CN104428002B - 热成形的抗篡改含锌药物剂型 - Google Patents

热成形的抗篡改含锌药物剂型 Download PDF

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Publication number
CN104428002B
CN104428002B CN201380024652.2A CN201380024652A CN104428002B CN 104428002 B CN104428002 B CN 104428002B CN 201380024652 A CN201380024652 A CN 201380024652A CN 104428002 B CN104428002 B CN 104428002B
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China
Prior art keywords
pharmaceutical dosage
dosage form
weight
polyalkylene oxide
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201380024652.2A
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English (en)
Chinese (zh)
Other versions
CN104428002A (zh
Inventor
L.巴恩沙伊德
E.加利亚
A.盖斯勒
J.珀茨
S.施维尔
J.巴龙斯基-普罗布斯特
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Gruenenthal GmbH
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Gruenenthal GmbH
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CN201380024652.2A 2012-05-11 2013-05-10 热成形的抗篡改含锌药物剂型 Expired - Fee Related CN104428002B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003743 2012-05-11
EP12003743.7 2012-05-11
PCT/EP2013/059728 WO2013167735A1 (en) 2012-05-11 2013-05-10 Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc

Publications (2)

Publication Number Publication Date
CN104428002A CN104428002A (zh) 2015-03-18
CN104428002B true CN104428002B (zh) 2017-08-11

Family

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Family Applications (1)

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CN201380024652.2A Expired - Fee Related CN104428002B (zh) 2012-05-11 2013-05-10 热成形的抗篡改含锌药物剂型

Country Status (21)

Country Link
EP (1) EP2846835B1 (enExample)
JP (2) JP2015516406A (enExample)
CN (1) CN104428002B (enExample)
AU (1) AU2013257943B2 (enExample)
BR (1) BR112014026768A2 (enExample)
CA (1) CA2870012A1 (enExample)
CY (1) CY1119637T1 (enExample)
DK (1) DK2846835T3 (enExample)
EA (1) EA029171B1 (enExample)
ES (1) ES2650945T3 (enExample)
HR (1) HRP20171718T1 (enExample)
HU (1) HUE035123T2 (enExample)
IL (1) IL234815A0 (enExample)
LT (1) LT2846835T (enExample)
MX (1) MX357783B (enExample)
NO (1) NO2846835T3 (enExample)
PL (1) PL2846835T3 (enExample)
PT (1) PT2846835T (enExample)
RS (1) RS56685B1 (enExample)
SI (1) SI2846835T1 (enExample)
WO (1) WO2013167735A1 (enExample)

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PL2997965T3 (pl) 2009-07-22 2019-06-28 Grünenthal GmbH Odporna na manipulacje postać dawkowania opioidów wrażliwych na utlenianie
WO2011009602A1 (en) 2009-07-22 2011-01-27 Grünenthal GmbH Hot-melt extruded controlled release dosage form
EP2611426B1 (en) 2010-09-02 2014-06-25 Grünenthal GmbH Tamper resistant dosage form comprising inorganic salt
ES2487244T3 (es) 2010-09-02 2014-08-20 Grünenthal GmbH Forma de dosificación resistente a la manipulación que comprende un polímero aniónico
CA2839123A1 (en) 2011-07-29 2013-02-07 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
US20130028972A1 (en) 2011-07-29 2013-01-31 Grunenthal Gmbh Tamper-resistant tablet providing immediate drug release
JP6117249B2 (ja) 2012-02-28 2017-04-19 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 薬理学的に活性な化合物および陰イオン性ポリマーを含むタンパーレジスタント剤形
HRP20181716T1 (hr) 2012-04-18 2018-12-28 Grünenthal GmbH Farmaceutski oblik doziranja otporan na zlonamjernu uporabu i naglo oslobađanje cjelokupne doze
US10064945B2 (en) 2012-05-11 2018-09-04 Gruenenthal Gmbh Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
US9737490B2 (en) 2013-05-29 2017-08-22 Grünenthal GmbH Tamper resistant dosage form with bimodal release profile
WO2014191397A1 (en) 2013-05-29 2014-12-04 Grünenthal GmbH Tamper-resistant dosage form containing one or more particles
WO2015004245A1 (en) 2013-07-12 2015-01-15 Grünenthal GmbH Tamper-resistant dosage form containing ethylene-vinyl acetate polymer
HK1224189A1 (zh) 2013-11-26 2017-08-18 Grünenthal GmbH 通过低温研磨制备粉状药物组合物
MX2016014738A (es) 2014-05-12 2017-03-06 Gruenenthal Gmbh Formulacion en capsula de liberacion inmediata resistente a alteraciones que comprende tapentadol.
MX2016015417A (es) 2014-05-26 2017-02-22 Gruenenthal Gmbh Multiparticulas protegidas contra vertido de dosis etanolico.
JP2018513872A (ja) 2015-04-24 2018-05-31 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング 異なる粒子から２種の薬物の急速放出をもたらすタンパレジスタントな固定用量組合せ
WO2016170094A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant fixed dose combination providing fast release of two drugs from particles
WO2016170093A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant fixed dose combination providing fast release of two drugs from particles and a matrix
EA035434B1 (ru) 2015-04-24 2020-06-15 Грюненталь Гмбх Защищенная от применения не по назначению лекарственная форма с немедленным высвобождением и устойчивостью к экстракции растворителями
US11234974B2 (en) 2015-05-28 2022-02-01 Lumosa Therapeutics Co., Ltd. Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
US10183018B2 (en) 2015-05-28 2019-01-22 Lumosa Therapeutics Co., Ltd. Pharmaceutical formulations for sustained release of sebacoyl dinalbuphine ester
EP3346991A1 (en) 2015-09-10 2018-07-18 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations

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CN101198317A (zh) * 2005-06-13 2008-06-11 弗拉梅技术公司 含抗滥用系统的口服剂型
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CN101027044A (zh) * 2004-07-01 2007-08-29 格吕伦塔尔有限公司 避免滥用的口服剂型
CN101198317A (zh) * 2005-06-13 2008-06-11 弗拉梅技术公司 含抗滥用系统的口服剂型

Also Published As

Publication number Publication date
RS56685B1 (sr) 2018-03-30
EP2846835B1 (en) 2017-09-06
ES2650945T3 (es) 2018-01-23
PT2846835T (pt) 2017-12-15
EP2846835A1 (en) 2015-03-18
DK2846835T3 (en) 2017-12-04
LT2846835T (lt) 2017-12-27
SI2846835T1 (en) 2018-01-31
JP6541748B2 (ja) 2019-07-10
JP2015516406A (ja) 2015-06-11
CY1119637T1 (el) 2018-04-04
CN104428002A (zh) 2015-03-18
EA201401240A1 (ru) 2015-04-30
HUE035123T2 (en) 2018-05-02
JP2018065810A (ja) 2018-04-26
HRP20171718T1 (hr) 2017-12-29
AU2013257943B2 (en) 2017-10-05
WO2013167735A1 (en) 2013-11-14
AU2013257943A1 (en) 2014-10-09
CA2870012A1 (en) 2013-11-14
BR112014026768A2 (pt) 2017-06-27
PL2846835T3 (pl) 2018-02-28
NO2846835T3 (enExample) 2018-02-03
EA029171B1 (ru) 2018-02-28
MX357783B (es) 2018-07-25
IL234815A0 (en) 2014-12-31
HK1207978A1 (en) 2016-02-19
MX2014013095A (es) 2014-12-08

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Granted publication date: 20170811

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CF01 Termination of patent right due to non-payment of annual fee