JP2015213495A5 - - Google Patents
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- Publication number
- JP2015213495A5 JP2015213495A5 JP2014260434A JP2014260434A JP2015213495A5 JP 2015213495 A5 JP2015213495 A5 JP 2015213495A5 JP 2014260434 A JP2014260434 A JP 2014260434A JP 2014260434 A JP2014260434 A JP 2014260434A JP 2015213495 A5 JP2015213495 A5 JP 2015213495A5
- Authority
- JP
- Japan
- Prior art keywords
- differentiation
- derived
- skin
- medium
- derived pluripotent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000004069 differentiation Effects 0.000 claims description 12
- 230000001939 inductive effect Effects 0.000 claims description 10
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 9
- 239000000556 agonist Substances 0.000 claims description 5
- 239000002609 medium Substances 0.000 claims 11
- 210000000130 stem cell Anatomy 0.000 claims 11
- 238000004519 manufacturing process Methods 0.000 claims 6
- 210000000933 neural crest Anatomy 0.000 claims 3
- 239000012583 B-27 Supplement Substances 0.000 claims 2
- 102100024785 Fibroblast growth factor 2 Human genes 0.000 claims 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 claims 2
- 239000007640 basal medium Substances 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001228 trophic effect Effects 0.000 claims 1
- 102000013814 Wnt Human genes 0.000 description 4
- 108050003627 Wnt Proteins 0.000 description 4
- 102000015735 Beta-catenin Human genes 0.000 description 3
- 108060000903 Beta-catenin Proteins 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 102000040945 Transcription factor Human genes 0.000 description 2
- 108091023040 Transcription factor Proteins 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000031712 Wnt receptor signaling pathway, planar cell polarity pathway Effects 0.000 description 1
- 102000044880 Wnt3A Human genes 0.000 description 1
- 108700013515 Wnt3A Proteins 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000009087 cell motility Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000008611 intercellular interaction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000005937 nuclear translocation Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014260434A JP6304818B2 (ja) | 2014-04-21 | 2014-12-24 | 皮膚由来多能性前駆細胞の作製方法 |
| CN201580025674.XA CN106459906B (zh) | 2014-04-21 | 2015-04-20 | 皮肤源性前体细胞的制造方法 |
| EP15721045.1A EP3134513B1 (en) | 2014-04-21 | 2015-04-20 | Method of producing skin-derived precursor cells |
| PCT/JP2015/002156 WO2015162908A1 (en) | 2014-04-21 | 2015-04-20 | Method of producing skin-derived precursor cells |
| KR1020167032087A KR102316007B1 (ko) | 2014-04-21 | 2015-04-20 | 피부 유래 전구 세포의 제작 방법 |
| US15/305,315 US20170044495A1 (en) | 2014-04-21 | 2015-04-20 | Method of producing skin-derived precursor cells |
| US17/825,366 US20220348868A1 (en) | 2014-04-21 | 2022-05-26 | Method of producing skin-derived precursor cells |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014087247 | 2014-04-21 | ||
| JP2014087247 | 2014-04-21 | ||
| JP2014260434A JP6304818B2 (ja) | 2014-04-21 | 2014-12-24 | 皮膚由来多能性前駆細胞の作製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015213495A JP2015213495A (ja) | 2015-12-03 |
| JP2015213495A5 true JP2015213495A5 (https=) | 2017-06-15 |
| JP6304818B2 JP6304818B2 (ja) | 2018-04-04 |
Family
ID=53055077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014260434A Expired - Fee Related JP6304818B2 (ja) | 2014-04-21 | 2014-12-24 | 皮膚由来多能性前駆細胞の作製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20170044495A1 (https=) |
| EP (1) | EP3134513B1 (https=) |
