JP2015502149A5 - - Google Patents
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- Publication number
- JP2015502149A5 JP2015502149A5 JP2014543973A JP2014543973A JP2015502149A5 JP 2015502149 A5 JP2015502149 A5 JP 2015502149A5 JP 2014543973 A JP2014543973 A JP 2014543973A JP 2014543973 A JP2014543973 A JP 2014543973A JP 2015502149 A5 JP2015502149 A5 JP 2015502149A5
- Authority
- JP
- Japan
- Prior art keywords
- mouse
- human
- heavy chain
- genome
- chromosome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000699666 Mus <mouse, genus> Species 0.000 claims 98
- 108090000623 proteins and genes Proteins 0.000 claims 66
- 210000000349 chromosome Anatomy 0.000 claims 43
- 241000283984 Rodentia Species 0.000 claims 39
- 241000700159 Rattus Species 0.000 claims 33
- 230000009261 transgenic effect Effects 0.000 claims 28
- 238000000034 method Methods 0.000 claims 24
- 210000004027 cell Anatomy 0.000 claims 21
- 108700019146 Transgenes Proteins 0.000 claims 20
- 239000003623 enhancer Substances 0.000 claims 18
- 210000001671 embryonic stem cell Anatomy 0.000 claims 16
- 239000000427 antigen Substances 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 238000011144 upstream manufacturing Methods 0.000 claims 12
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 claims 10
- 101150097493 D gene Proteins 0.000 claims 9
- 230000002068 genetic effect Effects 0.000 claims 8
- 238000004519 manufacturing process Methods 0.000 claims 7
- 238000003780 insertion Methods 0.000 claims 6
- 230000037431 insertion Effects 0.000 claims 6
- 241000699670 Mus sp. Species 0.000 claims 5
- 101100384798 Lupinus albus Cgamma gene Proteins 0.000 claims 4
- 230000003053 immunization Effects 0.000 claims 4
- 238000002649 immunization Methods 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 101150117115 V gene Proteins 0.000 claims 3
- 230000035558 fertility Effects 0.000 claims 3
- 230000004927 fusion Effects 0.000 claims 3
- 238000011830 transgenic mouse model Methods 0.000 claims 3
- 241001465754 Metazoa Species 0.000 claims 2
- 241001529936 Murinae Species 0.000 claims 2
- 238000009395 breeding Methods 0.000 claims 2
- 230000001488 breeding effect Effects 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 101001036686 Homo sapiens Melanoma-associated antigen B2 Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000013611 chromosomal DNA Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 210000003917 human chromosome Anatomy 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108700020296 rat Adam6a Proteins 0.000 claims 1
- 230000008707 rearrangement Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/310,431 | 2011-12-02 | ||
| US13/310,431 US20120204278A1 (en) | 2009-07-08 | 2011-12-02 | Animal models and therapeutic molecules |
| GB1122047.2 | 2011-12-21 | ||
| GBGB1122047.2A GB201122047D0 (en) | 2011-12-21 | 2011-12-21 | Transgenic animals |
| US13/416,684 | 2012-03-09 | ||
| US13/416,684 US9447177B2 (en) | 2009-07-08 | 2012-03-09 | Transgenic mouse homozygous for chimeric IgH locus |
| PCT/GB2012/052956 WO2013079953A1 (en) | 2011-12-02 | 2012-11-30 | Fertile transgenic animals useful for producing antibodies bearing human variable regions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235119A Division JP2018038428A (ja) | 2011-12-02 | 2017-12-07 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015502149A JP2015502149A (ja) | 2015-01-22 |
| JP2015502149A5 true JP2015502149A5 (enExample) | 2016-01-21 |
Family
ID=45572821
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543973A Pending JP2015502149A (ja) | 2011-12-02 | 2012-11-30 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
