ES2414290R1 - Metodo para el diagnostico y/o pronostico de dano renal agudo - Google Patents

Metodo para el diagnostico y/o pronostico de dano renal agudo

Info

Publication number
ES2414290R1
ES2414290R1 ES201132023A ES201132023A ES2414290R1 ES 2414290 R1 ES2414290 R1 ES 2414290R1 ES 201132023 A ES201132023 A ES 201132023A ES 201132023 A ES201132023 A ES 201132023A ES 2414290 R1 ES2414290 R1 ES 2414290R1
Authority
ES
Spain
Prior art keywords
diagnosis
acute renal
dano
forecast
marker
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201132023A
Other languages
English (en)
Other versions
ES2414290B1 (es
ES2414290A2 (es
Inventor
Fraile Elia Aguado
Munoz Miren Edurne Ramos
Toha Angel Manuel Candela
Garcia Fernando Liano
Bermejo Maria Laura Garcia
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon Y Cajal
Original Assignee
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon Y Cajal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES201232008A priority Critical patent/ES2432853B1/es
Application filed by Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon Y Cajal filed Critical Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon Y Cajal
Priority to ES201132023A priority patent/ES2414290B1/es
Priority to US14/364,644 priority patent/US20140378335A1/en
Priority to MX2014006811A priority patent/MX359369B/es
Priority to PCT/ES2012/070858 priority patent/WO2013087961A1/es
Priority to ES12857270.8T priority patent/ES2676449T3/es
Priority to RU2014123753A priority patent/RU2657422C2/ru
Priority to JP2014546594A priority patent/JP6356071B2/ja
Priority to CA2859081A priority patent/CA2859081A1/en
Priority to BR112014014279A priority patent/BR112014014279A2/pt
Priority to CN201280061797.5A priority patent/CN104080925B/zh
Priority to EP12857270.8A priority patent/EP2792752B1/en
Priority to CN201710541520.7A priority patent/CN107385025A/zh
Publication of ES2414290A2 publication Critical patent/ES2414290A2/es
Publication of ES2414290R1 publication Critical patent/ES2414290R1/es
Application granted granted Critical
Publication of ES2414290B1 publication Critical patent/ES2414290B1/es
Priority to US15/277,734 priority patent/US20170175191A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invención se refiere al miRNAsmiR-146a, como marcador de daño renal agudo y a un método y kit para el diagnóstico y/o pronóstico del daño renal agudo mediante dicho marcador.
ES201132023A 2011-12-15 2011-12-15 Metodo para el diagnóstico y/o pronóstico de daño renal agudo Active ES2414290B1 (es)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ES201132023A ES2414290B1 (es) 2011-12-15 2011-12-15 Metodo para el diagnóstico y/o pronóstico de daño renal agudo
ES201232008A ES2432853B1 (es) 2011-12-15 2011-12-15 Metodo para el diagnostico y/o pronostico de dano renal agudo
EP12857270.8A EP2792752B1 (en) 2011-12-15 2012-12-11 Method for the diagnosis of acute renal damage
PCT/ES2012/070858 WO2013087961A1 (es) 2011-12-15 2012-12-11 Metodo para el diagnostico y/o pronostico de daño renal agudo
ES12857270.8T ES2676449T3 (es) 2011-12-15 2012-12-11 Método para el diagnóstico de daño renal agudo
RU2014123753A RU2657422C2 (ru) 2011-12-15 2012-12-11 Способ диагностики и/или прогноза острого повреждения почек
JP2014546594A JP6356071B2 (ja) 2011-12-15 2012-12-11 急性腎障害の診断および／または予後診断方法
CA2859081A CA2859081A1 (en) 2011-12-15 2012-12-11 Method for the diagnosis and/or prognosis of acute renal damage
US14/364,644 US20140378335A1 (en) 2011-12-15 2012-12-11 Method for the diagnosis and/or prognosis of acute renal damage
CN201280061797.5A CN104080925B (zh) 2011-12-15 2012-12-11 用于对急性肾损伤进行诊断和/或预后的方法
MX2014006811A MX359369B (es) 2011-12-15 2012-12-11 Método para el diagnóstico y/o pronóstico de daño renal agudo.
CN201710541520.7A CN107385025A (zh) 2011-12-15 2012-12-11 用于对急性肾损伤进行诊断和/或预后的方法
BR112014014279A BR112014014279A2 (pt) 2011-12-15 2012-12-11 método para obter dados úteis para o diagnóstico e/ou prognóstico de insuficiência renal aguda; uso de pelo menos um micro-rna; kit para o diagnóstico e/ou prognóstico de insuficiência renal aguda e uso do kit
US15/277,734 US20170175191A1 (en) 2011-12-15 2016-09-27 Method for the diagnosis and/or prognosis of acute renal damage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201132023A ES2414290B1 (es) 2011-12-15 2011-12-15 Metodo para el diagnóstico y/o pronóstico de daño renal agudo

