JP6062036B2 - 集積化センサ - Google Patents
集積化センサ Download PDFInfo
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- JP6062036B2 JP6062036B2 JP2015506946A JP2015506946A JP6062036B2 JP 6062036 B2 JP6062036 B2 JP 6062036B2 JP 2015506946 A JP2015506946 A JP 2015506946A JP 2015506946 A JP2015506946 A JP 2015506946A JP 6062036 B2 JP6062036 B2 JP 6062036B2
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- ZLSHNNWILHDSOZ-UHFFFAOYSA-N CC1C(C2)N2C1 Chemical compound CC1C(C2)N2C1 ZLSHNNWILHDSOZ-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5088—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/161—Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
- G01N2035/00019—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones cassette structures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
本発明は、米国防総省国防高等研究計画局(Defense Advanced Research Projects Agency)(DARPA)からの認可、契約番号第HR0011−09−3−0002によって部分的に資金提供を受けた研究の過程で行われた。米国政府は本発明に一定の権利を有する。
Claims (9)
- 集積化センサであって、
基材と、
前記基材の表面上に形成された検知部材と、
を備え、
前記検知部材は、
毛管力により自己閉鎖する信号増幅構造と、
前記信号増幅構造を囲むエリアであって、該エリアに暴露される液滴を前記信号増幅構造に向けて誘導する、エリアと、
を含み、
前記信号増幅構造を囲むエリアは、前記信号増幅構造より疎水性が高く、かつ前記基材上に形成されたポリマピラーのグラジエントを含み、該ポリマピラーのグラジエントは、前記検知部材の周辺において、より密であり、それにより、該エリアに暴露される液滴が前記信号増幅構造に向かって誘導され、
前記信号増幅構造は、前記表面上に所定の形状に制御可能に位置決めされて、個別の多角形組立体を形成し、
前記検知部材は、制御されたパターンに配列された前記多角形組立体のアレイを含む、
集積化センサ。 - 前記信号増幅構造は、金属キャップ付きポリマピラー、金属コーティング式ポリマ・ナノフレーク、金属コーティング式マッシュルーム状構造、又は金属リング付きポリマピラーを含み、
前記グラジエント内のポリマピラーは信号増幅材料がない、請求項1に記載の集積化センサ。 - 複数の離間した検知部材を含む、請求項1に記載の集積化センサ。
- 検知システムであって、
請求項1に記載される集積化センサと、
前記集積化センサを受取り、分配点から受取り点まで前記基材を割出し送りする検知デバイスと、
を備え、前記検知デバイスは、
前記基材が割出し送りされるときに、前記検知部材上にサンプルを分注する分注システムと、
前記検知部材が前記サンプルに暴露された後に該検知部材上に光を投影するレーザ源と、
前記検知部材が前記光に暴露された後に放出される信号を検出する検出器と、
前記検出器に動作可能に接続されたプロセッサと、
を備える、検知システム。 - 前記プロセッサはクラウドコンピューティングシステムのコンポーネントである、請求項4に記載の検知システム。
- 請求項1に記載される集積化センサを使用する方法であって、
前記検知部材のエリアを、前記液滴の形態のサンプルに暴露するステップであって、それにより、前記エリアが、前記液滴を前記信号増幅構造に向かって移動させ、前記液滴からの毛管力が、前記信号増幅構造を自己閉鎖させる、前記暴露するステップと、
前記液滴が蒸発することを可能にするステップと、
前記検知部材において検知動作を実施するステップと、
を含む、方法。 - 前記集積化センサを熱又は超音波に暴露することによって前記液滴の流動性を増加させるステップを更に含む、請求項6に記載の方法。
- 集積化センサを作製する方法であって、
基材の表面上に検知部材を生成するステップを含み、該生成するステップは、
前記表面上に毛管力により自己閉鎖する複数の信号増幅構造を形成するステップと、
前記信号増幅構造を囲む前記表面の予め画定されたエリアを、該予め画定されたエリアが、該エリアに暴露される液滴を前記信号増幅構造に向けて誘導するように修飾するステップと、
を含み、
前記予め画定されたエリアを修飾するステップは、
前記基材上にポリマピラーのグラジエントを形成するステップであって、該ポリマピラーのグラジエントは、前記検知部材の周辺において、より密であり、それにより、該エリアに暴露される液滴が前記信号増幅構造に向かって誘導される、前記形成するステップ、
を含み、
前記信号増幅構造は、前記表面上に所定の形状に制御可能に位置決めされて、個別の多角形組立体を形成するように形成され、
前記検知部材は、制御されたパターンに配列された前記多角形組立体のアレイを含むように形成される、方法。 - 前記複数の信号増幅構造を形成するステップは、
ナノインプリント、エンボス加工、又はロール・ツー・ロール処理によって、複数のポリマピラー、ポリマ・ナノフレーク、又はポリママッシュルーム状構造を形成するステップと、
前記複数のポリマピラー、ポリマ・ナノフレーク、又はポリママッシュルーム状構造のそれぞれの少なくとも一部分上に信号増幅材料を堆積させるステップと、
を含む、請求項8に記載の方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2012/034448 WO2013158114A1 (en) | 2012-04-20 | 2012-04-20 | Integrated sensors |
Publications (2)
Publication Number | Publication Date |
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JP2015514991A JP2015514991A (ja) | 2015-05-21 |
JP6062036B2 true JP6062036B2 (ja) | 2017-01-18 |
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JP2015506946A Expired - Fee Related JP6062036B2 (ja) | 2012-04-20 | 2012-04-20 | 集積化センサ |