| JP2017235119A Pending JP2018038428A (ja) | 2011-12-02 | 2017-12-07 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
| JP2020092295A Pending JP2020124228A (ja) | 2011-12-02 | 2020-05-27 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
| JP2022128160A Pending JP2022159413A (ja) | 2011-12-02 | 2022-08-10 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017235119A Pending JP2018038428A (ja) | 2011-12-02 | 2017-12-07 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
| JP2020092295A Pending JP2020124228A (ja) | 2011-12-02 | 2020-05-27 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
| JP2022128160A Pending JP2022159413A (ja) | 2011-12-02 | 2022-08-10 | ヒト可変領域を保有している抗体を産生するために有用な繁殖可能遺伝子導入動物 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US20130243759A1 (enExample) |
| EP (4) | EP2989894B9 (enExample) |
| JP (4) | JP2015502149A (enExample) |
| CN (1) | CN104160031B (enExample) |
| AU (5) | AU2012343587B2 (enExample) |
| BR (1) | BR112014013121A2 (enExample) |
| CA (1) | CA2857569A1 (enExample) |
| DE (1) | DE202012013369U1 (enExample) |
| ES (1) | ES2816899T3 (enExample) |
| GB (1) | GB201122047D0 (enExample) |
| WO (1) | WO2013079953A1 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2747534C (en) * | 2008-12-18 | 2020-08-18 | Erasmus University Medical Center Rotterdam | Non-human transgenic animals expressing humanised antibodies and use therof |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| US9796788B2 (en) | 2010-02-08 | 2017-10-24 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US20130045492A1 (en) | 2010-02-08 | 2013-02-21 | Regeneron Pharmaceuticals, Inc. | Methods For Making Fully Human Bispecific Antibodies Using A Common Light Chain |
| HRP20151188T4 (hr) | 2010-02-08 | 2021-10-01 | Regeneron Pharmaceuticals, Inc. | Miš sa zajedničkim lakim lancem |
| KR102306967B1 (ko) | 2010-08-02 | 2021-10-01 | 리제너론 파아마슈티컬스, 인크. | Ｖｌ 도메인을 포함하는 결합 단백질을 생성하는 마우스 |
| LT2738259T (lt) | 2011-02-25 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Adam6 pelės |
| PT3865581T (pt) | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| KR20140082824A (ko) | 2011-10-17 | 2014-07-02 | 리제너론 파아마슈티컬스, 인크. | 제한된 면역글로불린 중쇄 마우스 |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| PT3527070T (pt) | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| US20140013456A1 (en) | 2012-03-16 | 2014-01-09 | Regeneron Pharmaceuticals, Inc. | Histidine Engineered Light Chain Antibodies and Genetically Modified Non-Human Animals for Generating the Same |
| HK1200271A1 (en) | 2012-03-16 | 2015-08-07 | 瑞泽恩制药公司 | Mice that produce antigen-binding proteins with ph-dependent binding characteristics |
| DK2825036T3 (en) | 2012-03-16 | 2018-07-16 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified rodents to generate them |
| KR102213535B1 (ko) | 2012-03-16 | 2021-02-08 | 리제너론 파마슈티칼스 인코포레이티드 | pH-민감성 면역글로불린 서열을 발현하는 비-사람 동물 |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| EP3912464A1 (en) | 2012-06-12 | 2021-11-24 | Regeneron Pharmaceuticals, Inc. | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| MY185881A (en) | 2013-02-20 | 2021-06-14 | Regeneron Pharma | Non-human animals with modified immunoglobulin heavy chain sequences |
| EP4218409B1 (en) * | 2013-03-13 | 2025-02-12 | Regeneron Pharmaceuticals, Inc. | Mice expressing a limited immunoglobulin light chain repertoire |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| ES2844174T3 (es) | 2013-09-18 | 2021-07-21 | Kymab Ltd | Métodos, células y organismos |
