JP2014513983A5 - - Google Patents
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- Publication number
- JP2014513983A5 JP2014513983A5 JP2014510518A JP2014510518A JP2014513983A5 JP 2014513983 A5 JP2014513983 A5 JP 2014513983A5 JP 2014510518 A JP2014510518 A JP 2014510518A JP 2014510518 A JP2014510518 A JP 2014510518A JP 2014513983 A5 JP2014513983 A5 JP 2014513983A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- zscan4
- seq
- reprogramming
- contacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 18
- 230000008672 reprogramming Effects 0.000 claims 17
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 210000001082 somatic cell Anatomy 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 230000001419 dependent effect Effects 0.000 claims 7
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 210000000130 stem cell Anatomy 0.000 claims 4
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 3
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101710135898 Myc proto-oncogene protein Proteins 0.000 claims 2
- 102100038895 Myc proto-oncogene protein Human genes 0.000 claims 2
- 101710150448 Transcriptional regulator Myc Proteins 0.000 claims 2
- 101150111214 lin-28 gene Proteins 0.000 claims 2
- 108020004999 messenger RNA Proteins 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims 1
- -1 Nanog Proteins 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 210000001789 adipocyte Anatomy 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 210000001130 astrocyte Anatomy 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims 1
- 210000003494 hepatocyte Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000002510 keratinocyte Anatomy 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 210000000663 muscle cell Anatomy 0.000 claims 1
- 210000001178 neural stem cell Anatomy 0.000 claims 1
- 210000004976 peripheral blood cell Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161486004P | 2011-05-13 | 2011-05-13 | |
| US61/486,004 | 2011-05-13 | ||
| US201161529055P | 2011-08-30 | 2011-08-30 | |
| US61/529,055 | 2011-08-30 | ||
| PCT/US2012/037643 WO2012158561A1 (en) | 2011-05-13 | 2012-05-11 | Use of zscan4 and zscan4-dependent genes for direct reprogramming of somatic cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017108578A Division JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014513983A JP2014513983A (ja) | 2014-06-19 |
| JP2014513983A5 true JP2014513983A5 (https=) | 2015-07-16 |
| JP6189829B2 JP6189829B2 (ja) | 2017-08-30 |
Family
ID=47177285
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014510518A Active JP6189829B2 (ja) | 2011-05-13 | 2012-05-11 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
| JP2017108578A Pending JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017108578A Pending JP2017212985A (ja) | 2011-05-13 | 2017-05-31 | Ｚｓｃａｎ４とｚｓｃａｎ４依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9932560B2 (https=) |
| EP (1) | EP2707479B1 (https=) |
| JP (2) | JP6189829B2 (https=) |
| AU (1) | AU2012256014B2 (https=) |
| CA (1) | CA2835825C (https=) |
| WO (1) | WO2012158561A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9932560B2 (en) | 2011-05-13 | 2018-04-03 | Elixirgen, Llc | Use of Zscan4 and Zscan4-dependent genes for direct reprogramming of somatic cells |
| EP3782628B1 (en) * | 2013-03-15 | 2024-08-07 | Elixirgen Therapeutics, Inc. | Methods of using zscan4 for rejuvenating human cells |
| WO2016099602A1 (en) * | 2014-12-18 | 2016-06-23 | University Of Utah Research Foundation | Induced pluripotent stem cell and method for producing the same |
| CN105219729B (zh) * | 2015-09-28 | 2018-09-25 | 首都医科大学宣武医院 | 一种利用非整合质粒载体诱导神经干细胞的方法及其用途 |
| CN106800590B (zh) * | 2015-11-25 | 2021-04-09 | 杭州智鹤丹谷生物医药有限公司 | 一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用 |
| WO2018112249A1 (en) * | 2016-12-15 | 2018-06-21 | Illumina, Inc. | Methods and systems for determining paralogs |
| CN107475378B (zh) * | 2017-08-03 | 2021-03-30 | 复旦大学 | 用于检测女性原发不孕的patl2基因及检测该基因突变的试剂盒 |
| WO2019060450A1 (en) * | 2017-09-19 | 2019-03-28 | The Broad Institute, Inc. | METHODS AND SYSTEMS FOR RECONSTRUCTION OF DEVELOPMENT LANDSCAPES BY OPTIMAL TRANSPORT ANALYSIS |
| CN107988147B (zh) * | 2017-12-19 | 2021-11-09 | 江汉大学 | 基于器官芯片与诱导多能干细胞的定向分化用于3d拟表皮构建的方法 |
| WO2020237209A1 (en) * | 2019-05-22 | 2020-11-26 | University Of Maryland, Baltimore | Methods of treating cancer by targeting zscan4 activity in cancer stem cells |
| CN110616232B (zh) * | 2019-09-23 | 2023-04-11 | 中国人民解放军陆军军医大学 | Sox30敲除和可恢复型小鼠动物模型构建方法及应用 |
| JP7699588B2 (ja) * | 2019-11-22 | 2025-06-27 | アルカメナ・ステム・セル・セラピューティクス、エルエルシー | Ｒｅ１サイレンシング転写因子標的遺伝子を抑制解除する組成物 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4980289A (en) | 1987-04-27 | 1990-12-25 | Wisconsin Alumni Research Foundation | Promoter deficient retroviral vector |
