JP2015500864A5 - - Google Patents
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- Publication number
- JP2015500864A5 JP2015500864A5 JP2014548063A JP2014548063A JP2015500864A5 JP 2015500864 A5 JP2015500864 A5 JP 2015500864A5 JP 2014548063 A JP2014548063 A JP 2014548063A JP 2014548063 A JP2014548063 A JP 2014548063A JP 2015500864 A5 JP2015500864 A5 JP 2015500864A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- immunogenic composition
- composition
- item
- stabilizing additive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 25
- 239000000427 antigen Substances 0.000 claims description 18
- 102000036639 antigens Human genes 0.000 claims description 18
- 108091007433 antigens Proteins 0.000 claims description 18
- 230000002163 immunogen Effects 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 230000000996 additive effect Effects 0.000 claims description 6
- 230000000087 stabilizing effect Effects 0.000 claims description 6
- 239000002671 adjuvant Substances 0.000 claims description 4
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 230000028993 immune response Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
- 229910052782 aluminium Inorganic materials 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 description 2
- 238000010845 search algorithm Methods 0.000 description 2
- PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161580191P | 2011-12-23 | 2011-12-23 | |
| US61/580,191 | 2011-12-23 | ||
| PCT/EP2012/076609 WO2013092985A1 (en) | 2011-12-23 | 2012-12-21 | Stable compositions for immunising against staphylococcus aureus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015500864A JP2015500864A (ja) | 2015-01-08 |
| JP2015500864A5 true JP2015500864A5 (cg-RX-API-DMAC10.html) | 2015-12-10 |
Family
ID=47520086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014548063A Pending JP2015500864A (ja) | 2011-12-23 | 2012-12-21 | 黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓａｕｒｅｕｓ）に対して免疫するための安定な組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20150044251A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2793939A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2015500864A (cg-RX-API-DMAC10.html) |
| CN (1) | CN104023744A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2013092985A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2012214677B2 (en) | 2011-02-08 | 2016-11-10 | Abvacc, Inc. | Immunogenic composition comprising alpha-hemolysin oligopeptides |
| WO2013162746A1 (en) * | 2012-04-26 | 2013-10-31 | University Of Chicago | Staphylococcal coagulase antigens and methods of their use |
| TR201910573T4 (tr) | 2012-08-31 | 2019-08-21 | Glaxosmithkline Biologicals Sa | Staphylococcus aureus'a karşı bağışıklık kazandırmak için stabilize edilmiş proteinler. |
| EP3077820B1 (en) * | 2013-12-03 | 2025-02-26 | Evaxion Biotech A/S | Proteins and nucleic acids useful in vaccines targeting staphylococcus aureus |
| MX377794B (es) | 2014-03-26 | 2025-03-10 | Glaxosmithkline Biologicals Sa | Antigenos estafilococicos mutantes. |
| CN104147599B (zh) * | 2014-06-24 | 2017-03-01 | 华中科技大学 | 一种疫苗佐剂、其制备方法及应用 |
| WO2016095832A1 (en) * | 2014-12-18 | 2016-06-23 | The University Of Hong Kong | Immunotherapeutic targets against staphylococcus aureus |
| US10946084B2 (en) | 2016-02-22 | 2021-03-16 | Evaxion Biotech Aps | Proteins and nucleic acids useful in vaccines targeting Staphylococcus aureus |
| CN113893340B (zh) * | 2021-09-30 | 2024-10-22 | 中牧实业股份有限公司 | 双相油佐剂口蹄疫疫苗的稳定剂及其应用 |
| WO2023172741A2 (en) * | 2022-03-11 | 2023-09-14 | The Children's Medical Center Corporation | A multiple antigen presenting system (maps)-based staphylococcus aureus vaccine comprising b- and t-cell antigens, immunogenic composition, and uses thereof |
