JP2015504874A5 - - Google Patents
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- Publication number
- JP2015504874A5 JP2015504874A5 JP2014547975A JP2014547975A JP2015504874A5 JP 2015504874 A5 JP2015504874 A5 JP 2015504874A5 JP 2014547975 A JP2014547975 A JP 2014547975A JP 2014547975 A JP2014547975 A JP 2014547975A JP 2015504874 A5 JP2015504874 A5 JP 2015504874A5
- Authority
- JP
- Japan
- Prior art keywords
- thiazole
- carboxylate
- ethyl
- oxy
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11194365.0 | 2011-12-19 | ||
| EP11194365.0A EP2606888A1 (en) | 2011-12-19 | 2011-12-19 | Trpm8 antagonists |
| EP12178327.8 | 2012-07-27 | ||
| EP12178327 | 2012-07-27 | ||
| PCT/EP2012/076147 WO2013092711A1 (en) | 2011-12-19 | 2012-12-19 | Trpm8 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017119493A Division JP2017197564A (ja) | 2011-12-19 | 2017-06-19 | Ｔｒｐｍ８拮抗薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504874A JP2015504874A (ja) | 2015-02-16 |
| JP2015504874A5 true JP2015504874A5 (https=) | 2015-10-29 |
| JP6238906B2 JP6238906B2 (ja) | 2017-11-29 |
Family
ID=47520061
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014547975A Active JP6238906B2 (ja) | 2011-12-19 | 2012-12-19 | Ｔｒｐｍ８拮抗薬 |
| JP2017119493A Withdrawn JP2017197564A (ja) | 2011-12-19 | 2017-06-19 | Ｔｒｐｍ８拮抗薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017119493A Withdrawn JP2017197564A (ja) | 2011-12-19 | 2017-06-19 | Ｔｒｐｍ８拮抗薬 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9585875B2 (https=) |
| EP (1) | EP2793883B1 (https=) |
| JP (2) | JP6238906B2 (https=) |
| KR (1) | KR102000319B1 (https=) |
| CN (1) | CN104220069B (https=) |
| AU (1) | AU2012357747B2 (https=) |
| CY (1) | CY1120403T1 (https=) |
| DK (1) | DK2793883T3 (https=) |
| EA (1) | EA025356B1 (https=) |
| ES (1) | ES2676884T3 (https=) |
| HR (1) | HRP20181086T1 (https=) |
| HU (1) | HUE038407T2 (https=) |
| LT (1) | LT2793883T (https=) |
| ME (1) | ME03038B (https=) |
| PL (1) | PL2793883T3 (https=) |
| PT (1) | PT2793883T (https=) |
| RS (1) | RS57389B1 (https=) |
| SI (1) | SI2793883T1 (https=) |
| SM (1) | SMT201800351T1 (https=) |
| TR (1) | TR201808861T4 (https=) |
| WO (1) | WO2013092711A1 (https=) |
| ZA (1) | ZA201404499B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2481727A1 (en) * | 2011-01-28 | 2012-08-01 | Dompe S.p.A. | TRPM8 receptor antagonists |
| US9585875B2 (en) | 2011-12-19 | 2017-03-07 | Dompé Farmaceutici S.P.A. | TRPM8 antagonists |
| CN105228601A (zh) * | 2013-05-24 | 2016-01-06 | 雀巢产品技术援助有限公司 | 使用薄荷醇、芳樟醇和/或冰素治疗或预防由脑外伤和中风引起的非炎性神经元损伤 |
| BR112016028404A2 (pt) | 2014-06-05 | 2018-07-03 | Bayer Cropscience Aktiengesellschaft | compostos bicíclicos como pesticidas |
| US10196368B2 (en) * | 2014-06-23 | 2019-02-05 | Dompé Farmaceutici S.P.A. | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma |
| MX389514B (es) * | 2015-10-01 | 2025-03-20 | Firmenich Incorporated | Compuestos útiles como moduladores de canal receptor 8 de potencial transitorio de melastatina (trpm8). |
| EP3184524A1 (en) * | 2015-12-21 | 2017-06-28 | Dompé farmaceutici S.p.A. | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists |
| KR20230005413A (ko) | 2016-06-13 | 2023-01-09 | 미쓰비시 타나베 파마 코퍼레이션 | 혈관운동증상의 치료 또는 예방을 위한 조성물 |
| WO2018117166A1 (ja) * | 2016-12-21 | 2018-06-28 | キッセイ薬品工業株式会社 | チアゾール誘導体、またはその薬理学的に許容される塩 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2713573A1 (de) * | 1977-03-28 | 1978-10-05 | Basf Ag | 4,5-disubstituierte thiazole und verfahren zu ihrer herstellung |
| JPS59220687A (ja) * | 1983-05-30 | 1984-12-12 | 株式会社日立製作所 | 直接サイクル型軽水原子炉一次冷却系の腐食環境抑制設備 |
