EA023067B1 - Соединение, представляющее собой антагонист лейкотриена b - Google Patents
Соединение, представляющее собой антагонист лейкотриена b Download PDFInfo
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- EA023067B1 EA023067B1 EA201491099A EA201491099A EA023067B1 EA 023067 B1 EA023067 B1 EA 023067B1 EA 201491099 A EA201491099 A EA 201491099A EA 201491099 A EA201491099 A EA 201491099A EA 023067 B1 EA023067 B1 EA 023067B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- compound
- cells
- pharmaceutically acceptable
- aaa
- ethyl
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- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
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| US201261584975P | 2012-01-10 | 2012-01-10 | |
| US201261585799P | 2012-01-12 | 2012-01-12 | |
| PCT/US2013/020195 WO2013106238A1 (en) | 2012-01-10 | 2013-01-04 | Leukotriene b4 antagonist compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201491099A1 EA201491099A1 (ru) | 2014-11-28 |
| EA023067B1 true EA023067B1 (ru) | 2016-04-29 |
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| EA201491099A EA023067B1 (ru) | 2012-01-10 | 2013-01-04 | Соединение, представляющее собой антагонист лейкотриена b |
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| JP (1) | JP2015509917A (enExample) |
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| CN (1) | CN104011012B (enExample) |
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| MX (1) | MX2014008452A (enExample) |
| WO (1) | WO2013106238A1 (enExample) |
| ZA (1) | ZA201404732B (enExample) |
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| EP3383868B1 (en) | 2015-11-30 | 2022-10-05 | Merck Sharp & Dohme LLC | Aryl sulfonamides as blt1 antagonists |
| WO2017095722A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| US10450309B2 (en) | 2015-11-30 | 2019-10-22 | Merch Sharp & Dohme Corp. | Aryl sulfonamides as BLT1 antagonists |
| US10370368B2 (en) | 2015-11-30 | 2019-08-06 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as BLT1 antagonists |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5462954A (en) * | 1991-11-25 | 1995-10-31 | Eli Lilly And Company | Substituted phenyl phenol leukotriene antagonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5105017A (en) * | 1983-07-18 | 1992-04-14 | Eli Lilly And Company | Leukotriene antagonist intermediates |
| GB9027023D0 (en) | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
| CN1035001C (zh) * | 1993-01-02 | 1997-05-28 | 伊莱利利公司 | 取代的苯基苯酚基白三烯拮抗物 |
| EP0743064A1 (en) * | 1995-05-17 | 1996-11-20 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease |
| AU6572298A (en) | 1997-03-21 | 1998-10-20 | Eli Lilly And Company | Leukotriene antagonists useful for treating ischemia reperfusion injury |
| EP1231939A2 (en) | 1999-11-11 | 2002-08-21 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| WO2001034198A2 (en) | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| AU2001261832A1 (en) | 2000-05-09 | 2001-11-20 | Creighton University | Methods for inhibiting proliferation and inducing apoptosis in cancer cells |
| WO2001094333A2 (en) * | 2000-06-02 | 2001-12-13 | Eli Lilly & Company | Process for the preparation of benzoyl substituted bicyclic compounds and chiral benzopyran derivatives |
| BRPI0407180A (pt) | 2003-02-14 | 2006-02-07 | Lilly Co Eli | Composto, composição farmacêutica, métodos para modular um receptor ativado pelo proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição, para diminuir a glicose no sangue em um mamìfero, para tratar ou prevenir diabetes mellitus, doença cardiovascular e sìndrome x em um mamìfero, e, uso de um composto |
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2013
- 2013-01-04 KR KR1020147018769A patent/KR20140099546A/ko not_active Withdrawn
- 2013-01-04 EA EA201491099A patent/EA023067B1/ru not_active IP Right Cessation
- 2013-01-04 WO PCT/US2013/020195 patent/WO2013106238A1/en not_active Ceased
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- 2013-01-04 AU AU2013208260A patent/AU2013208260A1/en not_active Abandoned
- 2013-01-04 BR BR112014016450A patent/BR112014016450A2/pt not_active IP Right Cessation
- 2013-01-04 CN CN201380004537.9A patent/CN104011012B/zh not_active Expired - Fee Related
- 2013-01-04 EP EP13701305.8A patent/EP2802557B1/en active Active
- 2013-01-04 JP JP2014552215A patent/JP2015509917A/ja not_active Withdrawn
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2014
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5462954A (en) * | 1991-11-25 | 1995-10-31 | Eli Lilly And Company | Substituted phenyl phenol leukotriene antagonists |
Also Published As
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| CA2857521A1 (en) | 2013-07-18 |
| CN104011012A (zh) | 2014-08-27 |
| US20140343151A1 (en) | 2014-11-20 |
| EA201491099A1 (ru) | 2014-11-28 |
| ZA201404732B (en) | 2015-11-25 |
| AU2013208260A1 (en) | 2014-06-05 |
| CA2857521C (en) | 2016-03-01 |
| JP2015509917A (ja) | 2015-04-02 |
| BR112014016450A2 (pt) | 2019-09-24 |
| WO2013106238A1 (en) | 2013-07-18 |
| EP2802557A1 (en) | 2014-11-19 |
| KR20140099546A (ko) | 2014-08-12 |
| MX2014008452A (es) | 2014-08-27 |
| ES2571452T3 (es) | 2016-05-25 |
| EP2802557B1 (en) | 2016-04-06 |
| CN104011012B (zh) | 2016-01-20 |
| US9187411B2 (en) | 2015-11-17 |
| IN2014MN01014A (enExample) | 2015-07-03 |
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