JP2015514714A5 - - Google Patents
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- Publication number
- JP2015514714A5 JP2015514714A5 JP2015503612A JP2015503612A JP2015514714A5 JP 2015514714 A5 JP2015514714 A5 JP 2015514714A5 JP 2015503612 A JP2015503612 A JP 2015503612A JP 2015503612 A JP2015503612 A JP 2015503612A JP 2015514714 A5 JP2015514714 A5 JP 2015514714A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- lyophilized
- temperature
- lung surfactant
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 28
- 238000000034 method Methods 0.000 claims 15
- 239000000596 artificial lung surfactant Substances 0.000 claims 12
- 238000001035 drying Methods 0.000 claims 8
- 238000004108 freeze drying Methods 0.000 claims 8
- 239000003960 organic solvent Substances 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 4
- 238000000137 annealing Methods 0.000 claims 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 4
- 238000005188 flotation Methods 0.000 claims 3
- 238000007710 freezing Methods 0.000 claims 3
- 230000008014 freezing Effects 0.000 claims 3
- 238000010438 heat treatment Methods 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- PAZGBAOHGQRCBP-ZCXUNETKSA-N 1-Palmitoyl-2-oleoylglycero-3-phosphoglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C/CCCCCCCC PAZGBAOHGQRCBP-ZCXUNETKSA-N 0.000 claims 2
- 235000021314 Palmitic acid Nutrition 0.000 claims 2
- ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 2
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 230000002209 hydrophobic effect Effects 0.000 claims 2
- 239000003580 lung surfactant Substances 0.000 claims 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 2
- 150000003904 phospholipids Chemical class 0.000 claims 2
- 230000008023 solidification Effects 0.000 claims 2
- 238000007711 solidification Methods 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 239000013557 residual solvent Substances 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261616827P | 2012-03-28 | 2012-03-28 | |
| US61/616,827 | 2012-03-28 | ||
| PCT/US2013/034464 WO2013149074A1 (en) | 2012-03-28 | 2013-03-28 | Lyophilization of synthetic liposomal pulmonary surfactant |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514714A JP2015514714A (ja) | 2015-05-21 |
| JP2015514714A5 true JP2015514714A5 (https=) | 2016-05-26 |
| JP6178402B2 JP6178402B2 (ja) | 2017-08-09 |
Family
ID=48096305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015503612A Active JP6178402B2 (ja) | 2012-03-28 | 2013-03-28 | 合成リポソーム肺サーファクタントの凍結乾燥 |
Country Status (35)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX359654B (es) * | 2012-03-28 | 2018-10-05 | Discovery Lab Inc | Liofilizacion de agente tensioactivo pulmonar liposomico sintetico. |
| WO2016080336A1 (ja) * | 2014-11-18 | 2016-05-26 | 国立研究開発法人物質・材料研究機構 | 多孔性粒子の製造方法 |
| WO2016108534A1 (ko) * | 2014-12-30 | 2016-07-07 | 주식회사 삼양바이오팜 | 고분자 나노입자 동결건조물 및 그 제조방법 |
| PL3319597T3 (pl) * | 2015-07-10 | 2021-10-11 | Byondis B.V. | Kompozycje zawierające koniugaty przeciwciało-duokarmycyna |
| HUE053990T2 (hu) | 2015-07-22 | 2021-08-30 | Nitto Denko Corp | Nanorészecske liofilizált formák készítményei és eljárások |
| JP7012512B2 (ja) * | 2017-11-13 | 2022-01-28 | 清水建設株式会社 | 管理装置、製造システムおよび管理方法 |
| CA3085944A1 (en) * | 2017-12-21 | 2019-06-27 | Civitas Therapeutics, Inc. | Surfactant formulations for inhalation |
| CN108853061A (zh) * | 2018-10-09 | 2018-11-23 | 兆科药业（合肥）有限公司 | 一种人工合成肺表面活性剂药物组合物及与之的肠溶胶囊和其制备方法及用途 |
| WO2020142420A1 (en) * | 2018-12-31 | 2020-07-09 | Novus Therapeutics, Inc. | Novel surfactant-lipid alloy drug substance, methods of making the same, and pharmaceutical compositions comprising the same |
| US11287185B1 (en) | 2020-09-09 | 2022-03-29 | Stay Fresh Technology, LLC | Freeze drying with constant-pressure and constant-temperature phases |
| KR102545292B1 (ko) * | 2021-01-28 | 2023-06-16 | 인천대학교 산학협력단 | 마이크로캡슐 형성용 생체 적합 계면활성제 합성방법 |
