JP2015131856A5 - - Google Patents
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- Publication number
- JP2015131856A5 JP2015131856A5 JP2015086575A JP2015086575A JP2015131856A5 JP 2015131856 A5 JP2015131856 A5 JP 2015131856A5 JP 2015086575 A JP2015086575 A JP 2015086575A JP 2015086575 A JP2015086575 A JP 2015086575A JP 2015131856 A5 JP2015131856 A5 JP 2015131856A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- compound
- cycloalkyl
- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 51
- 150000001875 compounds Chemical class 0.000 claims 26
- 125000000753 cycloalkyl group Chemical group 0.000 claims 13
- 150000001602 bicycloalkyls Chemical group 0.000 claims 6
- 125000004367 cycloalkylaryl group Chemical group 0.000 claims 6
- 230000004410 intraocular pressure Effects 0.000 claims 4
- 208000030533 eye disease Diseases 0.000 claims 3
- 208000010412 Glaucoma Diseases 0.000 claims 2
- 206010030043 Ocular hypertension Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24596009P | 2009-09-25 | 2009-09-25 | |
| US61/245,960 | 2009-09-25 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531012A Division JP5893561B2 (ja) | 2009-09-25 | 2010-09-23 | 新規ｎｐｒ−ｂアゴニスト |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017101128A Division JP2017137362A (ja) | 2009-09-25 | 2017-05-22 | 新規ｎｐｒ−ｂアゴニスト |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015131856A JP2015131856A (ja) | 2015-07-23 |
| JP2015131856A5 true JP2015131856A5 (https=) | 2016-05-12 |
| JP6211032B2 JP6211032B2 (ja) | 2017-10-11 |
Family
ID=43781057
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531012A Expired - Fee Related JP5893561B2 (ja) | 2009-09-25 | 2010-09-23 | 新規ｎｐｒ−ｂアゴニスト |
| JP2015086575A Expired - Fee Related JP6211032B2 (ja) | 2009-09-25 | 2015-04-21 | 新規ｎｐｒ−ｂアゴニスト |
| JP2017101128A Withdrawn JP2017137362A (ja) | 2009-09-25 | 2017-05-22 | 新規ｎｐｒ−ｂアゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012531012A Expired - Fee Related JP5893561B2 (ja) | 2009-09-25 | 2010-09-23 | 新規ｎｐｒ−ｂアゴニスト |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017101128A Withdrawn JP2017137362A (ja) | 2009-09-25 | 2017-05-22 | 新規ｎｐｒ−ｂアゴニスト |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US8546523B2 (https=) |
| EP (1) | EP2480247B1 (https=) |
| JP (3) | JP5893561B2 (https=) |
| KR (3) | KR101854820B1 (https=) |
| CN (2) | CN105732767A (https=) |
| AR (1) | AR078445A1 (https=) |
| AU (1) | AU2010298256B2 (https=) |
| BR (1) | BR112012006579A2 (https=) |
| CA (1) | CA2773949C (https=) |
| CL (2) | CL2012000715A1 (https=) |
| MX (3) | MX370645B (https=) |
| PH (1) | PH12012500562A1 (https=) |
| RU (3) | RU2636738C2 (https=) |
| TW (2) | TWI625126B (https=) |
| UY (1) | UY32902A (https=) |
| WO (1) | WO2011038061A2 (https=) |
| ZA (3) | ZA201201630B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1865976T3 (pl) | 2005-04-07 | 2012-11-30 | Cardiorentis Ag | Zastosowanie peptydu natriuretycznego do leczenia niewydolności serca |
| US20090311258A1 (en) * | 2006-08-02 | 2009-12-17 | Johannes Gutenberg-Universitaet Mainz | Medicament for lct poisoning |
