JP2015117181A - 敗血症治療剤 - Google Patents

敗血症治療剤 Download PDF

Info

Publication number
JP2015117181A
JP2015117181A JP2012035965A JP2012035965A JP2015117181A JP 2015117181 A JP2015117181 A JP 2015117181A JP 2012035965 A JP2012035965 A JP 2012035965A JP 2012035965 A JP2012035965 A JP 2012035965A JP 2015117181 A JP2015117181 A JP 2015117181A
Authority
JP
Japan
Prior art keywords
sepsis
therapeutic agent
seq
monoclonal antibody
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012035965A
Other languages
English (en)
Japanese (ja)
Inventor
藤 秀 次 佐
Hidetsugu Sato
藤 秀 次 佐
藤 武 後
Takeshi Goto
藤 武 後
森 直 哉 大
Naoya Omori
森 直 哉 大
貴 真 江
Takamasa Ko
貴 真 江
田 弥 生 島
Yayoi Shimada
田 弥 生 島
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Josai University
Original Assignee
Josai University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Josai University filed Critical Josai University
Priority to JP2012035965A priority Critical patent/JP2015117181A/ja
Priority to TW102106211A priority patent/TWI605059B/zh
Priority to KR1020147024978A priority patent/KR102159412B1/ko
Priority to US14/380,292 priority patent/US20150079090A1/en
Priority to EP13751092.1A priority patent/EP2815763B1/en
Priority to CN201380020995.1A priority patent/CN104379165B/zh
Priority to IN7875DEN2014 priority patent/IN2014DN07875A/en
Priority to PCT/JP2013/054551 priority patent/WO2013125687A1/ja
Publication of JP2015117181A publication Critical patent/JP2015117181A/ja
Priority to US15/292,450 priority patent/US20170096478A1/en
Pending legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622Single chain antibody (scFv)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2012035965A 2012-02-22 2012-02-22 敗血症治療剤 Pending JP2015117181A (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2012035965A JP2015117181A (ja) 2012-02-22 2012-02-22 敗血症治療剤
TW102106211A TWI605059B (zh) 2012-02-22 2013-02-22 Inflammatory disease treatment agent
KR1020147024978A KR102159412B1 (ko) 2012-02-22 2013-02-22 염증 질환 치료제
US14/380,292 US20150079090A1 (en) 2012-02-22 2013-02-22 Therapeutic agent for inflammatory disease
EP13751092.1A EP2815763B1 (en) 2012-02-22 2013-02-22 Therapeutic agent for inflammatory disease
CN201380020995.1A CN104379165B (zh) 2012-02-22 2013-02-22 炎症疾病治疗剂
IN7875DEN2014 IN2014DN07875A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2012-02-22 2013-02-22
PCT/JP2013/054551 WO2013125687A1 (ja) 2012-02-22 2013-02-22 炎症疾患治療剤
US15/292,450 US20170096478A1 (en) 2012-02-22 2016-10-13 Therapeutic agent for inflammatory disease

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012035965A JP2015117181A (ja) 2012-02-22 2012-02-22 敗血症治療剤

Publications (1)

Publication Number Publication Date
JP2015117181A true JP2015117181A (ja) 2015-06-25

Family

ID=49005863

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012035965A Pending JP2015117181A (ja) 2012-02-22 2012-02-22 敗血症治療剤

Country Status (8)

Country Link
US (2) US20150079090A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP2815763B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2015117181A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR102159412B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN104379165B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2014DN07875A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TW (1) TWI605059B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2013125687A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103534271B (zh) 2010-08-20 2016-06-22 学校法人城西大学 有免疫抑制活性的单克隆抗体或其抗原结合片段
US10980894B2 (en) 2016-03-29 2021-04-20 Obi Pharma, Inc. Antibodies, pharmaceutical compositions and methods
CN109311995A (zh) * 2016-03-29 2019-02-05 台湾浩鼎生技股份有限公司 抗体、药物组合物和方法
AU2017331889A1 (en) * 2016-09-23 2019-04-18 Tfk Co., Ltd. Compound or salt thereof, anti-inflammatory agent, anti-cancer agent against lung cancer, method of producing compound or salts thereof, method of treating inflammatory diseases and method of treating lung cancer
CN119912525B (zh) * 2025-04-02 2025-07-29 天津不二蛋白有限公司 含抗炎症肽序列的大豆蛋白水解物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006025580A1 (ja) 2004-09-03 2006-03-09 Amateraspharma Inc. 抗ヒストンh1モノクローナル抗体およびこれを産生するハイブリドーマ
JPWO2009044555A1 (ja) * 2007-10-04 2011-02-03 学校法人 城西大学 製剤、当該製剤を用いたワクチンの投与方法及びイオントフォレーシス装置
JP2011503012A (ja) * 2007-11-06 2011-01-27 オクラホマ・メディカル・リサーチ・ファウンデーション 予後に関するバイオマーカーおよび治療の分子標的としての細胞外ヒストン
CN103534271B (zh) * 2010-08-20 2016-06-22 学校法人城西大学 有免疫抑制活性的单克隆抗体或其抗原结合片段

Also Published As

Publication number Publication date
IN2014DN07875A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-04-24
CN104379165B (zh) 2018-08-03
EP2815763A4 (en) 2015-07-22
EP2815763A1 (en) 2014-12-24
US20170096478A1 (en) 2017-04-06
CN104379165A (zh) 2015-02-25
KR20140138699A (ko) 2014-12-04
TW201350502A (zh) 2013-12-16
EP2815763B1 (en) 2018-06-13
KR102159412B1 (ko) 2020-09-23
US20150079090A1 (en) 2015-03-19
TWI605059B (zh) 2017-11-11
WO2013125687A1 (ja) 2013-08-29

Similar Documents

Publication Publication Date Title
RU2705255C2 (ru) Антитела против эотаксина 2, которые распознают дополнительные связывающие CCR3 хемокины
KR20170075778A (ko) 항-tim-3 항체
US20210179717A1 (en) Antibodies against mac-1
US20170096478A1 (en) Therapeutic agent for inflammatory disease
JP5960596B2 (ja) 免疫抑制活性を有するモノクローナル抗体またはその抗原結合断片
CN110790839A (zh) 抗pd-1抗体、其抗原结合片段及医药用途
CN109384845B (zh) 一种cd40单克隆抗体、其制备方法及其应用
JP4855261B2 (ja) 抗ヒストンh1モノクローナル抗体およびこれを産生するハイブリドーマ
JPWO2013125687A1 (ja) 炎症疾患治療剤
JP2013013327A (ja) Mansc1蛋白質に結合し、抗癌活性を有する抗体
CN120418290A (zh) 抗人cx3cr1抗体
CN118591554A (zh) 抗人cxcl1抗体
JP2015105250A (ja) 肥満細胞の脱顆粒抑制剤
HK1262753B (zh) 调节性t细胞的激活剂及其应用