JP2014533954A - Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法 - Google Patents
Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法 Download PDFInfo
- Publication number
- JP2014533954A JP2014533954A JP2014542584A JP2014542584A JP2014533954A JP 2014533954 A JP2014533954 A JP 2014533954A JP 2014542584 A JP2014542584 A JP 2014542584A JP 2014542584 A JP2014542584 A JP 2014542584A JP 2014533954 A JP2014533954 A JP 2014533954A
- Authority
- JP
- Japan
- Prior art keywords
- egfr
- antibody
- cancer
- patient
- linker
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161562157P | 2011-11-21 | 2011-11-21 | |
| US61/562,157 | 2011-11-21 | ||
| US201261639452P | 2012-04-27 | 2012-04-27 | |
| US61/639,452 | 2012-04-27 | ||
| PCT/US2012/066205 WO2013078271A1 (en) | 2011-11-21 | 2012-11-21 | Method of treatment of tumors that are resistant to egfr therapies by egfr antibody cytotoxic agent conjugate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014533954A true JP2014533954A (ja) | 2014-12-18 |
| JP2014533954A5 JP2014533954A5 (cg-RX-API-DMAC7.html) | 2016-01-21 |
Family
ID=48470279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014542584A Pending JP2014533954A (ja) | 2011-11-21 | 2012-11-21 | Ｅｇｆｒ抗体細胞傷害性薬物複合体による、ｅｇｆｒ療法に耐性である腫瘍の治療方法 |
Country Status (16)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103298489A (zh) | 2010-10-29 | 2013-09-11 | 伊缪诺金公司 | 新型egfr结合分子及其免疫偶联物 |
| JP5828902B2 (ja) | 2010-10-29 | 2015-12-09 | イミュノジェン， インコーポレイテッド | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 |
| PT2668209T (pt) | 2011-01-24 | 2021-04-07 | Gilead Sciences Inc | Anticorpos seletivos para células que apresentam egfr em alta densidade |
| EP2794010A4 (en) | 2011-11-21 | 2015-10-21 | Immunogen Inc | METHOD OF TREATING TUMORS RESISTANT TO EGFR THERAPIES BY A CYTOTOXIC EGFR-AGENT ANTIBODY CONJUGATE |
| AU2014286872B2 (en) * | 2013-07-05 | 2020-01-23 | Formation Biologics Inc. | EGFR antibody conjugates |
| WO2015035410A1 (en) * | 2013-09-09 | 2015-03-12 | Triact Therapeutic, Inc. | Cancer therapy |
| WO2015073721A1 (en) | 2013-11-13 | 2015-05-21 | Zymeworks Inc. | Monovalent antigen binding constructs targeting egfr and/or her2 and uses thereof |
| CN113425727A (zh) | 2014-02-04 | 2021-09-24 | 安斯泰来制药株式会社 | 以二氨基杂环甲酰胺化合物为有效成分的医药组合物 |
| CN110841074B (zh) * | 2014-03-21 | 2023-07-18 | 艾伯维公司 | 抗-egfr抗体及抗体药物偶联物 |
| CN109147874A (zh) | 2014-09-02 | 2019-01-04 | 伊缪诺金公司 | 用于配制抗体药物缀合物组合物的方法 |
| MA40968A (fr) * | 2014-10-31 | 2017-10-04 | Formation Biologics Inc | Polythérapie à base d'anticorps anti-egfr |
| KR101692044B1 (ko) * | 2014-12-05 | 2017-01-04 | 사회복지법인 삼성생명공익재단 | 교모세포종에서 표피 성장인자 수용체 억제제의 치료 효과를 예측하는 방법 |
| US20180117053A1 (en) * | 2015-05-27 | 2018-05-03 | Metastat, Inc. | The Method of Use for Inhibitors of Epidermal Growth Factor Receptor Variants II, III and VI |
| US10426842B2 (en) | 2015-07-15 | 2019-10-01 | The Curators Of The University Of Missouri | Targeted nanoparticle conjugate and method for co-delivery of siRNA and drug |
| RU2019134769A (ru) * | 2017-03-31 | 2021-04-30 | Дзе Кьюрейторз Оф Дзе Юниверсити Оф Миссури | Композиции для лечения резистентных к лекарственным средствам опухолей и способы их применения |
