JP2014532628A5 - - Google Patents
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- JP2014532628A5 JP2014532628A5 JP2014537369A JP2014537369A JP2014532628A5 JP 2014532628 A5 JP2014532628 A5 JP 2014532628A5 JP 2014537369 A JP2014537369 A JP 2014537369A JP 2014537369 A JP2014537369 A JP 2014537369A JP 2014532628 A5 JP2014532628 A5 JP 2014532628A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- change
- composition
- nanoparticle
- functionalized biocompatible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 210000004027 cell Anatomy 0.000 claims description 52
- 239000002105 nanoparticle Substances 0.000 claims description 29
- 210000004962 mammalian cell Anatomy 0.000 claims description 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 12
- 108090000623 proteins and genes Proteins 0.000 claims description 10
- 102000004169 proteins and genes Human genes 0.000 claims description 10
- 230000000975 bioactive effect Effects 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 4
- 108091023040 Transcription factor Proteins 0.000 claims description 4
- 102000040945 Transcription factor Human genes 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 230000003915 cell function Effects 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 125000000524 functional group Chemical group 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229920000642 polymer Polymers 0.000 claims description 4
- 230000000877 morphologic effect Effects 0.000 claims description 3
- 230000000149 penetrating effect Effects 0.000 claims description 3
- 230000002062 proliferating effect Effects 0.000 claims description 3
- 210000000130 stem cell Anatomy 0.000 claims description 3
- 230000035899 viability Effects 0.000 claims description 3
- 101100239628 Danio rerio myca gene Proteins 0.000 claims description 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims description 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims description 2
- 238000009830 intercalation Methods 0.000 claims description 2
- 229910052742 iron Inorganic materials 0.000 claims description 2
- 101150111214 lin-28 gene Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 description 8
- 230000001413 cellular effect Effects 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550213P | 2011-10-21 | 2011-10-21 | |
| US61/550,213 | 2011-10-21 | ||
| PCT/US2012/061391 WO2013059831A1 (en) | 2011-10-21 | 2012-10-22 | Functionalized nanoparticles for intracellular delivery of biologically active molecules |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017128822A Division JP6560302B2 (ja) | 2011-10-21 | 2017-06-30 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014532628A JP2014532628A (ja) | 2014-12-08 |
| JP2014532628A5 true JP2014532628A5 (https=) | 2015-12-10 |
Family
ID=48141479
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537369A Withdrawn JP2014532628A (ja) | 2011-10-21 | 2012-10-22 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
| JP2017128822A Expired - Fee Related JP6560302B2 (ja) | 2011-10-21 | 2017-06-30 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
| JP2018164676A Pending JP2018184485A (ja) | 2011-10-21 | 2018-09-03 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017128822A Expired - Fee Related JP6560302B2 (ja) | 2011-10-21 | 2017-06-30 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
| JP2018164676A Pending JP2018184485A (ja) | 2011-10-21 | 2018-09-03 | 生物活性分子の細胞内輸送のための機能性ナノ粒子 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9675708B2 (https=) |
| EP (2) | EP2769217A4 (https=) |
