JP2015514778A5 - - Google Patents
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- Publication number
- JP2015514778A5 JP2015514778A5 JP2015507173A JP2015507173A JP2015514778A5 JP 2015514778 A5 JP2015514778 A5 JP 2015514778A5 JP 2015507173 A JP2015507173 A JP 2015507173A JP 2015507173 A JP2015507173 A JP 2015507173A JP 2015514778 A5 JP2015514778 A5 JP 2015514778A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- composition
- smad7
- antisense oligonucleotide
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101700026522 SMAD7 Proteins 0.000 claims description 28
- 102000049873 Smad7 Human genes 0.000 claims description 28
- 108091034117 Oligonucleotide Proteins 0.000 claims description 23
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 22
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 22
- 206010012601 diabetes mellitus Diseases 0.000 claims description 6
- 239000003112 inhibitor Substances 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 238000002054 transplantation Methods 0.000 claims description 4
- 210000004153 islets of langerhan Anatomy 0.000 claims description 3
- 230000001737 promoting effect Effects 0.000 claims description 3
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 208000004104 gestational diabetes Diseases 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 23
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 2
- 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 1
- 238000000034 method Methods 0.000 description 17
- 210000000056 organ Anatomy 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261625904P | 2012-04-18 | 2012-04-18 | |
| US61/625,904 | 2012-04-18 | ||
| PCT/US2013/037150 WO2013158868A1 (en) | 2012-04-18 | 2013-04-18 | Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018104372A Division JP2018131468A (ja) | 2012-04-18 | 2018-05-31 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514778A JP2015514778A (ja) | 2015-05-21 |
| JP2015514778A5 true JP2015514778A5 (cg-RX-API-DMAC7.html) | 2016-06-09 |
| JP6348484B2 JP6348484B2 (ja) | 2018-06-27 |
Family
ID=48326412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015507173A Expired - Fee Related JP6348484B2 (ja) | 2012-04-18 | 2013-04-18 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
| JP2018104372A Pending JP2018131468A (ja) | 2012-04-18 | 2018-05-31 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018104372A Pending JP2018131468A (ja) | 2012-04-18 | 2018-05-31 | 糖尿病を処置する方法および／または移植後の膵島の生存を促進する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10081809B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2839004B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6348484B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20150003824A (cg-RX-API-DMAC7.html) |
| CN (2) | CN107252492A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013249191B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2870547A1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2839004T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2732252T3 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014DN08158A (cg-RX-API-DMAC7.html) |
| MX (1) | MX370149B (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ630914A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2667960C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013158868A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| NZ592673A (en) | 2008-11-13 | 2013-01-25 | Giuliani Int Ltd | Antisense compositions with enteric coating for treating crohn's disease, colitis and bowel disease |
| KR102099990B1 (ko) | 2011-09-15 | 2020-04-13 | 노그라 파마 리미티드 | 항-smad7 요법의 반응성을 모니터링하는 방법 |
| CN107252492A (zh) | 2012-04-18 | 2017-10-17 | 诺格尔制药有限公司 | 治疗糖尿病和/或促进胰岛移植后存活的方法 |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| ES2704092T3 (es) * | 2014-04-30 | 2019-03-14 | Procter & Gamble | Composición limpiadora |
| CN106573065A (zh) | 2014-05-09 | 2017-04-19 | 诺格尔制药有限公司 | 用于治疗炎症性肠病的方法 |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| EP3162878A1 (en) * | 2015-10-29 | 2017-05-03 | The Procter and Gamble Company | Liquid detergent composition |
| EP3165593B1 (en) * | 2015-10-29 | 2019-01-23 | The Procter and Gamble Company | Liquid detergent composition |
| US11162097B2 (en) | 2016-02-23 | 2021-11-02 | Nogra Pharma Limited | Methods of treating intestinal fibrosis using SMAD7 inhibition |
| JP7495126B2 (ja) * | 2018-05-08 | 2024-06-04 | ユニヴァーシティー オブ マイアミ | 組織への治療用核酸の送達のための材料および方法 |
