AU2010298256B2 - Novel NPR-B agonists - Google Patents

Novel NPR-B agonists Download PDF

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Publication number
AU2010298256B2
AU2010298256B2 AU2010298256A AU2010298256A AU2010298256B2 AU 2010298256 B2 AU2010298256 B2 AU 2010298256B2 AU 2010298256 A AU2010298256 A AU 2010298256A AU 2010298256 A AU2010298256 A AU 2010298256A AU 2010298256 B2 AU2010298256 B2 AU 2010298256B2
Authority
AU
Australia
Prior art keywords
leu
arg
asp
occ
phe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2010298256A
Other languages
English (en)
Other versions
AU2010298256A1 (en
Inventor
Heiko Hawlisch
Mark R. Hellberg
Gerd Hummel
Tobias Knaute
Frank Osterkamp
Ulf Reimer
Ulrich Reineke
Uwe Richter
Bernadett Simon
Edgar Specker
Markus Woischnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43781057&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU2010298256(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical Co Ltd filed Critical Takeda Pharmaceutical Co Ltd
Publication of AU2010298256A1 publication Critical patent/AU2010298256A1/en
Assigned to SHIRE ORPHAN THERAPIES GMBH reassignment SHIRE ORPHAN THERAPIES GMBH Request for Assignment Assignors: ALCON RESEARCH, LTD.
Application granted granted Critical
Publication of AU2010298256B2 publication Critical patent/AU2010298256B2/en
Priority to AU2015255299A priority Critical patent/AU2015255299B2/en
Priority to AU2018202731A priority patent/AU2018202731A1/en
Assigned to TAKEDA PHARMACEUTICAL COMPANY LIMITED reassignment TAKEDA PHARMACEUTICAL COMPANY LIMITED Request for Assignment Assignors: SHIRE ORPHAN THERAPIES GMBH
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU2010298256A 2009-09-25 2010-09-23 Novel NPR-B agonists Ceased AU2010298256B2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2015255299A AU2015255299B2 (en) 2009-09-25 2015-11-13 Novel npr-b agonists
AU2018202731A AU2018202731A1 (en) 2009-09-25 2018-04-19 Novel npr-b agonists

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24596009P 2009-09-25 2009-09-25
US61/245,960 2009-09-25
PCT/US2010/049912 WO2011038061A2 (en) 2009-09-25 2010-09-23 Novel npr-b agonists

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2015255299A Division AU2015255299B2 (en) 2009-09-25 2015-11-13 Novel npr-b agonists

Publications (2)

Publication Number Publication Date
AU2010298256A1 AU2010298256A1 (en) 2012-04-12
AU2010298256B2 true AU2010298256B2 (en) 2015-08-13

Family

ID=43781057

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2010298256A Ceased AU2010298256B2 (en) 2009-09-25 2010-09-23 Novel NPR-B agonists

Country Status (17)

Country Link
US (5) US8546523B2 (https=)
EP (1) EP2480247B1 (https=)
JP (3) JP5893561B2 (https=)
KR (3) KR101854820B1 (https=)
CN (2) CN105732767A (https=)
AR (1) AR078445A1 (https=)
AU (1) AU2010298256B2 (https=)
BR (1) BR112012006579A2 (https=)
CA (1) CA2773949C (https=)
CL (2) CL2012000715A1 (https=)
MX (3) MX370645B (https=)
PH (1) PH12012500562A1 (https=)
RU (3) RU2636738C2 (https=)
TW (2) TWI625126B (https=)
UY (1) UY32902A (https=)
WO (1) WO2011038061A2 (https=)
ZA (3) ZA201201630B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1865976T3 (pl) 2005-04-07 2012-11-30 Cardiorentis Ag Zastosowanie peptydu natriuretycznego do leczenia niewydolności serca
US20090311258A1 (en) * 2006-08-02 2009-12-17 Johannes Gutenberg-Universitaet Mainz Medicament for lct poisoning
WO2011038061A2 (en) * 2009-09-25 2011-03-31 Alcon Research, Ltd. Novel npr-b agonists
AR078446A1 (es) 2009-12-18 2011-11-09 Alcon Res Ltd Agonistas de npr-b. uso.
HK1202433A1 (en) * 2011-12-16 2015-10-02 Kalos Therapeutics, Inc. Methods and uses of anp (atrial natriuretic peptide), bnp (brain natriuretic peptide) and cnp (c-type natriuretic peptide)-related peptides and derivatives thereof for treatment of retinal disorders and diseases
AP2015008624A0 (en) * 2013-01-25 2015-07-31 Cardiorentis Ltd Methods of treating cardiovascular indications
US11021514B2 (en) 2016-06-01 2021-06-01 Athira Pharma, Inc. Compounds
US20180215788A1 (en) 2017-02-01 2018-08-02 Shire Human Genetic Therapies, Inc. Compounds and Compositions for the Treatment of Ophthalmic Disorders
CN112566622A (zh) * 2018-06-19 2021-03-26 细胞疗法有限责任公司 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统
TWI828800B (zh) * 2018-11-16 2024-01-11 美商阿克思生物科學有限公司 Arg1及/或arg2之抑制劑
CN115803338A (zh) * 2020-06-12 2023-03-14 药明公司 C型利尿钠肽及其治疗急性肺损伤的方法
KR102677730B1 (ko) * 2023-03-27 2024-06-27 나인바이오팜 주식회사 지방 분해 효능을 갖는 펩타이드 및 이의 용도

Citations (1)

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US20080153747A1 (en) * 2004-07-15 2008-06-26 The University Of Queensland Proteinaceous compounds and uses therefor

Family Cites Families (20)

