JP2014534896A - 多段階式放射化学用の反応器 - Google Patents

多段階式放射化学用の反応器 Download PDF

Info

Publication number
JP2014534896A
JP2014534896A JP2014533343A JP2014533343A JP2014534896A JP 2014534896 A JP2014534896 A JP 2014534896A JP 2014533343 A JP2014533343 A JP 2014533343A JP 2014533343 A JP2014533343 A JP 2014533343A JP 2014534896 A JP2014534896 A JP 2014534896A
Authority
JP
Japan
Prior art keywords
reaction vessel
reaction
valve
vessel
port
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014533343A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014534896A5 (OSRAM
Inventor
ジャクソン，アレキサンダー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2014534896A publication Critical patent/JP2014534896A/ja
Publication of JP2014534896A5 publication Critical patent/JP2014534896A5/ja
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00792—One or more tube-shaped elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00788—Three-dimensional assemblies, i.e. the reactor comprising a form other than a stack of plates
    • B01J2219/00799—Cup-shaped
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00844—Comprising porous material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00867—Microreactors placed in series, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00873—Heat exchange
    • B01J2219/00876—Insulation elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2014533343A 2011-09-30 2012-09-28 多段階式放射化学用の反応器 Pending JP2014534896A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161541159P 2011-09-30 2011-09-30
US61/541,159 2011-09-30
PCT/US2012/057683 WO2013049431A2 (en) 2011-09-30 2012-09-28 Reactor for multi-step radiochemistry

Publications (2)

Publication Number Publication Date
JP2014534896A true JP2014534896A (ja) 2014-12-25
JP2014534896A5 JP2014534896A5 (OSRAM) 2015-11-12

Family

ID=47116342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014533343A Pending JP2014534896A (ja) 2011-09-30 2012-09-28 多段階式放射化学用の反応器

Country Status (6)

Country Link
US (1) US20140256970A1 (OSRAM)
EP (1) EP2760577A2 (OSRAM)
JP (1) JP2014534896A (OSRAM)
CN (1) CN103974762A (OSRAM)
AU (1) AU2012315883A1 (OSRAM)
WO (1) WO2013049431A2 (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015507602A (ja) * 2011-09-30 2015-03-12 ジーイー・ヘルスケア・リミテッド 区画反応器
JP2018515543A (ja) * 2015-05-20 2018-06-14 アウト アンド アウト ケミストリー エスピーアールエル 放射性医薬品を調製する複数の合成プロセスを連続して行う方法、この方法を行うためのデバイスおよびカセット

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101326000B1 (ko) * 2012-01-30 2013-11-07 재단법인 아산사회복지재단 수소이온 농도가 조절된 플루오린-18의 용리액 제조 및 이를 이용한 플루오린-18의 표지방법
US10087141B2 (en) 2013-08-22 2018-10-02 Ge Healthcare Limited Synthesis of [18F]-fluoroalkyl tosylate
EP3967674A1 (en) 2020-09-11 2022-03-16 Precirix N.V. Reactions of radioactive compounds facilitated by a solid phase
WO2023196893A1 (en) 2022-04-06 2023-10-12 The Trustees Of The University Of Pennsylvania Compositions and methods for treating her2 positive metastatic breast cancer and other cancers
WO2024130070A2 (en) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof
WO2024130067A2 (en) 2022-12-17 2024-06-20 The Trustees Of The University Of Pennsylvania Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57110962A (en) * 1980-09-23 1982-07-10 California Inst Of Techn Improved apparatus and method for sequentially executing chemical processes
JPH09507382A (ja) * 1993-07-09 1997-07-29 ケンブリッジ モレキュラー テクノロジーズ リミテッド 浄化方法及び装置
JP2008520636A (ja) * 2004-11-19 2008-06-19 ジーイー・ヘルスケア・リミテッド フッ素化法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610847A (en) * 1980-09-23 1986-09-09 California Institute Of Technology Conversion flask for sequential performance apparatus
US4603114A (en) * 1980-09-23 1986-07-29 California Institute Of Technology Method for the sequential performance of chemical processes
US5080868A (en) * 1990-05-16 1992-01-14 Elgas David H Sparger assembly
US8333952B2 (en) * 2009-09-23 2012-12-18 Abt Molecular Imaging, Inc. Dose synthesis module for biomarker generator system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57110962A (en) * 1980-09-23 1982-07-10 California Inst Of Techn Improved apparatus and method for sequentially executing chemical processes
JPH09507382A (ja) * 1993-07-09 1997-07-29 ケンブリッジ モレキュラー テクノロジーズ リミテッド 浄化方法及び装置
JP2008520636A (ja) * 2004-11-19 2008-06-19 ジーイー・ヘルスケア・リミテッド フッ素化法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015507602A (ja) * 2011-09-30 2015-03-12 ジーイー・ヘルスケア・リミテッド 区画反応器
JP2018515543A (ja) * 2015-05-20 2018-06-14 アウト アンド アウト ケミストリー エスピーアールエル 放射性医薬品を調製する複数の合成プロセスを連続して行う方法、この方法を行うためのデバイスおよびカセット

Also Published As

Publication number Publication date
AU2012315883A1 (en) 2014-04-17
WO2013049431A3 (en) 2013-06-27
WO2013049431A2 (en) 2013-04-04
EP2760577A2 (en) 2014-08-06
US20140256970A1 (en) 2014-09-11
CN103974762A (zh) 2014-08-06

Similar Documents

Publication Publication Date Title
US20140256970A1 (en) Reactor for multi-step radiochemistry
US9346771B2 (en) Purification method
Arima et al. Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals
Coenen et al. 18F-labelling innovations and their potential for clinical application
US10081005B2 (en) Automated, multi-pot high-pressure radio-synthesizer for production of pet tracers
Lemaire et al. Automated production at the curie level of no‐carrier‐added 6‐[18F] fluoro‐l‐dopa and 2‐[18F] fluoro‐l‐tyrosine on a FASTlab synthesizer
EP3271064B1 (en) Add-on radiosynthesiser device
Zhang et al. A simple microfluidic platform for rapid and efficient production of the radiotracer [18 F] fallypride
JP2017503752A (ja) １８ｆ標識組成物を合成するための二重使用カセット
MX2012003572A (es) Modulo de produccion quimica y tarjeta de sintesis de dosis para sistema de produccion de biomarcador de pet.
WO2011044422A2 (en) Solid phase extraction purification method
AU2012267998A1 (en) Distillation device and method
JP6843059B2 (ja) ディスコネクタデバイスを備える放射合成デバイス
JP6726665B2 (ja) Ｐｅｔトレーサー精製システム
US20140303381A1 (en) Partitioned reaction vessels
EP2562150A1 (en) A process and device for producing pet radiotracers
JP2018145137A (ja) 多剤合成装置
WO2016126875A1 (en) METHOD FOR FULLY AUTOMATED SYNTHESIS OF 16β-18F-FLUORO-5α-DIHYDROTESTOSTERONE (18F-FDHT)
AU2015258247B2 (en) Purification method
KR101903695B1 (ko) 고온 불활성 기체를 이용한 불소-18 화합물 합성장치
Phelps Institute for Molecular Medicine Research Program

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150918

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20150918

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20160422

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20160607

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20170110