JP2015504874A5 - - Google Patents
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- Publication number
- JP2015504874A5 JP2015504874A5 JP2014547975A JP2014547975A JP2015504874A5 JP 2015504874 A5 JP2015504874 A5 JP 2015504874A5 JP 2014547975 A JP2014547975 A JP 2014547975A JP 2014547975 A JP2014547975 A JP 2014547975A JP 2015504874 A5 JP2015504874 A5 JP 2015504874A5
- Authority
- JP
- Japan
- Prior art keywords
- thiazole
- carboxylate
- ethyl
- oxy
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194365.0 | 2011-12-19 | ||
| EP11194365.0A EP2606888A1 (en) | 2011-12-19 | 2011-12-19 | Trpm8 antagonists |
| EP12178327.8 | 2012-07-27 | ||
| EP12178327 | 2012-07-27 | ||
| PCT/EP2012/076147 WO2013092711A1 (en) | 2011-12-19 | 2012-12-19 | Trpm8 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017119493A Division JP2017197564A (ja) | 2011-12-19 | 2017-06-19 | Ｔｒｐｍ８拮抗薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504874A JP2015504874A (ja) | 2015-02-16 |
| JP2015504874A5 true JP2015504874A5 (https=) | 2015-10-29 |
| JP6238906B2 JP6238906B2 (ja) | 2017-11-29 |
Family
ID=47520061
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547975A Active JP6238906B2 (ja) | 2011-12-19 | 2012-12-19 | Ｔｒｐｍ８拮抗薬 |
| JP2017119493A Withdrawn JP2017197564A (ja) | 2011-12-19 | 2017-06-19 | Ｔｒｐｍ８拮抗薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017119493A Withdrawn JP2017197564A (ja) | 2011-12-19 | 2017-06-19 | Ｔｒｐｍ８拮抗薬 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9585875B2 (https=) |
| EP (1) | EP2793883B1 (https=) |
| JP (2) | JP6238906B2 (https=) |
| KR (1) | KR102000319B1 (https=) |
| CN (1) | CN104220069B (https=) |
| AU (1) | AU2012357747B2 (https=) |
| CY (1) | CY1120403T1 (https=) |
| DK (1) | DK2793883T3 (https=) |
| EA (1) | EA025356B1 (https=) |
| ES (1) | ES2676884T3 (https=) |
| HR (1) | HRP20181086T1 (https=) |
| HU (1) | HUE038407T2 (https=) |
| LT (1) | LT2793883T (https=) |
| ME (1) | ME03038B (https=) |
| PL (1) | PL2793883T3 (https=) |
| PT (1) | PT2793883T (https=) |
| RS (1) | RS57389B1 (https=) |
| SI (1) | SI2793883T1 (https=) |
| SM (1) | SMT201800351T1 (https=) |
| TR (1) | TR201808861T4 (https=) |
| WO (1) | WO2013092711A1 (https=) |
| ZA (1) | ZA201404499B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2481727A1 (en) * | 2011-01-28 | 2012-08-01 | Dompe S.p.A. | TRPM8 receptor antagonists |
| LT2793883T (lt) | 2011-12-19 | 2018-08-10 | Dompé Farmaceutici S.P.A. | Trpm8 antagonistai |
| EP3003292B1 (en) | 2013-05-24 | 2019-03-20 | Nestec S.A. | Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin |
| US10294243B2 (en) | 2014-06-05 | 2019-05-21 | Bayer Cropscience Aktiengesellschaft | Bicyclic compounds as pesticides |
| DK3157918T3 (da) * | 2014-06-23 | 2019-05-13 | Dompe Farm Spa | 2-aryl-4-hydroxy-1,3-thiazolderivater anvendelige som trpm8-inhibitorer i behandling af neuralgi, smerte, copd og astma |
| CN108473484B (zh) * | 2015-10-01 | 2021-06-29 | 弗门尼舍公司 | 可用作trpm8调节剂的化合物 |
| EP3184524A1 (en) * | 2015-12-21 | 2017-06-28 | Dompé farmaceutici S.p.A. | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists |
| CN114748624A (zh) | 2016-06-13 | 2022-07-15 | 田边三菱制药株式会社 | 用于治疗或预防血管舒缩症状的组合物 |
| JPWO2018117166A1 (ja) * | 2016-12-21 | 2019-10-31 | キッセイ薬品工業株式会社 | チアゾール誘導体、またはその薬理学的に許容される塩 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2713573A1 (de) * | 1977-03-28 | 1978-10-05 | Basf Ag | 4,5-disubstituierte thiazole und verfahren zu ihrer herstellung |
| JPS59220687A (ja) * | 1983-05-30 | 1984-12-12 | 株式会社日立製作所 | 直接サイクル型軽水原子炉一次冷却系の腐食環境抑制設備 |
