JP2015516420A5 - - Google Patents
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- Publication number
- JP2015516420A5 JP2015516420A5 JP2015511546A JP2015511546A JP2015516420A5 JP 2015516420 A5 JP2015516420 A5 JP 2015516420A5 JP 2015511546 A JP2015511546 A JP 2015511546A JP 2015511546 A JP2015511546 A JP 2015511546A JP 2015516420 A5 JP2015516420 A5 JP 2015516420A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- fluoro
- pharmaceutically acceptable
- acceptable salt
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001153 fluoro group Chemical group F* 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 19
- 239000011780 sodium chloride Substances 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- -1 (4) pyridinyl Chemical group 0.000 claims 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- CIISBYKBBMFLEZ-UHFFFAOYSA-N 1,2-oxazolidine Chemical compound C1CNOC1 CIISBYKBBMFLEZ-UHFFFAOYSA-N 0.000 claims 2
- HONIICLYMWZJFZ-UHFFFAOYSA-N Azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000005037 alkyl phenyl group Chemical group 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 150000002829 nitrogen Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 1
- 206010001897 Alzheimer's disease Diseases 0.000 claims 1
- 206010061666 Autonomic neuropathy Diseases 0.000 claims 1
- 206010057668 Cognitive disease Diseases 0.000 claims 1
- 208000001636 Diabetic Neuropathy Diseases 0.000 claims 1
- 206010012680 Diabetic neuropathy Diseases 0.000 claims 1
- 208000010412 Glaucoma Diseases 0.000 claims 1
- 201000001971 Huntington's disease Diseases 0.000 claims 1
- 206010029240 Neuritis Diseases 0.000 claims 1
- 206010029331 Neuropathy peripheral Diseases 0.000 claims 1
- 206010061536 Parkinson's disease Diseases 0.000 claims 1
- 208000001293 Peripheral Nervous System Disease Diseases 0.000 claims 1
- 206010034606 Peripheral neuropathy Diseases 0.000 claims 1
- 208000005613 Tauopathy Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001207 fluorophenyl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 201000002242 tauopathy Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2012/075185 WO2013166654A1 (en) | 2012-05-08 | 2012-05-08 | Permeable glycosidase inhibitors and uses thereof |
| CNPCT/CN2012/075185 | 2012-05-08 | ||
| US201261655641P | 2012-06-05 | 2012-06-05 | |
| US61/655,641 | 2012-06-05 | ||
| PCT/US2013/039377 WO2013169576A1 (en) | 2012-05-08 | 2013-05-03 | Permeable glycosidase inhibitors and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516420A JP2015516420A (ja) | 2015-06-11 |
| JP2015516420A5 true JP2015516420A5 (US07794700-20100914-C00152.png) | 2016-06-23 |
| JP6178843B2 JP6178843B2 (ja) | 2017-08-09 |
Family
ID=49551168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511546A Active JP6178843B2 (ja) | 2012-05-08 | 2013-05-03 | 透過性グリコシダーゼインヒビターおよびその用途 |
Country Status (10)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009276223B2 (en) | 2008-08-01 | 2015-04-02 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| WO2011140640A1 (en) | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| EP2638052B1 (en) | 2010-11-08 | 2017-03-22 | Alectos Therapeutics, Inc. | Selective glycosidase inhibitors and uses thereof |
| PT2655388T (pt) | 2010-12-23 | 2016-09-06 | Merck Sharp & Dohme | Inibidores de glicosidase seletivos e as suas utilizações |
| WO2012126091A1 (en) | 2011-03-24 | 2012-09-27 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2691407B1 (en) | 2011-03-31 | 2017-02-22 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| EP2726468B1 (en) | 2011-06-27 | 2017-04-12 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| CN103889996B (zh) | 2011-06-27 | 2016-02-03 | 阿列科托斯治疗有限公司 | 选择性糖苷酶抑制剂及其用途 |
