JP2015516240A5 - - Google Patents
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- JP2015516240A5 JP2015516240A5 JP2015511774A JP2015511774A JP2015516240A5 JP 2015516240 A5 JP2015516240 A5 JP 2015516240A5 JP 2015511774 A JP2015511774 A JP 2015511774A JP 2015511774 A JP2015511774 A JP 2015511774A JP 2015516240 A5 JP2015516240 A5 JP 2015516240A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo
- ophthalmic
- arm
- electrophilic
- nucleophilic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000001727 in vivo Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 11
- 238000009472 formulation Methods 0.000 claims 10
- 239000000178 monomer Substances 0.000 claims 10
- 229920005862 polyol Polymers 0.000 claims 10
- 150000003077 polyols Chemical class 0.000 claims 9
- 230000000269 nucleophilic effect Effects 0.000 claims 8
- 238000002360 preparation method Methods 0.000 claims 8
- 239000000499 gel Substances 0.000 claims 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 4
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 4
- PTJWCLYPVFJWMP-UHFFFAOYSA-N 2-[[3-hydroxy-2-[[3-hydroxy-2,2-bis(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propoxy]methyl]-2-(hydroxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC(CO)(CO)COCC(CO)(CO)CO PTJWCLYPVFJWMP-UHFFFAOYSA-N 0.000 claims 3
- 235000010443 alginic acid Nutrition 0.000 claims 3
- 229920000615 alginic acid Polymers 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 230000002708 enhancing effect Effects 0.000 claims 3
- 229920000609 methyl cellulose Polymers 0.000 claims 3
- 239000001923 methylcellulose Substances 0.000 claims 3
- 235000010981 methylcellulose Nutrition 0.000 claims 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 3
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 2
- 229920001661 Chitosan Polymers 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
- 206010038848 Retinal detachment Diseases 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229920002385 Sodium hyaluronate Polymers 0.000 claims 2
- 229940072056 alginate Drugs 0.000 claims 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 2
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 2
- 229940045110 chitosan Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 125000003827 glycol group Chemical group 0.000 claims 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 2
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 2
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 2
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 2
- 229960002900 methylcellulose Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
- 229940068984 polyvinyl alcohol Drugs 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- 230000004264 retinal detachment Effects 0.000 claims 2
- 229940010747 sodium hyaluronate Drugs 0.000 claims 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 1
- 150000003923 2,5-pyrrolediones Chemical class 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 241000416162 Astragalus gummifer Species 0.000 claims 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 claims 1
- 240000007472 Leucaena leucocephala Species 0.000 claims 1
- 229920002774 Maltodextrin Polymers 0.000 claims 1
- 239000005913 Maltodextrin Substances 0.000 claims 1
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 1
- 229920001100 Polydextrose Polymers 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- 229920001615 Tragacanth Polymers 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 229940023476 agar Drugs 0.000 claims 1
- 235000010419 agar Nutrition 0.000 claims 1
- 239000000783 alginic acid Substances 0.000 claims 1
- 229960001126 alginic acid Drugs 0.000 claims 1
- 150000004781 alginic acids Chemical class 0.000 claims 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 claims 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 claims 1