| WO2011038061A2 (en) * | 2009-09-25 | 2011-03-31 | Alcon Research, Ltd. | Novel npr-b agonists |
| AR078446A1 (es) | 2009-12-18 | 2011-11-09 | Alcon Res Ltd | Agonistas de npr-b. uso. |
| HK1202433A1 (en) * | 2011-12-16 | 2015-10-02 | Kalos Therapeutics, Inc. | Methods and uses of anp (atrial natriuretic peptide), bnp (brain natriuretic peptide) and cnp (c-type natriuretic peptide)-related peptides and derivatives thereof for treatment of retinal disorders and diseases |
| AP2015008624A0 (en) * | 2013-01-25 | 2015-07-31 | Cardiorentis Ltd | Methods of treating cardiovascular indications |
| US11021514B2 (en) | 2016-06-01 | 2021-06-01 | Athira Pharma, Inc. | Compounds |
| US20180215788A1 (en) | 2017-02-01 | 2018-08-02 | Shire Human Genetic Therapies, Inc. | Compounds and Compositions for the Treatment of Ophthalmic Disorders |
| CN112566622A (zh) * | 2018-06-19 | 2021-03-26 | 细胞疗法有限责任公司 | 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统 |
| TWI828800B (zh) * | 2018-11-16 | 2024-01-11 | 美商阿克思生物科學有限公司 | Arg1及/或arg2之抑制劑 |
| CN115803338A (zh) * | 2020-06-12 | 2023-03-14 | 药明公司 | C型利尿钠肽及其治疗急性肺损伤的方法 |
| KR102677730B1 (ko) * | 2023-03-27 | 2024-06-27 | 나인바이오팜 주식회사 | 지방 분해 효능을 갖는 펩타이드 및 이의 용도 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4757048A (en) * | 1985-11-05 | 1988-07-12 | Biotechnology Research Associates J.V. | Synthetic analogs of atrial natriuretic peptides |
| WO1989005654A1 (en) * | 1987-12-24 | 1989-06-29 | California Biotechnology Inc. | Linear analogs of atrial natriuretic peptides |
| JP2848411B2 (ja) | 1988-08-18 | 1999-01-20 | サイオス インコーポレイテッド | 心房性ナトリウム利尿ペプチドクリアランス阻害剤 |
| WO2000018422A1 (fr) | 1998-09-28 | 2000-04-06 | Santen Pharmaceutical Co., Ltd. | Promoteurs de secretion lacrymale ou gouttes ophtalmologiques contenant des peptides natriuretiques comme principes actifs pour traiter la keratoconjonctivite |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| US6025198A (en) | 1999-06-25 | 2000-02-15 | Isis Pharmaceuticals Inc. | Antisense modulation of Ship-2 expression |
| US6436703B1 (en) * | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
| IL142118A0 (en) * | 2001-03-20 | 2002-03-10 | Prochon Biotech Ltd | Method and composition for treatment of skeletal dysplasias |
| TWI231759B (en) | 2001-06-27 | 2005-05-01 | Alcon Inc | Olopatadine formulations for topical administration |
| US7648962B2 (en) * | 2002-11-26 | 2010-01-19 | Biocon Limited | Natriuretic compounds, conjugates, and uses thereof |
| US7297709B2 (en) | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| WO2006005140A2 (en) * | 2004-07-15 | 2006-01-19 | The University Of Queensland | Proteinaceous compounds and uses therefor |
| TW200640443A (en) | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
| US20090035287A1 (en) * | 2005-09-26 | 2009-02-05 | Zurit Levine | Atrial natriuretic peptide (anp) splice variants and methods of using same |
| WO2007047504A2 (en) | 2005-10-14 | 2007-04-26 | Biorexis Pharmaceutical Corporation | Natriuretic peptide modified transferrin fusion proteins |
| CA2647143A1 (en) | 2006-03-30 | 2007-10-11 | Palatin Technologies, Inc. | Cyclic natriuretic peptide constructs |
