JP2015511122A5 - - Google Patents
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- JP2015511122A5 JP2015511122A5 JP2014554934A JP2014554934A JP2015511122A5 JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5 JP 2014554934 A JP2014554934 A JP 2014554934A JP 2014554934 A JP2014554934 A JP 2014554934A JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- tissue
- subject
- rna
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 35
- 210000001519 tissue Anatomy 0.000 claims 20
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- 108091092259 cell-free RNA Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 238000012163 sequencing technique Methods 0.000 claims 8
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 2
- 239000013614 RNA sample Substances 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- -1 sweat Substances 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001638 cerebellum Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003016 hypothalamus Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000005059 placental tissue Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591642P | 2012-01-27 | 2012-01-27 | |
| US61/591,642 | 2012-01-27 | ||
| PCT/US2013/023471 WO2013113012A2 (en) | 2012-01-27 | 2013-01-28 | Methods for profiling and quantitating cell-free rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Division JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511122A JP2015511122A (ja) | 2015-04-16 |
| JP2015511122A5 true JP2015511122A5 (https=) | 2016-03-03 |
| JP6320302B2 JP6320302B2 (ja) | 2018-05-09 |
Family
ID=48874081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554934A Active JP6320302B2 (ja) | 2012-01-27 | 2013-01-28 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (15) | US20130252835A1 (https=) |
| EP (2) | EP3584327A1 (https=) |
| JP (2) | JP6320302B2 (https=) |
| CN (2) | CN104334742A (https=) |
| AU (1) | AU2013211850B8 (https=) |
| CA (1) | CA2863035C (https=) |
| HK (1) | HK1211624A1 (https=) |
| SG (2) | SG11201505515XA (https=) |
| WO (1) | WO2013113012A2 (https=) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010028288A2 (en) | 2008-09-05 | 2010-03-11 | Aueon, Inc. | Methods for stratifying and annotating cancer drug treatment options |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| EP2619329B1 (en) | 2010-09-24 | 2019-05-22 | The Board of Trustees of The Leland Stanford Junior University | Direct capture, amplification and sequencing of target dna using immobilized primers |
| US20160289762A1 (en) * | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| WO2015069900A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| HK1211624A1 (en) | 2012-01-27 | 2016-05-27 | The Board Of Trustees Of The University Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US10689652B2 (en) | 2013-10-02 | 2020-06-23 | The Regents Of The University Of California | Methods for immortalization of epithelial cells |
| WO2015069933A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| AU2014346562B2 (en) | 2013-11-07 | 2018-11-29 | The Board Of Trustees Of The Leland Stanford Junior University | Cell-free nucleic acids for the analysis of the human microbiome and components thereof |
| EP4358097A1 (en) | 2014-07-25 | 2024-04-24 | University of Washington | Methods of determining tissues and/or cell types giving rise to cell-free dna, and methods of identifying a disease or disorder using same |
| EP3218523B1 (en) | 2014-11-14 | 2020-02-12 | Liquid Genomics Inc. | Use of circulating cell-free rna for diagnosis and/or monitoring cancer |
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| WO2017062517A1 (en) * | 2015-10-06 | 2017-04-13 | The Regents Of The University Of California | Non-coding rnas linked to immortality and associated methods and compositions |
| WO2017079384A1 (en) * | 2015-11-04 | 2017-05-11 | Metabolon, Inc. | Automated sample quality assessment |
| EP3978627A1 (en) | 2016-03-25 | 2022-04-06 | Karius, Inc. | Methods using synthetic nucleic acid spike-ins |
| WO2018191563A1 (en) | 2017-04-12 | 2018-10-18 | Karius, Inc. | Sample preparation methods, systems and compositions |
| KR20200003917A (ko) * | 2017-05-10 | 2020-01-10 | 난토믹스, 엘엘씨 | 암의 검출, 예측, 및 모니터링을 위한 순환 rna(circulating rna for detection, prediction, and monitoring of cancer) |
| CN110869518A (zh) * | 2017-05-16 | 2020-03-06 | 香港中文大学 | 整合式单细胞和游离血浆rna分析 |
| EP3701043B1 (en) | 2017-10-23 | 2023-11-22 | CZ Biohub SF, LLC | A noninvasive molecular clock for fetal development predicts gestational age and preterm delivery |
| CN111526793A (zh) | 2017-10-27 | 2020-08-11 | 朱诺诊断学公司 | 用于超低体积液体活检的设备、系统和方法 |
| US11702703B2 (en) | 2017-11-07 | 2023-07-18 | Nanthealth Labs, Inc. | Targeted cell free nucleic acid analysis |
| CA3082601A1 (en) | 2018-03-16 | 2019-09-19 | Karius, Inc. | Sample series to differentiate target nucleic acids from contaminant nucleic acids |
| US12462935B2 (en) | 2018-03-30 | 2025-11-04 | Nucleix Ltd. | Deep learning-based methods, devices, and systems for prenatal testing |
