US4554101A
(en)
|
1981-01-09 |
1985-11-19 |
New York Blood Center, Inc. |
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4703008A
(en)
|
1983-12-13 |
1987-10-27 |
Kiren-Amgen, Inc. |
DNA sequences encoding erythropoietin
|
KR850004274A
(ko)
|
1983-12-13 |
1985-07-11 |
원본미기재 |
에리트로포이에틴의 제조방법
|
NZ210501A
(en)
|
1983-12-13 |
1991-08-27 |
Kirin Amgen Inc |
Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
|
US4667016A
(en)
|
1985-06-20 |
1987-05-19 |
Kirin-Amgen, Inc. |
Erythropoietin purification
|
US5567610A
(en)
|
1986-09-04 |
1996-10-22 |
Bioinvent International Ab |
Method of producing human monoclonal antibodies and kit therefor
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
US5175384A
(en)
|
1988-12-05 |
1992-12-29 |
Genpharm International |
Transgenic mice depleted in mature t-cells and methods for making transgenic mice
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
AU646822B2
(en)
|
1989-10-13 |
1994-03-10 |
Kirin-Amgen Inc. |
Erythropoietin isoforms
|
US7217689B1
(en)
|
1989-10-13 |
2007-05-15 |
Amgen Inc. |
Glycosylation analogs of erythropoietin
|
US5856298A
(en)
|
1989-10-13 |
1999-01-05 |
Amgen Inc. |
Erythropoietin isoforms
|
US5229275A
(en)
|
1990-04-26 |
1993-07-20 |
Akzo N.V. |
In-vitro method for producing antigen-specific human monoclonal antibodies
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
EP0814159B1
(en)
|
1990-08-29 |
2005-07-27 |
GenPharm International, Inc. |
Transgenic mice capable of producing heterologous antibodies
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
US5587458A
(en)
|
1991-10-07 |
1996-12-24 |
Aronex Pharmaceuticals, Inc. |
Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
|
WO1993011161A1
(en)
|
1991-11-25 |
1993-06-10 |
Enzon, Inc. |
Multivalent antigen-binding proteins
|
EP0625200B1
(en)
|
1992-02-06 |
2005-05-11 |
Chiron Corporation |
Biosynthetic binding protein for cancer marker
|
IL192290A0
(en)
|
1993-08-17 |
2008-12-29 |
Kirin Amgen Inc |
Erythropoietin analogs
|
US5773569A
(en)
|
1993-11-19 |
1998-06-30 |
Affymax Technologies N.V. |
Compounds and peptides that bind to the erythropoietin receptor
|
US5830851A
(en)
|
1993-11-19 |
1998-11-03 |
Affymax Technologies N.V. |
Methods of administering peptides that bind to the erythropoietin receptor
|
US5885574A
(en)
|
1994-07-26 |
1999-03-23 |
Amgen Inc. |
Antibodies which activate an erythropoietin receptor
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
US5767078A
(en)
|
1995-06-07 |
1998-06-16 |
Johnson; Dana L. |
Agonist peptide dimers
|
DE19544393A1
(de)
|
1995-11-15 |
1997-05-22 |
Hoechst Schering Agrevo Gmbh |
Synergistische herbizide Mischungen
|
DK1019490T3
(da)
*
|
1997-02-10 |
2010-03-15 |
Harvard College |
Fremgangsmåder til modulering af hæmatopoese og vaskulær vækst
|
US6753165B1
(en)
|
1999-01-14 |
2004-06-22 |
Bolder Biotechnology, Inc. |
Methods for making proteins containing free cysteine residues
|
WO1999003887A1
(en)
|