| JP2024524512A (ja) * | 2021-07-05 | 2024-07-05 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | 肺サーファクタントを調製する方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE751108R (fr) | 1969-06-06 | 1970-11-03 | Berliet Automobiles | Dispositif pour la mesure precise de la consommation specifiquedes moteurs a combustion |
| JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
| US5260273A (en) | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| PT877602E (pt) | 1996-01-24 | 2002-07-31 | Byk Gulden Lomberg Chem Fab | Processo para o fabrico de composicoes de surfactantes pulmonares em po |
| AU2322097A (en) * | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
| US5855913A (en) | 1997-01-16 | 1999-01-05 | Massachusetts Instite Of Technology | Particles incorporating surfactants for pulmonary drug delivery |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6652837B1 (en) | 1996-05-24 | 2003-11-25 | Massachusetts Institute Of Technology | Preparation of novel particles for inhalation |
| US7638493B2 (en) | 2004-04-29 | 2009-12-29 | Sannamu Lee | Artificial pulmonary surfactant compositions and use of the same |
| US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
| US7956160B2 (en) | 2005-07-22 | 2011-06-07 | Amgen Inc. | Concentrated protein lyophilates, methods, and uses |
| EP1997502A1 (en) | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| MX359654B (es) * | 2012-03-28 | 2018-10-05 | Discovery Lab Inc | Liofilizacion de agente tensioactivo pulmonar liposomico sintetico. |
-
2013
- 2013-03-28 MX MX2014011483A patent/MX359654B/es active IP Right Grant
- 2013-03-28 CA CA2867649A patent/CA2867649C/en active Active
- 2013-03-28 NZ NZ630219A patent/NZ630219A/en not_active IP Right Cessation
- 2013-03-28 US US14/387,707 patent/US9554999B2/en active Active
- 2013-03-28 RU RU2014143247A patent/RU2671500C2/ru active
- 2013-03-28 PE PE2014001494A patent/PE20142302A1/es not_active Application Discontinuation
- 2013-03-28 MY MYPI2014002699A patent/MY164868A/en unknown
- 2013-03-28 CN CN201380022948.0A patent/CN104271118B/zh active Active
- 2013-03-28 AU AU2013237985A patent/AU2013237985B2/en not_active Ceased
- 2013-03-28 WO PCT/US2013/034464 patent/WO2013149074A1/en not_active Ceased
- 2013-03-28 HR HRP20151392T patent/HRP20151392T1/hr unknown
- 2013-03-28 IN IN8538DEN2014 patent/IN2014DN08538A/en unknown
- 2013-03-28 SI SI201330112T patent/SI2723323T1/sl unknown
- 2013-03-28 PT PT137166559T patent/PT2723323E/pt unknown
- 2013-03-28 SG SG11201405944PA patent/SG11201405944PA/en unknown
- 2013-03-28 KR KR1020147029784A patent/KR102123129B1/ko active Active
- 2013-03-28 ES ES13716655.9T patent/ES2557805T3/es active Active
- 2013-03-28 PL PL13716655T patent/PL2723323T3/pl unknown
- 2013-03-28 RS RS20150867A patent/RS54513B1/sr unknown
- 2013-03-28 JP JP2015503612A patent/JP6178402B2/ja active Active
- 2013-03-28 DK DK13716655.9T patent/DK2723323T3/en active
- 2013-03-28 BR BR112014024057A patent/BR112014024057A8/pt not_active Application Discontinuation
- 2013-03-28 HU HUE13716655A patent/HUE026363T2/en unknown
- 2013-03-28 EP EP14188473.4A patent/EP2837377A1/en not_active Withdrawn
- 2013-03-28 WO PCT/US2013/034364 patent/WO2013149013A1/en not_active Ceased
- 2013-03-28 EP EP13716655.9A patent/EP2723323B1/en active Active
- 2013-11-27 US US14/091,712 patent/US8748397B2/en active Active
- 2013-11-27 US US14/091,608 patent/US8748396B2/en active Active
-
2014
- 2014-09-16 IL IL234688A patent/IL234688B/en active IP Right Grant
- 2014-09-25 CR CR20140449A patent/CR20140449A/es unknown
- 2014-09-25 CL CL2014002553A patent/CL2014002553A1/es unknown
- 2014-09-25 ZA ZA2014/06982A patent/ZA201406982B/en unknown
- 2014-09-29 CU CUP2014000116A patent/CU20140116A7/es unknown
- 2014-09-30 CO CO14216241A patent/CO7081146A2/es unknown
- 2014-10-22 MA MA37445A patent/MA37445B1/fr unknown
- 2014-10-24 EC ECIEPI201424363A patent/ECSP14024363A/es unknown
-
2015
- 2015-08-06 HK HK15107596.6A patent/HK1206979A1/en unknown
- 2015-12-21 SM SM201500320T patent/SMT201500320B/it unknown
- 2015-12-22 CY CY20151101180T patent/CY1117380T1/el unknown
-
2017
- 2017-10-06 AU AU2017239624A patent/AU2017239624B2/en active Active
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