JP2015510940A5 - - Google Patents
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- Publication number
- JP2015510940A5 JP2015510940A5 JP2015501814A JP2015501814A JP2015510940A5 JP 2015510940 A5 JP2015510940 A5 JP 2015510940A5 JP 2015501814 A JP2015501814 A JP 2015501814A JP 2015501814 A JP2015501814 A JP 2015501814A JP 2015510940 A5 JP2015510940 A5 JP 2015510940A5
- Authority
- JP
- Japan
- Prior art keywords
- liquid composition
- volume
- less
- composition according
- bendamustine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000007788 liquid Substances 0.000 claims 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 9
- YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 claims 8
- 229960002707 bendamustine Drugs 0.000 claims 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 5
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 239000003085 diluting agent Substances 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 235000021023 sodium intake Nutrition 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 230000008085 renal dysfunction Effects 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 230000004962 physiological condition Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 208000028564 B-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 claims 1
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261613173P | 2012-03-20 | 2012-03-20 | |
| US61/613,173 | 2012-03-20 | ||
| US201261669889P | 2012-07-10 | 2012-07-10 | |
| US61/669,889 | 2012-07-10 | ||
| US201261678715P | 2012-08-02 | 2012-08-02 | |
| US61/678,715 | 2012-08-02 | ||
| PCT/US2013/032295 WO2013142359A1 (en) | 2012-03-20 | 2013-03-15 | Method of treating bendamustine-responsive conditions in patients requiring reduced volumes for administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017193917A Division JP6381761B2 (ja) | 2012-03-20 | 2017-10-04 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015510940A JP2015510940A (ja) | 2015-04-13 |
| JP2015510940A5 true JP2015510940A5 (enExample) | 2016-04-28 |
| JP6224064B2 JP6224064B2 (ja) | 2017-11-01 |
Family
ID=49212373
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015501814A Active JP6224064B2 (ja) | 2012-03-20 | 2013-03-15 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2017193917A Active JP6381761B2 (ja) | 2012-03-20 | 2017-10-04 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2018143022A Active JP6738376B2 (ja) | 2012-03-20 | 2018-07-31 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2020093802A Pending JP2020143143A (ja) | 2012-03-20 | 2020-05-29 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2021186829A Pending JP2022028813A (ja) | 2012-03-20 | 2021-11-17 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2023212014A Pending JP2024037915A (ja) | 2012-03-20 | 2023-12-15 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017193917A Active JP6381761B2 (ja) | 2012-03-20 | 2017-10-04 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2018143022A Active JP6738376B2 (ja) | 2012-03-20 | 2018-07-31 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2020093802A Pending JP2020143143A (ja) | 2012-03-20 | 2020-05-29 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2021186829A Pending JP2022028813A (ja) | 2012-03-20 | 2021-11-17 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| JP2023212014A Pending JP2024037915A (ja) | 2012-03-20 | 2023-12-15 | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US9000021B2 (enExample) |
| EP (3) | EP3533447B1 (enExample) |
| JP (6) | JP6224064B2 (enExample) |
| CN (2) | CN104271135B (enExample) |
| CA (1) | CA2867343C (enExample) |
| DK (2) | DK2827863T3 (enExample) |
| ES (2) | ES2943668T3 (enExample) |
| FI (1) | FI3533447T3 (enExample) |
| HK (1) | HK1243346A1 (enExample) |
| HR (2) | HRP20190693T1 (enExample) |
| HU (2) | HUE044233T2 (enExample) |
| LT (1) | LT2827863T (enExample) |
| PL (2) | PL2827863T3 (enExample) |
| PT (2) | PT3533447T (enExample) |
| RS (2) | RS58744B1 (enExample) |
| SI (2) | SI2827863T1 (enExample) |
