JP2015511015A5 - - Google Patents
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- JP2015511015A5 JP2015511015A5 JP2015500646A JP2015500646A JP2015511015A5 JP 2015511015 A5 JP2015511015 A5 JP 2015511015A5 JP 2015500646 A JP2015500646 A JP 2015500646A JP 2015500646 A JP2015500646 A JP 2015500646A JP 2015511015 A5 JP2015511015 A5 JP 2015511015A5
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- JP
- Japan
- Prior art keywords
- substrate
- item
- reaction sites
- article
- glass
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 238000006243 chemical reaction Methods 0.000 claims description 70
- 239000000758 substrate Substances 0.000 claims description 50
- 238000000034 method Methods 0.000 claims description 29
- 230000003287 optical effect Effects 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 17
- 239000011521 glass Substances 0.000 claims description 16
- 239000012472 biological sample Substances 0.000 claims description 12
- 230000005284 excitation Effects 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 5
- 230000003746 surface roughness Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 239000003518 caustics Substances 0.000 claims description 3
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 2
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 2
- 238000005530 etching Methods 0.000 claims description 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 239000010453 quartz Substances 0.000 claims description 2
- 229910052710 silicon Inorganic materials 0.000 claims description 2
- 239000010703 silicon Substances 0.000 claims description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 2
- 238000003752 polymerase chain reaction Methods 0.000 description 7
- 239000007788 liquid Substances 0.000 description 5
- 238000007847 digital PCR Methods 0.000 description 4
- 238000003753 real-time PCR Methods 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000007844 allele-specific PCR Methods 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000007846 asymmetric PCR Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000006112 glass ceramic composition Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 238000007403 mPCR Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Applications Claiming Priority (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261612087P | 2012-03-16 | 2012-03-16 | |
| US201261612005P | 2012-03-16 | 2012-03-16 | |
| US201261612008P | 2012-03-16 | 2012-03-16 | |
| US61/612,008 | 2012-03-16 | ||
| US61/612,005 | 2012-03-16 | ||
| US61/612,087 | 2012-03-16 | ||
| US201261659029P | 2012-06-13 | 2012-06-13 | |
| US61/659,029 | 2012-06-13 | ||
| US201261723710P | 2012-11-07 | 2012-11-07 | |
| US201261723759P | 2012-11-07 | 2012-11-07 | |
| US201261723658P | 2012-11-07 | 2012-11-07 | |
| US201261723738P | 2012-11-07 | 2012-11-07 | |
| US61/723,710 | 2012-11-07 | ||
| US61/723,759 | 2012-11-07 | ||
| US61/723,738 | 2012-11-07 | ||
| US61/723,658 | 2012-11-07 | ||
| US201361774499P | 2013-03-07 | 2013-03-07 | |
| US61/774,499 | 2013-03-07 | ||
| PCT/US2013/032002 WO2013138706A2 (en) | 2012-03-16 | 2013-03-15 | Systems and methods for containing biological samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015511015A JP2015511015A (ja) | 2015-04-13 |
| JP2015511015A5 true JP2015511015A5 (cg-RX-API-DMAC7.html) | 2016-05-12 |
