JP2015505538A - 金属酵素阻害剤化合物 - Google Patents

金属酵素阻害剤化合物 Download PDF

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Publication number
JP2015505538A
JP2015505538A JP2014553493A JP2014553493A JP2015505538A JP 2015505538 A JP2015505538 A JP 2015505538A JP 2014553493 A JP2014553493 A JP 2014553493A JP 2014553493 A JP2014553493 A JP 2014553493A JP 2015505538 A JP2015505538 A JP 2015505538A
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JP
Japan
Prior art keywords
difluorophenyl
pyridin
difluoro
tetrazol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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JP2014553493A
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English (en)
Japanese (ja)
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JP2015505538A5 (enExample
Inventor
ホークストラ，ウイリアム，ジェイ．
ショットジンガー，ロバート，ジェイ
ラファティー，ステファン，ダブリュー．
Original Assignee
ヴィアメット ファーマスーティカルズ，インコーポレイテッド
ヴィアメット ファーマスーティカルズ，インコーポレイテッド
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Publication of JP2015505538A publication Critical patent/JP2015505538A/ja
Publication of JP2015505538A5 publication Critical patent/JP2015505538A5/ja
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catching Or Destruction (AREA)
JP2014553493A 2012-01-20 2013-01-18 金属酵素阻害剤化合物 Ceased JP2015505538A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589064P 2012-01-20 2012-01-20
US61/589,064 2012-01-20
PCT/US2013/022317 WO2013110002A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016243478A Division JP2017110004A (ja) 2012-01-20 2016-12-15 金属酵素阻害剤化合物

Publications (2)

Publication Number Publication Date
JP2015505538A true JP2015505538A (ja) 2015-02-23
JP2015505538A5 JP2015505538A5 (enExample) 2016-03-03

Family

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Family Applications (3)

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JP2014553493A Ceased JP2015505538A (ja) 2012-01-20 2013-01-18 金属酵素阻害剤化合物
JP2016243478A Pending JP2017110004A (ja) 2012-01-20 2016-12-15 金属酵素阻害剤化合物
JP2019018600A Pending JP2019116476A (ja) 2012-01-20 2019-02-05 金属酵素阻害剤化合物

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JP2016243478A Pending JP2017110004A (ja) 2012-01-20 2016-12-15 金属酵素阻害剤化合物
JP2019018600A Pending JP2019116476A (ja) 2012-01-20 2019-02-05 金属酵素阻害剤化合物

Country Status (17)

Country Link
US (1) US9414596B2 (enExample)
EP (1) EP2804479A4 (enExample)
JP (3) JP2015505538A (enExample)
KR (1) KR20140116515A (enExample)
CN (1) CN104135861A (enExample)
AU (1) AU2013209520A1 (enExample)
BR (1) BR112014017799A8 (enExample)
CA (1) CA2861341A1 (enExample)
CL (1) CL2014001892A1 (enExample)
CO (1) CO7111289A2 (enExample)
CR (1) CR20140387A (enExample)
EA (1) EA201491386A1 (enExample)
EC (1) ECSP14014530A (enExample)
IN (1) IN2014DN06812A (enExample)
MX (1) MX2014008729A (enExample)
PH (1) PH12014501653A1 (enExample)
WO (1) WO2013110002A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504095A (ja) * 2012-01-20 2015-02-05 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害薬化合物
JP2019502755A (ja) * 2015-12-30 2019-01-31 ヴィーピーエス−３・インコーポレイテッド 金属酵素阻害化合物

