JP2015511122A5 - - Google Patents
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- JP2015511122A5 JP2015511122A5 JP2014554934A JP2014554934A JP2015511122A5 JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5 JP 2014554934 A JP2014554934 A JP 2014554934A JP 2014554934 A JP2014554934 A JP 2014554934A JP 2015511122 A5 JP2015511122 A5 JP 2015511122A5
- Authority
- JP
- Japan
- Prior art keywords
- amount
- tissue
- subject
- rna
- specific
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 35
- 210000001519 tissue Anatomy 0.000 claims 20
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 14
- 239000012472 biological sample Substances 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 9
- 239000008280 blood Substances 0.000 claims 9
- 108091092259 cell-free RNA Proteins 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 8
- 238000012163 sequencing technique Methods 0.000 claims 8
- 102000040650 (ribonucleotides)n+m Human genes 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 239000012530 fluid Substances 0.000 claims 4
- 238000009396 hybridization Methods 0.000 claims 4
- 210000004556 brain Anatomy 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010036790 Productive cough Diseases 0.000 claims 2
- 239000013614 RNA sample Substances 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 238000002493 microarray Methods 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 238000003753 real-time PCR Methods 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 210000003296 saliva Anatomy 0.000 claims 2
- 210000000582 semen Anatomy 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- -1 sweat Substances 0.000 claims 2
- 210000002700 urine Anatomy 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001638 cerebellum Anatomy 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 210000003754 fetus Anatomy 0.000 claims 1
- 210000002216 heart Anatomy 0.000 claims 1
- 210000003016 hypothalamus Anatomy 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 210000001165 lymph node Anatomy 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 210000005059 placental tissue Anatomy 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000001541 thymus gland Anatomy 0.000 claims 1
- 210000001685 thyroid gland Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261591642P | 2012-01-27 | 2012-01-27 | |
| US61/591,642 | 2012-01-27 | ||
| PCT/US2013/023471 WO2013113012A2 (en) | 2012-01-27 | 2013-01-28 | Methods for profiling and quantitating cell-free rna |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Division JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511122A JP2015511122A (ja) | 2015-04-16 |
| JP2015511122A5 true JP2015511122A5 (https=) | 2016-03-03 |
| JP6320302B2 JP6320302B2 (ja) | 2018-05-09 |
Family
ID=48874081
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014554934A Active JP6320302B2 (ja) | 2012-01-27 | 2013-01-28 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017008768A Pending JP2017063799A (ja) | 2012-01-27 | 2017-01-20 | 無細胞ｒｎａをプロファイリングおよび定量するための方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (15) | US20130252835A1 (https=) |
| EP (2) | EP2807277A4 (https=) |
| JP (2) | JP6320302B2 (https=) |
| CN (2) | CN104334742A (https=) |
| AU (1) | AU2013211850B8 (https=) |
| CA (1) | CA2863035C (https=) |
| HK (1) | HK1211624A1 (https=) |
| SG (2) | SG11201505515XA (https=) |
| WO (1) | WO2013113012A2 (https=) |
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| RU2565550C2 (ru) | 2010-09-24 | 2015-10-20 | Те Борд Оф Трастиз Оф Те Лилэнд Стэнфорд Джуниор Юниверсити | Прямой захват, амплификация и секвенирование днк-мишени с использованием иммобилизированных праймеров |
| US20160289762A1 (en) | 2012-01-27 | 2016-10-06 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| WO2015069900A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiliing and quantitating cell-free rna |
| WO2013113012A2 (en) | 2012-01-27 | 2013-08-01 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for profiling and quantitating cell-free rna |
| US10689652B2 (en) | 2013-10-02 | 2020-06-23 | The Regents Of The University Of California | Methods for immortalization of epithelial cells |
| WO2015069933A1 (en) * | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| JP7451070B2 (ja) * | 2013-11-07 | 2024-03-18 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | ヒトミクロビオームおよびその成分の分析のための無細胞核酸 |
| CN107002122B (zh) | 2014-07-25 | 2023-09-19 | 华盛顿大学 | 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法 |
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| WO2017062517A1 (en) * | 2015-10-06 | 2017-04-13 | The Regents Of The University Of California | Non-coding rnas linked to immortality and associated methods and compositions |
