JP2015505538A - 金属酵素阻害剤化合物 - Google Patents

金属酵素阻害剤化合物 Download PDF

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Publication number
JP2015505538A
JP2015505538A JP2014553493A JP2014553493A JP2015505538A JP 2015505538 A JP2015505538 A JP 2015505538A JP 2014553493 A JP2014553493 A JP 2014553493A JP 2014553493 A JP2014553493 A JP 2014553493A JP 2015505538 A JP2015505538 A JP 2015505538A
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JP
Japan
Prior art keywords
difluorophenyl
pyridin
difluoro
tetrazol
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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JP2014553493A
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English (en)
Japanese (ja)
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JP2015505538A5 (enExample
Inventor
ホークストラ，ウイリアム，ジェイ．
ショットジンガー，ロバート，ジェイ
ラファティー，ステファン，ダブリュー．
Original Assignee
ヴィアメット ファーマスーティカルズ，インコーポレイテッド
ヴィアメット ファーマスーティカルズ，インコーポレイテッド
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Application filed by ヴィアメット ファーマスーティカルズ，インコーポレイテッド, ヴィアメット ファーマスーティカルズ，インコーポレイテッド filed Critical ヴィアメット ファーマスーティカルズ，インコーポレイテッド
Publication of JP2015505538A publication Critical patent/JP2015505538A/ja
Publication of JP2015505538A5 publication Critical patent/JP2015505538A5/ja
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/713—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/10—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds
    • A01N57/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-oxygen bonds or phosphorus-to-sulfur bonds containing heterocyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catching Or Destruction (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2014553493A 2012-01-20 2013-01-18 金属酵素阻害剤化合物 Ceased JP2015505538A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261589064P 2012-01-20 2012-01-20
US61/589,064 2012-01-20
PCT/US2013/022317 WO2013110002A1 (en) 2012-01-20 2013-01-18 Metalloenzyme inhibitor compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016243478A Division JP2017110004A (ja) 2012-01-20 2016-12-15 金属酵素阻害剤化合物

Publications (2)

Publication Number Publication Date
JP2015505538A true JP2015505538A (ja) 2015-02-23
JP2015505538A5 JP2015505538A5 (enExample) 2016-03-03

Family

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Family Applications (3)

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JP2014553493A Ceased JP2015505538A (ja) 2012-01-20 2013-01-18 金属酵素阻害剤化合物
JP2016243478A Pending JP2017110004A (ja) 2012-01-20 2016-12-15 金属酵素阻害剤化合物
JP2019018600A Pending JP2019116476A (ja) 2012-01-20 2019-02-05 金属酵素阻害剤化合物

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JP2016243478A Pending JP2017110004A (ja) 2012-01-20 2016-12-15 金属酵素阻害剤化合物
JP2019018600A Pending JP2019116476A (ja) 2012-01-20 2019-02-05 金属酵素阻害剤化合物

Country Status (17)

Country Link
US (1) US9414596B2 (enExample)
EP (1) EP2804479A4 (enExample)
JP (3) JP2015505538A (enExample)
KR (1) KR20140116515A (enExample)
CN (1) CN104135861A (enExample)
AU (1) AU2013209520A1 (enExample)
BR (1) BR112014017799A8 (enExample)
CA (1) CA2861341A1 (enExample)
CL (1) CL2014001892A1 (enExample)
CO (1) CO7111289A2 (enExample)
CR (1) CR20140387A (enExample)
EA (1) EA201491386A1 (enExample)
EC (1) ECSP14014530A (enExample)
IN (1) IN2014DN06812A (enExample)
MX (1) MX2014008729A (enExample)
PH (1) PH12014501653A1 (enExample)
WO (1) WO2013110002A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504095A (ja) * 2012-01-20 2015-02-05 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害薬化合物
JP2019502755A (ja) * 2015-12-30 2019-01-31 ヴィーピーエス−３・インコーポレイテッド 金属酵素阻害化合物