| DK0513379T3 (da) * | 1990-11-30 | 1996-09-30 | Teijin Ltd | 2-Arylthiazolderivater og farmaceutisk præparat indeholdende sådanne |
| EP1321463B1 (en) | 2001-12-21 | 2007-08-08 | Virochem Pharma Inc. | Thiazole derivatives and their use for the treatment or prevention of Flavivirus infections |
| JP2008515950A (ja) | 2004-10-13 | 2008-05-15 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 泌尿器系障害の処置用の冷メントール受容体−１（ｃｍｒ−１）アンタゴニストとしての４−置換ベンジルオキシ−フェニルメチルアミド誘導体 |
| WO2007017093A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 2-benzyloxy-benzoic acid amide derivatives |
| WO2007017092A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 4-benzyloxy-benzoic acid amide derivatives |
| WO2007017094A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted benzyloxy-phenylmethylcarbamate derivatives |
| WO2007080109A1 (en) | 2006-01-16 | 2007-07-19 | Bayer Healthcare Ag | Substituded benzyloxy-phenylmethylurea derivatives |
| WO2007089031A1 (en) | 2006-02-01 | 2007-08-09 | Takeda Pharmaceutical Company Limited | Piperidine derivatives as tachykinin receptor antagonists |
| WO2007134107A2 (en) | 2006-05-10 | 2007-11-22 | Janssen Pharmaceutica N.V. | Cold menthol receptor-1 antagonists |
| BRPI0815096A2 (pt) | 2007-07-18 | 2015-07-14 | Janssen Pharmaceutica Nv | Sulfonamidas como moduladores de trpm8 |
| WO2010080398A1 (en) * | 2008-12-18 | 2010-07-15 | Janssen Pharmaceutica Nv | Sulfonamides as trpm8 modulators |
| WO2010103381A1 (en) | 2009-03-13 | 2010-09-16 | Glenmark Pharmaceuticals S.A. | Spirocyclic piperidine derivatives as trpm 8 modulators |
| RU2011148937A (ru) | 2009-05-01 | 2013-06-10 | Раквалиа Фарма Инк. | Производные сульфамоилбензойной кислоты в качестве антагонистов trpm8 |
| WO2012036233A1 (ja) | 2010-09-17 | 2012-03-22 | 塩野義製薬株式会社 | メラニン凝集ホルモン受容体アンタゴニスト活性を有する縮合へテロ環誘導体 |
| US9585875B2 (en) | 2011-12-19 | 2017-03-07 | Dompé Farmaceutici S.P.A. | TRPM8 antagonists |
-
2012
- 2012-12-19 US US14/366,796 patent/US9585875B2/en active Active
- 2012-12-19 KR KR1020147019697A patent/KR102000319B1/ko active Active
- 2012-12-19 HR HRP20181086TT patent/HRP20181086T1/hr unknown
- 2012-12-19 EP EP12812229.8A patent/EP2793883B1/en active Active
- 2012-12-19 WO PCT/EP2012/076147 patent/WO2013092711A1/en not_active Ceased
- 2012-12-19 LT LTEP12812229.8T patent/LT2793883T/lt unknown
- 2012-12-19 SM SM20180351T patent/SMT201800351T1/it unknown
- 2012-12-19 DK DK12812229.8T patent/DK2793883T3/en active
- 2012-12-19 ME MEP-2018-177A patent/ME03038B/me unknown
- 2012-12-19 ES ES12812229.8T patent/ES2676884T3/es active Active
- 2012-12-19 PL PL12812229T patent/PL2793883T3/pl unknown
- 2012-12-19 PT PT128122298T patent/PT2793883T/pt unknown
- 2012-12-19 HU HUE12812229A patent/HUE038407T2/hu unknown
- 2012-12-19 TR TR2018/08861T patent/TR201808861T4/tr unknown
- 2012-12-19 EA EA201491213A patent/EA025356B1/ru unknown
- 2012-12-19 JP JP2014547975A patent/JP6238906B2/ja active Active
- 2012-12-19 CN CN201280069993.7A patent/CN104220069B/zh active Active
- 2012-12-19 AU AU2012357747A patent/AU2012357747B2/en active Active
- 2012-12-19 SI SI201231328T patent/SI2793883T1/en unknown
- 2012-12-19 RS RS20180793A patent/RS57389B1/sr unknown
-
2014
- 2014-06-19 ZA ZA2014/04499A patent/ZA201404499B/en unknown
-
2017
- 2017-01-25 US US15/414,803 patent/US9856246B2/en active Active
- 2017-06-19 JP JP2017119493A patent/JP2017197564A/ja not_active Withdrawn
-
2018
- 2018-07-10 CY CY20181100717T patent/CY1120403T1/el unknown
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