JP2015013837A - PPARγ活性向上剤及びそれを用いた経口組成物 - Google Patents
PPARγ活性向上剤及びそれを用いた経口組成物 Download PDFInfo
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Abstract
Description
すなわち、本発明は以下のとおりである。
(抽出物1)
23℃常圧下、バジル(南アフリカ産)の乾燥物5gを水95mlに浸し、回転数を800〜1200rpmに設定した撹拌機を使用して1時間撹拌した。続いて、得られた抽出液をろ紙No.2(アドバンテック東洋社製)を使用してろ過し、抽出物を得た。
抽出物を得るための植物として、ガーリック(南アフリカ産)を用いた以外はすべて抽出物1と同じ方法にて、抽出物を得た。
抽出物を得るための植物として、ルイボス(南アフリカ産)を用いた以外はすべて抽出物1と同じ方法にて、抽出物を得た。
抽出物1及び3を各15μl量り取り、混合抽出物30μlを調製し、PPARγ活性向上剤とした。
抽出物1〜3を表1に示す配合割合にて混合し、その抽出物をPPARγ活性向上剤とした。
10%ウシ胎仔血清を含むダルベッコ改変イーグル培地(DMEM)を用い、脂肪前駆体細胞3T3−L1を37℃、5%炭酸ガス雰囲気下にて、6ウエルプレートに2×104cell/mlにて分注し24時間培養した。続いて、リコンビナント低濃度インスリン分化誘導物質2μmol/lを添加し144時間培養した後、PPARγ活性向上剤として用いる前記抽出物を添加した。添加後に採取した細胞を、Fast pure RNA Kit(タカラバイオ株式会社製)を使用してtotal RNAを抽出し、PrimeScript RT reagent Kit(タカラバイオ株式会社製)を使用してcDNAを合成後、アディポネクチン及びPPARγ遺伝子発現量について、リアルタイムPCR装置(タカラバイオ株式会社製)を使用して測定した。得られた測定結果を表2及び表3に示す。なお、得られた数値はPPARγ活性向上剤を無添加とした場合におけるアディポネクチン及びPPARγ遺伝子発現量を1とし、それに対する相対値を示す。
このことから、本発明のPPARγ活性向上剤を含む食品、飲料、医薬品、愛玩動物用飼料などの経口組成物は、それらを摂取することにより、PPARγ活性を向上させ、アディポネクチンの分泌を促進し、インスリン抵抗性を効果的に改善することができる。そして、糖尿病、動脈硬化症、高血圧、高脂血症、肥満、メタボリックシンドローム、さらには2型糖尿病、内臓脂肪型肥満、脂肪肝を予防又は改善することができる。
Claims (4)
- マメ科植物の抽出物及びシソ科植物の抽出物を含有することを特徴とするPPARγ活性向上剤。
- 前記マメ科植物がルイボスであることを特徴とする請求項1記載のPPARγ活性向上剤。
- 前記シソ科植物がバジルであることを特徴とする請求項1記載のPPARγ活性向上剤。
- 請求項1〜3いずれかに記載のPPARγ活性向上剤を含有することを特徴とする経口組成物。
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017109971A (ja) * | 2015-12-18 | 2017-06-22 | 花王株式会社 | PPARδ活性化剤 |
KR20200029684A (ko) * | 2018-09-10 | 2020-03-19 | 경남과학기술대학교 산학협력단 | 바질 에센셜 오일을 유효성분으로 함유하는 고지혈증 또는 동맥경화증 예방 또는 치료용 약학적 조성물 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003037316A (ja) * | 2001-07-24 | 2003-02-07 | Fanuc Ltd | 固体レーザ励起用光源装置 |
JP2004250445A (ja) * | 2003-01-31 | 2004-09-09 | Yakult Honsha Co Ltd | グリケーション阻害剤及びその利用 |
JP2006273788A (ja) * | 2005-03-30 | 2006-10-12 | Kaneka Corp | Pparリガンド活性を有する植物由来の組成物 |
JP2007106718A (ja) * | 2005-10-14 | 2007-04-26 | Sunstar Inc | アディポネクチン分泌促進剤、並びにアディポネクチン分泌促進剤を含有する経口組成物。 |
JP2008088087A (ja) * | 2006-09-29 | 2008-04-17 | Kaneka Corp | 血糖値上昇抑制剤 |
JP2010100545A (ja) * | 2008-10-22 | 2010-05-06 | Theravalues Corp | 核内受容体および/または転写因子の活性化促進剤 |
-
2013
- 2013-07-05 JP JP2013142187A patent/JP6245867B2/ja active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003037316A (ja) * | 2001-07-24 | 2003-02-07 | Fanuc Ltd | 固体レーザ励起用光源装置 |
JP2004250445A (ja) * | 2003-01-31 | 2004-09-09 | Yakult Honsha Co Ltd | グリケーション阻害剤及びその利用 |
JP2006273788A (ja) * | 2005-03-30 | 2006-10-12 | Kaneka Corp | Pparリガンド活性を有する植物由来の組成物 |
JP2007106718A (ja) * | 2005-10-14 | 2007-04-26 | Sunstar Inc | アディポネクチン分泌促進剤、並びにアディポネクチン分泌促進剤を含有する経口組成物。 |
JP2008088087A (ja) * | 2006-09-29 | 2008-04-17 | Kaneka Corp | 血糖値上昇抑制剤 |
JP2010100545A (ja) * | 2008-10-22 | 2010-05-06 | Theravalues Corp | 核内受容体および/または転写因子の活性化促進剤 |
Non-Patent Citations (2)
Title |
---|
FOOD CHEM., vol. 117, JPN6017022248, 2009, pages 660 - 667, ISSN: 0003636222 * |
MINTEL GNPD ID#1948463, JPN6017033845, 2012, ISSN: 0003636221 * |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2017109971A (ja) * | 2015-12-18 | 2017-06-22 | 花王株式会社 | PPARδ活性化剤 |
KR20200029684A (ko) * | 2018-09-10 | 2020-03-19 | 경남과학기술대학교 산학협력단 | 바질 에센셜 오일을 유효성분으로 함유하는 고지혈증 또는 동맥경화증 예방 또는 치료용 약학적 조성물 |
KR102266837B1 (ko) | 2018-09-10 | 2021-06-22 | 경상국립대학교산학협력단 | 바질 에센셜 오일을 유효성분으로 함유하는 고지혈증 또는 동맥경화증 예방 또는 치료용 약학적 조성물 |
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