| GB201316644D0 (en) | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| CA2925723A1 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| US11160879B2 (en) | 2014-01-15 | 2021-11-02 | Masamichi Yamamoto | Transgenic animal for visualization of ATP and use thereof |
| CN106164092A (zh) | 2014-03-21 | 2016-11-23 | 瑞泽恩制药公司 | 表现不同结合特征的vl抗原结合蛋白 |
| CN106255410B (zh) | 2014-03-21 | 2020-01-10 | 瑞泽恩制药公司 | 产生单结构域结合蛋白的非人动物 |
| IL292311A (en) | 2014-04-03 | 2022-06-01 | Igm Biosciences Inc | J-chain qualified |
| PT3161128T (pt) * | 2014-06-26 | 2018-11-21 | Regeneron Pharma | Métodos e composições para modificações genéticas alvejadas e métodos de utilização |
| SG11201707144VA (en) | 2015-03-04 | 2017-09-28 | Igm Biosciences Inc | Cd20 binding molecules and uses thereof |
| US11111314B2 (en) | 2015-03-19 | 2021-09-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals that select for light chain variable regions that bind antigen |
| CA2999284C (en) | 2015-09-30 | 2023-06-13 | Igm Biosciences A/S | Binding molecules with modified j-chain |
| US11639389B2 (en) | 2015-09-30 | 2023-05-02 | Igm Biosciences, Inc. | Binding molecules with modified J-chain |
| TW202417497A (zh) | 2015-10-12 | 2024-05-01 | 美商再生元醫藥公司 | 活化瘦素受體的抗原結合蛋白 |
| CN118185874A (zh) * | 2016-04-04 | 2024-06-14 | 苏黎世联邦理工学院 | 一种重组哺乳动物b细胞 |
| SG11202003024WA (en) * | 2017-10-20 | 2020-05-28 | Hutchinson Fred Cancer Res | Systems and methods to produce b cells genetically modified to express selected antibodies |
| LT3773713T (lt) | 2018-04-06 | 2025-08-25 | Regeneron Pharmaceuticals, Inc. | Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija |
| CA3125380A1 (en) | 2019-02-18 | 2020-08-27 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animals with humanized immunoglobulin locus |
| DK3785536T4 (da) * | 2019-08-28 | 2025-10-27 | Trianni Inc | Adam6-knockin-mus |
| KR20230018439A (ko) | 2020-06-02 | 2023-02-07 | 바이오사이토젠 파마슈티컬스 (베이징) 컴퍼니 리미티드 | 공동 경쇄 면역글로불린 좌위를 갖는 유전자 변형 비인간 동물 |
| KR20230066386A (ko) | 2020-09-11 | 2023-05-15 | 리제너론 파마슈티칼스 인코포레이티드 | 항원 특이적 항체의 확인 및 제조 |
| AU2021400584A1 (en) | 2020-12-16 | 2023-06-29 | Regeneron Pharmaceuticals, Inc. | Mice expressing humanized fc alpha receptors |
| CN118325896A (zh) * | 2023-01-09 | 2024-07-12 | 上海交通大学医学院 | 一种抗体无功能等位基因小鼠模型及其构建方法和应用 |
| TW202600011A (zh) | 2023-01-18 | 2026-01-01 | 美商基利科學股份有限公司 | 具有經改變重鏈基因座之嵌合基因轉殖免疫球蛋白小鼠及其製造及使用方法 |
| WO2025055311A1 (zh) * | 2023-09-15 | 2025-03-20 | 赛业（苏州）生物科技有限公司 | 用于制备抗体的基因修饰小鼠及其制备方法 |
| WO2026030428A2 (en) | 2024-08-01 | 2026-02-05 | Regeneron Pharmaceuticals, Inc. | Prostate-specific antigen peptides and uses thereof |
| US20260123608A1 (en) | 2024-08-06 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Non-human animals having modified immunoglobulin heavy chain constant region locus and uses thereof |
| WO2026096736A1 (en) | 2024-10-31 | 2026-05-07 | Regeneron Pharmaceuticals, Inc. | Rodents expressing humanized polymeric immunoglobulin receptor |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3320448C2 (de) | 1983-06-07 | 1986-09-04 | Elasto-Press Schmitz GmbH, 3250 Hameln | Mangelband für Wäschemangeln |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| BE1007904A3 (nl) | 1993-12-23 | 1995-11-14 | Dsm Nv | Werkwijze voor de bereiding van een alkanol en/of een alkanon. |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| EP0907726A4 (en) | 1996-06-26 | 2001-11-07 | Baylor College Medicine | CHROMOSOMAL REORDERING BY INSERTING TWO RECOMBINATION SUBSTRATES |
| US6355412B1 (en) | 1999-07-09 | 2002-03-12 | The European Molecular Biology Laboratory | Methods and compositions for directed cloning and subcloning using homologous recombination |
