted therapy | |
| Jänne et al. | Combined pan-HER and ALK/ROS1/MET Inhibition with dacomitinib and crizotinib in advanced non–small cell lung cancer: results of a phase I study | |
| JP2015516806A5 (https=) | ||
| JP2018508469A5 (https=) | ||
| Charville et al. | Surgical pathology of gastrointestinal stromal tumors: practical implications of morphologic and molecular heterogeneity for precision medicine | |
| RU2014143805A (ru) | Способы диагностики и композиции для лечения рака | |
| JP2012532628A5 (https=) | ||
| JP2019518426A5 (https=) | ||
| RU2012109556A (ru) | Биологические маркеры для мониторирования ответа пациента на антагонисты vegf | |
| US20130252956A1 (en) | Methods of treating cancer | |
| JP2017523776A5 (https=) | ||
| Ordóñez-Morán et al. | Complex metastatic niches: already a target for therapy? | |
| Bagnasco et al. | Role of angiogenesis inhibitors in colorectal cancer: sensitive and insensitive tumors | |
| JP2015514062A5 (https=) | ||
| Harari et al. | Sirolimus therapy for patients with lymphangioleiomyomatosis leads to loss of chylous ascites and circulating LAM cells | |
| Méndez-Vidal et al. | SEOM SOGUG clinical guideline for treatment of kidney cancer (2022) | |
| WO2018015522A1 (en) | Treatment for use for preventing metastasis in a subject exposed to cancer treatment inducing p38 activation | |
| Steendam et al. | Randomized phase III study of docetaxel versus docetaxel plus intercalated erlotinib in patients with relapsed non-squamous non-small cell lung carcinoma | |
| WO2022072668A1 (en) | Patient selection biomarkers for treatment with ulk inhibitors |