| CN107496933B (zh) * | 2017-08-21 | 2019-12-24 | 山东新华制药股份有限公司 | 一种用于治疗胰腺癌的抗体药物偶联物及其制备方法 |
| KR20230106506A (ko) * | 2022-01-03 | 2023-07-13 | 한국생명공학연구원 | Cda 억제제를 포함하는 alk 저해제 내성 비소세포폐암 치료용 조성물 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010516770A (ja) * | 2007-01-25 | 2010-05-20 | ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド | Ｅｇｆｒ変異体仲介性疾患の治療における抗ｅｇｆｒ抗体の使用 |
| WO2010126551A1 (en) * | 2009-04-30 | 2010-11-04 | Immunogen, Inc. | Potent conjugates and hydrophilic linkers |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CU22545A1 (es) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico |
| US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
| US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
| JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
| JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
| JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
| JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
| EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
| WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
| US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
| US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
| US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
| US4563304A (en) | 1981-02-27 | 1986-01-07 | Pharmacia Fine Chemicals Ab | Pyridine compounds modifying proteins, polypeptides or polysaccharides |
| JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| US5470571A (en) | 1988-01-27 | 1995-11-28 | The Wistar Institute | Method of treating human EGF receptor-expressing gliomas using radiolabeled EGF receptor-specific MAB 425 |
| AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
| US5981725A (en) | 1989-09-08 | 1999-11-09 | The Johns Hopkins Univiersity | Structural alterations of the EGF receptor gene in human tumors |
| WO1991003489A1 (en) | 1989-09-08 | 1991-03-21 | The Johns Hopkins University | Structural alterations of the egf receptor gene in human gliomas |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5459061A (en) | 1990-01-26 | 1995-10-17 | W. Alton Jones Cell Science Center, Inc. | Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| ES2204890T3 (es) | 1991-03-06 | 2004-05-01 | Merck Patent Gmbh | Anticuerpos monoclonales humanizados. |
| HU218140B (hu) | 1991-04-25 | 2000-06-28 | Chugai Seiyaku Kabushiki Kaisha | Humán interleukin-6-receptorral szembeni átalakított humán antitest |
| DK0563475T3 (da) | 1992-03-25 | 2000-09-18 | Immunogen Inc | Konjugater af cellebindende midler og derivater af CC-1065 |
| US5756291A (en) | 1992-08-21 | 1998-05-26 | Gilead Sciences, Inc. | Aptamers specific for biomolecules and methods of making |
| ATE207366T1 (de) | 1993-12-24 | 2001-11-15 | Merck Patent Gmbh | Immunokonjugate |
| AU2071695A (en) | 1994-03-17 | 1995-10-03 | Merck Patent Gmbh | Anti-EGFR single-chain FVS and anti-EGFR antibodies |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5942602A (en) | 1997-02-13 | 1999-08-24 | Schering Aktiengessellschaft | Growth factor receptor antibodies |
| US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
| WO1999022008A1 (en) | 1997-10-27 | 1999-05-06 | Sumitomo Electric Industries, Ltd. | Inducer for production of antigen-specific antibody, expression vector containing gene therefor, and method of inducing production of antigen-specific antibody |
