JP2015516449A5 - - Google Patents
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- Publication number
- JP2015516449A5 JP2015516449A5 JP2015511955A JP2015511955A JP2015516449A5 JP 2015516449 A5 JP2015516449 A5 JP 2015516449A5 JP 2015511955 A JP2015511955 A JP 2015511955A JP 2015511955 A JP2015511955 A JP 2015511955A JP 2015516449 A5 JP2015516449 A5 JP 2015516449A5
- Authority
- JP
- Japan
- Prior art keywords
- pain
- weeks
- refers
- treated
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000002193 Pain Diseases 0.000 description 6
- 208000005298 acute pain Diseases 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000002831 pharmacologic agent Substances 0.000 description 2
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12003897.1 | 2012-05-18 | ||
| EP12003897 | 2012-05-18 | ||
| PCT/EP2013/001468 WO2013170969A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano'[3,4,b]indol]-4-amine and paracetamol or propacetamol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516449A JP2015516449A (ja) | 2015-06-11 |
| JP2015516449A5 true JP2015516449A5 (https=) | 2017-03-23 |
| JP6116676B2 JP6116676B2 (ja) | 2017-04-19 |
Family
ID=48468208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511955A Active JP6116676B2 (ja) | 2012-05-18 | 2013-05-16 | （１ｒ，４ｒ）−６’−フルオロ−Ｎ，Ｎ−ジメチル−４−フェニル−４’，９’−ジヒドロ−３’Ｈ−スピロ［シクロヘキサン−１，１’−ピラノ［３，４，ｂ］インドール］−４−アミンおよびパラセタモールまたはプロパセタモールを含む医薬組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US20130310435A1 (https=) |
| EP (1) | EP2849740B1 (https=) |
| JP (1) | JP6116676B2 (https=) |
| CN (2) | CN108524498A (https=) |
| AU (1) | AU2013262075B2 (https=) |
| BR (1) | BR112014028561A2 (https=) |
| CA (1) | CA2873644A1 (https=) |
| CY (1) | CY1119610T1 (https=) |
| DK (1) | DK2849740T3 (https=) |
| EA (1) | EA026949B1 (https=) |
| ES (1) | ES2650441T3 (https=) |
| HR (1) | HRP20171438T1 (https=) |
| HU (1) | HUE034676T2 (https=) |
| IL (1) | IL235651B (https=) |
| LT (1) | LT2849740T (https=) |
| MX (1) | MX352596B (https=) |
| NO (1) | NO2849740T3 (https=) |
| PL (1) | PL2849740T3 (https=) |
| PT (1) | PT2849740T (https=) |
| RS (1) | RS56617B1 (https=) |
| SI (1) | SI2849740T1 (https=) |
| WO (1) | WO2013170969A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および／または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
| JP7373904B2 (ja) | 2016-02-29 | 2023-11-06 | パーク・セラピューティクス・インコーポレイテッド | セブラノパドールの滴定 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0068838B1 (en) | 1981-06-26 | 1986-09-17 | The Upjohn Company | Analgesic process and composition |
| US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4404208A (en) | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
| IE55189B1 (en) | 1982-07-08 | 1990-06-20 | Wyeth John & Brother Ltd | Pharmaceutical compositions |
| US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
| US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
| US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
| DE3665538D1 (en) | 1985-01-23 | 1989-10-19 | Asta Pharma Ag | Synergistic combination of flupirtin and non-steroidal anti-phlogistics |
| KR0156231B1 (ko) | 1989-05-22 | 1998-11-16 | 존 레이 비핀 | 인도메타신의 2가 전이 금속염을 함유하는 조성물 |
| CA2112378A1 (en) | 1991-07-04 | 1993-01-21 | Masakazu Kanazawa | Analgesic preparation |
| JPH05221857A (ja) * | 1992-02-14 | 1993-08-31 | Arakusu:Kk | 配合解熱鎮痛剤 |
| US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
| US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
| JPH08511522A (ja) | 1993-06-07 | 1996-12-03 | メルク エンド カンパニー インコーポレーテッド | ニューロキニンアンタゴニストとしてのスピロ置換アザ環 |
| US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
| US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
| RS49982B (sr) | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| DE69905380T2 (de) | 1998-09-10 | 2003-11-27 | Nycomed Danmark A/S, Roskilde | Pharmazeutische zusammensetzungen mit schneller freisetzung von wirkstoffen |
| CA2350531A1 (en) | 1998-11-13 | 2000-05-25 | Smriti Iyengar | Method for treating pain |
| EP1219304B1 (de) | 2000-12-28 | 2004-10-20 | Fresenius Kabi Austria GmbH | Stabile Infusionslösung von Diclofenac-Salzen, deren Herstellung und Verwendung |