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US4757048A (en) * 1985-11-05 1988-07-12 Biotechnology Research Associates J.V. Synthetic analogs of atrial natriuretic peptides
WO1989005654A1 (en) * 1987-12-24 1989-06-29 California Biotechnology Inc. Linear analogs of atrial natriuretic peptides
JP2848411B2 (ja) 1988-08-18 1999-01-20 サイオス インコーポレイテッド 心房性ナトリウム利尿ペプチドクリアランス阻害剤
WO2000018422A1 (fr) 1998-09-28 2000-04-06 Santen Pharmaceutical Co., Ltd. Promoteurs de secretion lacrymale ou gouttes ophtalmologiques contenant des peptides natriuretiques comme principes actifs pour traiter la keratoconjonctivite
US20040266673A1 (en) * 2002-07-31 2004-12-30 Peter Bakis Long lasting natriuretic peptide derivatives
US6025198A (en) 1999-06-25 2000-02-15 Isis Pharmaceuticals Inc. Antisense modulation of Ship-2 expression
US6436703B1 (en) * 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
IL142118A0 (en) * 2001-03-20 2002-03-10 Prochon Biotech Ltd Method and composition for treatment of skeletal dysplasias
TWI231759B (en) 2001-06-27 2005-05-01 Alcon Inc Olopatadine formulations for topical administration
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US7297709B2 (en) 2003-05-22 2007-11-20 Abbott Laboratories Indazole, benzisoxazole, and benzisothiazole kinase inhibitors
TW200640443A (en) 2005-02-23 2006-12-01 Alcon Inc Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors
US20090035287A1 (en) * 2005-09-26 2009-02-05 Zurit Levine Atrial natriuretic peptide (anp) splice variants and methods of using same
WO2007047504A2 (en) 2005-10-14 2007-04-26 Biorexis Pharmaceutical Corporation Natriuretic peptide modified transferrin fusion proteins
CA2647143A1 (en) 2006-03-30 2007-10-11 Palatin Technologies, Inc. Cyclic natriuretic peptide constructs
EP2004633A4 (en) * 2006-03-30 2009-08-26 Palatin Technologies Inc LINEAR NATRIURETIC PEPTIDE CONSTRUCTS
EP2217620A2 (en) * 2007-11-21 2010-08-18 BioMarin Pharmaceutical Inc. Variants of c-type natriuretic peptide
US8551938B2 (en) 2009-09-25 2013-10-08 Alcon Research, Ltd. NPR-B agonists
WO2011038061A2 (en) * 2009-09-25 2011-03-31 Alcon Research, Ltd. Novel npr-b agonists
AR078446A1 (es) 2009-12-18 2011-11-09 Alcon Res Ltd Agonistas de npr-b. uso.

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Also Published As

Publication number Publication date
CN102548574A (zh) 2012-07-04
US20180334477A1 (en) 2018-11-22
EP2480247B1 (en) 2020-02-12
CL2017001190A1 (es) 2017-12-01
PH12012500562A1 (en) 2012-10-22
CA2773949A1 (en) 2011-03-31
TW201630619A (zh) 2016-09-01
WO2011038061A3 (en) 2011-07-28
US9982016B2 (en) 2018-05-29
TW201110974A (en) 2011-04-01
JP5893561B2 (ja) 2016-03-23
WO2011038061A2 (en) 2011-03-31
US9169293B2 (en) 2015-10-27
EP2480247A2 (en) 2012-08-01
CN102548574B (zh) 2016-03-23
RU2017139870A (ru) 2019-05-16
BR112012006579A2 (pt) 2016-11-22
UY32902A (es) 2011-02-28
MX2012003398A (es) 2012-04-10
US20170313743A1 (en) 2017-11-02
RU2636738C2 (ru) 2017-11-28
KR20180049198A (ko) 2018-05-10
KR101854820B1 (ko) 2018-05-04
ZA201702958B (en) 2018-08-29
CN105732767A (zh) 2016-07-06
JP2017137362A (ja) 2017-08-10
RU2015124607A (ru) 2015-12-10
AU2010298256A1 (en) 2012-04-12
MX370645B (es) 2019-12-19
MX354005B (es) 2018-02-08
KR20120091110A (ko) 2012-08-17
US10196423B2 (en) 2019-02-05
JP6211032B2 (ja) 2017-10-11
ZA201401625B (en) 2018-08-25
US20110077381A1 (en) 2011-03-31
CL2012000715A1 (es) 2012-11-30
US20160194357A1 (en) 2016-07-07
US8546523B2 (en) 2013-10-01
RU2017139870A3 (https=) 2019-05-16
RU2012116531A (ru) 2013-10-27
TWI577384B (zh) 2017-04-11
ZA201201630B (en) 2014-05-28
RU2557290C2 (ru) 2015-07-20
EP2480247A4 (en) 2013-09-04
JP2015131856A (ja) 2015-07-23
JP2013505937A (ja) 2013-02-21
US20130345394A1 (en) 2013-12-26
KR20170094564A (ko) 2017-08-18
KR101768661B1 (ko) 2017-08-16
AR078445A1 (es) 2011-11-09
TWI625126B (zh) 2018-06-01
CA2773949C (en) 2020-11-03
US9745344B2 (en) 2017-08-29

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Legal Events

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PC1 Assignment before grant (sect. 113)

Owner name: SHIRE ORPHAN THERAPIES GMBH

Free format text: FORMER APPLICANT(S): ALCON RESEARCH, LTD.

FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: TAKEDA PHARMACEUTICAL COMPANY LIMITED

Free format text: FORMER OWNER(S): SHIRE ORPHAN THERAPIES GMBH

MK14 Patent ceased section 143(a) (annual fees not paid) or expired