JP2015503329A5 - - Google Patents

Info

Publication number

JP2015503329A5

JP2015503329A5 JP2014548973A JP2014548973A JP2015503329A5 JP 2015503329 A5 JP2015503329 A5 JP 2015503329A5 JP 2014548973 A JP2014548973 A JP 2014548973A JP 2014548973 A JP2014548973 A JP 2014548973A JP 2015503329 A5 JP2015503329 A5 JP 2015503329A5

Authority

JP

Japan

Prior art keywords

feed

cell culture

medium

supplement composition

composition according

Prior art date

2012-12-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 22
• 239000013589 supplement Substances 0.000 claims 19
• 239000002609 medium Substances 0.000 claims 15
• 239000006143 cell culture medium Substances 0.000 claims 11
• 238000004113 cell culture Methods 0.000 claims 6
• 239000012592 cell culture supplement Substances 0.000 claims 6
• 239000006052 feed supplement Substances 0.000 claims 6
• -1 dextran sulfate Polymers 0.000 claims 5
• 239000011324 bead Substances 0.000 claims 4
• 229920002971 Heparan sulfate Polymers 0.000 claims 2
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 2
• 239000003963 antioxidant agent Substances 0.000 claims 2
• 230000003078 antioxidant effect Effects 0.000 claims 2
• 239000011248 coating agent Substances 0.000 claims 2
• 238000000576 coating method Methods 0.000 claims 2
• 230000005251 gamma ray Effects 0.000 claims 2
• 239000011159 matrix material Substances 0.000 claims 2
• 239000003094 microcapsule Substances 0.000 claims 2
• 239000000243 solution Substances 0.000 claims 2
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
• SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 229920000936 Agarose Polymers 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 229920001287 Chondroitin sulfate Polymers 0.000 claims 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• 229920000858 Cyclodextrin Polymers 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 1
• 108010010803 Gelatin Proteins 0.000 claims 1
• 229920002148 Gellan gum Polymers 0.000 claims 1
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 1
• 229920002907 Guar gum Polymers 0.000 claims 1
• WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 claims 1
• 239000004952 Polyamide Substances 0.000 claims 1
• 229920002732 Polyanhydride Polymers 0.000 claims 1
• 239000004698 Polyethylene Substances 0.000 claims 1
• 229920000954 Polyglycolide Polymers 0.000 claims 1
• 229920001710 Polyorthoester Polymers 0.000 claims 1
• 239000004743 Polypropylene Substances 0.000 claims 1
• 239000004793 Polystyrene Substances 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 235000010443 alginic acid Nutrition 0.000 claims 1
• 229920000615 alginic acid Polymers 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• 239000007864 aqueous solution Substances 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 235000010418 carrageenan Nutrition 0.000 claims 1
• 239000000679 carrageenan Substances 0.000 claims 1
• 229920001525 carrageenan Polymers 0.000 claims 1
• 229940113118 carrageenan Drugs 0.000 claims 1
• 150000001768 cations Chemical class 0.000 claims 1
• 239000001913 cellulose Substances 0.000 claims 1
• 229920002678 cellulose Polymers 0.000 claims 1
• 229940059329 chondroitin sulfate Drugs 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 239000000412 dendrimer Substances 0.000 claims 1
• 229920000736 dendritic polymer Polymers 0.000 claims 1
• 229960002086 dextran Drugs 0.000 claims 1
• 229960000633 dextran sulfate Drugs 0.000 claims 1
• 239000004205 dimethyl polysiloxane Substances 0.000 claims 1
• 238000001035 drying Methods 0.000 claims 1
• 239000008393 encapsulating agent Substances 0.000 claims 1
• 229920000159 gelatin Polymers 0.000 claims 1
• 239000008273 gelatin Substances 0.000 claims 1
• 229940014259 gelatin Drugs 0.000 claims 1
• 235000019322 gelatine Nutrition 0.000 claims 1
• 235000011852 gelatine desserts Nutrition 0.000 claims 1
• 235000010492 gellan gum Nutrition 0.000 claims 1
• 239000000216 gellan gum Substances 0.000 claims 1
• 238000005469 granulation Methods 0.000 claims 1
• 230000003179 granulation Effects 0.000 claims 1
• 239000001963 growth medium Substances 0.000 claims 1
• 239000000665 guar gum Substances 0.000 claims 1
• 235000010417 guar gum Nutrition 0.000 claims 1
• 229960002154 guar gum Drugs 0.000 claims 1
• 229920000669 heparin Polymers 0.000 claims 1
• 229960002897 heparin Drugs 0.000 claims 1
• 229920002674 hyaluronan Polymers 0.000 claims 1
• 229960003160 hyaluronic acid Drugs 0.000 claims 1
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000463 material Substances 0.000 claims 1
• 229910021645 metal ion Inorganic materials 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 229920001432 poly(L-lactide) Polymers 0.000 claims 1
• 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
• 229920001308 poly(aminoacid) Polymers 0.000 claims 1
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims 1
• 229920000747 poly(lactic acid) Polymers 0.000 claims 1
• 239000002745 poly(ortho ester) Substances 0.000 claims 1
• 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
• 229920002492 poly(sulfone) Polymers 0.000 claims 1
• 229920002647 polyamide Polymers 0.000 claims 1
• 229920001610 polycaprolactone Polymers 0.000 claims 1
• 229920000573 polyethylene Polymers 0.000 claims 1
• 239000004633 polyglycolic acid Substances 0.000 claims 1
• 239000004626 polylactic acid Substances 0.000 claims 1
• 239000004926 polymethyl methacrylate Substances 0.000 claims 1
• 229920002714 polyornithine Polymers 0.000 claims 1
• 108010055896 polyornithine Proteins 0.000 claims 1
• 229920001155 polypropylene Polymers 0.000 claims 1
• 229920002223 polystyrene Polymers 0.000 claims 1
• 239000004810 polytetrafluoroethylene Substances 0.000 claims 1
• 229920001343 polytetrafluoroethylene Polymers 0.000 claims 1
• 229920002635 polyurethane Polymers 0.000 claims 1
• 239000004814 polyurethane Substances 0.000 claims 1
• 239000004800 polyvinyl chloride Substances 0.000 claims 1
• 229920000915 polyvinyl chloride Polymers 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
• 235000013619 trace mineral Nutrition 0.000 claims 1
• 239000011573 trace mineral Substances 0.000 claims 1
• 235000010493 xanthan gum Nutrition 0.000 claims 1
• 239000000230 xanthan gum Substances 0.000 claims 1
• 229920001285 xanthan gum Polymers 0.000 claims 1
• 229940082509 xanthan gum Drugs 0.000 claims 1
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1