JP2014534266A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014534266A5 JP2014534266A5 JP2014543634A JP2014543634A JP2014534266A5 JP 2014534266 A5 JP2014534266 A5 JP 2014534266A5 JP 2014543634 A JP2014543634 A JP 2014543634A JP 2014543634 A JP2014543634 A JP 2014543634A JP 2014534266 A5 JP2014534266 A5 JP 2014534266A5
- Authority
- JP
- Japan
- Prior art keywords
- tsgl
- polypeptide
- molecule
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 4
- 102000002090 Fibronectin type III Human genes 0.000 claims 2
- 108050009401 Fibronectin type III Proteins 0.000 claims 2
- 108060003951 Immunoglobulin Proteins 0.000 claims 2
- 102100026061 Mannan-binding lectin serine protease 1 Human genes 0.000 claims 2
- 101710161855 Methionine aminopeptidase 1 Proteins 0.000 claims 2
- 101710103983 Modulator of apoptosis 1 Proteins 0.000 claims 2
- 102000008212 P-Selectin Human genes 0.000 claims 2
- 108010035766 P-Selectin Proteins 0.000 claims 2
- 102000003800 Selectins Human genes 0.000 claims 2
- 108090000184 Selectins Proteins 0.000 claims 2
- NIGUVXFURDGQKZ-UQTBNESHSA-N alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](O[C@]3(O[C@H]([C@H](NC(C)=O)[C@@H](O)C3)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O NIGUVXFURDGQKZ-UQTBNESHSA-N 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 102000018358 immunoglobulin Human genes 0.000 claims 2
- 125000001493 tyrosinyl group Chemical class [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564275P | 2011-11-28 | 2011-11-28 | |
| US61/564,275 | 2011-11-28 | ||
| PCT/US2012/066910 WO2013082200A1 (en) | 2011-11-28 | 2012-11-28 | Novel enhanced selectin antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014534266A JP2014534266A (ja) | 2014-12-18 |
| JP2014534266A5 true JP2014534266A5 (enExample) | 2015-12-24 |
| JP6181066B2 JP6181066B2 (ja) | 2017-08-16 |
Family
ID=48467086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014543634A Active JP6181066B2 (ja) | 2011-11-28 | 2012-11-28 | 新規な増強型セレクチンアンタゴニスト |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8889628B2 (enExample) |
| EP (1) | EP2785843B1 (enExample) |
| JP (1) | JP6181066B2 (enExample) |
| CA (1) | CA2857019C (enExample) |
| WO (1) | WO2013082200A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2914470C (en) | 2013-06-03 | 2022-09-27 | Emory University | Selectin inhibitors, composition, and uses related thereto |
| KR20250159733A (ko) | 2017-01-11 | 2025-11-11 | 브리스톨-마이어스 스큅 컴퍼니 | Psgl-1 길항제 및 그의 용도 |
| PE20250933A1 (es) | 2017-03-14 | 2025-04-02 | Five Prime Therapeutics Inc | Anticuerpos de union a vista a ph acido |
| US12479904B2 (en) | 2017-12-29 | 2025-11-25 | Gray D Shaw | Methods of treating cytokine release syndrome by administering a molecule comprising a soluble tandem selectin glycoprotein ligand |
| SG11202008593PA (en) | 2018-03-21 | 2020-10-29 | Five Prime Therapeutics Inc | ANTIBODIES BINDING TO VISTA AT ACIDIC pH |
| AU2019301120A1 (en) | 2018-07-11 | 2021-02-25 | Bristol-Myers Squibb Company | Antibodies binding to VISTA at acidic pH |
| US20230303657A1 (en) * | 2020-03-10 | 2023-09-28 | Gray D Shaw | Fusion Molecules of PSGL-1 or TSGL Anionic Domains to Checkpoint-Modulating Antibodies and Other Antibodies |
| WO2023049265A1 (en) * | 2021-09-23 | 2023-03-30 | Beth Israel Deaconess Medical Center, Inc. | P-selectin inhibitors and uses thereof |
| WO2026080432A1 (en) * | 2024-10-07 | 2026-04-16 | Beth Israel Deaconess Medical Center, Inc. | Dimeric p-selectin inhibitors and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6277975B1 (en) * | 1992-10-23 | 2001-08-21 | Genetics Institute, Inc. | Fusions of P-selectin ligand protein and polynucleotides encoding same |
| WO2000065068A1 (en) * | 1999-04-23 | 2000-11-02 | Ceptyr, Inc. | Dsp-10 dual-specificity map kinsase phosphatase |
| NZ521687A (en) * | 2000-03-31 | 2004-11-26 | Inst Genetics Llc | Modulating, e.g., preventing, inhibiting or treating thrombosis, comprising administering a P-selectin antagonist to subject with cardiovascular disorder such as atherosclerosis or hypertension |
| US20040086519A1 (en) * | 2000-09-12 | 2004-05-06 | Genetics Institute, Llc | Inhibition of stenosis or restenosis by P-selectin ligand antagonists |
| CA2457400A1 (en) * | 2001-08-03 | 2003-02-20 | Genetics Institute, Llc | Modulation of leukocyte-endothelial interactions following ischemia |
| CA2622772A1 (en) * | 2005-09-29 | 2007-04-12 | Viral Logic Systems Technology Corp. | Immunomodulatory compositions and uses therefor |
| DK3178835T3 (da) * | 2009-02-03 | 2019-06-24 | Amunix Pharmaceuticals Inc | Forlængede rekombinante polypeptider og sammensætninger omfattende samme |
-
2012
- 2012-11-28 JP JP2014543634A patent/JP6181066B2/ja active Active
- 2012-11-28 CA CA2857019A patent/CA2857019C/en active Active
- 2012-11-28 EP EP12854260.2A patent/EP2785843B1/en active Active
- 2012-11-28 WO PCT/US2012/066910 patent/WO2013082200A1/en not_active Ceased
- 2012-11-28 US US13/688,187 patent/US8889628B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016000731A5 (enExample) | ||
| JP2012522529A5 (enExample) | ||
| PE20221909A1 (es) | Moleculas de union a antigeno que comprenden un trimero de ligando de la familia de tnf | |
| JP2012082206A5 (enExample) | ||
| JP2015524403A5 (enExample) | ||
| RU2015152077A (ru) | Тримерные антигенсвязывающие молекулы | |
| JP2012025737A5 (enExample) | ||
| JP2012025766A5 (enExample) | ||
| JP2015525217A5 (enExample) | ||
| JP2010088434A5 (enExample) | ||
| FI3835310T3 (fi) | Fibronektiinipohjaisia telinedomeeniproteiineja, jotka sitoutuvat myostatiiniin | |
| EA201400568A1 (ru) | Альбуминсвязывающие антитела и их связывающие фрагменты | |
| JP2015212284A5 (enExample) | ||
| SI3191511T1 (en) | Improved TNF binders | |
| JP2016502512A5 (enExample) | ||
| RU2011138844A (ru) | Композиции бендамустина и циклополисахарида | |
| JP2015134758A5 (enExample) | ||
| AR071874A1 (es) | Proteinas de dominio de armazon basadas en fibronectina multivalentes | |
| HRP20250195T1 (hr) | Anti-fcrn antitijela | |
| JP2019527200A5 (enExample) | ||
| JP2014525735A5 (enExample) | ||
| JP2017512063A5 (enExample) | ||
| JP2013509879A5 (enExample) | ||
| JP2017509335A5 (enExample) | ||
| AR066311A1 (es) | Moleculas de anticuerpos anti proteina hsp90 fungica y acidos nucleicos que los codifican |