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HUE042624T2 (hu) 2009-10-07 2019-07-29 Dow Agrosciences Llc Szinergetikus fungicid keverékek gombák kontrollálására gabonafélékben
EA201490052A1 (ru) 2011-06-23 2014-04-30 Вайамет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
LT2938191T (lt) 2012-12-28 2018-05-10 Dow Agrosciences Llc Sinergistiniai fungicidiniai mišiniai, skirti grybelių kontrolei javuose
DK2938190T3 (en) 2012-12-31 2018-02-05 Dow Agrosciences Llc MACROCYCLIC PICOLINAMIDS AS FUNGICIDES
WO2015100184A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
US9549555B2 (en) 2013-12-26 2017-01-24 Dow Agrosciences Llc Macrocyclic picolinamide compounds with fungicidal activity
EP3119746A4 (en) * 2014-03-19 2017-08-16 Viamet Pharmaceuticals, Inc. Antifungal compound process
US10000465B2 (en) 2014-03-19 2018-06-19 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119748A4 (en) 2014-03-19 2017-08-30 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP6509897B2 (ja) * 2014-03-19 2019-05-08 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
US9981943B2 (en) * 2014-03-19 2018-05-29 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CN109678791B (zh) 2014-03-19 2022-07-01 美国陶氏益农公司 1-(2,4-二氟苯)-2,2-二氟-2-(5-取代吡啶-2-基)乙酮及制备方法
US10077250B2 (en) * 2014-03-19 2018-09-18 Mycovia Pharmaceuticals, Inc. Antifungal compound process
EP3119749A4 (en) * 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119754A4 (en) * 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP6613391B2 (ja) * 2014-03-19 2019-12-04 ブイピーエス‐３，インコーポレイテッド ２−（２，４−ジフルオロフェニル）−１，１−ジフルオロ−１−（５−置換ピリジン−２−イル）−３−（１ｈ−テトラゾール−１−イル）プロパン−２−オールおよびその調製工程
KR20160145640A (ko) 2014-04-15 2016-12-20 다우 아그로사이언시즈 엘엘씨 살진균제로서의 금속효소 억제제 화합물
CN106231901A (zh) 2014-04-15 2016-12-14 美国陶氏益农公司 作为杀真菌剂的金属酶抑制剂化合物
WO2015171408A1 (en) 2014-05-06 2015-11-12 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
EP3166936A4 (en) 2014-07-08 2017-11-22 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
CN106470983A (zh) 2014-07-08 2017-03-01 美国陶氏益农公司 作为杀真菌剂的大环吡啶酰胺
NZ732812A (en) 2014-12-30 2019-01-25 Dow Agrosciences Llc Use of picolinamides and other compounds as fungicides
WO2016109640A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Fungicidal compositions
EP3240412A4 (en) 2014-12-30 2018-04-25 Dow Agrosciences LLC Use of picolinamide compounds with fungicidal activity
AU2015374375B2 (en) 2014-12-30 2019-03-21 Dow Agrosciences Llc Picolinamides with fungicidal activity
US20170290333A1 (en) 2014-12-30 2017-10-12 Dow Agrosciences Llc Picolinamide compounds with fungicidal activity
CA2972408A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Use of picolinamide compounds with fungicidal activity
PL3271347T3 (pl) 2015-03-19 2022-11-21 Mycovia Pharmaceuticals, Inc. Związki przeciwgrzybicze i sposoby wytwarzania
EP3349753A4 (en) 2015-09-18 2019-01-23 VPS-3, Inc. FUNGICIDE COMPOUNDS AND METHOD OF PREPARING THEREOF
WO2018044987A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Thiopicolinamide compounds with fungicidal activity
WO2018045003A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Picolinamide n-oxide compounds with fungicidal activity
US10214490B2 (en) 2016-08-30 2019-02-26 Dow Agrosciences Llc Picolinamides as fungicides
US10334852B2 (en) 2016-08-30 2019-07-02 Dow Agrosciences Llc Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity
BR102018000183B1 (pt) 2017-01-05 2023-04-25 Dow Agrosciences Llc Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta
EP3580218A1 (en) * 2017-02-08 2019-12-18 Bayer CropScience Aktiengesellschaft Novel triazole derivatives
CN110996665B (zh) 2017-05-02 2021-10-26 陶氏益农公司 无环吡啶酰胺化合物作为针对草坪草上的真菌病害的杀真菌剂的用途
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
TWI774761B (zh) 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於穀物中的真菌防治之協同性混合物
BR102019004480B1 (pt) 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
US11639334B2 (en) 2018-10-15 2023-05-02 Corteva Agriscience Llc Methods for synthesis of oxypicolinamides
EP4044811A4 (en) 2019-10-18 2023-09-27 Corteva Agriscience LLC METHOD FOR SYNTHESIS OF PICOLINAMIDS
CN110981810A (zh) * 2019-12-19 2020-04-10 东莞市维琪科技有限公司 一种脱羧肌肽的合成方法
TW202140445A (zh) * 2020-01-17 2021-11-01 大陸商上海森輝醫藥有限公司 四氮唑類化合物的可藥用鹽及其結晶形式、製備方法和用途
WO2026006142A1 (en) * 2024-06-24 2026-01-02 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Azole compounds useful as inhibitors of voltage-dependent anion channel oligomerization

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504095A (ja) * 2012-01-20 2015-02-05 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害薬化合物
US10221160B2 (en) 2012-01-20 2019-03-05 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US10526312B2 (en) 2012-01-20 2020-01-07 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US11247981B2 (en) 2012-01-20 2022-02-15 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP2019502755A (ja) * 2015-12-30 2019-01-31 ヴィーピーエス−３・インコーポレイテッド 金属酵素阻害化合物

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Publication number Publication date
IN2014DN06812A (enExample) 2015-05-22
JP2017110004A (ja) 2017-06-22
CA2861341A1 (en) 2013-07-25
CR20140387A (es) 2014-11-27
CL2014001892A1 (es) 2014-11-14
EA201491386A1 (ru) 2014-11-28
EP2804479A1 (en) 2014-11-26
PH12014501653A1 (en) 2014-10-13
US20150024938A1 (en) 2015-01-22
US9414596B2 (en) 2016-08-16
BR112014017799A8 (pt) 2017-07-11
AU2013209520A1 (en) 2014-08-28
EP2804479A4 (en) 2015-07-22
BR112014017799A2 (enExample) 2017-06-20
CN104135861A (zh) 2014-11-05
WO2013110002A1 (en) 2013-07-25
KR20140116515A (ko) 2014-10-02
MX2014008729A (es) 2015-02-04
CO7111289A2 (es) 2014-11-10
JP2019116476A (ja) 2019-07-18
ECSP14014530A (es) 2015-06-30

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