JP2015516406A - 亜鉛を含む熱成形された不正使用防止医薬剤形 - Google Patents

亜鉛を含む熱成形された不正使用防止医薬剤形 Download PDF

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Publication number
JP2015516406A
JP2015516406A JP2015510834A JP2015510834A JP2015516406A JP 2015516406 A JP2015516406 A JP 2015516406A JP 2015510834 A JP2015510834 A JP 2015510834A JP 2015510834 A JP2015510834 A JP 2015510834A JP 2015516406 A JP2015516406 A JP 2015516406A
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JP
Japan
Prior art keywords
pharmaceutical dosage
dosage form
polyalkylene oxide
zinc
ppm
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Pending
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JP2015510834A
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English (en)
Japanese (ja)
Inventor
バルンシャイト・ルッツ
ガリア・エーリク
ガイスラー・アンヤ
ペッツ・ヤーナ
シュヴィーア・ゼバスティアン
バーロンスキー−プロープスト・ユーリア
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グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング
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Publication of JP2015516406A publication Critical patent/JP2015516406A/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2015510834A 2012-05-11 2013-05-10 亜鉛を含む熱成形された不正使用防止医薬剤形 Pending JP2015516406A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003743.7 2012-05-11
EP12003743 2012-05-11
PCT/EP2013/059728 WO2013167735A1 (en) 2012-05-11 2013-05-10 Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc

Related Child Applications (1)

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JP2017211487A Division JP6541748B2 (ja) 2012-05-11 2017-11-01 亜鉛を含む熱成形された不正使用防止医薬製剤

Publications (1)

Publication Number Publication Date
JP2015516406A true JP2015516406A (ja) 2015-06-11

Family

ID=48407572

Family Applications (2)

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JP2015510834A Pending JP2015516406A (ja) 2012-05-11 2013-05-10 亜鉛を含む熱成形された不正使用防止医薬剤形
JP2017211487A Expired - Fee Related JP6541748B2 (ja) 2012-05-11 2017-11-01 亜鉛を含む熱成形された不正使用防止医薬製剤

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JP2017211487A Expired - Fee Related JP6541748B2 (ja) 2012-05-11 2017-11-01 亜鉛を含む熱成形された不正使用防止医薬製剤

Country Status (21)

Country Link
EP (1) EP2846835B1 (enExample)
JP (2) JP2015516406A (enExample)
CN (1) CN104428002B (enExample)
AU (1) AU2013257943B2 (enExample)
BR (1) BR112014026768A2 (enExample)
CA (1) CA2870012A1 (enExample)
CY (1) CY1119637T1 (enExample)
DK (1) DK2846835T3 (enExample)
EA (1) EA029171B1 (enExample)
ES (1) ES2650945T3 (enExample)
HR (1) HRP20171718T1 (enExample)
HU (1) HUE035123T2 (enExample)
IL (1) IL234815A0 (enExample)
LT (1) LT2846835T (enExample)
MX (1) MX357783B (enExample)
NO (1) NO2846835T3 (enExample)
PL (1) PL2846835T3 (enExample)
PT (1) PT2846835T (enExample)
RS (1) RS56685B1 (enExample)
SI (1) SI2846835T1 (enExample)
WO (1) WO2013167735A1 (enExample)

