JP2015501808A5 - - Google Patents
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- JP2015501808A5 JP2015501808A5 JP2014543550A JP2014543550A JP2015501808A5 JP 2015501808 A5 JP2015501808 A5 JP 2015501808A5 JP 2014543550 A JP2014543550 A JP 2014543550A JP 2014543550 A JP2014543550 A JP 2014543550A JP 2015501808 A5 JP2015501808 A5 JP 2015501808A5
- Authority
- JP
- Japan
- Prior art keywords
- solid oral
- oral pharmaceutical
- compound
- formulation
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161563229P | 2011-11-23 | 2011-11-23 | |
| US61/563,229 | 2011-11-23 | ||
| PCT/US2012/066185 WO2013078264A1 (en) | 2011-11-23 | 2012-11-21 | Pharmaceutical formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017182214A Division JP2018035171A (ja) | 2011-11-23 | 2017-09-22 | 医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015501808A JP2015501808A (ja) | 2015-01-19 |
| JP2015501808A5 true JP2015501808A5 (cg-RX-API-DMAC7.html) | 2016-01-14 |
| JP6216325B2 JP6216325B2 (ja) | 2017-10-18 |
Family
ID=47501412
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543550A Active JP6216325B2 (ja) | 2011-11-23 | 2012-11-21 | 医薬製剤 |
| JP2017182214A Pending JP2018035171A (ja) | 2011-11-23 | 2017-09-22 | 医薬製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017182214A Pending JP2018035171A (ja) | 2011-11-23 | 2017-09-22 | 医薬製剤 |
Country Status (38)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| CA2855243C (en) | 2011-11-11 | 2020-04-14 | Novartis Ag | Method of treating a proliferative disease |
| PE20141994A1 (es) | 2011-11-23 | 2014-12-24 | Novartis Ag | Formulaciones farmaceuticas |
| EP3636283A1 (en) | 2015-06-04 | 2020-04-15 | Pfizer Inc | Solid dosage forms of palbociclib |
| RU2615986C1 (ru) * | 2016-02-25 | 2017-04-12 | Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") | Замещенные метил (2-{ 4-[3-(3-метансульфониламино-2-фтор-5-хлор-фенил)-1Н-пиразол-4-ил]пиримидин-2-иламино} -этил)карбаматы, способ их получения и применения |
| US10449195B2 (en) * | 2016-03-29 | 2019-10-22 | Shenzhen Pharmacin Co., Ltd. | Pharmaceutical formulation of palbociclib and a preparation method thereof |
| WO2017210538A1 (en) | 2016-06-03 | 2017-12-07 | Giordano Caponigro | Pharmaceutical combinations |
| CN106000220A (zh) * | 2016-06-30 | 2016-10-12 | 东华大学 | 一种含化学试剂的有机溶剂崩解片的制备方法与应用 |
| CN114306245A (zh) | 2020-09-29 | 2022-04-12 | 深圳市药欣生物科技有限公司 | 无定形固体分散体的药物组合物及其制备方法 |
| WO2022074011A1 (en) | 2020-10-05 | 2022-04-14 | Pierre Fabre Medicament | Combination of encorafenib and binimetinib as adjuvant treatment for resected stage ii melanoma |
| CN114557977A (zh) * | 2022-02-16 | 2022-05-31 | 北京康立生医药技术开发有限公司 | 一种治疗肠癌的药物的制备方法、制剂及纯度分析方法 |
| WO2023239337A1 (en) * | 2022-06-08 | 2023-12-14 | Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi | A pharmaceutical composition comprising palbociclib |
| WO2025003956A1 (en) | 2023-06-30 | 2025-01-02 | Pfizer Inc. | High drug loading formulations of encorafenib |
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| US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
| EP1000055A1 (en) | 1997-05-22 | 2000-05-17 | G.D. Searle & Co. | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| US6204467B1 (en) | 1998-03-24 | 2001-03-20 | Ford Global Technologies, Inc. | Method and apparatus for resistive welding |
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| US6316435B2 (en) | 1999-02-24 | 2001-11-13 | Supergen, Inc. | Combination therapy for lymphoproliferative diseases |
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| PE20020354A1 (es) | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| ATE374753T1 (de) | 2001-12-21 | 2007-10-15 | Vernalis Cambridge Ltd | 3-(2,4)dihydroxyphenyl-4-phenylpyrazole und deren medizinische verwendung |