Country Status (6)
Country | Link |
---|---|
US (1) | US9678013B2 (ja) |
EP (1) | EP2839295B1 (ja) |
JP (1) | JP6062036B2 (ja) |
CN (1) | CN104220878B (ja) |
DK (1) | DK2839295T3 (ja) |
WO (1) | WO2013158114A1 (ja) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI481858B (zh) * | 2013-06-05 | 2015-04-21 | Ind Tech Res Inst | 拉曼散射增強基板 |
WO2015061362A1 (en) | 2013-10-21 | 2015-04-30 | The Regents Of The University Of California | Enrichment and detection of nucleic acids with ultra-high sensitivity |
US9993185B2 (en) | 2014-02-12 | 2018-06-12 | California Institute Of Technology | Plasmonics nanostructures for multiplexing implantable sensors |
US9913603B2 (en) | 2014-02-12 | 2018-03-13 | California Institute Of Technology | Reflowed gold nanostructures for surface enhanced raman spectroscopy |
US9846125B2 (en) | 2014-09-05 | 2017-12-19 | California Institute Of Technology | Surface enhanced Raman spectroscopy detection of gases, particles and liquids through nanopillar structures |
US9987609B2 (en) | 2014-09-05 | 2018-06-05 | California Institute Of Technology | Multiplexed surface enhanced Raman sensors for early disease detection and in-situ bacterial monitoring |
US9512000B2 (en) | 2014-12-09 | 2016-12-06 | California Institute Of Technology | Fabrication and self-aligned local functionalization of nanocups and various plasmonic nanostructures on flexible substrates for implantable and sensing applications |
US20160349175A1 (en) * | 2015-05-28 | 2016-12-01 | Microaeth Corporation | Apparatus for receiving an analyte, method for characterizing an analyte, and substrate cartridge |
EP3271706B1 (en) * | 2015-07-29 | 2022-01-26 | Hewlett-Packard Development Company, L.P. | Analyte detection package housing |
TW201725385A (zh) * | 2016-01-05 | 2017-07-16 | 財團法人工業技術研究院 | 具有薄層層析之拉曼檢測晶片及分離檢測分析物之方法 |
WO2017131772A1 (en) | 2016-01-29 | 2017-08-03 | Hewlett-Packard Development Company, L.P. | Focal adjustment for analyte detection package |
EP3440699A4 (en) * | 2016-07-15 | 2019-11-27 | Hewlett-Packard Development Company, L.P. | FRAME LAYER RECEIVING ENHANCED LUMINESCENCE PLATE IN SURFACE SUPPORTED BY SUBSTRATE |
US10648916B2 (en) | 2017-01-31 | 2020-05-12 | Hewlett-Packard Development Company, L.P. | Nano fingers with asymmetric material composition |
WO2018219344A1 (en) * | 2017-06-01 | 2018-12-06 | The University Of Hong Kong | Sensors with gradient nanostructures and associated method of use |
CN110914655B (zh) * | 2017-07-19 | 2022-03-08 | 惠普发展公司,有限责任合伙企业 | 光谱装置和制造光谱装置的方法 |
WO2019017945A1 (en) * | 2017-07-20 | 2019-01-24 | Hewlett-Packard Development Company, L.P. | SURFACE-ENHANCED LUMINESCENCE ANALYTE QUERY PACKAGE AND STORAGE PACKAGING PACKAGING |
SE541514C2 (en) * | 2017-12-28 | 2019-10-22 | Delaval Holding Ab | A cassette |
CN109926110B (zh) * | 2019-03-26 | 2021-08-24 | 上海天马微电子有限公司 | 芯片基板和微流控芯片 |
CN110346350B (zh) * | 2019-08-08 | 2020-12-25 | 中国科学技术大学 | 微流体通道内的sers结构、微流体sers检测方法 |
EP4257957A1 (en) * | 2022-04-07 | 2023-10-11 | Robert Bosch GmbH | Chemosensor, use thereof, and method of detecting ions |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6174677B1 (en) | 1995-10-13 | 2001-01-16 | Ut-Battelle, Llc | Advanced surface-enhanced Raman gene probe systems and methods thereof |