Family
ID=48014371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500646A Pending JP2015511015A (ja) | 2012-03-16 | 2013-03-15 | 生体試料を収容するためのシステム及び方法 |
| JP2015500667A Pending JP2015516802A (ja) | 2012-03-16 | 2013-03-15 | 生物学的分析のためのシステムおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015500667A Pending JP2015516802A (ja) | 2012-03-16 | 2013-03-15 | 生物学的分析のためのシステムおよび方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US20150044686A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2825310A2 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2015511015A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20140140080A (cg-RX-API-DMAC7.html) |
| CN (2) | CN104302400B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2013231910A1 (cg-RX-API-DMAC7.html) |
| IN (1) | IN2014DN08135A (cg-RX-API-DMAC7.html) |
| RU (2) | RU2014140837A (cg-RX-API-DMAC7.html) |
| SG (2) | SG11201405785WA (cg-RX-API-DMAC7.html) |
| WO (2) | WO2013138767A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102012100824A1 (de) * | 2012-02-01 | 2013-09-05 | Albert-Ludwigs-Universität Freiburg | Gemultiplexte Digital PCR |
| CA2915475A1 (en) | 2013-05-24 | 2014-11-27 | Life Technologies Corporation | Case and case holder for biological samples and corresponding method of use |
| US20170080426A1 (en) * | 2014-05-14 | 2017-03-23 | University Of Limerick | Device and method for testing compounds on living cells |
| EP4220139B1 (en) * | 2015-02-06 | 2025-05-28 | Life Technologies Corporation | Systems and methods for assessing biological samples |
| SG10202001197UA (en) | 2015-02-06 | 2020-03-30 | Life Technologies Corp | Systems and methods for biological analysis |
| JP6661947B2 (ja) * | 2015-10-01 | 2020-03-11 | 凸版印刷株式会社 | 蛍光画像撮影装置及び蛍光画像撮影方法 |
| CN105543064B (zh) * | 2015-12-29 | 2018-04-17 | 西安交通大学 | 一种数字pcr芯片及其使用方法 |
| WO2017201198A1 (en) * | 2016-05-18 | 2017-11-23 | Illumina, Inc. | Self assembled patterning using patterned hydrophobic surfaces |
| US11719702B2 (en) | 2016-11-07 | 2023-08-08 | Battelle Memorial Institute | Methods and systems of proteome analysis and imaging |
| EP3535418B1 (en) | 2016-11-07 | 2021-12-15 | Battelle Memorial Institute | Nanoscale biochemical sample preparation and analysis |
| US11085039B2 (en) | 2016-12-12 | 2021-08-10 | xCella Biosciences, Inc. | Methods and systems for screening using microcapillary arrays |
| US11473081B2 (en) | 2016-12-12 | 2022-10-18 | xCella Biosciences, Inc. | Methods and systems for screening using microcapillary arrays |
| JP7208902B2 (ja) | 2016-12-30 | 2023-01-19 | エクセラ・バイオサイエンシーズ・インコーポレイテッド | マルチステージサンプル回収システム |
| CN107254511A (zh) * | 2017-04-27 | 2017-10-17 | 臻准生物科技（上海）有限公司 | 一种数字pcr芯片信号读取方法 |
| CN110878250A (zh) * | 2018-09-05 | 2020-03-13 | 上海新微技术研发中心有限公司 | 基于通孔结构和微流控的dPCR原位芯片及制作方法 |
| EP3890876B1 (en) | 2018-12-06 | 2024-05-01 | Xcella Biosciences, Inc. | Lateral loading of microcapillary arrays |
| CN111349555B (zh) * | 2018-12-21 | 2023-07-18 | 成都万众壹芯生物科技有限公司 | 一种基于微孔阵列芯片的数字pcr扩增装置及其使用方法 |
| JP7347931B2 (ja) * | 2018-12-26 | 2023-09-20 | スリーエム イノベイティブ プロパティズ カンパニー | マイクロ流体デバイス用フィルム、マイクロ流体デバイス及びその製造方法 |
| WO2020196817A1 (ja) * | 2019-03-28 | 2020-10-01 | 国立大学法人愛媛大学 | 分光分析用チップ |
| CN112239719A (zh) * | 2019-07-19 | 2021-01-19 | 成都万众壹芯生物科技有限公司 | 基于微孔阵列芯片的数字pcr扩增装置和利用其进行扩增的方法 |