Publications (3)

Publication Number Publication Date
ES2414290A2 ES2414290A2 (es) 2013-07-18
ES2414290R1 true ES2414290R1 (es) 2013-10-11
ES2414290B1 ES2414290B1 (es) 2014-04-16

Family

ID=48611890

Family Applications (3)

Application Number Title Priority Date Filing Date
ES201232008A Active ES2432853B1 (es) 2011-12-15 2011-12-15 Metodo para el diagnostico y/o pronostico de dano renal agudo
ES201132023A Active ES2414290B1 (es) 2011-12-15 2011-12-15 Metodo para el diagnóstico y/o pronóstico de daño renal agudo
ES12857270.8T Active ES2676449T3 (es) 2011-12-15 2012-12-11 Método para el diagnóstico de daño renal agudo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES201232008A Active ES2432853B1 (es) 2011-12-15 2011-12-15 Metodo para el diagnostico y/o pronostico de dano renal agudo

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES12857270.8T Active ES2676449T3 (es) 2011-12-15 2012-12-11 Método para el diagnóstico de daño renal agudo

Country Status (10)

Country Link
US (2) US20140378335A1 (es)
EP (1) EP2792752B1 (es)
JP (1) JP6356071B2 (es)
CN (2) CN104080925B (es)
BR (1) BR112014014279A2 (es)
CA (1) CA2859081A1 (es)
ES (3) ES2432853B1 (es)
MX (1) MX359369B (es)
RU (1) RU2657422C2 (es)
WO (1) WO2013087961A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105303261A (zh) * 2015-11-10 2016-02-03 北京大学第一医院 医院内急性肾损伤预警系统
US20220002803A1 (en) * 2018-10-04 2022-01-06 Jichi Medical University Acute kidney injury-specific biomarker, acute kidney injury diagnosis method, acute kidney injury test kit, animal treatment method and acute kidney injury medication
RU2749245C1 (ru) * 2020-11-13 2021-06-07 федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский университет) (ФГАОУ ВО Первый МГМУ им. И.М. Сеченова Минздрава России (Се Способ диагностики гипоксии паренхимы почек при экспериментальной интраабдоминальной гипертензии
RU2768578C1 (ru) * 2020-12-25 2022-03-24 федеральное государственное бюджетное образовательное учреждение высшего образования "Ульяновский государственный университет" Способ прогнозирования острого повреждения почек у пациентов с декомпенсацией хронической сердечной недостаточности на основе системы оценки риска
ES2950308A1 (es) * 2022-03-02 2023-10-06 Univ Oviedo Métodos y usos para cuantificar la sobredistensión pulmonar mediante la determinación de un conjunto de miARNs

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2198400C2 (ru) * 2001-04-12 2003-02-10 Российский НИИ геронтологии Способ диагностики гипоксически-ишемического поражения почек
ES2419129T3 (es) 2007-09-14 2013-08-19 The Ohio State University Research Foundation Expresión de miARN en microvesículas de sangre periférica humana y usos del mismo
CN101988120A (zh) 2009-07-30 2011-03-23 江苏命码生物科技有限公司 一种利用血清中的微小核糖核酸诊断肝癌的新技术
ES2363661B2 (es) * 2009-09-04 2012-05-30 Fundación Para La Investigación Biomédica Del Hospital Universitario Ramón Y Cajal. Método para el diagnóstico y/o pronóstico de daño renal agudo.
CN102218144B (zh) * 2010-04-13 2016-03-02 江苏命码生物科技有限公司 一种调节生物体内微小核糖核酸含量的方法及其用途
CA2796458A1 (en) * 2010-04-21 2011-10-27 Academisch Medisch Centrum Bij De Universiteit Van Amsterdam Means and methods for determining risk of cardiovascular disease

