JP2014531452A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014531452A5 JP2014531452A5 JP2014531303A JP2014531303A JP2014531452A5 JP 2014531452 A5 JP2014531452 A5 JP 2014531452A5 JP 2014531303 A JP2014531303 A JP 2014531303A JP 2014531303 A JP2014531303 A JP 2014531303A JP 2014531452 A5 JP2014531452 A5 JP 2014531452A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- light chain
- vertebrate
- gene segments
- lambda
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1116120.5 | 2011-09-19 | ||
| GB201116120A GB201116120D0 (en) | 2011-09-19 | 2011-09-19 | Manipulation of immunoglobulin gene diversity and multi antibody therapeutics, especially for infectious diseases |
| GB1116122.1 | 2011-09-19 | ||
| GB201116122A GB201116122D0 (en) | 2011-09-19 | 2011-09-19 | Synthetically-extended & ethnically diverse superhuman immunoglobulin gene repertoires |
| GBGB1203257.9A GB201203257D0 (en) | 2012-02-24 | 2012-02-24 | Animals, repertoires & methods |
| GB1203257.9 | 2012-02-24 | ||
| GB1204592.8 | 2012-03-15 | ||
| GBGB1204592.8A GB201204592D0 (en) | 2012-03-15 | 2012-03-15 | Animals, repertoires & methods |
| GB1205702.2 | 2012-03-29 | ||
| GBGB1205702.2A GB201205702D0 (en) | 2012-03-29 | 2012-03-29 | Animals,repertoires & methods |
| GB1207814.3 | 2012-05-04 | ||
| GB1207814.3A GB2501753A (en) | 2012-05-04 | 2012-05-04 | Human antibodies |
| GB1208749.0 | 2012-05-18 | ||
| GBGB1208749.0A GB201208749D0 (en) | 2012-05-18 | 2012-05-18 | Synthetically-extended & ethnically-diverse superhuman immunoglobulin gene repertoires |
| GB201211692A GB201211692D0 (en) | 2012-07-02 | 2012-07-02 | Animals, repertories & methods |
| GB1211692.7 | 2012-07-02 | ||
| PCT/GB2012/052297 WO2013041845A2 (en) | 2011-09-19 | 2012-09-18 | Animals, repertoires & methods |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017177720A Division JP2017213005A (ja) | 2011-09-19 | 2017-09-15 | 動物、レパートリーおよび方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014531452A JP2014531452A (ja) | 2014-11-27 |
| JP2014531452A5 true JP2014531452A5 (cg-RX-API-DMAC10.html) | 2015-11-12 |
Family
ID=46889369
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531303A Pending JP2014531452A (ja) | 2011-09-19 | 2012-09-18 | 動物、レパートリーおよび方法 |
| JP2017177720A Pending JP2017213005A (ja) | 2011-09-19 | 2017-09-15 | 動物、レパートリーおよび方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017177720A Pending JP2017213005A (ja) | 2011-09-19 | 2017-09-15 | 動物、レパートリーおよび方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20140323327A1 (cg-RX-API-DMAC10.html) |
| EP (2) | EP3741862A1 (cg-RX-API-DMAC10.html) |
| JP (2) | JP2014531452A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2013041845A2 (cg-RX-API-DMAC10.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3241435T3 (da) | 2009-07-08 | 2021-08-23 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
| EP2601298B1 (en) | 2010-08-02 | 2016-11-30 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| ES2872081T3 (es) | 2011-08-05 | 2021-11-02 | Regeneron Pharma | Ratones con cadena ligera universal humanizada |
| AU2012311286B2 (en) | 2011-09-19 | 2018-07-26 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