| US12209985B2 (en) * | 2020-09-18 | 2025-01-28 | Visera Technologies Company Limited | Sensor device and method of using the same |
| KR102595551B1 (ko) * | 2021-06-23 | 2023-10-30 | (주)옵토레인 | 다중 친수성을 갖는 체외진단칩 |
| KR102674118B1 (ko) * | 2021-07-08 | 2024-06-12 | (주)옵토레인 | Pcr 모듈 |
| KR20230138571A (ko) | 2022-03-23 | 2023-10-05 | 삼성전자주식회사 | 바이오 입자 검출 장치 및 방법 |
| CN117019248B (zh) * | 2023-08-17 | 2025-05-02 | 杭州跃真生物科技有限公司 | 一种微孔芯片与单细胞分析方法 |
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| US3473927A (en) * | 1965-12-14 | 1969-10-21 | Corning Glass Works | Double negative exposure method for photosensitively opacifiable glass |
| JPS582240A (ja) * | 1981-06-26 | 1983-01-07 | Hoya Corp | 化学切削性感光ガラスの露光方法 |
| US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US20020015997A1 (en) * | 1997-06-16 | 2002-02-07 | Lafferty William Michael | Capillary array-based sample screening |
| US6893877B2 (en) * | 1998-01-12 | 2005-05-17 | Massachusetts Institute Of Technology | Methods for screening substances in a microwell array |
| ATE477850T1 (de) * | 1998-01-12 | 2010-09-15 | Massachusetts Inst Technology | Vorrichtung zur mikrotestdurchführung |
| US6027695A (en) * | 1998-04-01 | 2000-02-22 | Dupont Pharmaceuticals Company | Apparatus for holding small volumes of liquids |
| AU3649199A (en) * | 1998-04-17 | 1999-11-08 | Ljl Biosystems, Inc. | Sample-holding devices and systems |
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| WO2011100445A1 (en) * | 2010-02-10 | 2011-08-18 | Life Bioscience, Inc. | Methods to fabricate a photoactive substrate suitable for microfabrication |
| SG11201405788UA (en) * | 2012-03-16 | 2014-11-27 | Life Technologies Corp | Coated substrate for biological reaction systems |
-
2013
- 2013-03-15 CN CN201380025569.7A patent/CN104302400B/zh not_active Expired - Fee Related
- 2013-03-15 JP JP2015500646A patent/JP2015511015A/ja active Pending
- 2013-03-15 JP JP2015500667A patent/JP2015516802A/ja active Pending
- 2013-03-15 KR KR20147029044A patent/KR20140140080A/ko not_active Withdrawn
- 2013-03-15 US US14/385,765 patent/US20150044686A1/en not_active Abandoned
- 2013-03-15 US US14/385,730 patent/US20150080247A1/en not_active Abandoned
- 2013-03-15 CN CN201380022560.0A patent/CN104411408B/zh not_active Expired - Fee Related
- 2013-03-15 WO PCT/US2013/032420 patent/WO2013138767A1/en not_active Ceased
- 2013-03-15 RU RU2014140837A patent/RU2014140837A/ru not_active Application Discontinuation
- 2013-03-15 AU AU2013231910A patent/AU2013231910A1/en not_active Abandoned
- 2013-03-15 IN IN8135DEN2014 patent/IN2014DN08135A/en unknown
- 2013-03-15 RU RU2014141637A patent/RU2014141637A/ru not_active Application Discontinuation
- 2013-03-15 SG SG11201405785WA patent/SG11201405785WA/en unknown
- 2013-03-15 SG SG11201406039WA patent/SG11201406039WA/en unknown
- 2013-03-15 WO PCT/US2013/032002 patent/WO2013138706A2/en not_active Ceased
- 2013-03-15 EP EP13713043.1A patent/EP2825310A2/en not_active Withdrawn
- 2013-03-15 EP EP13713049.8A patent/EP2825314A1/en not_active Withdrawn
- 2013-03-15 KR KR20147028892A patent/KR20150003738A/ko not_active Withdrawn
-
2019
- 2019-05-30 US US16/426,631 patent/US11590506B2/en active Active
-
2022
- 2022-12-21 US US18/086,416 patent/US20230201839A1/en active Pending
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