JP2015511931A5 - - Google Patents
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- Publication number
- JP2015511931A5 JP2015511931A5 JP2014519203A JP2014519203A JP2015511931A5 JP 2015511931 A5 JP2015511931 A5 JP 2015511931A5 JP 2014519203 A JP2014519203 A JP 2014519203A JP 2014519203 A JP2014519203 A JP 2014519203A JP 2015511931 A5 JP2015511931 A5 JP 2015511931A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- amino acid
- acid sequence
- hvr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 21
- 229940119218 CD83 agonist Drugs 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 6
- 210000004443 dendritic cell Anatomy 0.000 claims 6
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 239000013598 vector Substances 0.000 claims 4
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 3
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 3
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 3
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000011664 signaling Effects 0.000 claims 3
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 102000043136 MAP kinase family Human genes 0.000 claims 2
- 108091054455 MAP kinase family Proteins 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 230000003110 anti-inflammatory effect Effects 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 206010050245 Autoimmune thrombocytopenia Diseases 0.000 claims 1
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 1
- 101710155857 C-C motif chemokine 2 Proteins 0.000 claims 1
- 102100035793 CD83 antigen Human genes 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 102000005636 Cyclic AMP Response Element-Binding Protein Human genes 0.000 claims 1
- 108010045171 Cyclic AMP Response Element-Binding Protein Proteins 0.000 claims 1
- 206010018364 Glomerulonephritis Diseases 0.000 claims 1
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 1
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 1
- 101000946856 Homo sapiens CD83 antigen Proteins 0.000 claims 1
- 208000010159 IgA glomerulonephritis Diseases 0.000 claims 1
- 206010021263 IgA nephropathy Diseases 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000014158 Interleukin-12 Subunit p40 Human genes 0.000 claims 1
- 108010011429 Interleukin-12 Subunit p40 Proteins 0.000 claims 1
- 208000003456 Juvenile Arthritis Diseases 0.000 claims 1
- 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 206010043561 Thrombocytopenic purpura Diseases 0.000 claims 1
- 201000007023 Thrombotic Thrombocytopenic Purpura Diseases 0.000 claims 1
- 206010047115 Vasculitis Diseases 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 208000019069 chronic childhood arthritis Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 238000002513 implantation Methods 0.000 claims 1
- 102000009634 interleukin-1 receptor antagonist activity proteins Human genes 0.000 claims 1
- 108040001669 interleukin-1 receptor antagonist activity proteins Proteins 0.000 claims 1
- 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 206010028417 myasthenia gravis Diseases 0.000 claims 1
- 210000000066 myeloid cell Anatomy 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014519203A JP6198730B2 (ja) | 2011-07-01 | 2012-06-29 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161504127P | 2011-07-01 | 2011-07-01 | |
| US61/504,127 | 2011-07-01 | ||
| JP2011285585A JP2013040160A (ja) | 2011-07-01 | 2011-12-27 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| JP2011285585 | 2011-12-27 | ||
| JP2014519203A JP6198730B2 (ja) | 2011-07-01 | 2012-06-29 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| PCT/US2012/045142 WO2013006505A1 (en) | 2011-07-01 | 2012-06-29 | Use of anti-cd83 agonist antibodies for treating autoimmune diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511931A JP2015511931A (ja) | 2015-04-23 |
| JP2015511931A5 true JP2015511931A5 (OSRAM) | 2015-08-20 |
| JP6198730B2 JP6198730B2 (ja) | 2017-09-20 |
Family
ID=47888898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011285585A Pending JP2013040160A (ja) | 2011-07-01 | 2011-12-27 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| JP2014519203A Expired - Fee Related JP6198730B2 (ja) | 2011-07-01 | 2012-06-29 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011285585A Pending JP2013040160A (ja) | 2011-07-01 | 2011-12-27 | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9562097B2 (OSRAM) |
| EP (1) | EP2726509B1 (OSRAM) |
| JP (2) | JP2013040160A (OSRAM) |