| EP4074833A1 (en) | 2011-10-17 | 2022-10-19 | Regeneron Pharmaceuticals, Inc. | Restricted immunoglobulin heavy chain mice |
| US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
| SMT201900296T1 (it) | 2011-12-20 | 2019-07-11 | Regeneron Pharma | Topi di catena leggera umanizzata |
| US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
| GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
| NZ703689A (en) | 2012-06-12 | 2016-05-27 | Regeneron Pharma | Humanized non-human animals with restricted immunoglobulin heavy chain loci |
| RS57582B1 (sr) | 2013-02-20 | 2018-11-30 | Regeneron Pharma | Nehumane životinje sa modifikovanim sekvencama imunoglobulinskog teškog lanca |
| US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
| US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
| US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
| US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
| WO2015049517A2 (en) | 2013-10-01 | 2015-04-09 | Kymab Limited | Animal models and therapeutic molecules |
| AU2015230938C1 (en) | 2014-03-21 | 2021-10-14 | Regeneron Pharmaceuticals, Inc. | Non-human animals that make single domain binding proteins |
| SG10201808083VA (en) | 2014-03-21 | 2018-10-30 | Regeneron Pharma | Vl antigen binding proteins exhibiting distinct binding characteristics |
| CN107438622A (zh) | 2015-03-19 | 2017-12-05 | 瑞泽恩制药公司 | 选择结合抗原的轻链可变区的非人动物 |
| GB201710984D0 (en) | 2017-07-07 | 2017-08-23 | Kymab Ltd | Cells, vertebrates, populations & methods |
| WO2020169022A1 (en) | 2019-02-18 | 2020-08-27 | Beijing Biocytogen Co., Ltd | Genetically modified non-human animals with humanized immunoglobulin locus |
| CN115667532A (zh) | 2020-06-02 | 2023-01-31 | 百奥赛图(北京)医药科技股份有限公司 | 具有共有轻链免疫球蛋白基因座的经遗传修饰的非人动物 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| US7041871B1 (en) | 1995-10-10 | 2006-05-09 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| BE1007904A3 (nl) | 1993-12-23 | 1995-11-14 | Dsm Nv | Werkwijze voor de bereiding van een alkanol en/of een alkanon. |
| US6130364A (en) | 1995-03-29 | 2000-10-10 | Abgenix, Inc. | Production of antibodies using Cre-mediated site-specific recombination |
| GB9823930D0 (en) | 1998-11-03 | 1998-12-30 | Babraham Inst | Murine expression of human ig\ locus |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| GB0110029D0 (en) | 2001-04-24 | 2001-06-13 | Grosveld Frank | Transgenic animal |
| GB0115256D0 (en) | 2001-06-21 | 2001-08-15 | Babraham Inst | Mouse light chain locus |
| ES2645563T3 (es) * | 2001-11-30 | 2017-12-05 | Amgen Fremont Inc. | Animales transgénicos que portan genes de cadena ligera de Ig humana |
| WO2009013620A2 (en) | 2007-06-11 | 2009-01-29 | Erasmus University Medical Center Rotterdam | Homologous recombination |
| KR20100103810A (ko) | 2007-12-10 | 2010-09-28 | 알리바 바이오파마수티컬스, 아이엔씨. | 동종 재조합에 의한 표적화된 영역의 순차적인 치환 방법 |
| EP2669298A3 (en) | 2008-05-23 | 2014-02-26 | Ablexis, LLC | Single variable immunoglobulin domain comprising VL-DH-JL |
| PL2346994T3 (pl) | 2008-09-30 | 2022-04-19 | Ablexis, Llc | Myszy knock-in do wytwarzania chimerycznych przeciwciał |
| KR101711222B1 (ko) | 2008-12-18 | 2017-02-28 | 에라스무스 유니버시티 메디컬 센터 로테르담 | 인간화 항체들을 발현하는 비-인간 유전자이식 동물들 및 그의 이용 |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| DK3241435T3 (da) | 2009-07-08 | 2021-08-23 | Kymab Ltd | Dyremodeller og terapeutiske molekyler |