| WO (1) | WO2013142359A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE054836T2 (hu) | 2010-01-28 | 2021-10-28 | Eagle Pharmaceuticals Inc | Bendamusztin kiszerelései |
| JP6224064B2 (ja) | 2012-03-20 | 2017-11-01 | イーグル・ファーマシューティカルズ・インコーポレーテッド | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| HRP20240056T1 (hr) * | 2012-03-20 | 2024-03-29 | Eagle Pharmaceuticals, Inc. | Formulacije bendamustina |
| US20230241218A1 (en) * | 2012-07-10 | 2023-08-03 | Eagle Pharmaceuticals, Inc. | Formulations of bendamustine |
| US11826466B2 (en) | 2016-08-31 | 2023-11-28 | Navinta, Llc | Bendamustine solution formulations |
| US10905677B2 (en) | 2016-08-31 | 2021-02-02 | Navinta, Llc | Bendamustine solution formulations |
| CA3108321A1 (en) | 2018-08-17 | 2020-02-20 | Hospira Australia Pty Ltd | Liquid bendamustine pharmaceutical compositions |
| US11730815B2 (en) * | 2018-11-26 | 2023-08-22 | Good Health, Llc | Stable liquid pharmaceutical compositions comprising bendamustine |
| JP7235288B2 (ja) * | 2019-01-07 | 2023-03-08 | コーアイセイ株式会社 | ベンダムスチンの液体製剤 |
| CN110123747A (zh) * | 2019-04-26 | 2019-08-16 | 嘉兴市爵拓科技有限公司 | 苯达莫司汀的制剂 |
| JPWO2021014957A1 (enExample) * | 2019-07-22 | 2021-01-28 | ||
| WO2021161876A1 (ja) * | 2020-02-10 | 2021-08-19 | 富士フイルム株式会社 | ベンダムスチン液剤 |
| US20240148696A1 (en) | 2022-10-25 | 2024-05-09 | Softkemo Pharma Inc. | Lyophilized bendamustine-cyclodextrin composition |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE159289C (enExample) | 1903-10-08 | 1905-03-16 | ||
| US4071620A (en) | 1977-01-10 | 1978-01-31 | American Home Products Corporation | Stabilization of oxygen sensitive dose forms |
| DD159289A1 (de) | 1981-06-01 | 1983-03-02 | Uwe Olthoff | Verfahren zur herstellung stabiler injektionsloesungen von n-lostverbindungen |
| DE3446873A1 (de) | 1984-12-21 | 1986-07-10 | Merckle Gmbh | Fluessige diclofenac-zubereitungen |
| US5223515A (en) | 1988-08-18 | 1993-06-29 | Takeda Chemical Industries, Ltd. | Injectable solution containing a pyridyl methylsulfinylbenzimidazole |
| NZ279443A (en) | 1994-01-24 | 1998-04-27 | Procter & Gamble | Solubilizing difficultly soluble pharmaceutical agents using a mixture of polyethylene glycol, polyvinylpyrrolidone and propylene glycol |
| EP1004305B1 (en) | 1998-04-20 | 2011-09-28 | Eisai R&D Management Co., Ltd. | Stabilized compositions containing benzimidazole-type compounds |
| WO2002032427A1 (en) | 2000-10-20 | 2002-04-25 | Galephar M/F | Stable oral formulation containing benzimidazole derivative |
| ES2300622T3 (es) | 2002-07-30 | 2008-06-16 | Wyeth | Formulaciones parenterales que contienen un hidroxiester de rapamicina. |
| US20060035945A1 (en) | 2003-05-30 | 2006-02-16 | Giorgio Attardo | Triheterocyclic compounds, compositions, and methods for treating cancer or viral diseases |
| SE0401842D0 (sv) * | 2004-07-12 | 2004-07-12 | Dizlin Medical Design Ab | Infusion and injection solution of levodopa |
| CA2585659A1 (en) | 2004-11-05 | 2006-06-22 | Cephalon, Inc. | Cancer treatments |
| US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
| WO2007026771A1 (ja) * | 2005-08-31 | 2007-03-08 | Ono Pharmaceutical Co., Ltd. | 点滴用注射剤 |
| JPWO2008020584A1 (ja) | 2006-08-14 | 2010-01-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 安定な凍結乾燥製剤 |
| WO2008044029A1 (en) | 2006-10-12 | 2008-04-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8414909B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
| DE102007003184A1 (de) | 2007-01-22 | 2008-07-24 | Orlowski, Michael, Dr. | Verfahren zur Beladung von strukturierten Oberflächen |
| US20090082416A1 (en) | 2007-09-25 | 2009-03-26 | Protia, Llc | Deuterium-enriched bendamustine |
| AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
| EP2889029A1 (en) * | 2008-09-25 | 2015-07-01 | Cephalon, Inc. | Liquid formulations of bendamustine |
| US8076366B2 (en) | 2009-01-15 | 2011-12-13 | Cephalon, Inc. | Forms of bendamustine free base |
| CA2753641C (en) | 2009-02-25 | 2014-09-16 | Supratek Pharma, Inc. | Bendamustine cyclopolysaccharide compositions |
