WO2006089993B1 - Procedimiento de obtención de hidrogeles de ciclodextrinas con glicidiléteres, las composiciones obtenidas y sus aplicaciones - Google Patents

Procedimiento de obtención de hidrogeles de ciclodextrinas con glicidiléteres, las composiciones obtenidas y sus aplicaciones

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Publication number
WO2006089993B1
WO2006089993B1 PCT/ES2006/000096 ES2006000096W WO2006089993B1 WO 2006089993 B1 WO2006089993 B1 WO 2006089993B1 ES 2006000096 W ES2006000096 W ES 2006000096W WO 2006089993 B1 WO2006089993 B1 WO 2006089993B1
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WIPO (PCT)
Prior art keywords
hydrogels
cyclodextrins
compositions
ether
cyclodextrin
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PCT/ES2006/000096
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English (en)
French (fr)
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WO2006089993A2 (es
WO2006089993A3 (es
Inventor
Lorenzo Carmen Alvarez
Sanchez Car Rodriguez-Tenreiro
Labandeira Juan Jose Torres
Nine Angel Concheiro
Original Assignee
Univ Santiago Compostela
Lorenzo Carmen Alvarez
Sanchez Car Rodriguez-Tenreiro
Labandeira Juan Jose Torres
Nine Angel Concheiro
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Application filed by Univ Santiago Compostela, Lorenzo Carmen Alvarez, Sanchez Car Rodriguez-Tenreiro, Labandeira Juan Jose Torres, Nine Angel Concheiro filed Critical Univ Santiago Compostela
Priority to US11/887,167 priority Critical patent/US20090214604A1/en
Priority to EP06725794A priority patent/EP1873167A4/en
Publication of WO2006089993A2 publication Critical patent/WO2006089993A2/es
Publication of WO2006089993A3 publication Critical patent/WO2006089993A3/es
Publication of WO2006089993B1 publication Critical patent/WO2006089993B1/es

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Abstract

Procedimiento de obtención de hidrogeles a base de ciclodextrinas, de ciclodextrinas y éteres de celulosa, o de ciclodextrinas y goma guar o sus derivados, utilizando como agente reticulante moléculas que contienen dos o más grupos glicidiléter en su estructura; las composiciones obtenidas capaces de incorporar fármacos y sustancias activas, que forman complejos de inclusión con ciclodextrinas; su uso como componentes de dispositivos de liberación controlada, tales como formas farmacéuticas transdérmicas, formas transmucosales bucales, orales, rectales, oculares, óticas o vaginales, e implantes parenterales, destinadas a administrar fármacos o sustancias activas a humanos, animales o plantas, o como componentes de preparados cosméticos; y el uso de las composiciones como secuestrantes, en la extracción de moléculas tóxicas o biológicas en organismos vivos o de sustancias contaminantes en aguas.