| JP (3) | JP2014532628A (https=) |
| KR (3) | KR20200040924A (https=) |
| CN (2) | CN104094119A (https=) |
| AU (3) | AU2012325723A1 (https=) |
| BR (1) | BR112014009753B1 (https=) |
| CA (2) | CA2853128C (https=) |
| HK (1) | HK1201089A1 (https=) |
| IN (1) | IN2014DN03224A (https=) |
| MX (3) | MX367656B (https=) |
| RU (2) | RU2018135567A (https=) |
| SG (2) | SG11201401658SA (https=) |
| WO (1) | WO2013059831A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104094119A (zh) * | 2011-10-21 | 2014-10-08 | 斯特姆詹尼克斯公司 | 用于胞内传递生物活性分子的官能化纳米粒子 |
| CN110339339A (zh) | 2013-03-01 | 2019-10-18 | 康德生物医疗技术公司 | 治疗线粒体疾病的方法 |
| EP3626252A1 (en) * | 2013-03-01 | 2020-03-25 | Stealth Biotherapeutics Corp | Methods and compositions for the prevention or treatment of barth syndrome |
| US10047395B2 (en) | 2013-06-26 | 2018-08-14 | Stealth Biotherapeutics Corp | Methods and compositions for detecting and diagnosing diseases and conditions |
| US11306326B2 (en) | 2013-08-23 | 2022-04-19 | Rutgers, The State University Of New Jersey | Biologically active synthetic nanoparticle constructs and methods of use thereof |
| US10100332B2 (en) | 2013-08-23 | 2018-10-16 | Rutgers, The State University Of New Jersey | Biologically active synthetic nanoparticle constructs and methods of use thereof |
| US20170015975A1 (en) * | 2014-02-10 | 2017-01-19 | Nvigen, Inc. | Cell modulation nanocomposition, and methods of use |
| CN105440112A (zh) * | 2015-12-07 | 2016-03-30 | 国家纳米科学中心 | 多肽-白蛋白偶联药物、其制备方法及应用 |
| EP3463316A4 (en) * | 2016-06-03 | 2020-05-27 | Stemgenics, Inc. | FUNCTIONALIZED NANOPARTICLES FOR INTRACELLULAR DELIVERY OF BIOLOGICALLY ACTIVE MOLECULES AND METHODS OF MAKING AND USING THE SAME |
| CN114634908A (zh) * | 2016-06-03 | 2022-06-17 | 斯特姆詹尼克斯公司 | 用功能化纳米颗粒将人类体细胞直接重编程为选定的(预定的)分化细胞 |
| EP3525831A4 (en) * | 2016-10-11 | 2020-06-03 | Stemgenics, Inc. | NANOPARTICLES FUNCTIONALIZED WITH GENE EDITING TOOLS AND RELATED METHODS |
| US11491114B2 (en) | 2016-10-12 | 2022-11-08 | Curioralrx, Llc | Formulations for enteric delivery of therapeutic agents |
| US11065345B2 (en) * | 2017-01-04 | 2021-07-20 | Nanotics, Llc | Methods for assembling scavenging particles |
| JOP20190248A1 (ar) | 2017-04-21 | 2019-10-20 | Amgen Inc | بروتينات ربط مولد ضد trem2 واستخداماته |
| US11701433B2 (en) | 2017-06-05 | 2023-07-18 | The Regents Of The University Of Michigan | Complexes for delivery of antigenic peptides |
| WO2019099685A1 (en) | 2017-11-15 | 2019-05-23 | Rutgers, The State University Of New Jersey | Biodegradable hybrid inorganic nanoscaffolding materials and methods of use and manufacture thereof |
| CN108287235B (zh) * | 2018-02-07 | 2021-03-09 | 常州天地人和生物科技有限公司 | 一种高效、稳定的磁性免疫微球的制备和应用 |
| US20200326325A1 (en) | 2019-04-12 | 2020-10-15 | Lisa Diamond | Nanosensor chip with compound nanopores |
| CN112111042B (zh) * | 2019-06-21 | 2024-04-05 | 康码（上海）生物科技有限公司 | 一种生物磁性微球及其制备方法和使用方法 |
| CN110642876A (zh) * | 2019-10-10 | 2020-01-03 | 南京市口腔医院 | 半胱氨酸修饰金纳米颗粒和制备方法、应用及促进骨组织再生产品 |
| CN112472685B (zh) * | 2020-12-10 | 2023-03-24 | 哈尔滨工业大学 | 一种杂化中性粒细胞机器人的制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6767635B1 (en) * | 1999-09-14 | 2004-07-27 | Biomedical Apherese Systeme Gmbh | Magnetic nanoparticles having biochemical activity, method for the production thereof and their use |
| US7329638B2 (en) * | 2003-04-30 | 2008-02-12 | The Regents Of The University Of Michigan | Drug delivery compositions |
| JP4901471B2 (ja) * | 2004-02-19 | 2012-03-21 | 国立大学法人京都大学 | 体細胞核初期化物質のスクリーニング方法 |
| CN101389314A (zh) | 2005-03-14 | 2009-03-18 | 得克萨斯大学体系董事会 | 生物活性fus1肽和纳米颗粒-多肽复合物 |
