JP2015502970A5 - - Google Patents
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- Publication number
- JP2015502970A5 JP2015502970A5 JP2014548059A JP2014548059A JP2015502970A5 JP 2015502970 A5 JP2015502970 A5 JP 2015502970A5 JP 2014548059 A JP2014548059 A JP 2014548059A JP 2014548059 A JP2014548059 A JP 2014548059A JP 2015502970 A5 JP2015502970 A5 JP 2015502970A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazin
- triazolo
- dimethyl
- ethyl
- quinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- AOLYXBUFENUNSR-UHFFFAOYSA-N 2-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-6-fluoroquinoline Chemical compound C1=C(F)C=CC2=NC(CCC3=NN4C(C)=CN=C(C4=N3)C)=CC=C21 AOLYXBUFENUNSR-UHFFFAOYSA-N 0.000 claims 1
- VOASYVQFJORMOW-UHFFFAOYSA-N 2-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-7-fluoroquinoline Chemical compound Cc1ncc(C)n2nc(CCc3ccc4ccc(F)cc4n3)nc12 VOASYVQFJORMOW-UHFFFAOYSA-N 0.000 claims 1
- OBKFPUPSZAQTJF-UHFFFAOYSA-N 6-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-[1,3]dioxolo[4,5-g]quinoline Chemical compound C1=C2OCOC2=CC2=NC(CCC=3N=C4C(C)=NC=C(N4N=3)C)=CC=C21 OBKFPUPSZAQTJF-UHFFFAOYSA-N 0.000 claims 1
- MOIMSOJRAIPJMQ-UHFFFAOYSA-N 7-[2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)ethyl]-2,3-dihydro-[1,4]dioxino[2,3-g]quinoline Chemical compound O1CCOC2=CC3=NC(CCC=4N=C5C(C)=NC=C(N5N=4)C)=CC=C3C=C21 MOIMSOJRAIPJMQ-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000020016 psychiatric disease Diseases 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578320P | 2011-12-21 | 2011-12-21 | |
| DKPA201100990 | 2011-12-21 | ||
| US61/578,320 | 2011-12-21 | ||
| DKPA201100990 | 2011-12-21 | ||
| PCT/EP2012/076590 WO2013092974A1 (en) | 2011-12-21 | 2012-12-21 | Quinoline derivatives as pde10a enzyme inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015502970A JP2015502970A (ja) | 2015-01-29 |
| JP2015502970A5 true JP2015502970A5 (OSRAM) | 2016-02-04 |
| JP6073918B2 JP6073918B2 (ja) | 2017-02-01 |
Family
ID=48667762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548059A Expired - Fee Related JP6073918B2 (ja) | 2011-12-21 | 2012-12-21 | Ｐｄｅ１０ａ酵素阻害剤としてのキノリン誘導体 |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9216986B1 (OSRAM) |
| EP (1) | EP2794606A1 (OSRAM) |
| JP (1) | JP6073918B2 (OSRAM) |
| KR (1) | KR20140105574A (OSRAM) |
| CN (1) | CN104114554A (OSRAM) |
| AP (1) | AP2014007697A0 (OSRAM) |
| AR (1) | AR089361A1 (OSRAM) |
| AU (1) | AU2012356885B2 (OSRAM) |
| BR (1) | BR112014015192A2 (OSRAM) |
| CA (1) | CA2859702A1 (OSRAM) |
| CL (1) | CL2014001643A1 (OSRAM) |
| CO (1) | CO6990727A2 (OSRAM) |
| CR (1) | CR20140289A (OSRAM) |
| DO (1) | DOP2014000141A (OSRAM) |
| EA (1) | EA028824B1 (OSRAM) |
| EC (1) | ECSP14010000A (OSRAM) |
| GE (1) | GEP201706657B (OSRAM) |
| HK (1) | HK1202861A1 (OSRAM) |
| IL (1) | IL233226A (OSRAM) |
| MA (1) | MA35860B1 (OSRAM) |
| MD (1) | MD20140070A2 (OSRAM) |
| MX (1) | MX348792B (OSRAM) |
| MY (1) | MY165216A (OSRAM) |
| PE (1) | PE20141945A1 (OSRAM) |
| PH (1) | PH12014501434B1 (OSRAM) |
| RU (1) | RU2624440C2 (OSRAM) |
| SG (1) | SG11201403339YA (OSRAM) |
| TN (1) | TN2014000268A1 (OSRAM) |
| TW (1) | TWI570124B (OSRAM) |
| UA (1) | UA111871C2 (OSRAM) |
| WO (1) | WO2013092974A1 (OSRAM) |
| ZA (1) | ZA201404533B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI570124B (zh) | 2011-12-21 | 2017-02-11 | Ｈ 朗德貝克公司 | 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物 |
| CN105051042A (zh) * | 2012-11-29 | 2015-11-11 | 桑诺维恩药品公司 | 适用于治疗中枢神经系统病症的三唑并-吡嗪衍生物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| DE602004022415D1 (de) | 2003-06-30 | 2009-09-17 | Nycomed Gmbh | Pyrrolo-dihydroisochinolin-derivate als pde10-inhibitoren |
