JP2014530811A5 - - Google Patents
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- Publication number
- JP2014530811A5 JP2014530811A5 JP2014534558A JP2014534558A JP2014530811A5 JP 2014530811 A5 JP2014530811 A5 JP 2014530811A5 JP 2014534558 A JP2014534558 A JP 2014534558A JP 2014534558 A JP2014534558 A JP 2014534558A JP 2014530811 A5 JP2014530811 A5 JP 2014530811A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- pharmaceutical composition
- composition according
- cancer
- occurrence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 13
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims 7
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 150000002828 nitro derivatives Chemical class 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000002837 carbocyclic group Chemical group 0.000 claims 4
- 125000004432 carbon atom Chemical group C* 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 1
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 1
- 206010057644 Testis cancer Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 206010017758 gastric cancer Diseases 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000000664 rectum Anatomy 0.000 claims 1
- 201000011549 stomach cancer Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 201000003120 testicular cancer Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
- 0 C*(C(*)(*)*(C)[Al]*)C(*)(*)[N+]([O-])=O Chemical compound C*(C(*)(*)*(C)[Al]*)C(*)(*)[N+]([O-])=O 0.000 description 15
- ZHQGNENHUGQMQL-UHFFFAOYSA-N CC(C)CCC(C(C)=O)N Chemical compound CC(C)CCC(C(C)=O)N ZHQGNENHUGQMQL-UHFFFAOYSA-N 0.000 description 3
- OKJIRPAQVSHGFK-UHFFFAOYSA-N CC(NCC(O)=O)=O Chemical compound CC(NCC(O)=O)=O OKJIRPAQVSHGFK-UHFFFAOYSA-N 0.000 description 3
- SCDKQMGVRIMMLR-QMMMGPOBSA-O CC(N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[OH2+])=O)C(OC)=O)=O Chemical compound CC(N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[OH2+])=O)C(OC)=O)=O SCDKQMGVRIMMLR-QMMMGPOBSA-O 0.000 description 1
- PAPLXXXYKRVNKK-QMMMGPOBSA-N C[C@@H](CSCC(N(CC[N+]([O-])=O)CC[N+]([O-])=O)=O)C(O)=O Chemical compound C[C@@H](CSCC(N(CC[N+]([O-])=O)CC[N+]([O-])=O)=O)C(O)=O PAPLXXXYKRVNKK-QMMMGPOBSA-N 0.000 description 1
- TXIBECGXJIBQLR-LURJTMIESA-N N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[N+]([O-])=O)=O)C(NCC(O)=O)=O Chemical compound N[C@@H](CSCC(N(C1)CC1([N+]([O-])=O)[N+]([O-])=O)=O)C(NCC(O)=O)=O TXIBECGXJIBQLR-LURJTMIESA-N 0.000 description 1
- PRRWLOKOBULBHS-UHFFFAOYSA-N [O-][N+](C(C1)(CN1C=O)[N+]([O-])=O)=O Chemical compound [O-][N+](C(C1)(CN1C=O)[N+]([O-])=O)=O PRRWLOKOBULBHS-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161544378P | 2011-10-07 | 2011-10-07 | |
| US61/544,378 | 2011-10-07 | ||
| PCT/US2012/038592 WO2013052164A1 (en) | 2011-10-07 | 2012-05-18 | Organonitro thioether compounds and medical uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530811A JP2014530811A (ja) | 2014-11-20 |
| JP2014530811A5 true JP2014530811A5 (OSRAM) | 2015-07-02 |
| JP6019126B2 JP6019126B2 (ja) | 2016-11-02 |
Family
ID=48044064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014534558A Active JP6019126B2 (ja) | 2011-10-07 | 2012-05-18 | 有機ニトロチオエーテル化合物およびその医療用途 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US9139519B2 (OSRAM) |
| EP (1) | EP2763667B1 (OSRAM) |
| JP (1) | JP6019126B2 (OSRAM) |
| AU (1) | AU2012319071B2 (OSRAM) |
| CA (1) | CA2850723C (OSRAM) |
| ES (1) | ES2935573T3 (OSRAM) |
| WO (1) | WO2013052164A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7507842B2 (en) * | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| EP2763667B1 (en) * | 2011-10-07 | 2022-10-26 | EpicentRx, Inc. | Organonitro thioether compounds and medical uses thereof |
| KR101496681B1 (ko) * | 2014-05-19 | 2015-03-04 | 국방과학연구소 | N-치환된 3,3-디니트로아제티딘 고에너지 가소제 및 그의 제조방법 |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| EA201891606A1 (ru) * | 2016-01-11 | 2019-02-28 | Эписентарикс, Инк. | Композиции и способы для внутривенного введения 2-бром-1-(3,3-динитроазетидин-1-ил)этанона |