US5866430A (en) | 1996-06-13 | 1999-02-02 | Grow; Ann E. | Raman optrode processes and devices for detection of chemicals and microorganisms |
US7267948B2 (en) | 1997-11-26 | 2007-09-11 | Ut-Battelle, Llc | SERS diagnostic platforms, methods and systems microarrays, biosensors and biochips |
JP4387588B2 (ja) | 1998-02-04 | 2009-12-16 | メルク エンド カムパニー インコーポレーテッド | 高スループットスクリーニングアッセイ用仮想ウェル |
JP4566456B2 (ja) | 2001-05-31 | 2010-10-20 | 独立行政法人理化学研究所 | 微量液体制御機構および微量液体制御方法 |
CA2396408C (en) * | 2001-08-03 | 2006-03-28 | Nec Corporation | Fractionating apparatus having colonies of pillars arranged in migration passage at interval and process for fabricating pillars |
JP3603886B2 (ja) | 2001-08-03 | 2004-12-22 | 日本電気株式会社 | 分離装置およびその製造方法 |
US20030194709A1 (en) * | 2002-04-10 | 2003-10-16 | Xing Yang | Hydrophobic zone device |
US20050074784A1 (en) | 2003-10-07 | 2005-04-07 | Tuan Vo-Dinh | Integrated biochip with continuous sampling and processing (CSP) system |
US7048889B2 (en) * | 2004-03-23 | 2006-05-23 | Lucent Technologies Inc. | Dynamically controllable biological/chemical detectors having nanostructured surfaces |
KR101333936B1 (ko) | 2005-03-04 | 2013-11-27 | 노오쓰웨스턴 유니버시티 | 밀도 구배에 의한 탄소 나노튜브 분리 |
US8262998B2 (en) | 2005-04-15 | 2012-09-11 | Branislav Vlahovic | Detection methods and detection devices based on the quantum confinement effects |
US7651863B2 (en) | 2005-07-14 | 2010-01-26 | 3M Innovative Properties Company | Surface-enhanced spectroscopic method, flexible structured substrate, and method of making the same |
US7993585B2 (en) | 2005-07-14 | 2011-08-09 | Battelle Memorial Institute | Biological and chemical monitoring |
US7402531B1 (en) | 2005-12-09 | 2008-07-22 | Hewlett-Packard Development Company, L.P. | Method for selectively controlling lengths of nanowires |
US8003408B2 (en) | 2005-12-29 | 2011-08-23 | Intel Corporation | Modification of metal nanoparticles for improved analyte detection by surface enhanced Raman spectroscopy (SERS) |
US8329135B2 (en) | 2006-01-06 | 2012-12-11 | National Institute Of Advanced Industrial Science And Technology | Aligned carbon nanotube bulk structure having portions different in density |
GB0606088D0 (en) | 2006-03-27 | 2006-05-03 | E2V Biosensors Ltd | Improved serrs substrate |
US7528948B2 (en) * | 2006-07-25 | 2009-05-05 | Hewlett-Packard Development Company, L.P. | Controllable surface enhanced Raman spectroscopy |
US7605916B2 (en) | 2006-09-21 | 2009-10-20 | Intel Corporation | Online analyte detection by surface enhanced Raman scattering (SERS) |
US7898658B2 (en) * | 2007-01-23 | 2011-03-01 | The Regents Of The University Of California | Platform for chemical and biological sensing by surface-enhanced Raman spectroscopy |
US8958070B2 (en) | 2007-05-29 | 2015-02-17 | OptoTrace (SuZhou) Technologies, Inc. | Multi-layer variable micro structure for sensing substance |
US20090097022A1 (en) | 2007-08-24 | 2009-04-16 | Dynamic Throughput Inc. | Discovery tool with integrated microfluidic biomarker optical detection array device and methods for use |
JP2009162549A (ja) * | 2007-12-28 | 2009-07-23 | Nec Corp | 電気泳動チップ |