- 239000000440 bentonite Substances 0.000 claims 1
- 229940092782 bentonite Drugs 0.000 claims 1
- 229910000278 bentonite Inorganic materials 0.000 claims 1
- 235000012216 bentonite Nutrition 0.000 claims 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 claims 1
- 229960001631 carbomer Drugs 0.000 claims 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims 1
- 229940084030 carboxymethylcellulose calcium Drugs 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- 229940082500 cetostearyl alcohol Drugs 0.000 claims 1
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 1
- 229940086555 cyclomethicone Drugs 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 229960004667 ethyl cellulose Drugs 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229940014259 gelatin Drugs 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 238000001879 gelation Methods 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229960005150 glycerol Drugs 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 229910000271 hectorite Inorganic materials 0.000 claims 1
- KWLMIXQRALPRBC-UHFFFAOYSA-L hectorite Chemical compound [Li+].[OH-].[OH-].[Na+].[Mg+2].O1[Si]2([O-])O[Si]1([O-])O[Si]([O-])(O1)O[Si]1([O-])O2 KWLMIXQRALPRBC-UHFFFAOYSA-L 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000001341 hydroxy propyl starch Substances 0.000 claims 1
- 235000013828 hydroxypropyl starch Nutrition 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 229940035034 maltodextrin Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 claims 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
- 229940100655 ophthalmic gel Drugs 0.000 claims 1
- 229950005134 polycarbophil Drugs 0.000 claims 1
- 235000013856 polydextrose Nutrition 0.000 claims 1
- 239000001259 polydextrose Substances 0.000 claims 1
- 229940035035 polydextrose Drugs 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 229960003975 potassium Drugs 0.000 claims 1
- 239000001103 potassium chloride Substances 0.000 claims 1
- 235000011164 potassium chloride Nutrition 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 229910000275 saponite Inorganic materials 0.000 claims 1
- 235000010413 sodium alginate Nutrition 0.000 claims 1
- 239000000661 sodium alginate Substances 0.000 claims 1
- 229940005550 sodium alginate Drugs 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229960002668 sodium chloride Drugs 0.000 claims 1
- 229940012831 stearyl alcohol Drugs 0.000 claims 1
- -1 succinimidyl Chemical group 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 229960004793 sucrose Drugs 0.000 claims 1
- 229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 claims 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 235000010487 tragacanth Nutrition 0.000 claims 1
- 239000000196 tragacanth Substances 0.000 claims 1
- 229940116362 tragacanth Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261646227P | 2012-05-11 | 2012-05-11 | |
| US61/646,227 | 2012-05-11 | ||
| US201261669577P | 2012-07-09 | 2012-07-09 | |
| US61/669,577 | 2012-07-09 | ||
| US201361785358P | 2013-03-14 | 2013-03-14 | |
| US61/785,358 | 2013-03-14 | ||
| PCT/US2013/040619 WO2013170195A1 (en) | 2012-05-11 | 2013-05-10 | Biocompatible hydrogel treatments for retinal detachment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015516240A JP2015516240A (ja) | 2015-06-11 |
| JP2015516240A5 true JP2015516240A5 (enExample) | 2016-06-30 |
| JP6206987B2 JP6206987B2 (ja) | 2017-10-04 |
Family
ID=49551314
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015511774A Active JP6206987B2 (ja) | 2012-05-11 | 2013-05-10 | 網膜剥離の処置のための生体適合性ヒドロゲル製剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US9072809B2 (enExample) |
| EP (1) | EP2846847B1 (enExample) |
| JP (1) | JP6206987B2 (enExample) |
| CN (1) | CN104428014B (enExample) |
| AU (1) | AU2013259166B2 (enExample) |
| CA (1) | CA2873105C (enExample) |
