JP2015506704A5 - - Google Patents

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Publication number
JP2015506704A5
JP2015506704A5 JP2014555799A JP2014555799A JP2015506704A5 JP 2015506704 A5 JP2015506704 A5 JP 2015506704A5 JP 2014555799 A JP2014555799 A JP 2014555799A JP 2014555799 A JP2014555799 A JP 2014555799A JP 2015506704 A5 JP2015506704 A5 JP 2015506704A5
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JP
Japan
Prior art keywords
recombinant adenovirus
nucleic acid
adenovirus
heterologous nucleic
cancer
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JP2014555799A
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English (en)
Japanese (ja)
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JP2015506704A (ja
JP6325459B2 (ja
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Priority claimed from PCT/US2013/024506 external-priority patent/WO2013116778A2/en
Publication of JP2015506704A publication Critical patent/JP2015506704A/ja
Publication of JP2015506704A5 publication Critical patent/JP2015506704A5/ja
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JP2014555799A 2012-02-02 2013-02-01 腫瘍関連異種抗原を発現するアデノウイルス Active JP6325459B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594005P 2012-02-02 2012-02-02
US61/594,005 2012-02-02
PCT/US2013/024506 WO2013116778A2 (en) 2012-02-02 2013-02-01 Immunogenic adenovirus

Related Child Applications (1)

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JP2018076878A Division JP2018138033A (ja) 2012-02-02 2018-04-12 腫瘍関連異種抗原を発現するアデノウイルス

Publications (3)

Publication Number Publication Date
JP2015506704A JP2015506704A (ja) 2015-03-05
JP2015506704A5 true JP2015506704A5 (OSRAM) 2016-03-17
JP6325459B2 JP6325459B2 (ja) 2018-05-16

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JP2014555799A Active JP6325459B2 (ja) 2012-02-02 2013-02-01 腫瘍関連異種抗原を発現するアデノウイルス
JP2018076878A Withdrawn JP2018138033A (ja) 2012-02-02 2018-04-12 腫瘍関連異種抗原を発現するアデノウイルス

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JP2018076878A Withdrawn JP2018138033A (ja) 2012-02-02 2018-04-12 腫瘍関連異種抗原を発現するアデノウイルス

Country Status (14)