| US20250288657A1 (en) * | 2022-05-04 | 2025-09-18 | Evaxion Biotech A/S | Staphylococcal protein variants and truncates |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6314729A (ja) * | 1986-06-30 | 1988-01-21 | スミスクライン・バイオロジカルス・ソシエテ・アノニム | 生ワクチン用改良安定剤、その製造法およびそれを含有するワクチン |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| WO1995011700A1 (en) | 1993-10-29 | 1995-05-04 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| JP4142095B2 (ja) * | 1994-06-02 | 2008-08-27 | クアドラント・ドラツグ・デリバリー・リミテツド | 各種物質の再水和または融解時の凝集を防止する方法及び該方法により得られる組成物 |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| CA2330610A1 (en) | 1998-05-07 | 1999-11-11 | Corixa Corporation | Adjuvant composition and methods for its use |
| ES2284287T3 (es) | 1998-10-16 | 2007-11-01 | Glaxosmithkline Biologicals S.A. | Sistemas adyuvantes y vacunas. |
| US6355271B1 (en) | 1999-02-03 | 2002-03-12 | Biosante Pharmaceuticals, Inc. | Therapeutic calcium phosphate particles and methods of manufacture and use |
| AU5731200A (en) * | 1999-06-11 | 2001-01-02 | Endorex Corporation | Adjuvant-containing polymerized liposomes for oral, mucosal or intranasal vaccination |
| EP2292263A3 (en) * | 1999-12-02 | 2011-07-27 | Novartis Vaccines and Diagnostics, Inc. | Compositions and methods for stabilizing biological molecules upon lyophilization |
| EP2420247A1 (en) * | 2000-03-07 | 2012-02-22 | Merck Sharp & Dohme Corp. | Adenovirus formulations |
| EP1494651A4 (en) * | 2002-04-11 | 2010-10-13 | Medimmune Vaccines Inc | PRESERVATION OF BIOACTIVE MATERIALS WITH FREEZZED FOAM |
| CA2807534A1 (en) * | 2003-02-25 | 2005-02-17 | Medimmune Vaccines, Inc. | Methods of producing influenza vaccine compositions |
| ES2379267T3 (es) * | 2003-10-23 | 2012-04-24 | Novartis Vaccines And Diagnostics, Inc. | Composiciones estabilizadas |
| KR20110132416A (ko) | 2004-04-05 | 2011-12-07 | 화이자 프로덕츠 인코포레이티드 | 미세유체화된 수중유 유화액 및 백신 조성물 |
| US20090104226A1 (en) * | 2004-05-21 | 2009-04-23 | Novartis Vaccines And Diagnostics Inc. | Alphavirus Vectors for Respiratory Pathogen Vaccines |
| RS20070078A (sr) * | 2004-08-27 | 2008-11-28 | Panacea Biotec Ltd., | Inaktivirana vakcina protiv poliomijelitisa nastala iz sabinovog soja polio virusa |
| US20060228369A1 (en) | 2005-04-11 | 2006-10-12 | Program For Appropriate Technology In Health | Stabilization and preservation of temperature-sensitive vaccines |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| CN101180081B (zh) * | 2005-05-25 | 2015-08-26 | 诺沃-诺迪斯克有限公司 | 稳定的多肽制剂 |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| WO2007027076A1 (es) * | 2005-09-01 | 2007-03-08 | Nuno Ayala Jose Luis | Formula estabilizadora de vacunas con antígenos vivos para su uso en sistemas de vacunación masiva |
| ME01965B (me) * | 2005-09-16 | 2012-04-30 | Merial Ltd | Stabilizatori za vakcine osušene zamrzavanjem |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| AU2007281934B2 (en) | 2006-01-18 | 2012-11-15 | University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| JP2009539979A (ja) | 2006-06-12 | 2009-11-19 | ナビ バイオファーマシューティカルズ | ブドウ球菌感染症を治療および予防するための、α毒素の使用 |
| CN100460013C (zh) * | 2006-09-05 | 2009-02-11 | 重庆康卫生物科技有限公司 | 口服重组幽门螺杆菌疫苗及其制备方法 |
| CA2664619C (en) | 2006-10-12 | 2012-12-11 | Glaxosmithkline Biologicals S.A. | Immunogenic compositions comprising an oil-in-water emulsion adjuvant containing a reduced amount of squalene, tocol and an emulsifying agent |
| KR20100072228A (ko) | 2007-08-31 | 2010-06-30 | 유니버시티 오브 시카고 | 스타필로코커스 폐 질환 및 상태에 대한 면역화와 관련된 방법 및 조성물 |
| GB0821806D0 (en) * | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
| EP2419129A2 (en) * | 2009-04-14 | 2012-02-22 | Novartis AG | Compositions for immunising against staphylococcus aerus |
| US9950062B2 (en) | 2009-09-02 | 2018-04-24 | Glaxosmithkline Biologicals Sa | Compounds and compositions as TLR activity modulators |
| CN102258537B (zh) * | 2011-07-15 | 2012-07-04 | 骆延波 | 鸡传染性法氏囊病特异性转移因子的制备方法 |
-
2012
- 2012-12-21 US US14/366,362 patent/US20150044251A1/en not_active Abandoned
- 2012-12-21 EP EP12812257.9A patent/EP2793939A1/en not_active Withdrawn
- 2012-12-21 WO PCT/EP2012/076609 patent/WO2013092985A1/en not_active Ceased
- 2012-12-21 CN CN201280063615.8A patent/CN104023744A/zh active Pending
- 2012-12-21 JP JP2014548063A patent/JP2015500864A/ja active Pending
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