| BR0307268A (pt) | 2002-01-28 | 2004-12-14 | Pfizer | Compostos de espiropiperidina n-substituìda como ligantes para o receptor orl-1 |
| EP1374906B1 (en) | 2002-06-17 | 2007-04-18 | CHIESI FARMACEUTICI S.p.A. | A process for the preparation of piroxicam: beta-cyclodextrin inclusion compounds |
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
| US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
| US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| CA2612299A1 (en) | 2005-06-17 | 2006-12-21 | Pfizer Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
| PL2012764T3 (pl) * | 2006-04-28 | 2011-04-29 | Gruenenthal Gmbh | Kombinacja farmaceutyczna zawierająca 3-(3-dimetyloamino-1-etylo-2-metylopropylo)fenol i Paracetamol |
| ATE502629T1 (de) | 2006-04-28 | 2011-04-15 | Gruenenthal Gmbh | Pharmazeutische kombination mit 3- (3- dimethylamino-1-ethyl-2-methyl-propyl) phenol und einem nsar |
| CN101147735A (zh) * | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| DE102006056458A1 (de) * | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
| ES2416723T3 (es) | 2007-10-09 | 2013-08-02 | Merck Patent Gmbh | Composiciones farmacéuticas que contienen benfotiamina y gabapentina |
| CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
| AR073277A1 (es) | 2008-09-05 | 2010-10-28 | Gruenenthal Gmbh | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y paracetamol, y uso |
| KR101730924B1 (ko) * | 2008-09-05 | 2017-04-27 | 그뤼넨탈 게엠베하 | 3-（3-디메틸아미노-1-에틸-2-메틸-프로필）-페놀과 항간질제의 약제학적 병용물 |
| AR073495A1 (es) | 2008-09-05 | 2010-11-10 | Gruenenthal Gmbh | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1- (3-metoxi-fenil)-ciclohexano-1,3-diol y un nsaid |
| AU2011287952B2 (en) * | 2010-08-04 | 2014-08-21 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(N-methyl- or N,N-dimethyl-)-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane- 1,1'-pyrano[3,4,b]indol]-4-amine |
| KR20130097173A (ko) * | 2010-08-04 | 2013-09-02 | 그뤼넨탈 게엠베하 | 신경병증성 통증을 치료하기 위한 ６’플루오로（Ｎ메틸 또는 Ｎ，Ｎ디메틸）４페닐４’，９’디하이드로３’Ｈ스피로[사이클로헥산１，１’피라노[３，４，ｂ]인돌]４아민을 포함하는 약제학적 투여형 |
| WO2012016703A2 (en) * | 2010-08-04 | 2012-02-09 | Grünenthal GmbH | Pharmaceutical dosage form comprising 6'-fluoro-(n-methyl- or n,n-dimethyl-)-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine |
| US9320729B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-flouro-N,N-dimethyl-4-phenyl-4′,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano-[3,4,b]indol]-4-amine and a propionic acid derivative |
-
2013
- 2013-05-13 US US13/892,969 patent/US20130310435A1/en not_active Abandoned
- 2013-05-16 CA CA2873644A patent/CA2873644A1/en not_active Abandoned
- 2013-05-16 HR HRP20171438TT patent/HRP20171438T1/hr unknown
- 2013-05-16 WO PCT/EP2013/001468 patent/WO2013170969A1/en not_active Ceased
- 2013-05-16 PT PT137236741T patent/PT2849740T/pt unknown
- 2013-05-16 LT LTEP13723674.1T patent/LT2849740T/lt unknown
- 2013-05-16 NO NO13723674A patent/NO2849740T3/no unknown
- 2013-05-16 SI SI201330870T patent/SI2849740T1/en unknown
- 2013-05-16 BR BR112014028561A patent/BR112014028561A2/pt not_active IP Right Cessation
- 2013-05-16 DK DK13723674.1T patent/DK2849740T3/da active
- 2013-05-16 JP JP2015511955A patent/JP6116676B2/ja active Active
- 2013-05-16 CN CN201810706944.9A patent/CN108524498A/zh active Pending
- 2013-05-16 RS RS20171229A patent/RS56617B1/sr unknown
- 2013-05-16 AU AU2013262075A patent/AU2013262075B2/en not_active Ceased
- 2013-05-16 CN CN201380025683.XA patent/CN104302282A/zh active Pending
- 2013-05-16 ES ES13723674.1T patent/ES2650441T3/es active Active
- 2013-05-16 PL PL13723674T patent/PL2849740T3/pl unknown
- 2013-05-16 EP EP13723674.1A patent/EP2849740B1/en not_active Not-in-force
- 2013-05-16 HU HUE13723674A patent/HUE034676T2/hu unknown
- 2013-05-16 MX MX2014012723A patent/MX352596B/es active IP Right Grant
- 2013-05-16 EA EA201401272A patent/EA026949B1/ru not_active IP Right Cessation
-
2014
- 2014-11-12 IL IL235651A patent/IL235651B/en active IP Right Grant
-
2017
- 2017-10-06 US US15/726,761 patent/US20180092867A1/en not_active Abandoned
- 2017-11-20 CY CY20171101212T patent/CY1119610T1/el unknown
-
2019
- 2019-07-03 US US16/502,651 patent/US11311504B2/en active Active
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