| KR101364374B1 (ko) * | 2005-03-14 | 2014-02-17 | 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 | 생활성 ｆｕｓ1 펩티드 및 나노입자-폴리펩티드 복합체 |
| MX2007016039A (es) * | 2005-06-17 | 2008-10-27 | Univ North Carolina | Metodos, sistemas y materiales de fabricacion de nanoparticulas. |
| EP2099496A2 (en) * | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
| US20080166412A1 (en) | 2007-01-02 | 2008-07-10 | Kiminobu Sugaya | Methods and materials for stimulating proliferation of stem cell |
| KR100925689B1 (ko) * | 2007-07-25 | 2009-11-10 | 한국생명공학연구원 | 항체와 나노입자를 세포 내로 동시에 전달할 수 있는다기능성 단백질 |
| US8283344B2 (en) | 2007-09-10 | 2012-10-09 | Merck & Co., Inc. | Method of treating inherited severe neutropenia |
| KR100951719B1 (ko) * | 2007-10-02 | 2010-04-07 | 재단법인서울대학교산학협력재단 | 세포투과성 펩타이드와 형광표지 자성나노입자의 복합체 및그 용도 |
| AU2008329562A1 (en) | 2007-11-30 | 2009-06-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving Sox2 protein |
| US11260133B2 (en) * | 2008-02-21 | 2022-03-01 | Sanford-Burnham Medical Research Institute | Methods and compositions related to peptides and proteins with C-terminal elements |
| JP2012513218A (ja) * | 2008-12-23 | 2012-06-14 | ヴィヴォスクリプト，インコーポレイテッド | 遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法 |
| AR076225A1 (es) * | 2009-04-07 | 2011-05-26 | Dow Agrosciences Llc | Administracion de nanoparticulas revestidas de una secuencia de nucleasa especifica |
| CN104094119A (zh) * | 2011-10-21 | 2014-10-08 | 斯特姆詹尼克斯公司 | 用于胞内传递生物活性分子的官能化纳米粒子 |
-
2012
- 2012-10-22 CN CN201280063870.2A patent/CN104094119A/zh active Pending
- 2012-10-22 EP EP12842115.3A patent/EP2769217A4/en not_active Withdrawn
- 2012-10-22 WO PCT/US2012/061391 patent/WO2013059831A1/en not_active Ceased
- 2012-10-22 JP JP2014537369A patent/JP2014532628A/ja not_active Withdrawn
- 2012-10-22 CA CA2853128A patent/CA2853128C/en active Active
- 2012-10-22 US US14/353,280 patent/US9675708B2/en active Active - Reinstated
- 2012-10-22 RU RU2018135567A patent/RU2018135567A/ru not_active Application Discontinuation
- 2012-10-22 SG SG11201401658SA patent/SG11201401658SA/en unknown
- 2012-10-22 KR KR1020207010401A patent/KR20200040924A/ko not_active Ceased
- 2012-10-22 RU RU2014120465/15A patent/RU2014120465A/ru unknown
- 2012-10-22 EP EP18160010.7A patent/EP3400956A1/en not_active Withdrawn
- 2012-10-22 CN CN201610644097.9A patent/CN106822868A/zh active Pending
- 2012-10-22 MX MX2018002306A patent/MX367656B/es unknown
- 2012-10-22 KR KR1020197018256A patent/KR20190077124A/ko not_active Ceased
- 2012-10-22 KR KR20147010620A patent/KR20150001711A/ko not_active Ceased
- 2012-10-22 AU AU2012325723A patent/AU2012325723A1/en not_active Abandoned
- 2012-10-22 BR BR112014009753-4A patent/BR112014009753B1/pt not_active IP Right Cessation
- 2012-10-22 HK HK15101563.8A patent/HK1201089A1/xx unknown
- 2012-10-22 SG SG10201601746TA patent/SG10201601746TA/en unknown
- 2012-10-22 MX MX2014004778A patent/MX2014004778A/es unknown
- 2012-10-22 CA CA2938661A patent/CA2938661A1/en not_active Abandoned
- 2012-10-22 IN IN3224DEN2014 patent/IN2014DN03224A/en unknown
-
2014
- 2014-04-21 MX MX2018010696A patent/MX2018010696A/es unknown
-
2017
- 2017-06-30 JP JP2017128822A patent/JP6560302B2/ja not_active Expired - Fee Related
-
2018
- 2018-05-31 AU AU2018203848A patent/AU2018203848A1/en not_active Abandoned
- 2018-09-03 JP JP2018164676A patent/JP2018184485A/ja active Pending
-
2020
- 2020-08-27 AU AU2020223737A patent/AU2020223737A1/en not_active Abandoned
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