| WO2004050068A1 (en) * | 2002-11-29 | 2004-06-17 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| RU2006128788A (ru) | 2004-01-09 | 2008-02-20 | Новартис АГ (CH) | Производные фенил[4-(3-фенил-1н-пиразол-4-ил)пиримидин-2-ил] амина в качестве igf-1r ингибиторов |
| CA2567662C (en) | 2004-06-10 | 2012-11-27 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| AU2006279794B2 (en) | 2005-08-12 | 2011-04-07 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate HSP90 activity |
| JP2009504796A (ja) * | 2005-08-22 | 2009-02-05 | ノバルティス アクチエンゲゼルシャフト | ｐＨ依存性薬剤化合物、ｐＨ調整剤および遅延剤を含む医薬組成物 |
| WO2007024843A2 (en) | 2005-08-26 | 2007-03-01 | Smithkline Beecham Corporation | Pyrimidinyl-pyrazole inhibitors of aurora kinases |
| TW200804345A (en) | 2005-08-30 | 2008-01-16 | Novartis Ag | Substituted benzimidazoles and methods of preparation |
| JP2009530261A (ja) | 2006-03-16 | 2009-08-27 | ファイザー・プロダクツ・インク | ピラゾール化合物 |
| WO2007123892A2 (en) | 2006-04-17 | 2007-11-01 | Arqule Inc. | Raf inhibitors and their uses |
| CN101522661A (zh) | 2006-10-02 | 2009-09-02 | Irm责任有限公司 | 作为蛋白激酶抑制剂的化合物和组合物 |
| CN101522026A (zh) | 2006-10-06 | 2009-09-02 | Irm责任有限公司 | 蛋白激酶抑制剂及其应用方法 |
| US20090022789A1 (en) | 2007-07-18 | 2009-01-22 | Supernus Pharmaceuticals, Inc. | Enhanced formulations of lamotrigine |
| KR20100038119A (ko) | 2007-08-01 | 2010-04-12 | 화이자 인코포레이티드 | 피라졸 화합물 및 ｒａｆ 억제제로서 이의 용도 |
| BRPI0818340A2 (pt) | 2007-10-19 | 2015-04-22 | Abbott Gmbh & Co Kg | Produto de dispersão sólida de fármacos baseados em n-aril uréia |
| EP2220083B1 (en) | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| KR20130040258A (ko) | 2008-03-21 | 2013-04-23 | 노파르티스 아게 | 신규한 헤테로시클릭 화합물 및 그의 용도 |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| HRP20120577T1 (hr) | 2008-07-24 | 2012-08-31 | Nerviano Medical Sciences S.R.L. | 3,4-diarilpirazoli kao inhibitori proteinskih kinaza |
| EP2326622A1 (en) | 2008-07-28 | 2011-06-01 | Gilead Sciences, Inc. | Cycloalkylidene and heterocycloalkylidene histone deacetylase inhibitor compounds |
| CA2738448A1 (en) | 2008-09-29 | 2010-04-01 | Boehringer Ingelheim International Gmbh | New chemical compounds |
| CN102238945B (zh) * | 2008-10-07 | 2014-10-29 | 阿斯利康(英国)有限公司 | 药物制剂514 |
| WO2010056662A1 (en) | 2008-11-11 | 2010-05-20 | University Of Washington | Activated wnt-beta-catenin signaling in melanoma |
| JP5490137B2 (ja) | 2008-12-19 | 2014-05-14 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | プロテインキナーゼ阻害薬としての二環式ピラゾール |
| AR075180A1 (es) * | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| WO2010100127A1 (en) | 2009-03-04 | 2010-09-10 | Novartis Ag | Disubstituted imidazole derivatives as modulators of raf kinase |
| TWI532484B (zh) * | 2009-06-08 | 2016-05-11 | 艾伯維有限公司 | 包含凋亡促進劑之固態分散劑 |
| JP5789602B2 (ja) | 2009-06-15 | 2015-10-07 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 置換ピリミジニルピロロピリジノン誘導体、これらの製造のための方法およびキナーゼ阻害剤としてのこれらの使用 |
| KR101256018B1 (ko) | 2009-08-20 | 2013-04-18 | 한국과학기술연구원 | 단백질 키나아제 저해활성을 갖는 1,3,6-치환된 인돌 화합물 |
| US8242260B2 (en) | 2009-08-28 | 2012-08-14 | Novartis Ag | Compounds and compositions as protein kinase inhibitors |
| AR077975A1 (es) | 2009-08-28 | 2011-10-05 | Irm Llc | Derivados de pirazol pirimidina y composiciones como inhibidores de cinasa de proteina |
| BR112012017705B1 (pt) | 2010-01-27 | 2020-03-24 | Nerviano Medical Science S.R.L. | Derivados de sulfonamidas de 3,4-diarilpirazóis como inibidores da proteína cinase |
| RU2639876C2 (ru) | 2010-03-30 | 2017-12-25 | Версеон Корпорейшн | Мультизамещенные ароматические соединения в качестве ингибиторов тромбина |
