JP2015501650A - 急性腎障害の診断および/または予後診断方法 - Google Patents
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Abstract
Description
・血清クレアチニンなどの一般的臨床診断パラメーターにより示される最大腎障害時の虚血性病因を有する急性腎不全患者から得た2試料。
・血清クレアチニンによる再評価で腎機能が回復したときの腎不全後7または10日の同じ患者から得た2試料。
・腎毒性物質により生じた腎不全の患者から得た2試料。1つは最大損傷時、他の1つは腎機能回復時。
・最大腎損傷時に得た、敗血症による腎不全患者から得た試料。
・コントロールとして用いる5人の健康人からなる2群。
・虚血性病因を有する急性腎不全患者4人(PI1、PI2、PI3、PI4という)。各患者から得た0日(腎不全の診断時)、腎不全の診断後1、3、5および7日の試料を用いた。
・腎毒性物質により生じた急性腎不全の患者3人(PT1、PT2、PT3という)。各患者から得た0日(腎不全の診断時)、腎不全の診断後1、3、5および7日の試料を用いた。
・それぞれ10人の健常人からなる2コントロール群。
ARF患者のmiR-93発現(図6)は、健康コントロールに比べて低下し、何人かの患者で第7日のこのmiRNAがコントロールに近い値に回復する傾向を示したことにも注意すべきである。
表1:第0日におけるICUのARF患者のmiRNAに対するROC曲線分析。
表2.第7日におけるICUのARF患者のmiRNAに対するROC曲線分析
Claims (12)
- 対象から単離した試料中のmiR-26b、miR-29a、miR-454、miR-146a、miR-27a、mi-R93、およびmiR-10aから選ばれる少なくとも1のミクロRNAの発現レベルを測定することを含む急性腎障害の診断および/または予後診断に用いることができるデータを得るための方法。
- 該発現レベルをコントロール値と比較し、該発現レベルの変化が急性腎障害を示す、請求項1記載の方法を含む急性腎障害の診断および/または予後診断方法。
- 分析する試料が血液、血清、または尿から選ばれる先の請求項のいずれかに記載の急性腎障害の診断および/または予後診断方法。
- miR-26b、miR-29a、miR-454、miR-146a、miR-27a、mi-R93,および/またはmiR-10aの血清中発現レベルのコントロール値に対する減少が急性腎障害を示す請求項2または3に記載の急性腎障害の診断および/または予後診断方法。
- ミクロRNAの発現を定量的PCRにより測定する、先の請求項のいずれかに記載の急性腎障害の診断および/または予後診断方法。
- ミクロRNAの発現レベルをRNAミクロアレイにより測定する、先の請求項のいずれかに記載の方法。
- miR-26b、miR-29a、miR-454、miR-146a、miR-27a、mi-R93、およびmiR-10aの発現レベルをまとめて測定することを含むことを特徴とする先の請求項のいずれかに記載の方法。
- ミクロRNAの少なくとも1の発現レベルの減少が急性腎障害を示す請求項7記載の方法。
- 急性腎障害の診断および予後診断のための、miR-26b、miR-29a、miR-454、miR-146a、miR-27a、mi-R93、およびmiR-10aから選ばれる少なくとも1のミクロRNAの使用。
- 急性腎障害の診断および予後診断のための、miR-26b、miR-29a、miR-454、miR-146a、miR-27a、mi-R93、およびmiR-10aをまとめた使用。
- miR-26b、miR-29a、miR-454、miR-146a、miR-27a、mi-R93、およびmiR-10aからなる群から選ばれる少なくとも1のミクロRNAの発現レベルを測定するのに必要なプローブおよびプライマーを含む請求項1〜8のいずれかに記載の方法によって急性腎障害を診断および/または予後診断するためのキット。
- 急性腎障害の診断および/または予後診断のための請求項11記載のキットの使用。
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ES201132023A ES2414290B1 (es) | 2011-12-15 | 2011-12-15 | Metodo para el diagnóstico y/o pronóstico de daño renal agudo |
ESP201132023 | 2011-12-15 | ||
PCT/ES2012/070858 WO2013087961A1 (es) | 2011-12-15 | 2012-12-11 | Metodo para el diagnostico y/o pronostico de daño renal agudo |
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CN (2) | CN107385025A (ja) |
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ES (3) | ES2414290B1 (ja) |
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WO2020071518A1 (ja) * | 2018-10-04 | 2020-04-09 | 学校法人自治医科大学 | 急性腎障害特異的バイオマーカー、急性腎障害の診断方法、急性腎障害の検査用キット、動物治療方法、及び急性腎障害用医薬 |
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CN105303261A (zh) * | 2015-11-10 | 2016-02-03 | 北京大学第一医院 | 医院内急性肾损伤预警系统 |
RU2749245C1 (ru) * | 2020-11-13 | 2021-06-07 | федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се | Способ диагностики гипоксии паренхимы почек при экспериментальной интраабдоминальной гипертензии |
RU2768578C1 (ru) * | 2020-12-25 | 2022-03-24 | федеральное государственное бюджетное образовательное учреждение высшего образования "Ульяновский государственный университет" | Способ прогнозирования острого повреждения почек у пациентов с декомпенсацией хронической сердечной недостаточности на основе системы оценки риска |
ES2950308B2 (es) * | 2022-03-02 | 2024-06-19 | Univ Oviedo | Métodos y usos para cuantificar la sobredistensión pulmonar mediante la determinación de un conjunto de miARNs |
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WO2020071518A1 (ja) * | 2018-10-04 | 2020-04-09 | 学校法人自治医科大学 | 急性腎障害特異的バイオマーカー、急性腎障害の診断方法、急性腎障害の検査用キット、動物治療方法、及び急性腎障害用医薬 |
JPWO2020071518A1 (ja) * | 2018-10-04 | 2021-12-02 | 学校法人自治医科大学 | 急性腎障害特異的バイオマーカー、急性腎障害の診断方法、急性腎障害の検査用キット、動物治療方法、及び急性腎障害用医薬 |
JP7166659B2 (ja) | 2018-10-04 | 2022-11-08 | 学校法人自治医科大学 | 急性腎障害の検査方法、急性腎障害の検査用キット、動物治療方法、及び急性腎障害用医薬 |
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ES2432853R1 (es) | 2014-03-11 |
CN104080925B (zh) | 2017-08-01 |
CN104080925A (zh) | 2014-10-01 |
US20140378335A1 (en) | 2014-12-25 |
ES2414290B1 (es) | 2014-04-16 |
BR112014014279A2 (pt) | 2017-06-13 |
RU2657422C2 (ru) | 2018-06-13 |
RU2014123753A (ru) | 2016-02-10 |
ES2414290R1 (es) | 2013-10-11 |
ES2432853A2 (es) | 2013-12-05 |
US20170175191A1 (en) | 2017-06-22 |
WO2013087961A1 (es) | 2013-06-20 |
EP2792752A1 (en) | 2014-10-22 |
CN107385025A (zh) | 2017-11-24 |
CA2859081A1 (en) | 2013-06-20 |
ES2432853B1 (es) | 2015-03-09 |
MX2014006811A (es) | 2015-11-06 |
ES2414290A2 (es) | 2013-07-18 |
EP2792752B1 (en) | 2018-04-04 |
JP6356071B2 (ja) | 2018-07-11 |
EP2792752A4 (en) | 2015-12-02 |
MX359369B (es) | 2018-09-26 |
BR112014014279A8 (pt) | 2017-06-13 |
ES2676449T3 (es) | 2018-07-19 |
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