| EP2726492B1 (en) | 2011-06-27 | 2017-11-01 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| US9809537B2 (en) | 2012-08-31 | 2017-11-07 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| EP2890676B1 (en) | 2012-08-31 | 2018-12-05 | Alectos Therapeutics Inc. | Glycosidase inhibitors and uses thereof |
| KR20150079711A (ko) | 2012-10-31 | 2015-07-08 | 알렉토스 테라퓨틱스 인크. | 글리코시다아제 저해제 및 이의 용도 |
| WO2014100934A1 (en) | 2012-12-24 | 2014-07-03 | Merck Sharp & Dohme Corp. | Glycosidase inhibitors and uses thereof |
| EP3008170A4 (en) | 2013-06-11 | 2016-11-09 | Harvard College | SC-CELLS AND COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF |
| BR112017009497A2 (pt) | 2014-11-05 | 2018-02-06 | Voyager Therapeutics, Inc. | polinucleotídeos de aadc para o tratamento da doença de parkinson |
| KR20230145206A (ko) | 2014-11-14 | 2023-10-17 | 보이저 테라퓨틱스, 인크. | 조절성 폴리뉴클레오티드 |
| MX2018014154A (es) | 2016-05-18 | 2019-05-06 | Voyager Therapeutics Inc | Polinucleotidos moduladores. |
| RU2764587C2 (ru) | 2016-05-18 | 2022-01-18 | Вояджер Терапьютикс, Инк. | Способы и композиции для лечения хореи гентингтона |
| EP3619308A4 (en) | 2017-05-05 | 2021-01-27 | Voyager Therapeutics, Inc. | COMPOSITIONS AND METHODS OF TREATMENT FOR HUNTINGTON'S MORBUS |
| JOP20190269A1 (ar) | 2017-06-15 | 2019-11-20 | Voyager Therapeutics Inc | بولي نوكليوتيدات aadc لعلاج مرض باركنسون |
| CN110407674A (zh) * | 2018-08-14 | 2019-11-05 | 重庆市化工研究院 | 4-烯丙氧基苯甲醇、合成方法及应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU1441749A1 (ru) * | 1987-03-16 | 1996-01-10 | Институт Тонкой Органической Химии Им.А.Л.Мнджояна | 2-АМИНО-5,5-ДИМЕТИЛ-4,5-ДИГИДРО-7Н-ПИРАНО [4,3-d] ТИАЗОЛ, ОБЛАДАЮЩИЙ ТРАНКВИЛИЗИРУЮЩЕЙ АКТИВНОСТЬЮ |
| EP1734821A4 (en) | 2004-04-14 | 2011-07-06 | Uab Research Foundation | ACTIVATORS OF HEXOSAMIN BINOSYNTHESIS AS AN INHIBITORS FOR INDUCED DAMAGE CAUSED BY ISCHEMIC SHOCK OR HEMORRHAGIC SHOCK |
| JP5154954B2 (ja) * | 2005-03-01 | 2013-02-27 | サイモン フレイザー ユニバーシティ | 選択的なグリコシダーゼインヒビター、インヒビターを作製する方法、およびインヒビターの使用 |
| EP2322529B1 (en) * | 2006-08-31 | 2017-12-06 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| CN101595111A (zh) * | 2006-08-31 | 2009-12-02 | 西蒙·弗雷瑟大学 | 选择性糖苷酶抑制剂及其用途 |
| AU2009276223B2 (en) | 2008-08-01 | 2015-04-02 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| WO2010012106A1 (en) | 2008-08-01 | 2010-02-04 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| JP2012502884A (ja) | 2008-09-16 | 2012-02-02 | サイモン フレイザー ユニバーシティ | 選択的グリコシダーゼ阻害剤およびその使用 |
| WO2011140640A1 (en) * | 2010-05-11 | 2011-11-17 | Simon Fraser University | Selective glycosidase inhibitors and uses thereof |
| TW201249848A (en) * | 2010-11-08 | 2012-12-16 | Merck Sharp & Dohme | Selective glycosidase inhibitors and uses thereof |
| WO2012061972A1 (en) * | 2010-11-08 | 2012-05-18 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| WO2012159262A1 (en) * | 2011-05-24 | 2012-11-29 | Alectos Therapeutics Inc. | Selective glycosidase inhibitors and uses thereof |
| WO2013025452A1 (en) | 2011-08-18 | 2013-02-21 | Merck Sharp & Dohme Corp. | Selective glycosidase inhibitors and uses thereof |
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2013
- 2013-05-03 BR BR112014027724-9A patent/BR112014027724B1/pt active IP Right Grant
- 2013-05-03 US US14/399,146 patent/US9611275B2/en active Active
- 2013-05-03 AU AU2013259892A patent/AU2013259892B2/en active Active
- 2013-05-03 CA CA2871920A patent/CA2871920C/en active Active
- 2013-05-03 CN CN201380023214.4A patent/CN104395323B/zh active Active
- 2013-05-03 KR KR1020147031131A patent/KR102108586B1/ko active IP Right Grant
- 2013-05-03 RU RU2014149183A patent/RU2707292C2/ru active
- 2013-05-03 WO PCT/US2013/039377 patent/WO2013169576A1/en active Application Filing
- 2013-05-03 JP JP2015511546A patent/JP6178843B2/ja active Active
- 2013-05-03 EP EP13787989.6A patent/EP2847199B1/en active Active
