PH12014501434B1 - Quinoline derivatives as pde10a enzyme inhibitors - Google Patents
Quinoline derivatives as pde10a enzyme inhibitors Download PDFInfo
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- PH12014501434B1 PH12014501434B1 PH12014501434A PH12014501434A PH12014501434B1 PH 12014501434 B1 PH12014501434 B1 PH 12014501434B1 PH 12014501434 A PH12014501434 A PH 12014501434A PH 12014501434 A PH12014501434 A PH 12014501434A PH 12014501434 B1 PH12014501434 B1 PH 12014501434B1
- Authority
- PH
- Philippines
- Prior art keywords
- triazolo
- dimethyl
- pyrazin
- quinoline
- ethyl
- Prior art date
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Classifications
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- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161578320P | 2011-12-21 | 2011-12-21 | |
| DKPA201100990 | 2011-12-21 | ||
| PCT/EP2012/076590 WO2013092974A1 (en) | 2011-12-21 | 2012-12-21 | Quinoline derivatives as pde10a enzyme inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PH12014501434A1 PH12014501434A1 (en) | 2014-09-22 |
| PH12014501434B1 true PH12014501434B1 (en) | 2014-09-22 |
Family
ID=48667762
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH12014501434A PH12014501434B1 (en) | 2011-12-21 | 2014-06-20 | Quinoline derivatives as pde10a enzyme inhibitors |
Country Status (32)
| Country | Link |
|---|---|
| US (2) | US9216986B1 (OSRAM) |
| EP (1) | EP2794606A1 (OSRAM) |
| JP (1) | JP6073918B2 (OSRAM) |
| KR (1) | KR20140105574A (OSRAM) |
| CN (1) | CN104114554A (OSRAM) |
| AP (1) | AP2014007697A0 (OSRAM) |
| AR (1) | AR089361A1 (OSRAM) |
| AU (1) | AU2012356885B2 (OSRAM) |
| BR (1) | BR112014015192A8 (OSRAM) |
| CA (1) | CA2859702A1 (OSRAM) |
| CL (1) | CL2014001643A1 (OSRAM) |
| CO (1) | CO6990727A2 (OSRAM) |
| CR (1) | CR20140289A (OSRAM) |
| DO (1) | DOP2014000141A (OSRAM) |
| EA (1) | EA028824B1 (OSRAM) |
| EC (1) | ECSP14010000A (OSRAM) |
| GE (1) | GEP201706657B (OSRAM) |
| HK (1) | HK1202861A1 (OSRAM) |
| IL (1) | IL233226A (OSRAM) |
| MA (1) | MA35860B1 (OSRAM) |
| MD (1) | MD20140070A2 (OSRAM) |
| MX (1) | MX348792B (OSRAM) |
| MY (1) | MY165216A (OSRAM) |
| PE (1) | PE20141945A1 (OSRAM) |
| PH (1) | PH12014501434B1 (OSRAM) |
| RU (1) | RU2624440C2 (OSRAM) |
| SG (1) | SG11201403339YA (OSRAM) |
| TN (1) | TN2014000268A1 (OSRAM) |
| TW (1) | TWI570124B (OSRAM) |
| UA (1) | UA111871C2 (OSRAM) |
| WO (1) | WO2013092974A1 (OSRAM) |
| ZA (1) | ZA201404533B (OSRAM) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI570124B (zh) | 2011-12-21 | 2017-02-11 | Ｈ 朗德貝克公司 | 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物 |
| CN108690053A (zh) * | 2012-11-29 | 2018-10-23 | 桑诺维恩药品公司 | 杂芳基化合物和其使用方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| US20070105840A1 (en) | 2003-06-30 | 2007-05-10 | Altana Pharma Ag | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
| TW200510407A (en) | 2003-06-30 | 2005-03-16 | Altana Pharma Ag | Novel pyrrolodihydroisoquinolines as PDE 10 inhibitors |
| US20070032404A1 (en) | 2003-07-31 | 2007-02-08 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| CA2556413A1 (en) | 2004-02-18 | 2005-09-09 | Pfizer Products Inc. | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