| US20100273730A1 (en) * | 2009-04-27 | 2010-10-28 | Innopharmax, Inc. | Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof |
| EP2424506A1 (en) | 2009-04-28 | 2012-03-07 | Cephalon, Inc. | Oral formulations of bendamustine |
| CN101584668A (zh) * | 2009-06-19 | 2009-11-25 | 江苏奥赛康药业有限公司 | 盐酸苯达莫司汀冻干粉针剂 |
| WO2010148288A2 (en) | 2009-06-19 | 2010-12-23 | Lyotropic Therapeutics, Inc. | Pharmaceutical formulations with low aqueous levels of free unbound drug |
| US8389558B2 (en) | 2009-07-20 | 2013-03-05 | Supratek Pharma Inc. | Bendamustine amphiphilic anionic compositions |
| US20110015245A1 (en) | 2009-07-20 | 2011-01-20 | Valery Alakhov | Bendamustine amphiphilic cationic compositions |
| US7772274B1 (en) | 2009-10-19 | 2010-08-10 | Scidose, Llc | Docetaxel formulations with lipoic acid |
| HUE054836T2 (hu) | 2010-01-28 | 2021-10-28 | Eagle Pharmaceuticals Inc | Bendamusztin kiszerelései |
| US8604032B2 (en) * | 2010-05-21 | 2013-12-10 | Infinity Pharmaceuticals, Inc. | Chemical compounds, compositions and methods for kinase modulation |
| JP2013540104A (ja) | 2010-07-28 | 2013-10-31 | イーグル・ファーマシューティカルズ・インコーポレーテッド | 延長された保存安定性を有するペメトレキセドを含有する医薬組成物 |
| AU2012347972B2 (en) | 2011-12-05 | 2018-05-10 | X-Body, Inc. | PDGF receptor beta binding polypeptides |
| US20130210878A1 (en) * | 2012-01-24 | 2013-08-15 | Innopharma, Inc. | Bendamustine compositions and methods therefore |
| JP2015506989A (ja) | 2012-02-14 | 2015-03-05 | イーグル・ファーマシューティカルズ・インコーポレーテッド | ベンダムスチン製剤 |
| JP6224064B2 (ja) | 2012-03-20 | 2017-11-01 | イーグル・ファーマシューティカルズ・インコーポレーテッド | 低減された投与容量を必要とする患者におけるベンダムスチン応答性症状の治療方法 |
| HRP20240056T1 (hr) | 2012-03-20 | 2024-03-29 | Eagle Pharmaceuticals, Inc. | Formulacije bendamustina |
-
2013
- 2013-03-15 JP JP2015501814A patent/JP6224064B2/ja active Active
- 2013-03-15 SI SI201331394T patent/SI2827863T1/sl unknown
- 2013-03-15 PL PL13765020T patent/PL2827863T3/pl unknown
- 2013-03-15 DK DK13765020.6T patent/DK2827863T3/en active
- 2013-03-15 EP EP19151152.6A patent/EP3533447B1/en active Active
- 2013-03-15 RS RS20190433A patent/RS58744B1/sr unknown
- 2013-03-15 CA CA2867343A patent/CA2867343C/en active Active
- 2013-03-15 ES ES19151152T patent/ES2943668T3/es active Active
- 2013-03-15 PT PT191511526T patent/PT3533447T/pt unknown
- 2013-03-15 US US13/838,267 patent/US9000021B2/en active Active
- 2013-03-15 LT LTEP13765020.6T patent/LT2827863T/lt unknown
- 2013-03-15 CN CN201380023660.5A patent/CN104271135B/zh not_active Expired - Fee Related
- 2013-03-15 HU HUE13765020 patent/HUE044233T2/hu unknown
- 2013-03-15 HU HUE19151152A patent/HUE062230T2/hu unknown
- 2013-03-15 DK DK19151152.6T patent/DK3533447T3/da active
- 2013-03-15 CN CN201710292508.7A patent/CN107157988A/zh active Pending
- 2013-03-15 ES ES13765020T patent/ES2718902T3/es active Active
- 2013-03-15 PL PL19151152.6T patent/PL3533447T3/pl unknown
- 2013-03-15 WO PCT/US2013/032295 patent/WO2013142359A1/en not_active Ceased
- 2013-03-15 HR HRP20190693TT patent/HRP20190693T1/hr unknown
- 2013-03-15 PT PT13765020T patent/PT2827863T/pt unknown
- 2013-03-15 SI SI201332039T patent/SI3533447T1/sl unknown
- 2013-03-15 RS RS20230252A patent/RS64137B1/sr unknown
- 2013-03-15 HR HRP20230276TT patent/HRP20230276T1/hr unknown
- 2013-03-15 EP EP23161418.1A patent/EP4218756A1/en not_active Withdrawn
- 2013-03-15 EP EP13765020.6A patent/EP2827863B1/en active Active
-
2014
- 2014-11-26 US US14/554,269 patent/US20150080444A1/en not_active Abandoned
-
2015
- 2015-03-15 FI FIEP19151152.6T patent/FI3533447T3/fi active
- 2015-08-06 US US14/820,291 patent/US9579384B2/en active Active
-
2017
- 2017-10-04 JP JP2017193917A patent/JP6381761B2/ja active Active
-
2018
- 2018-02-28 HK HK18102930.9A patent/HK1243346A1/zh unknown
- 2018-07-31 JP JP2018143022A patent/JP6738376B2/ja active Active
-
2020
- 2020-05-29 JP JP2020093802A patent/JP2020143143A/ja active Pending
-
2021
- 2021-11-17 JP JP2021186829A patent/JP2022028813A/ja active Pending
-
2023
- 2023-12-15 JP JP2023212014A patent/JP2024037915A/ja active Pending
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