JP2015514991A - 集積化センサ - Google Patents
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- JP2015514991A JP2015514991A JP2015506946A JP2015506946A JP2015514991A JP 2015514991 A JP2015514991 A JP 2015514991A JP 2015506946 A JP2015506946 A JP 2015506946A JP 2015506946 A JP2015506946 A JP 2015506946A JP 2015514991 A JP2015514991 A JP 2015514991A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
- G01N2035/00019—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones cassette structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
本発明は、米国防総省国防高等研究計画局(Defense Advanced Research Projects Agency)(DARPA)からの認可、契約番号第HR0011−09−3−0002によって部分的に資金提供を受けた研究の過程で行われた。米国政府は本発明に一定の権利を有する。
Claims (15)
- 集積化センサであって、
基材と、
前記基材の表面上に形成された検知部材と、
を備え、
前記検知部材は、
崩壊可能信号増幅構造と、
前記崩壊可能信号増幅構造を囲むエリアであって、該エリアに暴露される液滴の前記崩壊可能信号増幅構造に向かう自己位置決めを可能にする、エリアと、
を含む、集積化センサ。 - 前記崩壊可能信号増幅構造を囲むエリアは、前記崩壊可能信号増幅構造より疎水性が高い、請求項1に記載の集積化センサ。
- 前記崩壊可能信号増幅構造を囲むエリアは、前記基材上に形成されたポリマピラーのグラジエントを含み、該ポリマピラーのグラジエントは、前記検知部材の周辺において、より密である、請求項2に記載の集積化センサ。
- 前記崩壊可能信号増幅構造は、金属キャップ付きポリマピラー、金属コーティング式ポリマ・ナノフレーク、金属コーティング式マッシュルーム状構造、又は金属リング付きポリマピラーを含み、
前記グラジエント内の前記ポリマピラーは信号増幅材料がない、請求項3に記載の集積化センサ。 - 前記崩壊可能信号増幅構造を囲むエリアは、該エリア上に堆積された疎水性分子を含む、請求項2に記載の集積化センサ。
- 前記崩壊可能信号増幅構造を囲むエリアは、前記基材の表面内に画定された溝を含み、該溝は、前記液滴を前記崩壊可能信号増幅構造に向かって方向付ける形状を有する、請求項1に記載の集積化センサ。
- 前記崩壊可能信号増幅構造は、所定の形状に制御可能に位置決めされて、多角形組立体を形成し、
前記検知部材は、制御されたパターンに配列された多角形組立体のアレイを含む、請求項1に記載の集積化センサ。 - 複数の離間した検知部材を含む、請求項1に記載の集積化センサ。
- 検知システムであって、
請求項1に記載される集積化センサと、
前記集積化センサを受取り、分配点から受取り点まで前記基材を割出し送りする検知デバイスと、
を備え、前記検知デバイスは、
前記基材が割出し送りされるときに、前記検知部材上にサンプルを分注する分注システムと、
前記検知部材が前記サンプルに暴露された後に該検知部材上に光を投影するレーザ源と、
前記検知部材が前記光に暴露された後に放出される信号を検出する検出器と、
前記検出器に動作可能に接続されたプロセッサと、
を備える、検知システム。 - 前記プロセッサはクラウドコンピューティングシステムのコンポーネントである、請求項9に記載の検知システム。
- 請求項1に記載される集積化センサを使用する方法であって、
前記検知部材のエリアを、前記液滴の形態のサンプルに暴露するステップであって、それにより、前記エリアが、前記液滴を前記崩壊可能信号増幅構造に向かって移動させ、前記液滴からの毛管力が、前記崩壊可能信号増幅構造を崩壊させる、前記暴露するステップと、
前記液滴が蒸発することを可能にするステップと、
前記検知部材において検知動作を実施するステップと、
を含む、方法。 - 前記集積化センサを熱又は超音波に暴露することによって前記液滴の流動性を増加させるステップを更に含む、請求項11に記載の方法。
- 集積化センサを作製する方法であって、
基材の表面上に検知部材を生成するステップを含み、該生成するステップは、
前記表面上に複数の崩壊可能信号増幅構造を形成するステップと、
前記崩壊可能信号増幅構造を囲む前記表面の予め画定されたエリアを、該予め画定されたエリアが、該エリアに暴露される液滴の前記崩壊可能信号増幅構造に向かう自己位置決めを可能にするように修飾するステップと、
によって行われる、方法。 - 前記予め画定されたエリアを修飾するステップは、
i)前記基材上にポリマピラーのグラジエント形成するステップであって、該ポリマピラーのグラジエントは、前記検知部材の周辺において、より密である、形成するステップと、
ii)前記予め画定されたエリア上に疎水性分子を堆積させるステップと、
iii)前記表面内に複数の溝を形成するステップであって、該溝は、前記液滴を前記崩壊可能信号増幅構造に向かって方向付ける形状を有する、形成するステップと、
によって達成される、請求項13に記載の方法。 - 前記複数の崩壊可能信号増幅構造を形成するステップは、
ナノインプリント、エンボス加工、又はロール・ツー・ロール処理によって、複数のポリマピラー、ポリマ・ナノフレーク、又はポリママッシュルーム状構造を形成するステップと、
前記複数のポリマピラー、ポリマ・ナノフレーク、又はポリママッシュルーム状構造のそれぞれの少なくとも一部分上に信号増幅材料を堆積させるステップと、
によって達成される、請求項13に記載の方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2012/034448 WO2013158114A1 (en) | 2012-04-20 | 2012-04-20 | Integrated sensors |
Publications (2)
Publication Number | Publication Date |
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JP2015514991A true JP2015514991A (ja) | 2015-05-21 |
JP6062036B2 JP6062036B2 (ja) | 2017-01-18 |
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JP2015506946A Expired - Fee Related JP6062036B2 (ja) | 2012-04-20 | 2012-04-20 | 集積化センサ |
Country Status (6)
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US (1) | US9678013B2 (ja) |
EP (1) | EP2839295B1 (ja) |
JP (1) | JP6062036B2 (ja) |
CN (1) | CN104220878B (ja) |
DK (1) | DK2839295T3 (ja) |
WO (1) | WO2013158114A1 (ja) |
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2012
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- 2012-04-20 US US14/394,295 patent/US9678013B2/en active Active
- 2012-04-20 JP JP2015506946A patent/JP6062036B2/ja not_active Expired - Fee Related
- 2012-04-20 WO PCT/US2012/034448 patent/WO2013158114A1/en active Application Filing
- 2012-04-20 CN CN201280072502.4A patent/CN104220878B/zh not_active Expired - Fee Related
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EP2839295B1 (en) | 2017-04-19 |
US9678013B2 (en) | 2017-06-13 |
EP2839295A4 (en) | 2016-04-20 |
JP6062036B2 (ja) | 2017-01-18 |
DK2839295T3 (en) | 2017-05-15 |
US20150065390A1 (en) | 2015-03-05 |
CN104220878A (zh) | 2014-12-17 |
WO2013158114A1 (en) | 2013-10-24 |
CN104220878B (zh) | 2018-04-06 |
EP2839295A1 (en) | 2015-02-25 |
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