1997-07-14 |
1999-01-28 |
Bolder Biotechnology, Inc. |
Derivatives of growth hormone and related proteins
|
KR100641969B1
(ko)
|
1997-07-23 |
2006-11-06 |
로셰 디아그노스틱스 게엠베하 |
내인성 유전자 활성화에 의한 에리트로포이에틴의제조방법
|
US7078500B1
(en)
|
1998-01-30 |
2006-07-18 |
The General Hospital Corporation |
Genetic immunization with nonstructural proteins of hepatitis C virus
|
US6030086A
(en)
|
1998-03-02 |
2000-02-29 |
Becton, Dickinson And Company |
Flash tube reflector with arc guide
|
US6310078B1
(en)
|
1998-04-20 |
2001-10-30 |
Ortho-Mcneil Pharmaceutical, Inc. |
Substituted amino acids as erythropoietin mimetics
|
DK1088084T3
(da)
|
1998-06-15 |
2007-01-29 |
Gtc Biotherapeutics Inc |
Erythropoietin analog-humant serumalbumin fusionsprotein
|
US20050181482A1
(en)
|
2004-02-12 |
2005-08-18 |
Meade Harry M. |
Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk
|
DK1123313T3
(da)
|
1998-10-23 |
2007-06-18 |
Amgen Inc |
Fremgangsmåder og sammensætninger til forebyggelse og behandling af anæmi
|
EP1169352A4
(en)
|
1999-04-14 |
2005-05-04 |
Smithkline Beecham Corp |
ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR
|
US7297680B2
(en)
|
1999-04-15 |
2007-11-20 |
Crucell Holland B.V. |
Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content
|
CZ299516B6
(cs)
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
US6824780B1
(en)
|
1999-10-29 |
2004-11-30 |
Genentech, Inc. |
Anti-tumor antibody compositions and methods of use
|
EP1228214A2
(en)
|
1999-11-12 |
2002-08-07 |
MERCK PATENT GmbH |
Erythropoietin forms with improved properties
|
US20050202538A1
(en)
|
1999-11-12 |
2005-09-15 |
Merck Patent Gmbh |
Fc-erythropoietin fusion protein with improved pharmacokinetics
|
US20030224501A1
(en)
|
2000-03-17 |
2003-12-04 |
Young Paul E. |
Bone morphogenic protein polynucleotides, polypeptides, and antibodies
|
US6586398B1
(en)
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
EP1961425B1
(en)
|
2000-04-21 |
2017-07-19 |
Amgen Inc. |
Methods and erythropoeitin analogs for the prevention and treatment of anemia
|
US7078376B1
(en)
|
2000-08-11 |
2006-07-18 |
Baxter Healthcare S.A. |
Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects
|
US20030191291A1
(en)
|
2000-09-08 |
2003-10-09 |
Kochendoerfer Gerd G. |
Synthetic erythropoiesis stimulating proteins
|
WO2002049673A2
(en)
|
2000-12-20 |
2002-06-27 |
F. Hoffmann-La Roche Ag |
Conjugates of erythropoietin (pep) with polyethylene glycol (peg)
|
EP1383927B1
(en)
|
2001-04-04 |
2009-07-08 |
GenOdyssee |
New polynucleotides and polypeptides of the erythropoietin gene
|
JP4944360B2
(ja)
*
|
2001-05-25 |
2012-05-30 |
アンスティテュ ナシオナル ド ラ サント エ ド ラ ルシュルシェ メディカル(アンセルム) |
鉄ホメオスタシスの障害を治療するための医薬品を製造するためのヘプシジンの使用
|
US6900292B2
(en)
|
2001-08-17 |
2005-05-31 |
Lee-Hwei K. Sun |
Fc fusion proteins of human erythropoietin with increased biological activities
|
US6930086B2
(en)
|
2001-09-25 |
2005-08-16 |
Hoffmann-La Roche Inc. |
Diglycosylated erythropoietin
