JP2015183003A - 生地黄、枸杞子、沈香、茯苓、高麗人蔘と蜂蜜の混合物を有効成分として含有する男性不妊予防および治療用薬学的組成物 - Google Patents
生地黄、枸杞子、沈香、茯苓、高麗人蔘と蜂蜜の混合物を有効成分として含有する男性不妊予防および治療用薬学的組成物 Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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Abstract
Description
1)生地黄、枸杞子、沈香、茯苓、高麗人蔘と蜂蜜を入れて混合する工程と、
2)工程1)の混合物に保存剤と矯味剤を追加する工程と、
3)工程2)の保存剤と矯味剤が添加された混合物を加熱して軟エキスの状態になるまで蒸熟する工程、および
4)工程3)の混合物を放置して冷却する工程。
1)生地黄、枸杞子、沈香、茯苓、高麗人蔘と蜂蜜を入れて混合する工程と、
2)工程1)の混合物に保存剤と矯味剤(甘味料)を追加する工程と、
3)工程2)の保存剤と矯味剤が添加された混合物を加熱して軟エキスの状態になるまで蒸熟する工程、および
4)工程3)の混合物を放置して冷却する工程。
1)生地黄、枸杞子、沈香、茯苓、高麗人蔘と蜂蜜の抽出溶媒を加えて抽出する工程と、
2)工程1)の抽出物を冷却後、濾過する工程、および
3)工程2)の濾過された抽出物を減圧濃縮した後、乾燥する工程。
採取した生地黄60gをきれいに水で洗浄し、土砂を除去し、水気を抜いて細かく破砕し圧搾して生地黄汁32gを作った。また、枸杞子1.0g、沈香の木部0.15g、茯苓8.2gを乾燥した後、粉砕して粉にし、人蔘3.0gの細い根を除去して乾燥した後、粉砕して粉にした。最終収得した生地黄汁32gに枸杞子の粉末0.9g、沈香の粉末0.1g、茯苓の粉末8gと人蔘の粉末2.8gを入れ、蜂蜜38.5gと混合した。前記混合物を加熱して軟エキス(soft extract)の状態になるまで約3日〜5日間蒸熟した。蒸熟が完了した混合物は、放置して冷却した後使用した。
採取した生地黄60gをきれいに水で洗浄し、土砂を除去して水気を抜いて細かく破砕し圧搾して生地黄汁32gを作った。また、枸杞子1.0g、沈香の木部0.15g、茯苓8.2gを乾燥した後、粉砕して、それぞれの粉末にして、人蔘3.0gの細い根を除去して乾燥した後、粉砕して粉末にして、蜂蜜38.5gと混合した後、3Lフラスコに入れ、精製水2,000mlを用いて、100℃で還流攪拌させながら8時間加熱抽出を3回反復実施した。前記抽出液を集めて濾過した後、40℃以下で回転式真空濃縮蒸発器を用いて真空減圧濃縮させて、500mlに濃縮し、遠心分離(3,000rpm、20分)後、上澄み液だけを集めて、これを再び凍結乾燥させて粉末化して実験に用いた。
抽出溶媒として水の代わりに25%の水と75%のエタノールを用いたことを除いて、前記<実施例2>の抽出方法と同様に抽出した。
<4-1>熱ストレスによる男性不妊が誘発されたマウスモデルの製造
本発明の熱ストレスによる不妊マウスを製造するために、下記のような実験を行った。
抗癌剤投与による不妊が誘発されたマウスを製造するために、下記のような実験を行った。
雄マウス(male ICR mice、7週齢)の分譲を受けて、温度23±1℃、湿度60±10%に維持し、昼夜を12時間ずつに調整して、水と一般餌を十分に供給しながら、7日間動物室で適合させた。抗癌剤の投与のためにシクロホスファミド(cyclophosphamide;CYP)を150mg/kg/日で週に1回、合計5週間5回腹腔投与した。
前記実施例<4-1>で製造した熱ストレスによる不妊モデルにおいて、前記<実施例1>で製造した本発明の混合物の男性不妊改善効果を確認するために、下記のような実験を行った。