| KR (1) | KR20140051272A (OSRAM) |
| CN (1) | CN103906766B (OSRAM) |
| AU (1) | AU2012279175B2 (OSRAM) |
| BR (1) | BR112013033968A2 (OSRAM) |
| CA (1) | CA2840426A1 (OSRAM) |
| MX (1) | MX2014000142A (OSRAM) |
| RU (1) | RU2014103498A (OSRAM) |
| WO (1) | WO2013006505A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013150592A (ja) * | 2011-07-01 | 2013-08-08 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| JP2013040160A (ja) | 2011-07-01 | 2013-02-28 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
| PT2951208T (pt) * | 2013-02-01 | 2019-12-30 | Univ California | Anticorpos anti-cd83 e sua utilização |
| CA2965170A1 (en) * | 2014-10-23 | 2016-04-28 | Dendrocyte Biotech Pty Ltd | Cd83 binding proteins and uses thereof |
| US9982057B2 (en) | 2014-11-17 | 2018-05-29 | Pelican Therapeutics, Inc. | Human TNFRSF25 antibody |
| CN104610452B (zh) * | 2015-01-27 | 2018-11-20 | 中国科学技术大学先进技术研究院 | 抗人cd83单克隆抗体及其制备、鉴定和应用 |
| SG11201810853UA (en) | 2016-06-09 | 2019-01-30 | Pelican Therapeutics Inc | Anti-tnfrsf25 antibodies |
| US11192943B2 (en) * | 2017-09-30 | 2021-12-07 | Hefei Lifeon Pharmaceutical Co., Ltd. | Protein binding to fibronectin B domain |
| US12492254B2 (en) * | 2018-02-23 | 2025-12-09 | H. Lee Moffitt Cancer Center and Research Intitute. Inc. | CD83-binding chimeric antigen receptors |
| JP7701908B2 (ja) * | 2019-08-16 | 2025-07-02 | エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド | 抗ｃｄ３８キメラ抗原受容体を発現する制御性ｔ細胞 |
| CN114929341A (zh) * | 2019-08-16 | 2022-08-19 | H.李.莫菲特癌症中心和研究所股份有限公司 | 用于治疗髓系恶性肿瘤的嵌合抗原受体 |
| WO2021127212A2 (en) * | 2019-12-18 | 2021-06-24 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Systems and methods for producing efficacious regulatory t cells |
| EP3895723A1 (en) | 2020-04-16 | 2021-10-20 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Scd83 for wound healing, hair growth, and skin and hair care |
| WO2024077052A1 (en) * | 2022-10-04 | 2024-04-11 | Emergent Product Development Gaithersburg Inc. | Novel vsv virus formulations |
| DE102024110866A1 (de) * | 2024-04-18 | 2025-10-23 | Christian Arnold | Pharmazeutische Zusammensetzung zur Heilung einer Wunde |
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| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
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| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
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| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
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| WO2003045318A2 (en) * | 2001-11-21 | 2003-06-05 | Celltech R & D, Inc. | Manipulation of cytokine levels using cd83 gene products |
| AU2002950779A0 (en) * | 2002-08-15 | 2002-09-12 | The Corporation Of The Trustees Of The Order Of The Sisters Of Mercy In Queensland | A method of immunomodulation |
| EP2258724A1 (en) | 2002-11-21 | 2010-12-08 | Celltech R & D, Inc. | Modulating immune responses using multimerized anti-CD83 antibodies |
| US7169898B2 (en) * | 2002-12-04 | 2007-01-30 | Alexander Steinkasserer | Soluble CD83 proteins and use thereof for the treatment or prevention of a disease or medical condition caused by dysfunction or undesired function of a cellular immune response involving T cells |
| JP2008523083A (ja) * | 2004-12-08 | 2008-07-03 | イムノメディクス， インコーポレイテッド | 炎症性疾患および免疫調節不全疾患、感染性疾患、病的血管新生およびがんの免疫療法および検出のための方法および組成物 |
| JP2013040160A (ja) | 2011-07-01 | 2013-02-28 | Genentech Inc | 自己免疫疾患を治療するための抗ｃｄ８３アゴニスト抗体の使用 |
-
2011
- 2011-12-27 JP JP2011285585A patent/JP2013040160A/ja active Pending
-
2012
- 2012-06-29 KR KR1020147002210A patent/KR20140051272A/ko not_active Withdrawn
- 2012-06-29 MX MX2014000142A patent/MX2014000142A/es unknown
- 2012-06-29 EP EP12807315.2A patent/EP2726509B1/en not_active Not-in-force
- 2012-06-29 CA CA2840426A patent/CA2840426A1/en not_active Abandoned
- 2012-06-29 BR BR112013033968A patent/BR112013033968A2/pt not_active IP Right Cessation
- 2012-06-29 AU AU2012279175A patent/AU2012279175B2/en not_active Ceased
- 2012-06-29 US US14/129,053 patent/US9562097B2/en not_active Expired - Fee Related
- 2012-06-29 RU RU2014103498/10A patent/RU2014103498A/ru not_active Application Discontinuation
- 2012-06-29 JP JP2014519203A patent/JP6198730B2/ja not_active Expired - Fee Related
- 2012-06-29 WO PCT/US2012/045142 patent/WO2013006505A1/en not_active Ceased
- 2012-06-29 CN CN201280042210.6A patent/CN103906766B/zh not_active Expired - Fee Related
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