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| AU2018269103A1 (en) * | 2017-05-16 | 2019-10-31 | The Chinese University Of Hong Kong | Integrative single-cell and cell-free plasma RNA analysis |
| JP7319553B2 (ja) * | 2017-10-23 | 2023-08-02 | シーゼット・バイオハブ・エスエフ・リミテッド・ライアビリティ・カンパニー | 在胎週数および早産を予測する胎児発達のための非侵襲的分子時計 |
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| AU2018365883A1 (en) | 2017-11-07 | 2020-05-14 | Nanthealth Labs, Inc. | Targeted cell free nucleic acid analysis |
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| US12540319B2 (en) | 2018-10-04 | 2026-02-03 | Clearnote Health, Inc. | Simultaneous, sequencing-based analysis of proteins, nucleosomes, and cell-free nucleic acids from a single biological sample |
| EP3874042A4 (en) * | 2018-10-29 | 2023-06-28 | Molecular Stethoscope, Inc. | Characterization of bone marrow using cell-free messenger-rna |
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| US11512349B2 (en) | 2018-12-18 | 2022-11-29 | Grail, Llc | Methods for detecting disease using analysis of RNA |
| MX2020014095A (es) * | 2019-01-24 | 2021-03-09 | Illumina Inc | Metodos y sistemas para monitorear la salud y enfermedad de organos. |
| GB2612911B (en) * | 2019-02-14 | 2023-11-22 | Mirvie Inc | Methods and systems for determining a pregnancy-related state of a subject |
| AU2020253585A1 (en) * | 2019-04-02 | 2021-11-18 | Mission Bio, Inc. | Methods, systems, and apparatus for nucleic acid detection |
| CA3138806A1 (en) | 2019-05-22 | 2020-11-26 | Dalia Dhingra | Method and apparatus for simultaneous targeted sequencing of dna, rna and protein |
| US11948684B2 (en) * | 2019-06-20 | 2024-04-02 | Latha Chakravarthy | Diagnostic process for disease detection using gene expression based multi layer PCA classifier |
| CN110964800B (zh) * | 2019-09-20 | 2021-10-22 | 北京航空航天大学 | 用于预测早产风险的cfRNA标志物 |
| WO2021092224A1 (en) * | 2019-11-05 | 2021-05-14 | Cofactor Genomics, Inc. | Methods and systems of processing complex data sets using artificial intelligence and deconvolution |
| AU2020378080B2 (en) * | 2019-11-08 | 2026-02-19 | Regeneron Pharmaceuticals, Inc. | Accurate and robust information-deconvolution from bulk tissue transcriptomes |
| CA3162391A1 (en) * | 2019-12-20 | 2021-06-24 | Jesse Worth ROWLEY | Methods and compositions for monitoring and diagnosing healthy and disease states |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| CN115701286A (zh) * | 2020-03-18 | 2023-02-07 | 分子听诊器公司 | 使用无循环mRNA谱分析检测阿尔茨海默病风险的系统和方法 |
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| WO2024182491A1 (en) * | 2023-02-28 | 2024-09-06 | Virginia Commonwealth University | Polygenic risk estimator for cervical length change during pregnancy |
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-
2013
- 2013-01-28 WO PCT/US2013/023471 patent/WO2013113012A2/en not_active Ceased
- 2013-01-28 JP JP2014554934A patent/JP6320302B2/ja active Active
- 2013-01-28 EP EP13740984.3A patent/EP2807277A4/en not_active Ceased
- 2013-01-28 SG SG11201505515XA patent/SG11201505515XA/en unknown
- 2013-01-28 HK HK15104602.5A patent/HK1211624A1/xx unknown
- 2013-01-28 AU AU2013211850A patent/AU2013211850B8/en active Active
- 2013-01-28 SG SG10201906331TA patent/SG10201906331TA/en unknown
- 2013-01-28 CN CN201380017554.6A patent/CN104334742A/zh active Pending
- 2013-01-28 CA CA2863035A patent/CA2863035C/en active Active
- 2013-01-28 US US13/752,131 patent/US20130252835A1/en not_active Abandoned
- 2013-01-28 CN CN201810084289.8A patent/CN108359711A/zh active Pending
- 2013-01-28 EP EP19173751.9A patent/EP3584327A1/en active Pending
-
2015
- 2015-09-22 US US14/861,650 patent/US10240200B2/en active Active
-
2016
- 2016-12-13 US US15/377,901 patent/US10155986B2/en active Active
- 2016-12-13 US US15/377,894 patent/US10287632B2/en active Active
- 2016-12-13 US US15/377,904 patent/US10240204B2/en active Active
-
2017
- 2017-01-20 JP JP2017008768A patent/JP2017063799A/ja active Pending
-
2018
- 2018-05-02 US US15/969,603 patent/US20180357379A1/en not_active Abandoned
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2019
- 2019-04-03 US US16/373,996 patent/US20190226029A1/en not_active Abandoned
-
2020
- 2020-08-05 US US16/986,042 patent/US20200362416A1/en not_active Abandoned
- 2020-08-05 US US16/986,057 patent/US20200370121A1/en not_active Abandoned
-
2021
- 2021-02-26 US US17/187,298 patent/US20220042098A1/en active Pending
- 2021-08-06 US US17/396,490 patent/US20220010381A1/en not_active Abandoned
- 2021-08-06 US US17/396,457 patent/US20210363584A1/en not_active Abandoned
-
2022
- 2022-02-03 US US17/592,311 patent/US20220290236A1/en not_active Abandoned
- 2022-02-10 US US17/669,081 patent/US12365947B2/en active Active
-
2025
- 2025-06-10 US US19/234,022 patent/US20260055464A1/en active Pending
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