| CA2530316A1 (en) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolodihydroisoquinolines as pde10 inhibitors |
| US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| CA2556413A1 (en) | 2004-02-18 | 2005-09-09 | Pfizer Products Inc. | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
| JP2008501776A (ja) | 2004-06-07 | 2008-01-24 | ファイザー・プロダクツ・インク | 肥満に関連し、かつメタボリックシンドロームに関連する状態の治療としてのホスホジエステラーゼ１０の阻害 |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| AU2005282721A1 (en) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
| SI2565191T1 (sl) | 2008-05-14 | 2014-12-31 | Astellas Pharma Inc. | Derivati 4-(indol-7-ilkarbonilaminometil)cikloheksan karboksilne kisline kot EP4 receptorski antagonisti, uporabni za zdravljenje kronične ledvične odpovedi ali diabetične nefropatije |
| TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
| TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| JP2011201873A (ja) * | 2010-03-03 | 2011-10-13 | Mitsubishi Tanabe Pharma Corp | 三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用 |
| NZ603789A (en) * | 2010-05-26 | 2015-03-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| TWI570124B (zh) | 2011-12-21 | 2017-02-11 | Ｈ 朗德貝克公司 | 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物 |
-
2012
- 2012-12-20 TW TW101148618A patent/TWI570124B/zh not_active IP Right Cessation
- 2012-12-20 AR ARP120104861A patent/AR089361A1/es unknown
- 2012-12-21 AU AU2012356885A patent/AU2012356885B2/en not_active Ceased
- 2012-12-21 JP JP2014548059A patent/JP6073918B2/ja not_active Expired - Fee Related
- 2012-12-21 BR BR112014015192A patent/BR112014015192A2/pt active Search and Examination
- 2012-12-21 CA CA2859702A patent/CA2859702A1/en not_active Abandoned
- 2012-12-21 SG SG11201403339YA patent/SG11201403339YA/en unknown
- 2012-12-21 HK HK15103345.9A patent/HK1202861A1/xx unknown
- 2012-12-21 RU RU2014127984A patent/RU2624440C2/ru not_active IP Right Cessation
- 2012-12-21 PE PE2014000989A patent/PE20141945A1/es not_active Application Discontinuation
- 2012-12-21 CN CN201280069658.7A patent/CN104114554A/zh active Pending
- 2012-12-21 MX MX2014007409A patent/MX348792B/es active IP Right Grant
- 2012-12-21 KR KR1020147019800A patent/KR20140105574A/ko not_active Ceased
- 2012-12-21 GE GEAP201213526A patent/GEP201706657B/en unknown
- 2012-12-21 UA UAA201407913A patent/UA111871C2/uk unknown
- 2012-12-21 US US14/305,736 patent/US9216986B1/en not_active Expired - Fee Related
- 2012-12-21 MD MDA20140070A patent/MD20140070A2/ro not_active Application Discontinuation
- 2012-12-21 EP EP12815695.7A patent/EP2794606A1/en not_active Withdrawn
- 2012-12-21 EA EA201491152A patent/EA028824B1/ru not_active IP Right Cessation
- 2012-12-21 AP AP2014007697A patent/AP2014007697A0/xx unknown
- 2012-12-21 WO PCT/EP2012/076590 patent/WO2013092974A1/en not_active Ceased
- 2012-12-21 MY MYPI2014001793A patent/MY165216A/en unknown
-
2014
- 2014-06-16 TN TNP2014000268A patent/TN2014000268A1/en unknown
- 2014-06-17 CR CR20140289A patent/CR20140289A/es unknown
- 2014-06-17 DO DO2014000141A patent/DOP2014000141A/es unknown
- 2014-06-18 IL IL233226A patent/IL233226A/en not_active IP Right Cessation
- 2014-06-19 CL CL2014001643A patent/CL2014001643A1/es unknown
- 2014-06-20 ZA ZA2014/04533A patent/ZA201404533B/en unknown
- 2014-06-20 PH PH12014501434A patent/PH12014501434B1/en unknown
- 2014-06-20 CO CO14134658A patent/CO6990727A2/es unknown
- 2014-07-11 MA MA37201A patent/MA35860B1/fr unknown
- 2014-07-18 EC ECIEPI201410000A patent/ECSP14010000A/es unknown
-
2015
- 2015-11-13 US US14/940,272 patent/US9801878B2/en not_active Expired - Fee Related
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