| JP2022504078A (ja) | 2018-10-04 | 2022-01-13 | ブルースター ジェノミクス， インコーポレイテッド | 単一の生物学的サンプル由来のタンパク質、ヌクレオソームおよび無細胞核酸のシーケンシングベースの同時分析 |
| CN113874525A (zh) * | 2018-10-29 | 2021-12-31 | 分子听诊器公司 | 使用无细胞信使rna的骨髓表征 |
| EP4700161A3 (en) | 2018-11-21 | 2026-03-11 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| AU2019403269A1 (en) * | 2018-12-18 | 2021-06-17 | Grail, Llc | Methods for detecting disease using analysis of RNA |
| EP3914731A1 (en) * | 2019-01-24 | 2021-12-01 | Illumina, Inc. | Methods and systems for monitoring organ health and disease |
| GB2615975B (en) | 2019-02-14 | 2023-11-29 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| CA3132030A1 (en) * | 2019-04-02 | 2020-10-08 | Dalia Dhingra | Methods, systems, and apparatus for nucleic acid detection |
| AU2020280104A1 (en) | 2019-05-22 | 2022-01-20 | Mission Bio, Inc. | Method and apparatus for simultaneous targeted sequencing of DNA, RNA and protein |
| US11948684B2 (en) * | 2019-06-20 | 2024-04-02 | Latha Chakravarthy | Diagnostic process for disease detection using gene expression based multi layer PCA classifier |
| CN110964800B (zh) * | 2019-09-20 | 2021-10-22 | 北京航空航天大学 | 用于预测早产风险的cfRNA标志物 |
| US11742058B2 (en) | 2019-11-05 | 2023-08-29 | Cofactor Genomics, Inc. | Methods and systems of processing complex data sets using artificial intelligence and deconvolution |
| CN115136242A (zh) * | 2019-11-08 | 2022-09-30 | 雷杰纳荣制药公司 | 来自大量组织转录组的准确稳健的信息反卷积 |
| EP4077710A4 (en) * | 2019-12-20 | 2024-02-21 | University of Utah Research Foundation | Methods and compositions for monitoring and diagnosing healthy and disease states |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| CA3172199A1 (en) * | 2020-03-18 | 2021-09-23 | Michael Nerenberg | Systems and methods of detecting a risk of alzheimer's disease using a circulating-free mrna profiling assay |
| MX2023001781A (es) * | 2020-08-13 | 2023-04-26 | Mirvie Inc | Metodos y sistemas para determinar un estado relacionado con el embarazo de un sujeto. |
| WO2024182491A1 (en) * | 2023-02-28 | 2024-09-06 | Virginia Commonwealth University | Polygenic risk estimator for cervical length change during pregnancy |
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| US5432054A (en) | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
| US20050123938A1 (en) * | 1999-01-06 | 2005-06-09 | Chondrogene Limited | Method for the detection of osteoarthritis related gene transcripts in blood |
| CA2702148C (en) * | 1999-01-06 | 2014-03-04 | Genenews Inc. | Method of profiling gene expression in a human subject having an infectious disease |
| US20080009467A1 (en) | 2000-05-01 | 2008-01-10 | Accera, Inc. | Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimers disease and other diseases resulting from reduced neuronal metabolism |
| US6727066B2 (en) | 2000-07-28 | 2004-04-27 | Incyte Corporation | Genes expressed in treated human C3A liver cell cultures |
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-
2013
- 2013-01-28 HK HK15104602.5A patent/HK1211624A1/xx unknown
- 2013-01-28 SG SG11201505515XA patent/SG11201505515XA/en unknown
- 2013-01-28 EP EP19173751.9A patent/EP3584327A1/en active Pending
- 2013-01-28 CN CN201380017554.6A patent/CN104334742A/zh active Pending
- 2013-01-28 WO PCT/US2013/023471 patent/WO2013113012A2/en not_active Ceased
- 2013-01-28 US US13/752,131 patent/US20130252835A1/en not_active Abandoned
- 2013-01-28 JP JP2014554934A patent/JP6320302B2/ja active Active
- 2013-01-28 EP EP13740984.3A patent/EP2807277A4/en not_active Ceased
- 2013-01-28 SG SG10201906331TA patent/SG10201906331TA/en unknown
- 2013-01-28 AU AU2013211850A patent/AU2013211850B8/en active Active
- 2013-01-28 CA CA2863035A patent/CA2863035C/en active Active
- 2013-01-28 CN CN201810084289.8A patent/CN108359711A/zh active Pending
-
2015
- 2015-09-22 US US14/861,650 patent/US10240200B2/en active Active
-
2016
- 2016-12-13 US US15/377,901 patent/US10155986B2/en active Active
- 2016-12-13 US US15/377,904 patent/US10240204B2/en active Active
- 2016-12-13 US US15/377,894 patent/US10287632B2/en active Active
-
2017
- 2017-01-20 JP JP2017008768A patent/JP2017063799A/ja active Pending
-
2018
- 2018-05-02 US US15/969,603 patent/US20180357379A1/en not_active Abandoned
-
2019
- 2019-04-03 US US16/373,996 patent/US20190226029A1/en not_active Abandoned
-
2020
- 2020-08-05 US US16/986,057 patent/US20200370121A1/en not_active Abandoned
- 2020-08-05 US US16/986,042 patent/US20200362416A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/187,298 patent/US20220042098A1/en active Pending
- 2021-08-06 US US17/396,457 patent/US20210363584A1/en not_active Abandoned
- 2021-08-06 US US17/396,490 patent/US20220010381A1/en not_active Abandoned
-
2022
- 2022-02-03 US US17/592,311 patent/US20220290236A1/en not_active Abandoned
- 2022-02-10 US US17/669,081 patent/US12365947B2/en active Active
-
2025
- 2025-06-10 US US19/234,022 patent/US20260055464A1/en active Pending
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