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US20070048228A1 (en) 2003-08-06 2007-03-01 Elisabeth Arkenau-Maric Abuse-proofed dosage form
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de) 2004-07-01 2006-01-19 Grünenthal GmbH Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
NZ586792A (en) 2008-01-25 2012-09-28 Gruenenthal Chemie Tamper resistant controlled release pharmaceutical tablets form having convex and concave surfaces
RU2555531C2 (ru) 2009-07-22 2015-07-10 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма для чувствительных к окислению опиоидов
EP2456427B1 (en) 2009-07-22 2015-03-04 Grünenthal GmbH Hot-melt extruded controlled release dosage form
PE20131102A1 (es) 2010-09-02 2013-10-12 Gruenenthal Chemie Forma de dosificacion resistente a manipulacion que comprende una sal inorganica
NZ608865A (en) 2010-09-02 2015-03-27 Gruenenthal Chemie Tamper resistant dosage form comprising an anionic polymer
CN103857386A (zh) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 提供药物立即释放的抗破碎片剂
NO2736495T3 (enExample) 2011-07-29 2018-01-20
BR112014019988A8 (pt) 2012-02-28 2017-07-11 Gruenenthal Gmbh Forma de dosagem resistente a socamento compreendendo um composto farmacologicamente ativo e um polímero aniônico
AR090695A1 (es) 2012-04-18 2014-12-03 Gruenenthal Gmbh Forma de dosificacion farmaceutica resistente a la adulteracion y resistente a la liberacion inmediata de la dosis
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
AR096439A1 (es) 2013-05-29 2015-12-30 Gruenenthal Gmbh Forma de dosificación resistente al uso indebido que contiene una o más partículas
WO2014191397A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
CA2917136C (en) 2013-07-12 2022-05-31 Grunenthal Gmbh Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
JP6480936B2 (ja) 2013-11-26 2019-03-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング クライオミリングによる粉末状医薬組成物の調製
JP2017518980A (ja) 2014-05-12 2017-07-13 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング タペンタドールを含む、改変防止即時放出カプセル製剤
US9872835B2 (en) 2014-05-26 2018-01-23 Grünenthal GmbH Multiparticles safeguarded against ethanolic dose-dumping
BR112017022856A2 (pt) 2015-04-24 2018-07-17 Gruenenthal Gmbh combinação de dose fixa inviolável que proporciona rápida liberação de duas drogas a partir de partículas
AU2016251302A1 (en) 2015-04-24 2017-11-23 Grünenthal GmbH Tamper-resistant fixed dose combination providing fast release of two drugs from particles and a matrix
AU2016251853A1 (en) 2015-04-24 2017-11-23 Grünenthal GmbH Tamper-resistant fixed dose combination providing fast release of two drugs from different particles
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
US11234974B2 (en) 2015-05-28 2022-02-01 Lumosa Therapeutics Co., Ltd. Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
US10183018B2 (en) 2015-05-28 2019-01-22 Lumosa Therapeutics Co., Ltd. Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
US10842750B2 (en) 2015-09-10 2020-11-24 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

Citations (4)

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Publication number Priority date Publication date Assignee Title
JPH0517566A (ja) * 1991-07-11 1993-01-26 Sumitomo Seika Chem Co Ltd アルキレンオキシド重合体の製造方法
JP2007501201A (ja) * 2003-08-06 2007-01-25 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 乱用防止剤形
WO2011009603A1 (en) * 2009-07-22 2011-01-27 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive oploids
EP2402004A2 (en) * 2003-11-26 2012-01-04 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms

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DE10361596A1 (de) 2003-12-24 2005-09-29 Grünenthal GmbH Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de) 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE10336400A1 (de) 2003-08-06 2005-03-24 Grünenthal GmbH Gegen Missbrauch gesicherte Darreichungsform
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JPH0517566A (ja) * 1991-07-11 1993-01-26 Sumitomo Seika Chem Co Ltd アルキレンオキシド重合体の製造方法
JP2007501201A (ja) * 2003-08-06 2007-01-25 グリューネンタ−ル・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 乱用防止剤形
EP2402004A2 (en) * 2003-11-26 2012-01-04 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
WO2011009603A1 (en) * 2009-07-22 2011-01-27 Grünenthal GmbH Tamper-resistant dosage form for oxidation-sensitive oploids

Also Published As

Publication number Publication date
PL2846835T3 (pl) 2018-02-28
LT2846835T (lt) 2017-12-27
RS56685B1 (sr) 2018-03-30
MX357783B (es) 2018-07-25
PT2846835T (pt) 2017-12-15
NO2846835T3 (enExample) 2018-02-03
HRP20171718T1 (hr) 2017-12-29
AU2013257943B2 (en) 2017-10-05
CN104428002B (zh) 2017-08-11
EA029171B1 (ru) 2018-02-28
JP2018065810A (ja) 2018-04-26
CN104428002A (zh) 2015-03-18
MX2014013095A (es) 2014-12-08
AU2013257943A1 (en) 2014-10-09
HUE035123T2 (en) 2018-05-02
HK1207978A1 (en) 2016-02-19
CA2870012A1 (en) 2013-11-14
JP6541748B2 (ja) 2019-07-10
WO2013167735A1 (en) 2013-11-14
BR112014026768A2 (pt) 2017-06-27
EP2846835A1 (en) 2015-03-18
IL234815A0 (en) 2014-12-31
DK2846835T3 (en) 2017-12-04
SI2846835T1 (en) 2018-01-31
CY1119637T1 (el) 2018-04-04
ES2650945T3 (es) 2018-01-23
EP2846835B1 (en) 2017-09-06
EA201401240A1 (ru) 2015-04-30

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