JP2015509917A - ロイコトリエンｂ４アンタゴニスト化合物 - Google Patents
ロイコトリエンｂ４アンタゴニスト化合物 Download PDFInfo
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- JP2015509917A JP2015509917A JP2014552215A JP2014552215A JP2015509917A JP 2015509917 A JP2015509917 A JP 2015509917A JP 2014552215 A JP2014552215 A JP 2014552215A JP 2014552215 A JP2014552215 A JP 2014552215A JP 2015509917 A JP2015509917 A JP 2015509917A
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- compound
- pharmaceutically acceptable
- atherosclerosis
- propyl
- ltb
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- DNEDJNUUHQACIE-UHFFFAOYSA-M sodium;4-[3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]-2-propylanilino]-2,2-dimethyl-4-oxobutanoate Chemical compound [Na+].CCCC1=C(NC(=O)CC(C)(C)C([O-])=O)C=CC=C1OCCCOC1=CC(O)=C(C=2C=CC(F)=CC=2)C=C1CC DNEDJNUUHQACIE-UHFFFAOYSA-M 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 229960002317 succinimide Drugs 0.000 description 1
- 230000006103 sulfonylation Effects 0.000 description 1
- 238000005694 sulfonylation reaction Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 208000037816 tissue injury Diseases 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 238000005533 tritiation Methods 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261584975P | 2012-01-10 | 2012-01-10 | |
| US61/584,975 | 2012-01-10 | ||
| US201261585799P | 2012-01-12 | 2012-01-12 | |
| US61/585,799 | 2012-01-12 | ||
| PCT/US2013/020195 WO2013106238A1 (en) | 2012-01-10 | 2013-01-04 | Leukotriene b4 antagonist compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015509917A true JP2015509917A (ja) | 2015-04-02 |
| JP2015509917A5 JP2015509917A5 (enExample) | 2016-01-14 |
Family
ID=47604162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014552215A Withdrawn JP2015509917A (ja) | 2012-01-10 | 2013-01-04 | ロイコトリエンｂ４アンタゴニスト化合物 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9187411B2 (enExample) |
| EP (1) | EP2802557B1 (enExample) |
| JP (1) | JP2015509917A (enExample) |
| KR (1) | KR20140099546A (enExample) |
| CN (1) | CN104011012B (enExample) |
| AU (1) | AU2013208260A1 (enExample) |
| BR (1) | BR112014016450A2 (enExample) |
| CA (1) | CA2857521C (enExample) |
| EA (1) | EA023067B1 (enExample) |
| ES (1) | ES2571452T3 (enExample) |
| IN (1) | IN2014MN01014A (enExample) |
| MX (1) | MX2014008452A (enExample) |
| WO (1) | WO2013106238A1 (enExample) |
| ZA (1) | ZA201404732B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10370368B2 (en) | 2015-11-30 | 2019-08-06 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as BLT1 antagonists |
| WO2017095725A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| US10336733B2 (en) | 2015-11-30 | 2019-07-02 | Merk Sharp & Dohme Corp. | Aryl acylsulfonamides as BLT1 antagonists |
| WO2017095724A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5105017A (en) * | 1983-07-18 | 1992-04-14 | Eli Lilly And Company | Leukotriene antagonist intermediates |
| GB9027023D0 (en) | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
| PH30449A (en) | 1991-11-25 | 1997-05-28 | Lilly Co Eli | Substituted phenyl phenol leukotriene antagonists |
| CN1035001C (zh) * | 1993-01-02 | 1997-05-28 | 伊莱利利公司 | 取代的苯基苯酚基白三烯拮抗物 |
| WO1996036347A1 (en) | 1995-05-17 | 1996-11-21 | Eli Lilly And Company | Use of leukotriene antagonists for alzheimer's disease |
| WO1998042346A1 (en) | 1997-03-21 | 1998-10-01 | Eli Lilly And Company | Leukotriene antagonists useful for treating ischemia reperfusion injury |
| EP1231939A2 (en) | 1999-11-11 | 2002-08-21 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| WO2001034198A2 (en) | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| CN1237968C (zh) | 2000-05-09 | 2006-01-25 | 克赖顿大学 | 抑制癌细胞的增殖和诱导其凋亡的方法 |
| EP1286982A2 (en) * | 2000-06-02 | 2003-03-05 | Eli Lilly & Company | Process for the preparation of benzoyl substituted bicylic compounds and chiral bnezopyran derivatives |
| CN1751037A (zh) | 2003-02-14 | 2006-03-22 | 伊莱利利公司 | 作为ppar调节剂的磺酰胺衍生物 |
-
2013
- 2013-01-04 ES ES13701305T patent/ES2571452T3/es active Active
- 2013-01-04 BR BR112014016450A patent/BR112014016450A2/pt not_active IP Right Cessation
- 2013-01-04 JP JP2014552215A patent/JP2015509917A/ja not_active Withdrawn
- 2013-01-04 CN CN201380004537.9A patent/CN104011012B/zh not_active Expired - Fee Related
- 2013-01-04 AU AU2013208260A patent/AU2013208260A1/en not_active Abandoned
- 2013-01-04 WO PCT/US2013/020195 patent/WO2013106238A1/en not_active Ceased
- 2013-01-04 EA EA201491099A patent/EA023067B1/ru not_active IP Right Cessation
- 2013-01-04 KR KR1020147018769A patent/KR20140099546A/ko not_active Withdrawn
- 2013-01-04 EP EP13701305.8A patent/EP2802557B1/en active Active
- 2013-01-04 MX MX2014008452A patent/MX2014008452A/es unknown
- 2013-01-04 US US14/359,924 patent/US9187411B2/en not_active Expired - Fee Related
- 2013-01-04 CA CA2857521A patent/CA2857521C/en not_active Expired - Fee Related
-
2014
- 2014-05-26 IN IN1014MUN2014 patent/IN2014MN01014A/en unknown
- 2014-06-26 ZA ZA2014/04732A patent/ZA201404732B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9187411B2 (en) | 2015-11-17 |
| EP2802557B1 (en) | 2016-04-06 |
| CA2857521A1 (en) | 2013-07-18 |
| CA2857521C (en) | 2016-03-01 |
| KR20140099546A (ko) | 2014-08-12 |
| EA201491099A1 (ru) | 2014-11-28 |
| AU2013208260A1 (en) | 2014-06-05 |
| CN104011012A (zh) | 2014-08-27 |
| EP2802557A1 (en) | 2014-11-19 |
| IN2014MN01014A (enExample) | 2015-07-03 |
| CN104011012B (zh) | 2016-01-20 |
| MX2014008452A (es) | 2014-08-27 |
| WO2013106238A1 (en) | 2013-07-18 |
| US20140343151A1 (en) | 2014-11-20 |
| ES2571452T3 (es) | 2016-05-25 |
| BR112014016450A2 (pt) | 2019-09-24 |
| EA023067B1 (ru) | 2016-04-29 |
| ZA201404732B (en) | 2015-11-25 |
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