Country Link
US (1) US11155599B2 (OSRAM)
EP (1) EP2809788B1 (OSRAM)
JP (2) JP6325459B2 (OSRAM)
KR (1) KR102100092B1 (OSRAM)
CN (2) CN110042086A (OSRAM)
AU (1) AU2013214776B2 (OSRAM)
BR (1) BR112014019049A2 (OSRAM)
CA (1) CA2863523A1 (OSRAM)
DK (1) DK2809788T3 (OSRAM)
ES (1) ES2759785T3 (OSRAM)
NZ (1) NZ628213A (OSRAM)
SG (3) SG11201404495RA (OSRAM)
WO (1) WO2013116778A2 (OSRAM)
ZA (1) ZA201405755B (OSRAM)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2170384T3 (en) 2007-07-02 2016-07-25 Etubics Corp METHODS AND COMPOSITIONS FOR THE PRODUCTION OF AN adenovirus vector for use in higher vaccination
DK2806883T3 (da) 2012-01-25 2019-07-22 Dnatrix Inc Biomarkører og kombinationsterapier under anvendelse af onkolytisk virus og immunomodulation
WO2014031178A1 (en) 2012-08-24 2014-02-27 Etubics Corporation Replication defective adenovirus vector in vaccination
JP6576326B2 (ja) 2013-03-14 2019-09-18 ソーク インスティテュート フォー バイオロジカル スタディーズ 腫瘍溶解性アデノウイルス組成物
CA2931322A1 (en) * 2013-11-22 2015-05-28 Dnatrix, Inc. Adenovirus expressing immune cell stimulatory receptor agonist(s)
CN104328140B (zh) * 2014-10-08 2018-06-05 兰州大学 一种高嗜性膀胱癌靶向性肿瘤杀伤腺病毒
JP6647315B2 (ja) 2015-01-09 2020-02-14 イーチュービクス コーポレイション 組み合わせ免疫療法のための方法および組成物
KR20170102002A (ko) 2015-01-09 2017-09-06 이투빅스 코포레이션 에볼라 바이러스 백신접종을 위한 방법 및 조성물
CN104762269A (zh) * 2015-03-18 2015-07-08 红土生物技术有限公司 一种增强肿瘤抗原免疫原性的新策略及其在肺癌免疫治疗中的应用
WO2016172249A1 (en) * 2015-04-20 2016-10-27 Etubics Corporation Methods and compositions for combination immunotherapy
US11000560B2 (en) 2015-05-04 2021-05-11 Vcn Biosciences, S.L. Oncolytic adenoviruses with mutations in immunodominant adenovirus epitopes and their use in cancer treatment
CN105087648B (zh) * 2015-06-17 2018-05-25 深圳益世康宁生物科技有限公司 携带mage-a3抗原基因的重组腺相关病毒载体及构建方法与应用
CN105087647B (zh) * 2015-06-17 2018-10-02 深圳益世康宁生物科技有限公司 一种携带Survivin抗原基因的重组腺相关病毒载体及其构建方法与应用
WO2017112797A1 (en) 2015-12-22 2017-06-29 Thomas Jefferson University Intra-lesional cmv-based cancer vaccines
FI127460B (en) * 2016-01-15 2018-06-29 Targovax Oy Combining adenovirus and chemotherapeutic agents for treating cancer
KR20220163505A (ko) 2016-02-23 2022-12-09 솔크 인스티튜트 포 바이올로지칼 스터디즈 바이러스 동역학에 미치는 영향 최소화를 위한 치료용 아데노바이러스의 외인성 유전자 발현
JP7054527B2 (ja) 2016-02-23 2022-04-14 ソーク インスティテュート フォー バイオロジカル スタディーズ アデノウイルスの複製動態を測定するための高スループットアッセイ
CN105779480B (zh) * 2016-03-24 2020-03-20 成都康景生物科技有限公司 一种携带多位点突变型egfr新抗原基因的重组腺相关病毒载体及构建方法和应用
DK3436591T5 (da) * 2016-03-31 2024-09-16 The European Molecular Biology Laboratory Adenovirale coat-protein-afledte transportvehikler
EP3463405A4 (en) * 2016-05-27 2020-02-26 DNAtrix, Inc. ADENOVIRUS AND IMMUNO MODULATOR COMBINATION THERAPY
JP2019536468A (ja) 2016-12-12 2019-12-19 ソーク インスティテュート フォー バイオロジカル スタディーズ 腫瘍を標的にする合成アデノウイルスおよびその使用
WO2018118967A1 (en) 2016-12-21 2018-06-28 Memgen, Llc Armed replication-competent oncolytic adenoviruses
KR20190128634A (ko) * 2017-01-30 2019-11-18 에피센트알엑스, 인코포레이티드 다중 트랜스진 재조합 아데노바이러스
EA201990822A1 (ru) 2017-04-12 2020-01-09 Эписентарикс, Инк. Иммуномодулирующие слитые белки
EP3714038A1 (en) 2017-11-22 2020-09-30 Mesoblast International Sàrl Cellular compositions and methods of treatment i
GB201804468D0 (en) 2018-03-21 2018-05-02 Valo Therapeutics Oy PeptiCRAd Cancer Therapy
AU2019251356B2 (en) 2018-04-09 2025-06-12 Salk Institute For Biological Studies Oncolytic adenovirus compositions with enhanced replication properties
WO2019237371A1 (zh) * 2018-06-16 2019-12-19 深圳市博奥康生物科技有限公司 定点插入 ct1.1 基因的 cho 细胞株的构建方法及其用途
CN109081873B (zh) * 2018-08-10 2022-04-22 固安鼎泰海规生物科技有限公司 一种抗肿瘤重组nmm融合抗原质粒dna疫苗
US20210340279A1 (en) 2018-08-31 2021-11-04 Yale University Compositions and methods of using cell-penetrating antibodies in combination with immune checkpoint modulators
CN110684800B (zh) * 2018-11-02 2020-11-03 深圳益世康宁生物科技有限公司 一种携带肿瘤-睾丸抗原10基因的重组腺相关病毒载体及其应用价值
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
WO2020259189A1 (zh) * 2019-06-27 2020-12-30 北京太东生物科技有限公司 Sox11作为精神分裂症诊断标记物的应用
CA3149478A1 (en) 2019-08-05 2021-02-11 Mesoblast International Sarl Cellular compositions comprising viral vectors and methods of treatment
EP3812465A1 (en) * 2019-10-21 2021-04-28 Universität Ulm Adenovirus comprising a modified adenovirus hexon protein
PH12022551208A1 (en) 2019-11-18 2023-04-24 Janssen Biotech Inc Vaccines based on mutant calr and jak2 and their uses
KR102601875B1 (ko) * 2020-03-25 2023-11-14 (주)큐리진 면역 회피성 항종양 아데노바이러스
WO2022009052A2 (en) 2020-07-06 2022-01-13 Janssen Biotech, Inc. Prostate neoantigens and their uses
CN111850041A (zh) * 2020-07-30 2020-10-30 药鼎(北京)国际细胞医学技术有限公司 一种治疗肝癌的含il12双顺反子的病毒构建体及其用途和构建方法
EP4192940A1 (en) 2020-08-10 2023-06-14 Mesoblast International Sárl Cellular compositions and methods of treatment