Claims

27REIVINDICACIONES MODIFICADAS recibidas por Ia oficina Internacional el 14 septiembre 2006 (14.09.2006)
1. Procedimiento de obtención de hidrogcles caracterizado por que los hidrogeles están constituidos por: i. ciclodextrinas o sus derivados, y éteres de celulosa hidrosolubles o sus derivados hidrosolubles ; o ii. ciclodextrinas o sus derivados, y gomas guar o sus derivados; iii, y, además, empleando como agente reticulante moléculas que contienen en su estructura dos o más grupos glicidiléter,
2. Procedimiento de obtención de hidrogeles, según la reivindicación 1, caracterizado porque en el caso i) comprende las siguientes etapas: a) disolución de la ciclodextrina o de in derivado de ciclodextrina y del éter de celulosa o de un derivado del éter de celulosa en agua o medio hidroalcohólico; b) ajuste del pH de la disolución; c) incorporación del agente reticulante y homogeneización de la mezcla; d) transferencia a un molde; e) mantenimiento en cámara termostatizada a temperatura comprendida entra 0 y 100°C; f) extracción del molde; g) lavado del hidrogcl; b) división en porciones de forma y tamaño adecuados.
3. Procedimiento de obtención de hidrogeles, según la reivindicación 1 caracterizado porque en el caso ii) comprende las siguientes etapas: a) disolución de la ciclodextrina o de un derivado de ciclodextrina, y de la goma guar o de un derivado de goma guar en agua o medio hidroalcohólico; y a continuación las etapas b) a h) de la reivindicación 2.
4. Procedimiento de obtención de hidrogeles, según las reivindicaciones 1, 2 y 3, caracterizado porque en las etapas a) y b) el medio de reacción es agua o medio hidroalcobólico y presenta un pH ácido, neutro o alcalino.
5- Procedimiento de obtención de hidrogeles, según las reivindicaciones 1, 2, 3 y 4, que incluye una etapa de secado de los hidrogeles en estufa de vacio o con corriente de aire, o por liofilización, entre las etapas g) y h) o después de la h).
6. Procedimiento de obtención de hidrogeles, según las reivindicaciones anteriores, caracterizado porque las ciclodextrinas o sus derivados son las α-, β- y γ- ciclodextrinas, las ciclodextrinas compuestas por más de ocho unidades de α-1.4- glucopiranosa, y los derivados metil-, etil-, butil-, hidroxietil-, 2-hidroxipropil- , 2- hidroxibutil-, acetil-, propionil-, butiril-, succinil-, benzoil-. palmitil-, toluensulfonil-, acetilmetil-, acetil outil-, glucosil-, maltosil-, carboximetil éter-, carboximetil etil-, fosfato éster-, 3-tr..τfietilainoi-iun-- sulfobutil éter- ciclodextrina- y los polímeros de ciclodextrina.
7. Procedimiento de obtención de hidrogeles, según las reivindicaciones 1 y 2, caracterizado porque los éteres de celnlosa o sus derivados son éteres iónicos o no iónicos, tales como metilcelulosa (MC), hidroxietilmetilcelulosa (HEMC), hidroxipropilcelulosa (HPC), hjdroxipropilmetilcelulosa (HPMC), hidroxietilcelulosa (HEC), elilhidroxío;ilcelulosa (EHEC), carboximetilcelulosa sódica (CMCNa), las sales de amonio cuaterrario de hidroxietilcelulosa con sustituyente trimetilarnonio y los copolímeros de hid: oxietil celulosa y cloruro de dimetil dialilamonio.
S. Procedir- iento de obtención de hidrogeles. según las reivindicaciones 1 y 3, caracterizado porqi. e las gomas guar o sus derivados son cualquier goma guar, cualquier goma guar modif cada o cualquier derivado de goma guar, como cualquier éter hidroxipropilado o carboxibidroxipropüado, cualquier derivado catióπico o cualquier producto resultanti; de su depolimerización.
9. Procedimiento de obtención de hidrogeles, según las reivindicaciones 1 a 5, caracterizado porque el agente reticulante es una sustancia que contiene en su estructura dos o más grupos glicidiléter; entendiéndose por glicidiléter: oxírano, epóxido, u óxido de alqueno; tales como: diglicidiléter. etüenglicoldiglicidileter, dietilenglicoJdiglieidileter, propilenglicoldiglicidiléter, polietilεnglicolpoliglicidileier,
Figure imgf000004_0001
gliceroltriglicidileter, poliglicerolpoliglicidileter y bisfenol A diglicidilcter-
10. Procedimiento de obtención de hidrogeles, según las reivindicaciones 1, 2, 7 y 9, caracterizado porque la proporción de ciclodextrina o del derivado de ciclodextrina está comprendida intre el 1% y el 95%; la proporción de éter de celulosa o del derivado de éter de celulosa está comprendida entre el 0,05% y el 95%; y la proporción del agente reticulante está comprendida entre 98.95% y el 4% del total de los componentes del lήdrogel.
11. Procedimiento deobtención de hidrogeles, según las reivindicaciones 1, 3, 8 y 9, caracterizado porque la proporción de ciclodextriπa o del derivado de ciclodextrina está comprendida entre el 1% y el 95%: la proporción de goma guar o del derivado de goma guar está co.nprendida entre el 0.05% y el 95%; y la proporción del agente reticulante está comprendida entre 98.95% y el 4% del total de los componentes del hidrogel.
12. Procedí -niento de obtención de hidrogeles, según las reivindicaciones anteriores, que incluye una etapa de incorporación de fármaco o de sustancia activa por inmersión del hidrogel, húmedo o previamente desecado, en una disolución o en una suspensión del fármaco o de la sustancia activa, a temperatura comprendida entre 0 y 100°C y a la presión atmosférica, con ayuda o no de ultrasonidos. La incorporación también se puede levar a cabo en autoclave a temperatura comprendida entre 100 y 130°C
13. Composiciones obtenidas según las reivindicaciones anteriores.
14. Composiciones, según las reivindicaciones anteriores, que incorporan a los hidrogeles, fármacos, sustancias activas o nutrientes para su liberación controlada.
15. Composiciones, según las reivindicaciones anteriores, caracterizadas porque, en organismos vivos o en el medioambiente, capturan sustancias biológicas o tóxicas actuando como age ntes secuestrantes.
16. Uso de las composiciones, según las reivindicaciones anteriores, para la elaboración de un medicamento o un producto fitosanitario para el tratamiento de estados patológico 3 o fisiológicos en humanos, animales y plantas.
17.- Uso de las composiciones, según la reivindicación 18, para la elaboración de un medicamen:o para administrar por vía transdérmica, transmucosal, bucal, oral, rectal, ocular, nasal, ótica o vaginal, o como implante parenteral
18.- Uso de las composiciones, según las reivindicaciones 1 a 15, para la preparación de cosméticos.
19. Uso de las composiciones, según la reivindicación 15, para la elaboración de un agente secucsirante de sustancias biológicas o tóxicas para actuar en organismos vivos o en el medi'oambiente.
PCT/ES2006/000096 2005-02-25 2006-02-15 Procedimiento de obtención de hidrogeles de ciclodextrinas con glicidiléteres, las composiciones obtenidas y sus aplicaciones WO2006089993A2 (es)

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