| SG183149A1 (en) * | 2010-02-08 | 2012-09-27 | Regeneron Pharma | Common light chain mouse |
| CN103228130B (zh) | 2010-06-17 | 2016-03-16 | 科马布有限公司 | 动物模型及治疗分子 |
| MY195217A (en) | 2010-06-22 | 2023-01-11 | Regeneron Pharma | MICE Expressing An Immunoglobulin Hybrid Light Chain |
| EP2601298B1 (en) | 2010-08-02 | 2016-11-30 | Regeneron Pharmaceuticals, Inc. | Mice that make binding proteins comprising vl domains |
| CN105861548B (zh) | 2011-02-25 | 2020-01-10 | 瑞泽恩制药公司 | Adam6小鼠 |
| WO2013041845A2 (en) | 2011-09-19 | 2013-03-28 | Kymab Limited | Animals, repertoires & methods |
| SMT201900296T1 (it) | 2011-12-20 | 2019-07-11 | Regeneron Pharma | Topi di catena leggera umanizzata |
-
2012
- 2012-09-18 WO PCT/GB2012/052297 patent/WO2013041845A2/en not_active Ceased
- 2012-09-18 EP EP20171931.7A patent/EP3741862A1/en not_active Withdrawn
- 2012-09-18 JP JP2014531303A patent/JP2014531452A/ja active Pending
- 2012-09-18 EP EP12762377.5A patent/EP2758534B1/en active Active
-
2014
- 2014-03-19 US US14/220,099 patent/US20140323327A1/en not_active Abandoned
-
2017
- 2017-09-15 JP JP2017177720A patent/JP2017213005A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20201403T1 (hr) | Neljudske životinje koje imaju genetski modificiran lokus imunoglobulinskog lambda lakog lanca | |
| CY1124341T1 (el) | Ποντικοι me εξανθρωπισμενη καθολικη ελαφρια αλυσιδα | |
| ME02442B (me) | Miševi koji ispoljavaju laki lanac hibridnog imunoglobulina sa promenljivim regionom čovjeka | |
| EP2758534B1 (en) | Animals, repertoires & methods for the production of human antibodies | |
| RU2008134517A (ru) | Получение антител из одних тяжелых цепей в трансгенных животных | |
| CY1125119T1 (el) | Διαγονιδιακο ζωο ποντικος που παραγει αντισωματα | |
| HRP20211126T1 (hr) | Humanizirane nehumane životinje s ograničenim lokusima imunoglobulinskog teškog lanca | |
| US11707056B2 (en) | Animals, repertoires and methods | |
| RU2012128856A (ru) | Мыши, которые производят антитела, имеющие только тяжелую цепь | |
| MX2011007660A (es) | Animales transgenicos no humanos que expresan anticuerpos humanizados y usos de los mismos. | |
| RU2015135884A (ru) | Не являющиеся человеком животные с модифицированными последовательностями тяжелых цепей иммуноглобулинов | |
| JP2014516518A5 (cg-RX-API-DMAC10.html) | ||
| JP2015510767A5 (cg-RX-API-DMAC10.html) | ||
| CY1120599T1 (el) | Αντισωματα ελαφριων αλυσιδων τροποποιημενων με ιστιδινη και γενετικα τροποποιημενα τρωκτικα για τη δημιουργια αυτων | |
| JP2018138047A5 (cg-RX-API-DMAC10.html) | ||
| WO2015143414A3 (en) | Non-human animals that make single domain binding proteins | |
| HRP20171357T1 (hr) | Ograničeni teški lanac imunoglobulina u miševa | |
| HRP20192311T1 (hr) | Adam6 miševi | |
| ME02817B (me) | Generisanje vezujućih molekula | |
| JP2015505477A5 (cg-RX-API-DMAC10.html) | ||
| JP2020530760A5 (cg-RX-API-DMAC10.html) | ||
| JP2012532598A5 (cg-RX-API-DMAC10.html) | ||
| RU2014127339A (ru) | Мыши с гуманизированной легкой цепью | |
| RU2014140239A (ru) | Мышь с общей легкой цепью | |
| RU2014133653A (ru) | Гуманизированные грызуны, которые экспрессируют тяжелые цепи, содержащие домены vl |