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
WO2003055526A2
(en)
|
2001-12-21 |
2003-07-10 |
Maxygen Aps |
Erythropoietin conjugates
|
EP1470232A1
(en)
|
2002-01-31 |
2004-10-27 |
Oxford Biomedica (UK) Limited |
Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia
|
GB0202252D0
(en)
|
2002-01-31 |
2002-03-20 |
Oxford Biomedica Ltd |
Anemia
|
US20050153879A1
(en)
|
2002-03-26 |
2005-07-14 |
Monica Svetina |
Process for the preparation of a desired erythropoietin glyco-isoform profile
|
WO2003084477A2
(en)
|
2002-03-29 |
2003-10-16 |
Centocor, Inc. |
Mammalian cdr mimetibodies, compositions, methods and uses
|
US7319138B2
(en)
*
|
2002-04-18 |
2008-01-15 |
The General Hospital Corporation |
Human DRG11-Responsive Axonal Guidance and Outgrowth of Neurite (DRAGON) proteins and variants thereof
|
US20040009902A1
(en)
|
2002-05-13 |
2004-01-15 |
Irving Boime |
CTP extended erythropoietin
|
CA2542171C
(en)
|
2002-06-26 |
2015-12-15 |
Abbott Gmbh & Co. Kg |
Modulators and modulation of the interaction between rgm and neogenin
|
WO2004002417A2
(en)
|
2002-06-28 |
2004-01-08 |
Centocor, Inc. |
Mammalian ch1 deleted mimetibodies, compositions, methods and uses
|
AU2003256336A1
(en)
|
2002-06-28 |
2004-01-19 |
Centocor, Inc. |
Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
|
DE10230381A1
(de)
|
2002-07-05 |
2004-01-22 |
Institut für Medizintechnologie Magdeburg GmbH, IMTM |
Verwendung von Inhibitoren der Alanyl-Aminopeptidasen und diese umfassende pharmazeutischen Zubereitungen
|
AU2003246486A1
(en)
|
2002-07-19 |
2004-02-09 |
Cangene Corporation |
Pegylated erythropoietic compounds
|
GB0217786D0
(en)
|
2002-07-31 |
2002-09-11 |
Glaxo Group Ltd |
Compounds
|
JP4406607B2
(ja)
|
2002-08-26 |
2010-02-03 |
オンコセラピー・サイエンス株式会社 |
ペプチド及びこれを含む医薬
|
JP2006516534A
(ja)
|
2002-09-11 |
2006-07-06 |
フレセニウス・カビ・ドイッチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング |
Has化ポリペプチド、特にhas化エリスロポエチン
|
US20040071694A1
(en)
|
2002-10-14 |
2004-04-15 |
Devries Peter J. |
Erythropoietin receptor binding antibodies
|
US7396913B2
(en)
|
2002-10-14 |
2008-07-08 |
Abbott Laboratories |
Erythropoietin receptor binding antibodies
|
TWI320716B
(en)
|
2002-10-14 |
2010-02-21 |
Abbott Lab |
Erythropoietin receptor binding antibodies
|
US20040091961A1
(en)
|
2002-11-08 |
2004-05-13 |
Evans Glen A. |
Enhanced variants of erythropoietin and methods of use
|
JP4660471B2
(ja)
*
|
2003-03-14 |
2011-03-30 |
セルテック アール アンド ディー, インコーポレイテッド |
TGFβ結合タンパク質のリガンドおよびその使用
|
TWI353991B
(en)
|
2003-05-06 |
2011-12-11 |
Syntonix Pharmaceuticals Inc |
Immunoglobulin chimeric monomer-dimer hybrids
|
US20070184052A1
(en)
|
2003-05-09 |
2007-08-09 |
Lin Herbert Y |
Soluble tgf-b type III receptor fusion proteins
|
JP2007530440A
(ja)
|
2003-05-12 |
2007-11-01 |
アフィーマックス・インコーポレイテッド |
新規ポリ(エチレングリコール)修飾化合物およびその用途
|
MXPA05012316A
(es)
|
2003-05-12 |
2006-04-18 |
Affymax Inc |
Peptidos novedosos que se unen al receptor de la eritropoyetina.
