WO2011129627A3 - Docetaxel-loaded thermosensitive liquid suppository composition for rectal administration - Google Patents

Docetaxel-loaded thermosensitive liquid suppository composition for rectal administration Download PDF

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Publication number
WO2011129627A3
WO2011129627A3 PCT/KR2011/002662 KR2011002662W WO2011129627A3 WO 2011129627 A3 WO2011129627 A3 WO 2011129627A3 KR 2011002662 W KR2011002662 W KR 2011002662W WO 2011129627 A3 WO2011129627 A3 WO 2011129627A3
Authority
WO
WIPO (PCT)
Prior art keywords
docetaxel
rectal administration
suppository composition
thermosensitive liquid
liquid suppository
Prior art date
Application number
PCT/KR2011/002662
Other languages
French (fr)
Other versions
WO2011129627A2 (en
Inventor
Han-Gon Choi
Chul-Soon Yong
Woo-Hyun Yeo
Original Assignee
Industry-University Cooperation Foundation Hanyang University
Industry Academic Cooperation Foundation Of Yeungnam University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Industry-University Cooperation Foundation Hanyang University, Industry Academic Cooperation Foundation Of Yeungnam University filed Critical Industry-University Cooperation Foundation Hanyang University
Publication of WO2011129627A2 publication Critical patent/WO2011129627A2/en
Publication of WO2011129627A3 publication Critical patent/WO2011129627A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a novel docetaxel-loaded thermosensitive liquid suppository composition for rectal administration, which have properties in that it exists as a liquid at room temperature and forms a gel in vivo so as to adhere to the mucosa. The composition contains 25-35 wt% poloxamer, 2-10 wt% polysorbate 80, 54-72.99 wt% water, and 0.01-1 wt% docetaxel as an active ingredient, and has a gelation temperature of 30-36°C. This composition provides a novel, safe, convenient and effective formulation of docetaxel.
PCT/KR2011/002662 2010-04-14 2011-04-14 Docetaxel-loaded thermosensitive liquid suppository composition for rectal administration WO2011129627A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0034417 2010-04-14
KR1020100034417A KR101003890B1 (en) 2010-04-14 2010-04-14 Composition of docetaxel-loaded thermosensitive liquid suppository for rectal administration

Publications (2)

Publication Number Publication Date
WO2011129627A2 WO2011129627A2 (en) 2011-10-20
WO2011129627A3 true WO2011129627A3 (en) 2012-02-02

Family

ID=43513369

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/002662 WO2011129627A2 (en) 2010-04-14 2011-04-14 Docetaxel-loaded thermosensitive liquid suppository composition for rectal administration

Country Status (2)

Country Link
KR (1) KR101003890B1 (en)
WO (1) WO2011129627A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101646181B1 (en) * 2015-08-18 2016-08-05 한양대학교 에리카산학협력단 Composition of irinotecan-loaded dual-reverse thermosensitive hydrogel
WO2020213983A1 (en) * 2019-04-19 2020-10-22 한양대학교 산학협력단 Thermosensitive composition containing phosphatidic acid and use thereof
US20230310317A1 (en) * 2020-08-27 2023-10-05 The University Of Queensland Sol-gel composition
CN114712316B (en) * 2020-12-18 2023-10-20 江苏恒瑞医药股份有限公司 Indissolvable pharmaceutical composition and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034580A1 (en) * 1996-03-21 1997-09-25 Dong Wha Pharmaceutical Industrial Co., Ltd. Suppository composition of the drug which has gastro-intestinal disturbances or undergoes the decomposition by gastric acid
KR20020071407A (en) * 2001-03-06 2002-09-12 최한곤 Novel composite of liquid suppository for rectal administration
KR20030046553A (en) * 2001-12-04 2003-06-18 김종국 Composition of thermosensitive emulsion for external use of prostaglandin E1
KR20040028336A (en) * 2002-09-30 2004-04-03 김종국 Novel composite of thermosensitive antifungal gel for vaginal administration
US20080220074A1 (en) * 2002-10-04 2008-09-11 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997034580A1 (en) * 1996-03-21 1997-09-25 Dong Wha Pharmaceutical Industrial Co., Ltd. Suppository composition of the drug which has gastro-intestinal disturbances or undergoes the decomposition by gastric acid
KR20020071407A (en) * 2001-03-06 2002-09-12 최한곤 Novel composite of liquid suppository for rectal administration
KR20030046553A (en) * 2001-12-04 2003-06-18 김종국 Composition of thermosensitive emulsion for external use of prostaglandin E1
KR20040028336A (en) * 2002-09-30 2004-04-03 김종국 Novel composite of thermosensitive antifungal gel for vaginal administration
US20080220074A1 (en) * 2002-10-04 2008-09-11 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Y. YANG ET AL.: "A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel", JOURNAL OF CONTROLLED RELEASE, vol. 135, 2009, pages 175 - 182 *

Also Published As

Publication number Publication date
KR101003890B1 (en) 2010-12-30
WO2011129627A2 (en) 2011-10-20

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