前記実施例<4-2>で製造した抗癌剤投与による不妊モデルで、本発明の混合物の男性不妊改善効果を確認するために、下記のような実験を行なった。
Claims (14)
- 生地黄(Rehmannia glutinosa Liboschitz var.purpurae Makino)、茯苓(Poria cocos Wolf)、人蔘(Panax ginseng CA Meyer)および蜂蜜(honey)からなる群から選択される複数の生薬混合物を有効成分として含有する男性不妊予防および治療用薬学的組成物。
- 前記生薬混合物が、枸杞子(Lycium chinense Miller)または沈香(Aquillaria agallocha Roxburgh)をさらに含むことを特徴とする、請求項1に記載の男性不妊予防および治療用薬学的組成物。
- 前記組成物が、生地黄28〜37重量部、茯苓3〜13重量部、人蔘1.5〜3.5重量部、蜂蜜30〜45重量部、枸杞子0.4〜1.4重量部および沈香0.1〜6重量部からなることを特徴とする、請求項2に記載の男性不妊予防および治療用薬学的組成物。
- 前記組成物が、錠剤、丸剤、散剤、顆粒剤、カプセル剤、懸濁剤、内用液剤、乳剤、シロップ剤、エキス剤、エアロゲルおよび注射溶液からなる群から選択されたいずれかの剤形であることを特徴とする、請求項1に記載の男性不妊予防および治療用薬学的組成物。
- 前記生薬混合物が、軟エキスのあることを特徴とする、請求項1に記載の男性不妊予防および治療用薬学的組成物。
- 前記組成物が、精子の数を増加させることを特徴とする、請求項1に記載の男性不妊予防および治療用薬学的組成物。
- 前記組成物が、精子の運動性を増加させることを特徴とする、請求項1に記載の男性不妊予防および治療用薬学的組成物。
- 生地黄、茯苓、人蔘と蜂蜜からなる群から選択される複数の生薬混合物を有効成分として含有する男性不妊予防および改善用健康機能食品。
- 前記生薬混合物が、枸杞子および沈香をさらに含むことを特徴とする、請求項8に記載の男性不妊予防および改善用健康機能食品。
- 前記組成物が、生地黄28〜37重量部、茯苓3〜13重量部、人蔘1.5〜3.5重量部、蜂蜜30〜45重量部、枸杞子0.4〜1.4重量部および沈香0.1〜6重量部からなることを特徴とする、請求項9に記載の男性不妊予防および改善用健康機能食品。
- 生地黄、茯苓、人蔘と蜂蜜からなる群から選択される複数の生薬混合物の抽出物を有効成分として含有する男性不妊予防および治療用薬学的組成物。
- 前記生薬混合物が、枸杞子および沈香をさらに含むことを特徴とする、請求項11に記載の男性不妊予防および治療用組成物。
- 生地黄、茯苓、人蔘と蜂蜜からなる群から選択される複数の生薬混合物の抽出物を有効成分として含有する男性不妊予防および改善用健康機能食品。
- 前記生薬混合物が、枸杞子および沈香をさらに含むことを特徴とする、請求項13に記載の男性不妊予防および改善用健康機能食品。
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JPN4006020652; 世界薬用植物百科事典 p.316, 2000, 株式会社 誠文堂新光社 * |
JPN4006020655; 産婦人科 漢方研究のあゆみ No.14, 1997, pp.35-47 * |
JPN6015051170; Syst. Biol. Reprod. Med. Vol.54, 2008, pp.185-195 * |
JPN6015051172; 中薬大辞典第二巻 初版第三刷, 1998, pp.1310-1312 * |
JPN6016030029; PLoS One Vol.9 Iss.2, 201402, pp.1-14 * |
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