|
WO2004101611A2
(en)
|
2003-05-12 |
2004-11-25 |
Affymax, Inc. |
Peptides that bind to the erythropoietin receptor
|
US7074755B2
(en)
|
2003-05-17 |
2006-07-11 |
Centocor, Inc. |
Erythropoietin conjugate compounds with extended half-lives
|
US6995245B2
(en)
|
2003-05-30 |
2006-02-07 |
Centocor, Inc. |
Formation of novel erythropoietin conjugates using transglutaminase
|
US20050037390A1
(en)
|
2003-06-04 |
2005-02-17 |
Irm Llc, A Delaware Limited Liability Company |
Methods and compositions for modulating erythropoietin expression
|
US8614204B2
(en)
|
2003-06-06 |
2013-12-24 |
Fibrogen, Inc. |
Enhanced erythropoiesis and iron metabolism
|
US20050019914A1
(en)
|
2003-07-24 |
2005-01-27 |
Aventis Pharma Deutschland Gmbh |
Perfusion process for producing erythropoietin
|
JP2007512001A
(ja)
|
2003-08-28 |
2007-05-17 |
バイオレクシス ファーマシューティカル コーポレイション |
Epoミメティックペプチドおよび融合タンパク質
|
CN1882355A
(zh)
|
2003-09-09 |
2006-12-20 |
沃伦药品公司 |
保持内源性促红细胞生成素组织保护活性的长效促红细胞生成素
|
CN1890383A
(zh)
|
2003-09-30 |
2007-01-03 |
森托科尔公司 |
人铰链核心模拟体、组合物、方法和用途
|
UA89481C2
(uk)
|
2003-09-30 |
2010-02-10 |
Центокор, Инк. |
Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
US7405198B2
(en)
|
2003-11-24 |
2008-07-29 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
EP1548031A1
(en)
|
2003-12-22 |
2005-06-29 |
Dubai Genetics FZ-LLC |
Nature-identical erythropoietin
|
US20050170457A1
(en)
|
2003-12-31 |
2005-08-04 |
Chadler Pool |
Novel recombinant proteins with N-terminal free thiol
|
WO2005063808A1
(en)
|
2003-12-31 |
2005-07-14 |
Merck Patent Gmbh |
Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS
|
US7423139B2
(en)
|
2004-01-20 |
2008-09-09 |
Insight Biopharmaceuticals Ltd. |
High level expression of recombinant human erythropoietin having a modified 5′-UTR
|
WO2005070451A1
(en)
|
2004-01-22 |
2005-08-04 |
Zafena Aktiebolag |
Pharmaceutical composition comprising non-glycosylated erythropoietin
|
WO2005084711A1
(fr)
|
2004-03-02 |
2005-09-15 |
Chengdu Institute Of Biological Products |
Erythropoietine recombinante pegylee a activite in vivo
|
AR048918A1
(es)
|
2004-03-11 |
2006-06-14 |
Fresenius Kabi De Gmbh |
Conjugados de almidon de hidroxietilo y eritropoyetina
|
US20050227289A1
(en)
|
2004-04-09 |
2005-10-13 |
Reilly Edward B |
Antibodies to erythropoietin receptor and uses thereof
|
WO2005103076A2
(en)
|
2004-04-23 |
2005-11-03 |
Cambridge Antibody Technology Limited |
Erythropoietin protein variants
|
ATE429444T1
(de)
|
2004-07-07 |
2009-05-15 |
Lundbeck & Co As H |
Neues carbamyliertes epo und verfahren zu dessen herstellung
|
US20060063208A1
(en)
*
|
2004-08-02 |
2006-03-23 |
Woolf Clifford J |
DRG11-responsive (DRAGON) gene and uses thereof
|
US20060073563A1
(en)
|
2004-09-02 |
2006-04-06 |
Xencor, Inc. |
Erythropoietin derivatives with altered immunogenicity
|
AU2005303887A1
(en)
|
2004-11-10 |
2006-05-18 |
Aplagen Gmbh |
Molecules which promote hematopoiesis
|
EP1858541B1
(en)
|
2005-02-16 |
2012-07-25 |
The General Hospital Corporation |
Use of bmp antagonists to regulate hepcidin-mediated iron metabolism and treat iron deficiency
|
MX2007011591A
(es)
*
|
2005-03-30 |
2007-12-10 |
Wyeth Corp |
Metodo para estimular el crecimiento de cabello administrando bmps.
|
US8895002B2
(en)
|
2007-04-09 |
2014-11-25 |
The General Hospital Corporation |
Hemojuvelin fusion proteins and uses thereof
|