JP2015117211A5 - - Google Patents
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- Publication number
- JP2015117211A5 JP2015117211A5 JP2013262377A JP2013262377A JP2015117211A5 JP 2015117211 A5 JP2015117211 A5 JP 2015117211A5 JP 2013262377 A JP2013262377 A JP 2013262377A JP 2013262377 A JP2013262377 A JP 2013262377A JP 2015117211 A5 JP2015117211 A5 JP 2015117211A5
- Authority
- JP
- Japan
- Prior art keywords
- ester
- steroid
- alcohol
- ointment containing
- weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002674 ointment Substances 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims description 11
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims description 9
- -1 ester steroid Chemical class 0.000 claims description 9
- 229940055577 oleyl alcohol Drugs 0.000 claims description 9
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims description 9
- 150000005846 sugar alcohols Polymers 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- 229960000520 diphenhydramine Drugs 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 4
- 229930195729 fatty acid Natural products 0.000 claims description 4
- 239000000194 fatty acid Substances 0.000 claims description 4
- 150000004665 fatty acids Chemical class 0.000 claims description 4
- 229910052751 metal Inorganic materials 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 239000007853 buffer solution Substances 0.000 claims description 2
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 claims 5
- 150000002148 esters Chemical class 0.000 claims 5
- 150000003431 steroids Chemical class 0.000 claims 5
- 235000019441 ethanol Nutrition 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 2
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 claims 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical group [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 235000019437 butane-1,3-diol Nutrition 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229960005069 calcium Drugs 0.000 claims 1
- 229940046978 chlorpheniramine maleate Drugs 0.000 claims 1
- 229960004646 diphenhydramine tannate Drugs 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229960002800 prednisolone acetate Drugs 0.000 claims 1
- DGYSDXLCLKPUBR-SLPNHVECSA-N prednisolone valerate acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(C)=O)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O DGYSDXLCLKPUBR-SLPNHVECSA-N 0.000 claims 1
- 229950008480 prednisolone valerate acetate Drugs 0.000 claims 1
- 229940070710 valerate Drugs 0.000 claims 1
- 239000007788 liquid Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013262377A JP6031024B2 (ja) | 2013-12-19 | 2013-12-19 | 吉草酸酢酸プレドニゾロンを配合した固形軟膏剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013262377A JP6031024B2 (ja) | 2013-12-19 | 2013-12-19 | 吉草酸酢酸プレドニゾロンを配合した固形軟膏剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015117211A JP2015117211A (ja) | 2015-06-25 |
| JP2015117211A5 true JP2015117211A5 (enExample) | 2015-08-20 |
| JP6031024B2 JP6031024B2 (ja) | 2016-11-24 |
Family
ID=53530274
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013262377A Expired - Fee Related JP6031024B2 (ja) | 2013-12-19 | 2013-12-19 | 吉草酸酢酸プレドニゾロンを配合した固形軟膏剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6031024B2 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI833741B (zh) * | 2018-03-30 | 2024-03-01 | 日商樂敦製藥股份有限公司 | 外用油性固形組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05286860A (ja) * | 1992-04-03 | 1993-11-02 | Kowa Co | ゲル軟膏剤 |
| US5597849A (en) * | 1994-11-14 | 1997-01-28 | Medical Polymer Technologies, Inc. | Stick formulations for topical drug delivery of therapeutic agents and uses thereof |
| JP3851371B2 (ja) * | 1995-02-25 | 2006-11-29 | 久光製薬株式会社 | 非水系油性軟膏基剤及び皮膚外用軟膏剤 |
| JP2001002573A (ja) * | 1999-06-23 | 2001-01-09 | Sato Pharmaceutical Co Ltd | 酪酸ヒドロコルチゾン製剤 |
| JP5300038B2 (ja) * | 2000-03-07 | 2013-09-25 | 株式会社 資生堂 | 皮膚外用剤 |
| JP2002356430A (ja) * | 2001-05-30 | 2002-12-13 | Ikeda Mohandou:Kk | 吉草酸酢酸プレドニゾロン及び抗ヒスタミン剤を含む皮膚外用剤 |
| JP2005350379A (ja) * | 2004-06-09 | 2005-12-22 | Ikeda Mohandou:Kk | 吉草酸酢酸プレドニゾロンを安定化させる方法及び安定性に優れた吉草酸酢酸プレドニゾロン配合皮膚外用剤 |
| JP4686144B2 (ja) * | 2004-07-20 | 2011-05-18 | 岩城製薬株式会社 | 油脂性軟膏剤 |
| JP4690672B2 (ja) * | 2004-07-20 | 2011-06-01 | 岩城製薬株式会社 | 乳剤性皮膚外用剤 |
-
2013
- 2013-12-19 JP JP2013262377A patent/JP6031024B2/ja not_active Expired - Fee Related
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