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DK3178321T3 (da) 2009-10-07 2019-08-26 Dow Agrosciences Llc Synergistiske fungicide blandninger af epoxiconazol til bekæmpelse af svamp i korn
US8940735B2 (en) 2011-06-23 2015-01-27 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
EP2938191B1 (en) 2012-12-28 2018-01-31 Dow AgroSciences LLC Synergistic fungicidal mixtures for fungal control in cereals
BR112015015243B8 (pt) 2012-12-31 2022-08-23 Dow Agrosciences Llc Composto contendo picolinamidas macrocíclicas, composição e método para controle e prevenção de doença em planta
WO2015100182A1 (en) 2013-12-26 2015-07-02 Dow Agrosciences Llc Use of macrocyclic picolinamides as fungicides
EP3099170A4 (en) 2013-12-26 2017-06-21 Dow AgroSciences LLC Use of macrocyclic picolinamides as fungicides
AU2015231216B2 (en) * 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
KR102441243B1 (ko) 2014-03-19 2022-09-07 브이피에스-3, 엘엘씨 2-(2,4-디플루오르페닐)-1,1-디플루오르-1-(5-치환된-피리딘-2-일)-3-(1h-테트라졸-1-일)프로판-2-올 및 이의 제조방법
WO2015143184A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
CA2942936A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
JP6606508B2 (ja) 2014-03-19 2019-11-13 マイコヴィア ファーマシューティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
AU2015231275B2 (en) * 2014-03-19 2019-03-07 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP2017509646A (ja) * 2014-03-19 2017-04-06 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
CN109970629B (zh) * 2014-03-19 2023-04-11 迈科维亚医药公司 抗真菌化合物的制备方法
US9802914B2 (en) 2014-03-19 2017-10-31 Viamet Pharmaceuticals, Inc. Antifungal compound process
EP3119753B1 (en) 2014-03-19 2020-11-04 Dow AgroSciences LLC 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
WO2015160665A1 (en) 2014-04-15 2015-10-22 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
WO2015160664A1 (en) 2014-04-15 2015-10-22 Dow Agrosciences Llc Metalloenzyme inhibitor compounds as fungicides
EP3139916A4 (en) 2014-05-06 2017-11-15 Dow AgroSciences LLC Macrocyclic picolinamides as fungicides
WO2016007529A1 (en) 2014-07-08 2016-01-14 Dow Agrosciences Llc Macrocyclic picolinamides as fungicides
BR112017000104A2 (pt) 2014-07-08 2017-10-31 Dow Agrosciences Llc picolinamidas macrocíclicas como fungicidas
AU2015374459A1 (en) 2014-12-30 2017-06-29 Dow Agrosciences Llc Picolinamide compounds with fungicidal activity
MX2017008444A (es) 2014-12-30 2017-10-02 Dow Agrosciences Llc Picolinamidas como fungicidas.
EP3240408B1 (en) 2014-12-30 2020-04-08 Dow Agrosciences LLC Picolinamides with fungicidal activity
WO2016109634A1 (en) 2014-12-30 2016-07-07 Dow Agrosciences Llc Fungicidal compositions
US20170290333A1 (en) 2014-12-30 2017-10-12 Dow Agrosciences Llc Picolinamide compounds with fungicidal activity
MX2017008439A (es) 2014-12-30 2017-10-02 Dow Agrosciences Llc Compuestos de picolinamida con actividad fungicida.
KR102603277B1 (ko) 2015-03-19 2023-11-17 마이코비아 파마슈티컬즈, 인코포레이티드 항진균성 화합물 및 이의 제조 방법
CN108289457B (zh) 2015-09-18 2021-08-06 迈科维亚医药公司 抗真菌化合物制备方法
US10111432B2 (en) 2016-08-30 2018-10-30 Dow Agrosciences Llc Picolinamide N-oxide compounds with fungicidal activity
US10214490B2 (en) 2016-08-30 2019-02-26 Dow Agrosciences Llc Picolinamides as fungicides
US10172358B2 (en) 2016-08-30 2019-01-08 Dow Agrosciences Llc Thiopicolinamide compounds with fungicidal activity
WO2018045012A1 (en) 2016-08-30 2018-03-08 Dow Agrosciences Llc Pyrido-1,3-oxazine-2,4-dione compounds with fungicidal activity
BR102018000183B1 (pt) 2017-01-05 2023-04-25 Dow Agrosciences Llc Picolinamidas, composição para controle de um patógeno fúngico, e método para controle e prevenção de um ataque por fungos em uma planta
WO2018145934A1 (en) * 2017-02-08 2018-08-16 Bayer Cropscience Aktiengesellschaft Novel triazole derivatives
TW201842851A (zh) 2017-05-02 2018-12-16 美商陶氏農業科學公司 用於穀類中的真菌防治之協同性混合物
US11191269B2 (en) 2017-05-02 2021-12-07 Dow Agrosciences Llc Use of an acyclic picolinamide compound as a fungicide for fungal diseases on turfgrasses
TWI774761B (zh) 2017-05-02 2022-08-21 美商科迪華農業科技有限責任公司 用於穀物中的真菌防治之協同性混合物
BR102019004480B1 (pt) 2018-03-08 2023-03-28 Dow Agrosciences Llc Picolinamidas como fungicidas
KR20210076072A (ko) 2018-10-15 2021-06-23 코르테바 애그리사이언스 엘엘씨 옥시피콜린아미드의 합성 방법
CN114554848A (zh) 2019-10-18 2022-05-27 科迪华农业科技有限责任公司 用于合成吡啶酰胺的方法
CN110981810A (zh) * 2019-12-19 2020-04-10 东莞市维琪科技有限公司 一种脱羧肌肽的合成方法
WO2021143811A1 (zh) * 2020-01-17 2021-07-22 上海森辉医药有限公司 四氮唑类化合物的可药用盐及其结晶形式、制备方法和用途
WO2026006142A1 (en) * 2024-06-24 2026-01-02 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services Azole compounds useful as inhibitors of voltage-dependent anion channel oligomerization

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JP2014517069A (ja) * 2011-06-23 2014-07-17 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素化合物

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015504095A (ja) * 2012-01-20 2015-02-05 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 金属酵素阻害薬化合物
US10221160B2 (en) 2012-01-20 2019-03-05 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US10526312B2 (en) 2012-01-20 2020-01-07 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
US11247981B2 (en) 2012-01-20 2022-02-15 Mycovia Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
JP2019502755A (ja) * 2015-12-30 2019-01-31 ヴィーピーエス−３・インコーポレイテッド 金属酵素阻害化合物

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JP2017110004A (ja) 2017-06-22
CR20140387A (es) 2014-11-27
ECSP14014530A (es) 2015-06-30
US9414596B2 (en) 2016-08-16
JP2019116476A (ja) 2019-07-18
EP2804479A4 (en) 2015-07-22
BR112014017799A8 (pt) 2017-07-11
KR20140116515A (ko) 2014-10-02
CO7111289A2 (es) 2014-11-10
AU2013209520A1 (en) 2014-08-28
CN104135861A (zh) 2014-11-05
WO2013110002A1 (en) 2013-07-25
BR112014017799A2 (enExample) 2017-06-20
MX2014008729A (es) 2015-02-04
EA201491386A1 (ru) 2014-11-28
EP2804479A1 (en) 2014-11-26
CL2014001892A1 (es) 2014-11-14
CA2861341A1 (en) 2013-07-25
PH12014501653A1 (en) 2014-10-13
IN2014DN06812A (enExample) 2015-05-22
US20150024938A1 (en) 2015-01-22

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