| WO2012016993A1 (en) | 2010-08-03 | 2012-02-09 | Nerviano Medical Sciences S.R.L. | Derivatives of pyrazolophenyl-benzenesulfonamide compounds and use thereof as antitumor agents |
| CN103442715A (zh) | 2011-03-21 | 2013-12-11 | 瓦尔库里亚公司 | 包括hdac抑制剂以及类固醇的药用组合物及其用途 |
| SG195141A1 (en) | 2011-06-14 | 2013-12-30 | Novartis Ag | Combination of panobinostat and ruxolitinib in the treatment of cancer suchas a myeloproliferative neoplasm |
| PE20141994A1 (es) | 2011-11-23 | 2014-12-24 | Novartis Ag | Formulaciones farmaceuticas |
| AU2013343425A1 (en) | 2012-11-08 | 2015-06-11 | Novartis Ag | Pharmaceutical combination comprising a B-Raf inhibitor and a histone deacetylase inhibitor and their use in the treatment of proliferative diseases |
-
2012
- 2012-11-21 PE PE2014000678A patent/PE20141994A1/es active IP Right Grant
- 2012-11-21 LT LTEP12809882.9T patent/LT2782557T/lt unknown
- 2012-11-21 SI SI201231455T patent/SI2782557T1/sl unknown
- 2012-11-21 MY MYPI2014000970A patent/MY172729A/en unknown
- 2012-11-21 HU HUE12809882A patent/HUE040370T2/hu unknown
- 2012-11-21 MX MX2014006278A patent/MX353446B/es active IP Right Grant
- 2012-11-21 CA CA2856406A patent/CA2856406C/en active Active
- 2012-11-21 CN CN201280056985.9A patent/CN103945831A/zh active Pending
- 2012-11-21 SM SM20180595T patent/SMT201800595T1/it unknown
- 2012-11-21 AU AU2012340759A patent/AU2012340759C1/en active Active
- 2012-11-21 AR ARP120104373A patent/AR088936A1/es not_active Application Discontinuation
- 2012-11-21 RS RS20181376A patent/RS58048B1/sr unknown
- 2012-11-21 EA EA201491007A patent/EA025389B1/ru unknown
- 2012-11-21 PT PT12809882T patent/PT2782557T/pt unknown
- 2012-11-21 EP EP12809882.9A patent/EP2782557B1/en active Active
- 2012-11-21 WO PCT/US2012/066185 patent/WO2013078264A1/en not_active Ceased
- 2012-11-21 SG SG11201401260QA patent/SG11201401260QA/en unknown
- 2012-11-21 DK DK12809882.9T patent/DK2782557T3/en active
- 2012-11-21 ES ES12809882T patent/ES2695099T3/es active Active
- 2012-11-21 UA UAA201403227A patent/UA115039C2/uk unknown
- 2012-11-21 EP EP18188984.1A patent/EP3449911B8/en active Active
- 2012-11-21 JP JP2014543550A patent/JP6216325B2/ja active Active
- 2012-11-21 KR KR1020147013457A patent/KR102091295B1/ko active Active
- 2012-11-21 PL PL12809882T patent/PL2782557T3/pl unknown
- 2012-11-21 HR HRP20181896TT patent/HRP20181896T1/hr unknown
- 2012-11-21 US US14/359,121 patent/US9387208B2/en active Active
- 2012-11-21 ES ES18188984T patent/ES3037966T3/es active Active
- 2012-11-21 BR BR112014011981A patent/BR112014011981B8/pt active IP Right Grant
- 2012-11-21 CN CN201610104236.9A patent/CN105708819B/zh active Active
- 2012-11-22 JO JOP/2012/0353A patent/JO3493B1/ar active
- 2012-11-22 TW TW101143808A patent/TWI649098B/zh active
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2014
- 2014-04-02 ZA ZA2014/02418A patent/ZA201402418B/en unknown
- 2014-04-08 TN TNP2014000145A patent/TN2014000145A1/en unknown
- 2014-04-28 CO CO14090466A patent/CO6940426A2/es unknown
- 2014-04-28 IL IL232305A patent/IL232305B/en active IP Right Grant
- 2014-05-15 MA MA37033A patent/MA35716B1/fr unknown
- 2014-05-22 PH PH12014501157A patent/PH12014501157A1/en unknown
- 2014-05-22 CL CL2014001337A patent/CL2014001337A1/es unknown
- 2014-05-23 GT GT201400100A patent/GT201400100A/es unknown
-
2016
- 2016-06-10 US US15/179,190 patent/US9763941B2/en active Active
-
2017
- 2017-03-07 US US15/452,239 patent/US10258622B2/en active Active
- 2017-09-22 JP JP2017182214A patent/JP2018035171A/ja active Pending
-
2018
- 2018-03-14 US US15/921,306 patent/US10561654B2/en active Active
- 2018-11-20 CY CY20181101222T patent/CY1121421T1/el unknown
-
2023
- 2023-05-15 EC ECSENADI202334537A patent/ECSP23034537A/es unknown
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