| WO2005120514A1 (en) | 2004-06-07 | 2005-12-22 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| AU2005282721A1 (en) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
| KR101612971B1 (ko) | 2008-05-14 | 2016-04-15 | 아스테라스 세이야쿠 가부시키가이샤 | 아미드 화합물 |
| TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| UA102693C2 (ru) | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
| TWI485151B (zh) | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
| TWI481607B (zh) | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| JP2011201873A (ja) * | 2010-03-03 | 2011-10-13 | Mitsubishi Tanabe Pharma Corp | 三置換ピリミジン化合物及びそのｐｄｅ１０阻害薬としての使用 |
| NZ705135A (en) * | 2010-05-26 | 2017-10-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| TWI570124B (zh) | 2011-12-21 | 2017-02-11 | Ｈ 朗德貝克公司 | 作為ｐｄｅ１０ａ酵素抑制劑的喹啉衍生物 |
-
2012
- 2012-12-20 TW TW101148618A patent/TWI570124B/zh not_active IP Right Cessation
- 2012-12-20 AR ARP120104861A patent/AR089361A1/es unknown
- 2012-12-21 SG SG11201403339YA patent/SG11201403339YA/en unknown
- 2012-12-21 CA CA2859702A patent/CA2859702A1/en not_active Abandoned
- 2012-12-21 HK HK15103345.9A patent/HK1202861A1/xx unknown
- 2012-12-21 KR KR1020147019800A patent/KR20140105574A/ko not_active Ceased
- 2012-12-21 GE GEAP201213526A patent/GEP201706657B/en unknown
- 2012-12-21 CN CN201280069658.7A patent/CN104114554A/zh active Pending
- 2012-12-21 BR BR112014015192A patent/BR112014015192A8/pt active Search and Examination
- 2012-12-21 MY MYPI2014001793A patent/MY165216A/en unknown
- 2012-12-21 EP EP12815695.7A patent/EP2794606A1/en not_active Withdrawn
- 2012-12-21 UA UAA201407913A patent/UA111871C2/uk unknown
- 2012-12-21 US US14/305,736 patent/US9216986B1/en not_active Expired - Fee Related
- 2012-12-21 PE PE2014000989A patent/PE20141945A1/es not_active Application Discontinuation
- 2012-12-21 AU AU2012356885A patent/AU2012356885B2/en not_active Ceased
- 2012-12-21 AP AP2014007697A patent/AP2014007697A0/xx unknown
- 2012-12-21 RU RU2014127984A patent/RU2624440C2/ru not_active IP Right Cessation
- 2012-12-21 MX MX2014007409A patent/MX348792B/es active IP Right Grant
- 2012-12-21 WO PCT/EP2012/076590 patent/WO2013092974A1/en not_active Ceased
- 2012-12-21 EA EA201491152A patent/EA028824B1/ru not_active IP Right Cessation
- 2012-12-21 JP JP2014548059A patent/JP6073918B2/ja not_active Expired - Fee Related
- 2012-12-21 MD MDA20140070A patent/MD20140070A2/ro not_active Application Discontinuation
-
2014
- 2014-06-16 TN TNP2014000268A patent/TN2014000268A1/en unknown
- 2014-06-17 CR CR20140289A patent/CR20140289A/es unknown
- 2014-06-17 DO DO2014000141A patent/DOP2014000141A/es unknown
- 2014-06-18 IL IL233226A patent/IL233226A/en not_active IP Right Cessation
- 2014-06-19 CL CL2014001643A patent/CL2014001643A1/es unknown
- 2014-06-20 CO CO14134658A patent/CO6990727A2/es unknown
- 2014-06-20 ZA ZA2014/04533A patent/ZA201404533B/en unknown
- 2014-06-20 PH PH12014501434A patent/PH12014501434B1/en unknown
- 2014-07-11 MA MA37201A patent/MA35860B1/fr unknown
- 2014-07-18 EC ECIEPI201410000A patent/ECSP14010000A/es unknown
-
2015
- 2015-11-13 US US14/940,272 patent/US9801878B2/en not_active Expired - Fee Related
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