| JOP20210298A1 (ar) | 2019-05-14 | 2023-01-30 | Provention Bio Inc | طرق وتركيبات للوقاية من مرض السكري من النوع الأول |
| KR20230092863A (ko) | 2020-06-11 | 2023-06-26 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| ES2388968T3 (es) | 2001-11-02 | 2012-10-22 | Giuliani International Limited | Inhibidores de Smad7 para el tratamiento de enfermedades del SNC |
| ITRM20030149A1 (it) | 2003-04-02 | 2004-10-03 | Giuliani Spa | Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico |
| EP3604537B1 (en) | 2003-06-13 | 2021-12-08 | Alnylam Europe AG | Double-stranded ribonucleic acid with increased effectiveness in an organism |
| ITRM20030393A1 (it) * | 2003-08-11 | 2005-02-12 | Giuliani Spa | Uso di oligonucleotidi (odn) antisenso per smad7 per il trattamento delle patologie mediate dal fattore di trascrizione nucleare nf-kb. |
| GB0326778D0 (en) * | 2003-11-18 | 2003-12-24 | Imp College Innovations Ltd | Biological materials and uses thereof |
| KR101357016B1 (ko) | 2004-09-28 | 2014-02-03 | 쿠아크 파마수티칼스 인코퍼레이티드 | 탈모증, 급성신부전증 및 다른 질환의 치료를 위한올리고리보뉴클레오티드 및 그것의 사용방법 |
| RU2434942C2 (ru) * | 2004-09-28 | 2011-11-27 | Кварк Фармасьютикалс, Инк. | Олигорибонуклеотиды и способы их применения для лечения острой почечной недостаточности и других заболеваний |
| WO2007039151A1 (en) * | 2005-09-28 | 2007-04-12 | Universität Zürich | Blockers of transforming growth factor beta and its receptors for the treatment of infectious diseases |
| WO2009129544A1 (en) * | 2008-04-18 | 2009-10-22 | Baxter International Inc. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
| NZ592673A (en) | 2008-11-13 | 2013-01-25 | Giuliani Int Ltd | Antisense compositions with enteric coating for treating crohn's disease, colitis and bowel disease |
| KR102099990B1 (ko) | 2011-09-15 | 2020-04-13 | 노그라 파마 리미티드 | 항-smad7 요법의 반응성을 모니터링하는 방법 |
| CN107252492A (zh) | 2012-04-18 | 2017-10-17 | 诺格尔制药有限公司 | 治疗糖尿病和/或促进胰岛移植后存活的方法 |
| ES2673209T3 (es) | 2013-03-15 | 2018-06-20 | Nogra Pharma Limited | Procedimientos de tratamiento del cáncer colorrectal |
| US10006029B2 (en) | 2013-03-15 | 2018-06-26 | Nogra Pharma Limited | Methods of treating colorectal cancer |
| CN106573065A (zh) | 2014-05-09 | 2017-04-19 | 诺格尔制药有限公司 | 用于治疗炎症性肠病的方法 |
| EP3693736A3 (en) | 2014-10-17 | 2020-10-14 | Nogra Pharma Limited | Methods for dosing and monitoring smad7 antisense oligonucleotide treatment using biomarker levels |
| WO2016059239A1 (en) | 2014-10-17 | 2016-04-21 | Nogra Pharma Limited | Methods and compositions for treating a subject with a smad7 antisense oligonucleotide |
| CA3000569A1 (en) | 2015-09-30 | 2017-04-06 | Nogra Pharma Limited | Methods of using smad7 antisense oligonucleotides based on biomarker expression |
| CA3014383A1 (en) | 2016-02-24 | 2017-08-31 | Nogra Pharma Limited | Methods of treating celiac disease using smad7 inhibition |
| CA3048334A1 (en) | 2016-12-30 | 2018-07-05 | Nogra Pharma Limited | Compositions of smad7 antisense oligonucleotide and methods of treating or preventing psoriasis |
-
2013
- 2013-04-18 CN CN201710440085.9A patent/CN107252492A/zh active Pending
- 2013-04-18 RU RU2014146170A patent/RU2667960C2/ru not_active IP Right Cessation
- 2013-04-18 JP JP2015507173A patent/JP6348484B2/ja not_active Expired - Fee Related
- 2013-04-18 AU AU2013249191A patent/AU2013249191B2/en not_active Ceased
- 2013-04-18 IN IN8158DEN2014 patent/IN2014DN08158A/en unknown
- 2013-04-18 ES ES13721452T patent/ES2732252T3/es active Active
- 2013-04-18 DK DK13721452.4T patent/DK2839004T3/da active
- 2013-04-18 US US14/394,999 patent/US10081809B2/en not_active Expired - Fee Related
- 2013-04-18 CA CA2870547A patent/CA2870547A1/en not_active Abandoned
- 2013-04-18 EP EP13721452.4A patent/EP2839004B1/en active Active
- 2013-04-18 CN CN201380020520.2A patent/CN104487574B/zh not_active Expired - Fee Related
- 2013-04-18 NZ NZ630914A patent/NZ630914A/en not_active IP Right Cessation
- 2013-04-18 KR KR1020147032172A patent/KR20150003824A/ko not_active Abandoned
- 2013-04-18 WO PCT/US2013/037150 patent/WO2013158868A1/en not_active Ceased
- 2013-04-18 MX MX2014012650A patent/MX370149B/es active IP Right Grant
-
2018
- 2018-05-31 JP JP2018104372A patent/JP2018131468A/ja active Pending
- 2018-08-10 US US16/100,906 patent/US10443056B2/en not_active Expired - Fee Related
-
2019
- 2019-09-04 US US16/559,974 patent/US20200239884A1/en not_active Abandoned
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