| WO2001062613A1 (en) * | 2000-02-24 | 2001-08-30 | Santen, Inc. | Containers for preventing contamination from product labels |
| US6596541B2 (en) * | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| EP1458852B1 (en) * | 2001-12-21 | 2011-03-09 | ThromboGenics N.V. | Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability and for the culture of adult stem cells |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| CN101864392B (zh) | 2005-12-13 | 2016-03-23 | 国立大学法人京都大学 | 核重新编程因子 |
| RU2448979C2 (ru) * | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Антитела человека к дельта-подобному лиганду-4 человека |
| EP3399025B1 (en) | 2007-03-23 | 2025-05-07 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| EP2626416A3 (en) | 2007-04-07 | 2013-12-18 | The Whitehead Institute for Biomedical Research | Reprogramming of somatic cells |
| US20100184051A1 (en) | 2007-05-30 | 2010-07-22 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| AU2008335178A1 (en) | 2007-12-10 | 2009-06-18 | Ablexis Llc | Methods for sequential replacement of targeted region by homologous recombination |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| CN102638971B (zh) | 2009-07-08 | 2015-10-07 | 科马布有限公司 | 动物模型及治疗分子 |
| GB0915523D0 (en) | 2009-09-07 | 2009-10-07 | Genome Res Ltd | Cells and methods for obtaining them |
| US8541646B2 (en) | 2009-10-06 | 2013-09-24 | Regeneron Pharmaceuticals, Inc. | Genetically modified mice and engraftment |
| LT2738259T (lt) * | 2011-02-25 | 2020-03-10 | Regeneron Pharmaceuticals, Inc. | Adam6 pelės |
| PT3865581T (pt) * | 2011-08-05 | 2024-10-04 | Regeneron Pharma | Murganhos da cadeia leve universal humanizada |
| PT3527070T (pt) * | 2011-12-20 | 2025-12-19 | Regeneron Pharma | Murganhos de cadeia leve humanizada |
| NZ810648A (en) * | 2012-02-01 | 2025-11-28 | Regeneron Pharma | Humanized rodents that express heavy chains containing vl domains |
-
2011
- 2011-12-21 GB GBGB1122047.2A patent/GB201122047D0/en not_active Ceased
-
2012
- 2012-11-30 CA CA2857569A patent/CA2857569A1/en active Pending
- 2012-11-30 EP EP15188522.5A patent/EP2989894B9/en active Active
- 2012-11-30 DE DE202012013369.1U patent/DE202012013369U1/de not_active Expired - Lifetime
- 2012-11-30 AU AU2012343587A patent/AU2012343587B2/en active Active
- 2012-11-30 CN CN201280059193.7A patent/CN104160031B/zh active Active
- 2012-11-30 WO PCT/GB2012/052956 patent/WO2013079953A1/en not_active Ceased
- 2012-11-30 BR BR112014013121A patent/BR112014013121A2/pt not_active IP Right Cessation
- 2012-11-30 JP JP2014543973A patent/JP2015502149A/ja active Pending
- 2012-11-30 EP EP23201805.1A patent/EP4282879A3/en active Pending
- 2012-11-30 EP EP12795606.8A patent/EP2649184B1/en active Active
- 2012-11-30 ES ES15188522T patent/ES2816899T3/es active Active
- 2012-11-30 EP EP17196214.5A patent/EP3298889A1/en not_active Withdrawn
-
2013
- 2013-03-15 US US13/843,528 patent/US20130243759A1/en not_active Abandoned
-
2016
- 2016-06-30 US US15/199,575 patent/US20160353719A1/en not_active Abandoned
- 2016-09-12 AU AU2016101604A patent/AU2016101604B4/en not_active Expired
- 2016-10-13 AU AU2016244295A patent/AU2016244295A1/en not_active Abandoned
-
2017
- 2017-12-07 JP JP2017235119A patent/JP2018038428A/ja active Pending
-
2018
- 2018-08-17 AU AU2018217308A patent/AU2018217308A1/en not_active Abandoned
-
2020
- 2020-05-27 JP JP2020092295A patent/JP2020124228A/ja active Pending
-
2021
- 2021-06-11 AU AU2021203905A patent/AU2021203905A1/en not_active Abandoned
-
2022
- 2022-08-10 JP JP2022128160A patent/JP2022159413A/ja active Pending
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