| JP (1) | JP6304818B2 (https=) |
| KR (1) | KR102316007B1 (https=) |
| CN (1) | CN106459906B (https=) |
| WO (1) | WO2015162908A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015287978B2 (en) * | 2014-07-09 | 2021-04-29 | Sanford-Burnham Medical Research Institute | Methods and compositions to modulate hair growth |
| KR20180105236A (ko) | 2016-02-05 | 2018-09-27 | 메모리얼 슬로안-케터링 캔서 센터 | 줄기 세포-유래 외배엽 계통 전구체의 분화 방법 |
| WO2019017691A2 (ko) * | 2017-07-19 | 2019-01-24 | 서울대학교 산학협력단 | 인간 유래 만능줄기세포에서 모유두전구세포로의 분화방법 및 이의 용도 |
| KR102122039B1 (ko) | 2017-07-19 | 2020-06-11 | 서울대학교산학협력단 | 인간 유래 만능줄기세포에서 모유두전구세포로의 분화방법 및 이의 용도 |
| CA3075036A1 (en) * | 2017-09-07 | 2019-03-14 | Memorial Sloan-Kettering Cancer Center | Methods of differentiating stem cell-derived ectodermal lineage precursors |
| MX2020005668A (es) | 2017-11-30 | 2020-11-24 | Univ Kyoto | Metodo de cultivo de celulas. |
| JP7702229B2 (ja) * | 2018-11-19 | 2025-07-03 | 株式会社 資生堂 | 毛包を有するヒト皮膚組織を再構成するための組成物、ヒト皮膚組織モデル動物およびその製造方法 |
| US20220340868A1 (en) * | 2019-08-06 | 2022-10-27 | Kao Corporation | Method for preparing skin-derived pluripotent precursor cells |
| CN114591894B (zh) * | 2022-02-28 | 2024-01-09 | 中国人民解放军总医院 | 一种皮肤多能前体干细胞的制备方法及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4652645B2 (ja) | 1999-07-12 | 2011-03-16 | ゲーリング、ウォルター | Ｎｏｔｃｈ経路を用いた組織型または器官型の操作 |
| WO2001068815A1 (en) * | 2000-03-14 | 2001-09-20 | Es Cell International Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
| EP2329833A1 (en) * | 2004-01-27 | 2011-06-08 | The Hospital for Sick Children Research Institute | Methods of making and using skin-derived stem cells |
| US20080194021A1 (en) * | 2005-07-29 | 2008-08-14 | Mays Robert W | Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells |
| CA2663749A1 (en) | 2005-09-21 | 2007-03-29 | Dask Technologies, Llc | Methods and compositions for organ and tissue functionality |
| US20080213892A1 (en) * | 2007-03-02 | 2008-09-04 | The Board Of Trustees Of The Leland Stanford Junior University | Self-renewal of neural stem cells is promoted by wnt proteins |
| EP2042592A1 (en) | 2007-09-28 | 2009-04-01 | IMBA-Institut für Molekulare Biotechnologie GmbH | Methods for modulating the proliferation and differentiation potential of stem cells and progenitor cells |
| AU2009274517B2 (en) * | 2008-07-25 | 2015-03-26 | The University Of Georgia Research Foundation, Inc. | Compositions for Mesoderm derived ISL1+ Multipotent cells (IMPs), epicardial progenitor cells (EPCs) and multipotent CXCR4+CD56+ cells (C56Cs) and methods of use |
| WO2012091978A2 (en) * | 2010-12-31 | 2012-07-05 | University Of Georgia Research Foundation, Inc. | Differentiation of human pluripotent stem cells to multipotent neural crest cells |
| EP2765188B1 (en) * | 2011-10-06 | 2017-12-06 | Keio University | Method for producing corneal endothelial cell |
| CN103230623A (zh) * | 2013-05-10 | 2013-08-07 | 南通大学 | 一种体外构建组织工程化神经的方法 |
-
2014
- 2014-12-24 JP JP2014260434A patent/JP6304818B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-20 EP EP15721045.1A patent/EP3134513B1/en not_active Not-in-force
- 2015-04-20 CN CN201580025674.XA patent/CN106459906B/zh not_active Expired - Fee Related
- 2015-04-20 US US15/305,315 patent/US20170044495A1/en not_active Abandoned
- 2015-04-20 KR KR1020167032087A patent/KR102316007B1/ko not_active Expired - Fee Related
- 2015-04-20 WO PCT/JP2015/002156 patent/WO2015162908A1/en not_active Ceased
-
2022
- 2022-05-26 US US17/825,366 patent/US20220348868A1/en not_active Abandoned
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