| US20040031072A1 (en) | 1999-05-06 | 2004-02-12 | La Rosa Thomas J. | Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| HK1049787B (en) | 1999-10-01 | 2014-07-25 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| AU765588C (en) | 1999-11-24 | 2004-12-16 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
| PL357448A1 (en) * | 2000-02-25 | 2004-07-26 | The Government Of The United States, As Represented By The Secretary Of The Department Of Health And Human Services | Anti-egfrviii scfvs with improved cytotoxicity and yield, immunotoxins based thereon, and methods of use thereof |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
| BR0207283A (pt) | 2001-02-19 | 2004-08-17 | Merck Patent Gmbh | Anticorpos anti-egfr modificados com imunogenicidade reduzida |
| ATE446317T1 (de) | 2001-05-11 | 2009-11-15 | Ludwig Inst For Cancer Res Ltd | Spezifische bindungsproteine und ihre verwendung |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| KR100945108B1 (ko) | 2001-06-13 | 2010-03-02 | 젠맵 에이/에스 | 표피 성장 인자 수용체 (ｅｇｆｒ)에 대한 인간모노클로날 항체 |
| US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
| GB0122914D0 (en) | 2001-09-22 | 2001-11-14 | Univ Nottingham | Modulation of stat activity |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US7657380B2 (en) | 2003-12-04 | 2010-02-02 | Xencor, Inc. | Methods of generating variant antibodies with increased host string content |
| DK1620544T3 (en) | 2003-04-17 | 2019-01-14 | Alnylam Pharmaceuticals Inc | MODIFIED iRNA AGENTS |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| CN1930187B (zh) * | 2003-06-27 | 2015-08-19 | 艾默根佛蒙特有限公司 | 针对表皮生长因子受体的缺失突变体的抗体及其使用 |
| KR101531400B1 (ko) | 2003-06-27 | 2015-06-26 | 암젠 프레몬트 인코포레이티드 | 상피 성장 인자 수용체의 결실 돌연변이체 지향 항체 및 그용도 |
| TWI333977B (en) | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| DE602004031772D1 (de) | 2003-12-04 | 2011-04-21 | Abbott Biotherapeutics Corp | Anti-ip-10-antikörper |
| DE602004022871D1 (de) | 2003-12-22 | 2009-10-08 | Glaxo Group Ltd | Nogo-a-neutralisierende immunglobuline zur behandlung neurologischer krankheiten |
| MXPA06010715A (es) | 2004-03-19 | 2007-05-23 | Imclone Systems Inc | Anticuerpo del receptor del factor de crecimiento humano anti-epidermico. |
| DK2439285T3 (da) | 2004-03-31 | 2019-07-29 | Massachusetts Gen Hospital | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| AU2005249490B2 (en) | 2004-06-01 | 2010-07-29 | Genentech, Inc. | Antibody drug conjugates and methods |
| US20070009972A1 (en) | 2005-02-16 | 2007-01-11 | Ginger Chao | Epidermal growth factor receptor polypeptides and antibodies |
| US20060233814A1 (en) | 2005-04-15 | 2006-10-19 | Immunogen Inc. | Elimination of heterogeneous or mixed cell population in tumors |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| US20070213292A1 (en) | 2005-08-10 | 2007-09-13 | The Rockefeller University | Chemically modified oligonucleotides for use in modulating micro RNA and uses thereof |
| US20090252681A1 (en) | 2005-10-11 | 2009-10-08 | Ablynx N.V. | Nanobodies and Polypeptides Against EGFR and IGF-IR |
| CA2660463C (en) | 2006-08-11 | 2013-07-16 | Schering Corporation | Antibodies to il-17a |