| EP2004633A4 (en) * | 2006-03-30 | 2009-08-26 | Palatin Technologies Inc | LINEAR NATRIURETIC PEPTIDE CONSTRUCTS |
| EP2217620A2 (en) * | 2007-11-21 | 2010-08-18 | BioMarin Pharmaceutical Inc. | Variants of c-type natriuretic peptide |
| US8551938B2 (en) | 2009-09-25 | 2013-10-08 | Alcon Research, Ltd. | NPR-B agonists |
| WO2011038061A2 (en) * | 2009-09-25 | 2011-03-31 | Alcon Research, Ltd. | Novel npr-b agonists |
| AR078446A1 (es) | 2009-12-18 | 2011-11-09 | Alcon Res Ltd | Agonistas de npr-b. uso. |
-
2010
- 2010-09-23 WO PCT/US2010/049912 patent/WO2011038061A2/en not_active Ceased
- 2010-09-23 KR KR1020177022310A patent/KR101854820B1/ko not_active Expired - Fee Related
- 2010-09-23 CN CN201610116122.6A patent/CN105732767A/zh active Pending
- 2010-09-23 JP JP2012531012A patent/JP5893561B2/ja not_active Expired - Fee Related
- 2010-09-23 MX MX2017012681A patent/MX370645B/es unknown
- 2010-09-23 RU RU2015124607A patent/RU2636738C2/ru active
- 2010-09-23 CN CN201080042799.0A patent/CN102548574B/zh not_active Expired - Fee Related
- 2010-09-23 RU RU2012116531/04A patent/RU2557290C2/ru active
- 2010-09-23 US US12/888,556 patent/US8546523B2/en not_active Expired - Fee Related
- 2010-09-23 AU AU2010298256A patent/AU2010298256B2/en not_active Ceased
- 2010-09-23 CA CA2773949A patent/CA2773949C/en not_active Expired - Fee Related
- 2010-09-23 MX MX2012003398A patent/MX2012003398A/es active IP Right Grant
- 2010-09-23 MX MX2014001528A patent/MX354005B/es unknown
- 2010-09-23 UY UY0001032902A patent/UY32902A/es not_active Application Discontinuation
- 2010-09-23 PH PH1/2012/500562A patent/PH12012500562A1/en unknown
- 2010-09-23 KR KR1020127010423A patent/KR101768661B1/ko not_active Expired - Fee Related
- 2010-09-23 BR BR112012006579A patent/BR112012006579A2/pt not_active Application Discontinuation
- 2010-09-23 EP EP10819424.2A patent/EP2480247B1/en active Active
- 2010-09-23 KR KR1020187012130A patent/KR20180049198A/ko not_active Ceased
- 2010-09-24 AR ARP100103479A patent/AR078445A1/es active IP Right Grant
- 2010-09-24 TW TW104137551A patent/TWI625126B/zh not_active IP Right Cessation
- 2010-09-24 TW TW099132370A patent/TWI577384B/zh not_active IP Right Cessation
-
2012
- 2012-03-05 ZA ZA2012/01630A patent/ZA201201630B/en unknown
- 2012-03-22 CL CL2012000715A patent/CL2012000715A1/es unknown
-
2013
- 2013-08-28 US US14/011,855 patent/US9169293B2/en not_active Expired - Fee Related
-
2014
- 2014-03-04 ZA ZA2014/01625A patent/ZA201401625B/en unknown
-
2015
- 2015-04-21 JP JP2015086575A patent/JP6211032B2/ja not_active Expired - Fee Related
- 2015-08-12 US US14/824,353 patent/US9745344B2/en not_active Expired - Fee Related
-
2017
- 2017-04-26 ZA ZA2017/02958A patent/ZA201702958B/en unknown
- 2017-05-11 CL CL2017001190A patent/CL2017001190A1/es unknown
- 2017-05-22 JP JP2017101128A patent/JP2017137362A/ja not_active Withdrawn
- 2017-07-10 US US15/645,680 patent/US9982016B2/en active Active
- 2017-11-16 RU RU2017139870A patent/RU2017139870A/ru unknown
-
2018
- 2018-05-09 US US15/975,172 patent/US10196423B2/en not_active Expired - Fee Related
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