| JP7332469B2 (ja) * | 2016-10-14 | 2023-08-23 | エピセントアールエックス，インコーポレイテッド | スルホキシアルキル有機窒素および関連のある化合物ならびに医学における使用のための医薬組成物 |
| WO2019010447A1 (en) | 2017-07-07 | 2019-01-10 | Epicentrx, Inc. | COMPOSITIONS FOR PARENTERAL ADMINISTRATION OF THERAPEUTIC AGENTS |
| WO2019164593A2 (en) | 2018-01-08 | 2019-08-29 | Epicentrx, Inc. | Methods and compositions utilizing rrx-001 combination therapy for radioprotection |
| CN116917009A (zh) | 2021-02-19 | 2023-10-20 | 美国迈胜医疗系统有限公司 | 用于粒子治疗系统的机架 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2978453A (en) | 1956-12-12 | 1961-04-04 | Aerojet General Co | 3, 3, 5, 5-tetranitropiperidine |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4935450A (en) | 1982-09-17 | 1990-06-19 | Therapeutical Systems Corporation | Cancer therapy system for effecting oncolysis of malignant neoplasms |
| GB8504253D0 (en) | 1985-02-19 | 1985-03-20 | Ici Plc | Electrostatic spraying apparatus |
| GB8728418D0 (en) | 1987-12-04 | 1988-01-13 | Jenkins T C | Nitro-substituted aromatic/hetero-aromatic compounds for use in cancer treatment |
| DE3815221C2 (de) | 1988-05-04 | 1995-06-29 | Gradinger F Hermes Pharma | Verwendung einer Retinol- und/oder Retinsäureester enthaltenden pharmazeutischen Zubereitung zur Inhalation zur Einwirkung auf die Schleimhäute des Tracheo-Bronchialtraktes einschließlich der Lungenalveolen |
| US5693794A (en) | 1988-09-30 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Navy | Caged polynitramine compound |
| JP2659614B2 (ja) | 1990-11-13 | 1997-09-30 | 株式会社日立製作所 | 表示制御装置 |
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| DE69226197T2 (de) | 1991-11-08 | 1999-02-11 | Somatogen, Inc., Boulder | Hämoglobine als arzneimittelabgabesystem |
| US5336784A (en) | 1993-06-07 | 1994-08-09 | The Regents Of The University Of California | Synthesis of 1,3,3-trinitroazetidine |
| PT1051972E (pt) | 1994-05-27 | 2007-12-07 | Strakan Internat Ltd Uma Socie | Composição dadora de óxido nítrico para tratamento de distúrbios anais |
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| US5580988A (en) | 1995-05-15 | 1996-12-03 | The United States Of America As Represented By The Secretary Of The Army | Substituted azetidines and processes of using them |
| WO1996036602A1 (en) | 1995-05-15 | 1996-11-21 | The United States Of America | Adnaz, compositions and processes |
| US5898038A (en) | 1996-03-19 | 1999-04-27 | Board Of Regents, The University Of Texas System | Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors |
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| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
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| KR20080054417A (ko) | 2005-09-27 | 2008-06-17 | 노파르티스 아게 | 카르복시아민 화합물 및 ｈｄａｃ 의존성 질환의 치료에있어서의 그의 용도 |
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| US8471041B2 (en) | 2010-02-09 | 2013-06-25 | Alliant Techsystems Inc. | Methods of synthesizing and isolating N-(bromoacetyl)-3,3-dinitroazetidine and a composition including the same |
| US20120149678A1 (en) | 2010-12-09 | 2012-06-14 | Oronsky Bryan T | Organonitro Compounds for Use in Treating Non-Hodgkin's Lymphoma and Leukemia, and Methods Relating Thereto |
| US8664247B2 (en) | 2011-08-26 | 2014-03-04 | Radiorx, Inc. | Acyclic organonitro compounds for use in treating cancer |
| EP2763667B1 (en) * | 2011-10-07 | 2022-10-26 | EpicentRx, Inc. | Organonitro thioether compounds and medical uses thereof |
-
2012
- 2012-05-18 EP EP12839088.7A patent/EP2763667B1/en active Active
- 2012-05-18 JP JP2014534558A patent/JP6019126B2/ja active Active
- 2012-05-18 CA CA2850723A patent/CA2850723C/en active Active
- 2012-05-18 US US14/349,004 patent/US9139519B2/en active Active
- 2012-05-18 AU AU2012319071A patent/AU2012319071B2/en active Active
- 2012-05-18 WO PCT/US2012/038592 patent/WO2013052164A1/en not_active Ceased
- 2012-05-18 ES ES12839088T patent/ES2935573T3/es active Active
-
2015
- 2015-09-10 US US14/849,783 patent/US9468625B2/en active Active
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