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GODWIN, J. G. et al. Identification of a microRNA signature of renal ischemia reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. Agosto 2010, Vol. 107, Nº 32, páginas: 14339-14344. ISSN 0027-8424. <Doi:10.1073/pnas.0912701107>GODWIN, J. G. et al. Identification of a microRNA signature of renal ischemia reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. Agosto 2010, Vol. 107, Nº 32, páginas: 14339-14344. ISSN 0027-8424. <Doi:10.1073/pnas.0912701107> *
SHAPIRO, M. D. et al. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One. Agosto 2011, Vol. 6, Nº 8, Nº artículo: e23011. ISSN 1932-6203. <Doi:10.1371/journal.pone.0023011>SHAPIRO, M. D. et al. MicroRNA expression data reveals a signature of kidney damage following ischemia reperfusion injury. PLoS One. Agosto 2011, Vol. 6, Nº 8, Nº artículo: e23011. ISSN 1932-6203. <Doi:10.1371/journal.pone.0023011> *
WANG, G. et al. Elevated levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy. Disease Markers. 2011, Vol. 30, Nº 4, páginas: 171-179. ISSN 0278-0240 (impreso) ISSN 1875-8630 (electrónico) <Doi:10.3233/DMA-2011-0766> Publicado en línea el 21.06.2011.WANG, G. et al. Elevated levels of miR-146a and miR-155 in kidney biopsy and urine from patients with IgA nephropathy. Disease Markers. 2011, Vol. 30, Nº 4, páginas: 171-179. ISSN 0278-0240 (impreso) ISSN 1875-8630 (electrónico) <Doi:10.3233/DMA-2011-0766> Publicado en línea el 21.06.2011. *

Also Published As

Publication number Publication date
US20170175191A1 (en) 2017-06-22
CA2859081A1 (en) 2013-06-20
EP2792752B1 (en) 2018-04-04
RU2014123753A (ru) 2016-02-10
JP6356071B2 (ja) 2018-07-11
ES2414290B1 (es) 2014-04-16
WO2013087961A1 (es) 2013-06-20
MX2014006811A (es) 2015-11-06
RU2657422C2 (ru) 2018-06-13
ES2432853B1 (es) 2015-03-09
ES2432853R1 (es) 2014-03-11
US20140378335A1 (en) 2014-12-25
CN107385025A (zh) 2017-11-24
EP2792752A4 (en) 2015-12-02
MX359369B (es) 2018-09-26
BR112014014279A2 (pt) 2017-06-13
CN104080925B (zh) 2017-08-01
EP2792752A1 (en) 2014-10-22
CN104080925A (zh) 2014-10-01
ES2414290A2 (es) 2013-07-18
JP2015501650A (ja) 2015-01-19
ES2676449T3 (es) 2018-07-19
ES2432853A2 (es) 2013-12-05

Similar Documents

Publication Publication Date Title
UY34697A (es) Métodos para preparar análogos de nucleótidos
CR20140463A (es) Compuestos de heterociclilo como inhibidores de mek
UY34550A (es) Bencilpirazoles sustituidos
CO6960518A2 (es) Conjunto de desgaste
UY34765A (es) Compuestos novedosos.
UY34177A (es) Nuevos compuestos inhibidores de la fosfodiesterasa tipo 10a
UY34472A (es) Derivados modificados de 4-fenil-piridina
UY34156A (es) Compuestos inhibidores de metaloenzimas
UY34503A (es) ?sal de bromhidrato de pridopidina?
UY34095A (es) 4-aril-n-fenil-1,3,5-triazin-2-aminas que contienen un grupo sulfoximina
UY33925A (es) Inhibidores tricíclicos de quinasas
IN2014DN09567A (es)
UY34374A (es) Benzilindazoles sustituidos
UY34051A (es) Derivados de pirrolotriazinona como inhibidores de pi3k
BR112014030064A2 (pt) composição do ácido carboxílico.
UY34817A (es) Tienopirimidinas
UY34302A (es) COMPUESTOS DE HEXAHIDROPIRANO[3,4-d][1,3]TIAZIN-2- AMINA
UY34034A (es) Triazolopiridinas
UY34006A (es) Imidazopiridazinas
BR112013011752A2 (pt) curtimento não metálico
UY4148Q (es) Golosina para mascota
CR20130473A (es) Genes que proporcionan resistencia al mildiú polvoroso en cucumis melo
DK3135774T3 (da) Komplekse mirna-sæt som ikke-invasive biomarkører for nyrecancer
ES2414290R1 (es) Metodo para el diagnostico y/o pronostico de dano renal agudo
BR112013030897A2 (pt) composição.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 2414290

Country of ref document: ES

Kind code of ref document: B1

Effective date: 20140416