US9013689B2 (en) | 2009-01-09 | 2015-04-21 | Trustees Of Boston University | Engineered SERS substrates employing nanoparticle cluster arrays with multiscale signal enhancement |
JP5500571B2 (ja) | 2009-03-26 | 2014-05-21 | 株式会社ニデック | 試験片,該試験片の製造方法 |
US20120081703A1 (en) | 2009-05-07 | 2012-04-05 | Nant Holdings Ip, Llc | Highly Efficient Plamonic Devices, Molecule Detection Systems, and Methods of Making the Same |
US8223331B2 (en) * | 2009-06-19 | 2012-07-17 | Hewlett-Packard Development Company, L.P. | Signal-amplification device for surface enhanced raman spectroscopy |
US8865402B2 (en) * | 2009-08-26 | 2014-10-21 | Clemson University Research Foundation | Nanostructured substrates for surface enhanced raman spectroscopy (SERS) and detection of biological and chemical analytes by electrical double layer (EDL) capacitance |
WO2011026136A1 (en) * | 2009-08-31 | 2011-03-03 | Life Technologies Corporation | Low-volume sequencing system and method of use |
JP2011075348A (ja) * | 2009-09-30 | 2011-04-14 | Nidek Co Ltd | 試験片の製造方法 |
DK2491372T3 (da) | 2009-10-23 | 2021-10-18 | Univ Danmarks Tekniske | Overfladeforbedrede raman-spredningssubstratforbrugsvarer til raman-spektroskopi |
US9244015B2 (en) | 2010-04-20 | 2016-01-26 | Hewlett-Packard Development Company, L.P. | Self-arranging, luminescence-enhancement device for surface-enhanced luminescence |
US20130040862A1 (en) | 2010-04-20 | 2013-02-14 | Zhiyong Li | Multi-pillar structure for molecular analysis |
US8269963B2 (en) | 2010-04-30 | 2012-09-18 | Hewlett-Packard Development Company, L.P. | Tunable apparatus for performing SERS |
US8665432B2 (en) | 2010-10-29 | 2014-03-04 | Hewlett-Packard Development Company, L.P. | Apparatus for performing SERS |
US8404491B2 (en) * | 2010-10-29 | 2013-03-26 | Hewlett-Packard Development Company, L.P. | Luminescent chemical sensor integrated with at least one molecular trap |
US8593629B2 (en) | 2011-02-17 | 2013-11-26 | Hewlett-Packard Development Company, L.P. | Apparatus for performing SERS |
US8994937B2 (en) | 2012-04-18 | 2015-03-31 | Hewlett-Packard Development Company, L.P. | Surface enhanced Raman spectroscopy calibration curve generating systems |
US9453793B2 (en) * | 2012-04-20 | 2016-09-27 | Hewlett-Packard Development Company, L.P. | Integrated sensors |
-
2012
- 2012-04-20 US US14/394,295 patent/US9678013B2/en active Active
- 2012-04-20 EP EP12874752.4A patent/EP2839295B1/en not_active Not-in-force
- 2012-04-20 DK DK12874752.4T patent/DK2839295T3/en active
- 2012-04-20 CN CN201280072502.4A patent/CN104220878B/zh not_active Expired - Fee Related
- 2012-04-20 WO PCT/US2012/034448 patent/WO2013158114A1/en active Application Filing
- 2012-04-20 JP JP2015506946A patent/JP6062036B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DK2839295T3 (en) | 2017-05-15 |
EP2839295B1 (en) | 2017-04-19 |
EP2839295A1 (en) | 2015-02-25 |
US9678013B2 (en) | 2017-06-13 |
JP2015514991A (ja) | 2015-05-21 |
US20150065390A1 (en) | 2015-03-05 |
EP2839295A4 (en) | 2016-04-20 |
WO2013158114A1 (en) | 2013-10-24 |
CN104220878A (zh) | 2014-12-17 |
CN104220878B (zh) | 2018-04-06 |
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