| WO (1) | WO2013170195A1 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US10189773B2 (en) | 2010-05-07 | 2019-01-29 | Medicus Biosciences, Llc | In-vivo gelling pharmaceutical pre-formulation |
| US11083821B2 (en) | 2011-08-10 | 2021-08-10 | C.P. Medical Corporation | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| US10111985B2 (en) | 2011-08-10 | 2018-10-30 | Medicus Biosciences, Llc | Biocompatible hydrogel polymer formulations for the controlled delivery of biomolecules |
| EP2846847B1 (en) | 2012-05-11 | 2020-03-25 | C.P. Medical Corporation | Biocompatible hydrogel treatments for retinal detachment |
| HK1219440A1 (zh) | 2013-03-14 | 2017-04-07 | 塞乐杰利克斯公司 | 基於聚二醇的固体生物相容性预制剂 |
| AU2014305778B2 (en) | 2013-08-08 | 2019-11-21 | Ligand Pharmaceuticals Incorporated | Topical compositions and methods of using the same |
| JP6552511B2 (ja) | 2013-10-11 | 2019-07-31 | マサチューセッツ アイ アンド イヤー インファーマリー | 祖先ウイルス配列を予測する方法およびその使用 |
| US10322082B2 (en) | 2014-07-11 | 2019-06-18 | Novan, Inc. | Topical antiviral compositions and methods of using the same |
| WO2016100355A1 (en) * | 2014-12-15 | 2016-06-23 | The Regents Of The University Of Colorado, A Body Corporate | Biocompatible hydrogels, systems including the hydrogels, and methods of using and forming same |
| EP3291765A4 (en) * | 2015-05-07 | 2019-01-23 | Massachusetts Eye & Ear Infirmary | METHOD FOR THE DELIVERY OF AN ACTIVE SUBSTANCE TO THE EYE |
| JP2018531634A (ja) * | 2015-10-28 | 2018-11-01 | テクノロジー イノベーション モメンタム ファンド（イスラエル）リミテッド パートナーシップＴｅｃｈｎｏｌｏｇｙ Ｉｎｎｏｖａｔｉｏｎ Ｍｏｍｅｎｔｕｍ Ｆｕｎｄ（ｉｓｒａｅｌ）Ｌｉｍｉｔｅｄ Ｐａｒｔｎｅｒｓｈｉｐ | 複合生体接着性シーラント |
| CA3006032A1 (en) * | 2015-12-14 | 2017-06-22 | Novartis Ag | Patch for sealing retinal breaks and associated devices, systems, and methods |
| BR122021015728B1 (pt) * | 2016-07-13 | 2022-02-22 | Massachusetts Eye And Ear Infirmary | Formulação ocular injetável para a formação de um hidrogel no olho de um indivíduo |
| WO2018213433A1 (en) * | 2017-05-16 | 2018-11-22 | Biocure, Inc. | Hydrogel medical adhesives |
| EP3649175A1 (en) * | 2017-07-07 | 2020-05-13 | Basf Se | Alkoxylated esteramines and salts thereof |
| CA3070212A1 (en) * | 2017-07-20 | 2019-01-24 | Riken | Method for preserving neural tissue |
| BR112020014071A2 (pt) * | 2018-01-12 | 2020-12-01 | Pykus Therapeutics, Inc. | métodos, formulações contendo polímero e composições de polímero para tratamento de descolamento da retina e outros distúrbios oculares |
| EP3775266A4 (en) | 2018-04-05 | 2021-06-30 | Massachusetts Eye and Ear Infirmary | METHOD OF MANUFACTURING AND USING COMBINATIONAL BAR-CODED NUCLEIC ACID LIBRARIES WITH DEFINED VARIATION |
| JP2021530480A (ja) * | 2018-07-09 | 2021-11-11 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | ハイドロゲルにおける放出速度の調整 |
| US12089893B2 (en) | 2018-07-19 | 2024-09-17 | Sanulus Medical, LLC | Devices and methods for targeted delivery of a substance |
| KR102850290B1 (ko) | 2018-07-19 | 2025-08-25 | 사눌러스 메디칼, 엘엘씨 | 물질의 타겟화된 전달을 위한 디바이스 및 방법 |
| JP2023510380A (ja) * | 2020-01-16 | 2023-03-13 | 香港科技大学 | 標的剤の放出制御のための組成物及び方法 |
| TW202139993A (zh) * | 2020-03-16 | 2021-11-01 | 瑞士商辛鐵堤卡公司 | 具有經改良之功能性的眼用氯普魯卡因(chloroprocaine)凝膠 |
| CN115209926B (zh) * | 2020-03-25 | 2024-05-14 | 学校法人福冈大学 | 用于眼内膜剥离术的制剂 |
| US20210346208A1 (en) * | 2020-05-05 | 2021-11-11 | Meghana Sai Sunkara | AlgaeAid |
| WO2023086098A1 (en) * | 2021-11-12 | 2023-05-19 | Ocular Therapeutix, Inc. | Ocular sealant formulations and systems and methods of preparation and use thereof |
| US11883378B2 (en) | 2021-11-24 | 2024-01-30 | Pykus Therapeutics, Inc. | Hydrogel formulations and methods and devices for focal administration of the same |
| US12233157B1 (en) | 2024-07-24 | 2025-02-25 | Pykus Therapeutics, Inc. | Hydrogel formulations and methods and devices for administration of the same |
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