| US20090258442A1 (en) | 2006-08-31 | 2009-10-15 | Cell Signaling Technology, Inc. | Reagents for the detection of protein phosphorylation in carcinoma signaling pathways |
| WO2008098145A1 (en) | 2007-02-07 | 2008-08-14 | University Of Washington | Methods for modulating antigen-specific b cell responses |
| DK2132229T3 (en) | 2007-03-01 | 2016-06-20 | Symphogen As | Recombinant anti-epidermal growth factor receptor-ANTIBODY COMPOSITIONS |
| US7892777B2 (en) | 2007-07-17 | 2011-02-22 | The Regents Of The University Of Michigan | Methods for measuring whether a treatment affects RPTP-κ activity |
| WO2009030239A1 (en) | 2007-09-06 | 2009-03-12 | Genmab A/S | Novel methods and antibodies for treating cancer |
| US20090269343A1 (en) * | 2008-04-11 | 2009-10-29 | Duke University | Dual Specific Immunotoxin for Brain Tumor Therapy |
| RU2503687C2 (ru) | 2008-04-30 | 2014-01-10 | Иммьюноджен, Инк. | Сшивающие реагенты и их применение |
| RU2487877C2 (ru) | 2008-04-30 | 2013-07-20 | Иммьюноджен, Инк. | Высокоэффективные конъюгаты и гидрофильные сшивающие агенты (линкеры) |
| RU2523419C2 (ru) | 2008-07-15 | 2014-07-20 | Дженетек, Инк. | Конъюгаты производного антрациклина, способы их получения и их применение в качестве противоопухолевых соединений |
| WO2010022736A2 (en) | 2008-08-29 | 2010-03-04 | Symphogen A/S | Recombinant anti-epidermal growth factor receptor antibody compositions |
| CN105218673A (zh) | 2008-10-10 | 2016-01-06 | 新兴产品开发西雅图有限公司 | Tcr复合物免疫治疗剂 |
| US20110287036A1 (en) | 2008-11-17 | 2011-11-24 | Riken | Novel cancer targeting therapy using complex of subtance capable of binding specifically to constituent factor of cancer stroma and anti-tumor compound |
| CN103003424B (zh) | 2010-05-18 | 2015-05-13 | 株式会社医学生物学研究所 | 结合转化生长因子α且对Ras基因突变的癌具有增殖抑制活性的抗体 |
| CN103298489A (zh) * | 2010-10-29 | 2013-09-11 | 伊缪诺金公司 | 新型egfr结合分子及其免疫偶联物 |
| JP5828902B2 (ja) | 2010-10-29 | 2015-12-09 | イミュノジェン， インコーポレイテッド | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 |
| EP2794010A4 (en) | 2011-11-21 | 2015-10-21 | Immunogen Inc | METHOD OF TREATING TUMORS RESISTANT TO EGFR THERAPIES BY A CYTOTOXIC EGFR-AGENT ANTIBODY CONJUGATE |
-
2012
- 2012-11-21 EP EP12850911.4A patent/EP2794010A4/en not_active Withdrawn
- 2012-11-21 US US13/682,948 patent/US9233171B2/en not_active Expired - Fee Related
- 2012-11-21 WO PCT/US2012/066205 patent/WO2013078271A1/en not_active Ceased
- 2012-11-21 SG SG11201402343SA patent/SG11201402343SA/en unknown
- 2012-11-21 JP JP2014542584A patent/JP2014533954A/ja active Pending
- 2012-11-21 AU AU2012340686A patent/AU2012340686A1/en not_active Abandoned
- 2012-11-21 CA CA2856411A patent/CA2856411A1/en not_active Abandoned
- 2012-11-21 HK HK15102403.0A patent/HK1201772A1/xx unknown
- 2012-11-21 KR KR1020147016745A patent/KR20140105765A/ko not_active Withdrawn
- 2012-11-21 CN CN201280056769.4A patent/CN104066481A/zh active Pending
- 2012-11-21 RU RU2014121820/15A patent/RU2014121820A/ru not_active Application Discontinuation
- 2012-11-21 MX MX2014006087A patent/MX2014006087A/es not_active Application Discontinuation
- 2012-11-21 BR BR112014012155A patent/BR112014012155A2/pt not_active IP Right Cessation
-
2014
- 2014-05-15 CL CL2014001282A patent/CL2014001282A1/es unknown