| ES2092580T3 (es) * | 1990-11-30 | 1996-12-01 | Teijin Ltd | Derivado de 2-ariltiazol y composicion farmaceutica que contiene el mismo. |
| DE60221627D1 (de) * | 2001-12-21 | 2007-09-20 | Virochem Pharma Inc | Thiazolderivate und ihre Verwendung zur Behandlung oder Vorbeugung von Infektionen durch Flaviviren |
| JP2008515950A (ja) | 2004-10-13 | 2008-05-15 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 泌尿器系障害の処置用の冷メントール受容体−１（ｃｍｒ−１）アンタゴニストとしての４−置換ベンジルオキシ−フェニルメチルアミド誘導体 |
| WO2007017093A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 2-benzyloxy-benzoic acid amide derivatives |
| WO2007017094A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted benzyloxy-phenylmethylcarbamate derivatives |
| WO2007017092A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 4-benzyloxy-benzoic acid amide derivatives |
| WO2007080109A1 (en) | 2006-01-16 | 2007-07-19 | Bayer Healthcare Ag | Substituded benzyloxy-phenylmethylurea derivatives |
| WO2007089031A1 (en) * | 2006-02-01 | 2007-08-09 | Takeda Pharmaceutical Company Limited | Piperidine derivatives as tachykinin receptor antagonists |
| WO2007134107A2 (en) | 2006-05-10 | 2007-11-22 | Janssen Pharmaceutica N.V. | Cold menthol receptor-1 antagonists |
| EA201070158A1 (ru) | 2007-07-18 | 2010-08-30 | Янссен Фармацевтика Н.В. | Сульфонамиды в качестве trpm8 модуляторов |
| CN102325750A (zh) * | 2008-12-18 | 2012-01-18 | 詹森药业有限公司 | 作为trpm8调节剂的磺酰胺 |
| WO2010103381A1 (en) | 2009-03-13 | 2010-09-16 | Glenmark Pharmaceuticals S.A. | Spirocyclic piperidine derivatives as trpm 8 modulators |
| MX2011011428A (es) | 2009-05-01 | 2011-11-29 | Raqualia Pharma Inc | Derivados de acido sulfamoilbenzoico como antagonistas de trpm8. |
| WO2012036233A1 (ja) * | 2010-09-17 | 2012-03-22 | 塩野義製薬株式会社 | メラニン凝集ホルモン受容体アンタゴニスト活性を有する縮合へテロ環誘導体 |
| LT2793883T (lt) | 2011-12-19 | 2018-08-10 | Dompé Farmaceutici S.P.A. | Trpm8 antagonistai |
-
2012
- 2012-12-19 LT LTEP12812229.8T patent/LT2793883T/lt unknown
- 2012-12-19 WO PCT/EP2012/076147 patent/WO2013092711A1/en not_active Ceased
- 2012-12-19 TR TR2018/08861T patent/TR201808861T4/tr unknown
- 2012-12-19 SI SI201231328T patent/SI2793883T1/en unknown
- 2012-12-19 HU HUE12812229A patent/HUE038407T2/hu unknown
- 2012-12-19 US US14/366,796 patent/US9585875B2/en active Active
- 2012-12-19 KR KR1020147019697A patent/KR102000319B1/ko active Active
- 2012-12-19 EP EP12812229.8A patent/EP2793883B1/en active Active
- 2012-12-19 SM SM20180351T patent/SMT201800351T1/it unknown
- 2012-12-19 DK DK12812229.8T patent/DK2793883T3/en active
- 2012-12-19 PT PT128122298T patent/PT2793883T/pt unknown
- 2012-12-19 ME MEP-2018-177A patent/ME03038B/me unknown
- 2012-12-19 AU AU2012357747A patent/AU2012357747B2/en active Active
- 2012-12-19 RS RS20180793A patent/RS57389B1/sr unknown
- 2012-12-19 JP JP2014547975A patent/JP6238906B2/ja active Active
- 2012-12-19 HR HRP20181086TT patent/HRP20181086T1/hr unknown
- 2012-12-19 EA EA201491213A patent/EA025356B1/ru unknown
- 2012-12-19 CN CN201280069993.7A patent/CN104220069B/zh active Active
- 2012-12-19 ES ES12812229.8T patent/ES2676884T3/es active Active
- 2012-12-19 PL PL12812229T patent/PL2793883T3/pl unknown
-
2014
- 2014-06-19 ZA ZA2014/04499A patent/ZA201404499B/en unknown
-
2017
- 2017-01-25 US US15/414,803 patent/US9856246B2/en active Active
- 2017-06-19 JP JP2017119493A patent/JP2017197564A/ja not_active Withdrawn
-
2018
- 2018-07-10 CY CY20181100717T patent/CY1120403T1/el unknown
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