JP2025536260A (ja) 2022-10-11 2025-11-05 イェール ユニバーシティー 細胞透過性抗体の組成物および使用方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4514506A (en) 1982-02-23 1985-04-30 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Method for the identification and purification of human lung tumor-associated antigens (hLTAA) and clinical detection and determination of these antigens
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US5981725A (en) 1989-09-08 1999-11-09 The Johns Hopkins Univiersity Structural alterations of the EGF receptor gene in human tumors
DE4228457A1 (de) 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US7252989B1 (en) 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
FR2722208B1 (fr) 1994-07-05 1996-10-04 Inst Nat Sante Rech Med Nouveau site interne d'entree des ribosomes, vecteur le contenant et utilisation therapeutique
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
AU716045B2 (en) 1994-11-28 2000-02-17 Genetic Therapy, Inc. Vectors for tissue-specific replication
DE69628744D1 (de) 1995-04-17 2003-07-24 Univ Texas System Austin Board Adenovirus helfervirus system
US20030026789A1 (en) 1995-05-03 2003-02-06 Richard J. Gregory Gene therapy using replication competent targeted adenoviral vectors
US5928906A (en) 1996-05-09 1999-07-27 Sequenom, Inc. Process for direct sequencing during template amplification
US6080578A (en) 1996-12-31 2000-06-27 Onyx Pharmaceuticals, Inc. Cytopathic adenoviral E1B mutated viruses for therapy and prophylaxis of neoplasia
US6403370B1 (en) 1997-02-10 2002-06-11 Genstar Therapeutics Corporation Oncolytic/immunogenic complementary-adenoviral vector system
WO1998039467A2 (en) 1997-03-03 1998-09-11 Calydon, Inc. Adenovirus vectors specific for cells expressing carcinoembryonic antigen and methods of use thereof
US6096718A (en) 1997-06-05 2000-08-01 Gene Targeting Corp. Tissue specific adenovirus vectors for breast cancer treatment
CA2351587A1 (en) 1998-11-18 2000-05-25 Canji, Inc. Viral vectors with late transgene expression
GB9906815D0 (en) 1999-03-24 1999-05-19 Isrec Anti-neoplastic viral agents
AU767904B2 (en) 1999-05-12 2003-11-27 Uab Research Foundation, The Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
US20040175362A1 (en) 1999-05-12 2004-09-09 Curiel David T. Infectivity-enhanced conditionally-replicative adenovirus and uses thereof
AU1190901A (en) 1999-09-30 2001-04-30 Trustees Of The University Of Pennsylvania, The Replication selective adenoviruses for use in cancer therapy
EP1223947A4 (en) 1999-10-15 2004-12-08 Canji Inc TARGETED VECTORS
US6756044B1 (en) 2000-02-09 2004-06-29 Genvec, Inc. Antigenic complexes and methods
AU2001234981A1 (en) 2000-02-09 2001-08-20 Genvec, Inc. Adenoviral capsid containing chimeric protein ix
US20030138405A1 (en) 2001-04-17 2003-07-24 Juan Fueyo Conditionally replicative adenovirus to target the Rb and Rb-related pathways
US20030211477A1 (en) * 2002-04-05 2003-11-13 Holmes Kathryn V. Carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1) structure and uses thereof in drug identification and screening
CN104059147A (zh) 2003-06-27 2014-09-24 艾默根佛蒙特有限公司 针对表皮生长因子受体的缺失突变体的抗体及其使用
US20070134202A1 (en) 2003-10-15 2007-06-14 The New Industry Reserch Organization Cancer gene therapeutic drug
WO2005086922A2 (en) 2004-03-10 2005-09-22 Board Of Regents, University Of Texas System Oncolytic adenovirus armed with therapeutic genes
WO2009117656A2 (en) * 2008-03-21 2009-09-24 Vectorlogics,Inc. Capsid-incorporated antigen for novel adenovirus vaccine
CN101607985B (zh) * 2008-12-24 2013-03-27 中国科学院生物物理研究所 抗人cea的单克隆抗体,包含其的组合物,及其用途
US20100297072A1 (en) 2009-05-19 2010-11-25 Depinho Ronald A Combinations of Immunostimulatory Agents, Oncolytic Virus, and Additional Anticancer Therapy
EP2407177A1 (en) * 2010-07-13 2012-01-18 Institut Gustave Roussy Adenovirus vaccine vectors
EP2383577A1 (en) 2010-04-30 2011-11-02 Deutsches Krebsforschungszentrum Diagnostic method for predicting the response of a patient to chemovirotherapy or radiovirotherapy
WO2011140284A2 (en) * 2010-05-04 2011-11-10 Fred Hutchinson Cancer Research Center Conditional superagonist ctl ligands for the promotion of tumor-specific ctl responses
FI123955B (en) 2011-11-25 2014-01-15 Oncos Therapeutics Ltd Oncolytic adenovirus
DK2806883T3 (da) 2012-01-25 2019-07-22 Dnatrix Inc Biomarkører og kombinationsterapier under anvendelse af onkolytisk virus og immunomodulation
AU2014281826B2 (en) 2013-06-18 2019-10-17 Board Of Regents, The University Of Texas System Treatment of brain cancer with oncolytic adenovirus

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