- 2014-05-18 IL IL232666A patent/IL232666A0/en unknown
- 2014-05-19 PH PH12014501119A patent/PH12014501119A1/en unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010516770A (ja) * | 2007-01-25 | 2010-05-20 | ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド | Ｅｇｆｒ変異体仲介性疾患の治療における抗ｅｇｆｒ抗体の使用 |
| WO2010126551A1 (en) * | 2009-04-30 | 2010-11-04 | Immunogen, Inc. | Potent conjugates and hydrophilic linkers |
Non-Patent Citations (1)
| Title |
|---|
| INT. J. ONCOL., vol. 33, JPN6016034360, 2008, pages 1165 - 1176, ISSN: 0003395215 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2013078271A1 (en) | 2013-05-30 |
| CN104066481A (zh) | 2014-09-24 |
| US20130156796A1 (en) | 2013-06-20 |
| US9233171B2 (en) | 2016-01-12 |
| PH12014501119A1 (en) | 2014-08-04 |
| CA2856411A1 (en) | 2013-05-30 |
| MX2014006087A (es) | 2014-08-01 |
| HK1201772A1 (en) | 2015-09-11 |
| EP2794010A4 (en) | 2015-10-21 |
| SG11201402343SA (en) | 2014-06-27 |
| BR112014012155A2 (pt) | 2017-05-30 |
| KR20140105765A (ko) | 2014-09-02 |
| EP2794010A1 (en) | 2014-10-29 |
| IL232666A0 (en) | 2014-07-31 |
| AU2012340686A1 (en) | 2014-06-19 |
| CL2014001282A1 (es) | 2014-11-14 |
| RU2014121820A (ru) | 2015-12-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9233171B2 (en) | Method of treatment of tumors that are resistant to EGFR antibody therapies by EGFR antibody cytotoxic agent conjugate | |
| JP7401126B2 (ja) | 抗ｃｕｂドメイン含有タンパク質１（ｃｄｃｐ１）抗体、抗体薬物コンジュゲート、およびその使用方法 | |
| JP5828902B2 (ja) | 非拮抗性ｅｇｆｒ結合分子およびその免疫複合体 | |
| US9125896B2 (en) | EGFR-binding molecules and immunoconjugates thereof | |
| KR101982317B1 (ko) | Folr1 암 치료의 효능을 증가시키기 위한 방법 | |
| JP6581279B2 (ja) | 抗ｆｏｌｒ１免疫抱合体投薬レジメン | |
| BR112019023832A2 (pt) | anticorpo, fragmento funcional do anticorpo, polinucleotídeo, vetor de expressão, células hospedeiras, métodos para produzir um anticorpo de interesse ou um fragmento funcional do anticorpo, para tratamento de um tumor e para produzir um conjugado anticorpo-fármaco, conjugado anticorpo-fármaco, e, composição farmacêutica | |
| Lewis et al. | The HER2-directed antibody-drug conjugate DHES0815A in advanced and/or metastatic breast cancer: preclinical characterization and phase 1 trial results | |
| CN114901690A (zh) | 用结合191p4d12蛋白的抗体药物偶联物（adc）治疗癌症 | |
| WO2024050031A2 (en) | Novel camptothecin derivatves as antibody-drug conjugates (adc) payloads | |
| KR20250012631A (ko) | 항-cdh6 항체-약물 접합체의 투약 | |
| KR102905497B1 (ko) | 항체-약물 컨쥬게이트와 parp 저해제의 조합 | |
| KR20250170119A (ko) | 항체 약물 접합체 | |
| TW202333800A (zh) | 抗體-藥物結合物及rasg12c抑制劑之組合 | |
| Merlino | Characterization of MEN1309/OBT076, a new antibody conjugated to the DM4 maytansinoide toxin | |
| TW202440169A (zh) | 抗體-藥物結合物與dnmt抑制劑之組合 | |
| TW202444760A (zh) | 抗ｃｄ２５抗體及抗ｃｄ２５抗體－藥物複合體 | |
| RU2801307C1 (ru) | Схемы применения иммуноконъюгата анти-folr1 | |
| CN120153254A (zh) | 膀胱癌的治疗和诊断方法 | |
| HK40075918A (en) | Treatment of cancers with antibody drug conjugates (adc) that bind to 191p4d12 proteins |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20151124 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20151124 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160906 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20170414 |