| US5888762A (en) | 1990-06-05 | 1999-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Neurotropic growth factors comprising a homeobox peptide |
| KR100201352B1 (ko) | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
| US7198784B2 (en) | 1996-10-17 | 2007-04-03 | Oxford Biomedica (Uk) Limited | Retroviral vectors |
| FR2762615B1 (fr) | 1997-04-28 | 1999-07-16 | Inst Nat Sante Rech Med | Nouveau site interne d'entree des ribosomes et vecteur le contenant |
| US6979568B1 (en) | 1999-06-22 | 2005-12-27 | Dnavec Research, Inc. | Vector for the expression of two foreign genes |
| US20110171185A1 (en) * | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| DE19933492B4 (de) | 1999-07-16 | 2008-01-10 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Konjugat zur Vermittlung eines zell-, kompartiment- oder membranspezifischen Transports von Wirksubstanzen, Verfahren zu dessen Herstellung und dessen Verwendung |
| EP1235914A2 (en) | 1999-11-24 | 2002-09-04 | Joseph Rosenecker | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| US7211247B2 (en) | 2001-04-09 | 2007-05-01 | University Of Southern California | Lentivirus vectors for gene transfer to alveolar epithelial cells |
| US7081489B2 (en) | 2001-08-09 | 2006-07-25 | Florida State University Research Foundation | Polymeric encapsulation of nanoparticles |
| US20040014209A1 (en) | 2002-01-23 | 2004-01-22 | Lassar Andrew B. | Compositions and methods for modulating cell differentiation |
| US7354763B2 (en) | 2002-04-16 | 2008-04-08 | Technion Research & Development Foundation Ltd. | Generating vascular smooth muscle cells in vitro from ES cells |
| EP1575992A4 (en) | 2002-08-05 | 2007-02-21 | Univ Rochester | CHEMICAL PROTEINS FROM PROTEIN TRANSDUCATING DOMAIN / DEAMINASE, RELATED COMPOUNDS AND THEIR USES |
| KR100591936B1 (ko) | 2002-11-12 | 2006-06-22 | 포휴먼텍(주) | 세포내 ｄｎａ／ｒｎａ 전달 방법, 및 이것의 기초 및임상학적 응용 |
| EP1583473A2 (en) | 2003-01-16 | 2005-10-12 | St. Johns University New York | Nanoparticle based stabilization of ir fluorescent dyes |
| US7166692B2 (en) | 2003-03-04 | 2007-01-23 | Canbrex Bio Science Walkersville, Inc. | Intracellular delivery of small molecules, proteins, and nucleic acids |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| EP2929782A1 (en) | 2004-01-23 | 2015-10-14 | Ocata Therapeutics, Inc. | Improved modalities for the treatment of degenerative diseases of the retina |
| WO2006052285A2 (en) | 2004-05-13 | 2006-05-18 | The Trustees Of Columbia University In The City Of New York | Polymeric nanoparticles and nanogels for extraction and release of compounds |
| US20060024331A1 (en) | 2004-08-02 | 2006-02-02 | Ester Fernandez-Salas | Toxin compounds with enhanced membrane translocation characteristics |
| WO2006083782A2 (en) | 2005-01-31 | 2006-08-10 | Es Cell International Pte Ltd. | Directed differentiation of embryonic stem cells and uses thereof |
| ATE382337T1 (de) | 2005-04-28 | 2008-01-15 | Nipro Corp | Bioabsorbierbare pharmazeutische zusammensetzung enthaltend einen plga-copolymer |
| CA2605551A1 (en) | 2005-05-10 | 2006-11-16 | Naomi Balaban | Compositions for administering rnaiii-inhibiting peptides |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| CA2678901C (en) * | 2007-03-26 | 2017-11-14 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for modulating embryonic stem cell differentiation |
| US20100279404A1 (en) | 2008-05-02 | 2010-11-04 | Shinya Yamanaka | Method of nuclear reprogramming |
| AU2010289423B2 (en) * | 2009-09-04 | 2014-03-27 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods for enhancing genome stability and telomere elongation in embryonic stem cells |
| JP6204345B2 (ja) | 2011-03-23 | 2017-09-27 | ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンティド・バイ・ザ・セクレタリー・フォー・ザ・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシズ | 幹細胞の多能性を高めるための組成物及び方法 |
| US9932560B2 (en) | 2011-05-13 | 2018-04-03 | Elixirgen, Llc | Use of Zscan4 and Zscan4-dependent genes for direct reprogramming of somatic cells |
-
2012
- 2012-05-11 US US14/117,589 patent/US9932560B2/en active Active
- 2012-05-11 JP JP2014510518A patent/JP6189829B2/ja active Active
- 2012-05-11 EP EP12785169.9A patent/EP2707479B1/en active Active
- 2012-05-11 WO PCT/US2012/037643 patent/WO2012158561A1/en not_active Ceased
- 2012-05-11 CA CA2835825A patent/CA2835825C/en active Active
- 2012-05-11 AU AU2012256014A patent/AU2012256014B2/en active Active
-
2017
- 2017-05-31 JP JP2017108578A patent/JP2017212985A/ja active Pending
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