JP2014527801A5 - - Google Patents
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- Publication number
- JP2014527801A5 JP2014527801A5 JP2014528669A JP2014528669A JP2014527801A5 JP 2014527801 A5 JP2014527801 A5 JP 2014527801A5 JP 2014528669 A JP2014528669 A JP 2014528669A JP 2014528669 A JP2014528669 A JP 2014528669A JP 2014527801 A5 JP2014527801 A5 JP 2014527801A5
- Authority
- JP
- Japan
- Prior art keywords
- library
- peptide
- biotin
- rna
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 13
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 7
- 229960002685 biotin Drugs 0.000 claims 6
- 235000020958 biotin Nutrition 0.000 claims 6
- 239000011616 biotin Substances 0.000 claims 6
- 108020004705 Codon Proteins 0.000 claims 4
- 150000001413 amino acids Chemical class 0.000 claims 4
- 108020004566 Transfer RNA Proteins 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 108010067902 Peptide Library Proteins 0.000 claims 2
- 150000001615 biotins Chemical class 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000001502 supplementing effect Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 108091005804 Peptidases Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000001268 conjugating effect Effects 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161530372P | 2011-09-01 | 2011-09-01 | |
| US201161530352P | 2011-09-01 | 2011-09-01 | |
| US201161530327P | 2011-09-01 | 2011-09-01 | |
| US61/530,327 | 2011-09-01 | ||
| US61/530,372 | 2011-09-01 | ||
| US61/530,352 | 2011-09-01 | ||
| PCT/US2012/053526 WO2013033636A2 (en) | 2011-09-01 | 2012-08-31 | Methods for preparing high throughput peptidomimetics, orally bioavailable drugs and compositions containing same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017230546A Division JP2018064573A (ja) | 2011-09-01 | 2017-11-30 | ハイスループットペプチドミメティックを調製するための方法、経口バイオアベイラブルな薬物およびそれを含有する組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014527801A JP2014527801A (ja) | 2014-10-23 |
| JP2014527801A5 true JP2014527801A5 (enExample) | 2015-10-08 |
Family
ID=47757194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014528669A Pending JP2014527801A (ja) | 2011-09-01 | 2012-08-31 | ハイスループットペプチドミメティックを調製するための方法、経口バイオアベイラブルな薬物およびそれを含有する組成物 |
| JP2017230546A Pending JP2018064573A (ja) | 2011-09-01 | 2017-11-30 | ハイスループットペプチドミメティックを調製するための方法、経口バイオアベイラブルな薬物およびそれを含有する組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017230546A Pending JP2018064573A (ja) | 2011-09-01 | 2017-11-30 | ハイスループットペプチドミメティックを調製するための方法、経口バイオアベイラブルな薬物およびそれを含有する組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US9944675B2 (enExample) |
| EP (2) | EP2751291B1 (enExample) |
| JP (2) | JP2014527801A (enExample) |
| WO (1) | WO2013033636A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014143806A1 (en) * | 2013-03-15 | 2014-09-18 | The Penn State Research Foundation | Acid stable liposomal compositions |
| JP6667432B2 (ja) * | 2013-05-02 | 2020-03-18 | ファリス バイオテック ゲーエムベーハー | 遺伝子移入促進因子プロトランスズジン（Ｐｒｏｔｒａｎｓｄｕｚｉｎ）Ｂ |
| US20180327453A1 (en) * | 2015-11-06 | 2018-11-15 | Evorx Technologies, Inc. | Her-2-specific cyclized supr peptides |
| GB201812331D0 (en) * | 2018-07-27 | 2018-09-12 | Mologic Ltd | Bacterial vaginosis diagnostic |
| WO2020242268A1 (ko) * | 2019-05-31 | 2020-12-03 | (주)디앤디파마텍 | 비오틴 모이어티와 결합된 생리활성 물질 및 이를 포함하는 경구 투여용 조성물 |
| EP3978027A4 (en) * | 2019-05-31 | 2023-10-11 | D&D Pharmatech Inc. | PHYSIOLOGICALLY ACTIVE SUBSTANCE LINKED TO A BIOTIN FRACTION, AND COMPOSITION FOR ORAL ADMINISTRATION COMPRISING IT |
| WO2022114908A1 (ko) * | 2020-11-27 | 2022-06-02 | (주)디앤디파마텍 | 비오틴 모이어티, 지방산 모이어티 또는 이의 조합이 결합된 생리활성 물질 접합체의 경구 제형 |
| GB2617717A (en) * | 2020-11-27 | 2023-10-18 | D&D Pharmatech Inc | Biologically active material conjugate having biotin moiety, fatty acid moiety, or combination thereof coupled thereto |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3995631A (en) | 1971-01-13 | 1976-12-07 | Alza Corporation | Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient |
| US3760984A (en) | 1971-09-29 | 1973-09-25 | Alza Corp | Osmotically powered agent dispensing device with filling means |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US3923426A (en) | 1974-08-15 | 1975-12-02 | Alza Corp | Electroosmotic pump and fluid dispenser including same |
| US4036228A (en) | 1975-09-11 | 1977-07-19 | Alza Corporation | Osmotic dispenser with gas generating means |
| US3987790A (en) | 1975-10-01 | 1976-10-26 | Alza Corporation | Osmotically driven fluid dispenser |
| US4016880A (en) | 1976-03-04 | 1977-04-12 | Alza Corporation | Osmotically driven active agent dispenser |
| US4111203A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system with means for improving delivery kinetics of system |
| US4111202A (en) | 1976-11-22 | 1978-09-05 | Alza Corporation | Osmotic system for the controlled and delivery of agent over time |
| US4203442A (en) | 1977-08-29 | 1980-05-20 | Alza Corporation | Device for delivering drug to a fluid environment |
| US4203440A (en) | 1978-10-23 | 1980-05-20 | Alza Corporation | Device having variable volume chamber for dispensing useful agent |
| US4210139A (en) | 1979-01-17 | 1980-07-01 | Alza Corporation | Osmotic device with compartment for governing concentration of agent dispensed from device |
| US4360019A (en) | 1979-02-28 | 1982-11-23 | Andros Incorporated | Implantable infusion device |
| US4692147A (en) | 1980-04-02 | 1987-09-08 | Medtronic, Inc. | Drug administration device |
| US4327725A (en) | 1980-11-25 | 1982-05-04 | Alza Corporation | Osmotic device with hydrogel driving member |
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| DE3424893A1 (de) | 1984-07-06 | 1986-02-06 | Agfa-Gevaert Ag, 5090 Leverkusen | Photographisches silberhalogenidaufzeichnungsmaterial |
| US4754065A (en) | 1984-12-18 | 1988-06-28 | Cetus Corporation | Precursor to nucleic acid probe |
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| US5968502A (en) | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| JP3532566B2 (ja) | 1993-06-24 | 2004-05-31 | エル． グラハム，フランク | 遺伝子治療のためのアデノウイルスベクター |
| JP3875990B2 (ja) | 1993-10-25 | 2007-01-31 | カンジ，インコーポレイテッド | 組換えアデノウイルスベクターおよび使用方法 |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
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| CA2399509A1 (en) * | 2000-02-03 | 2001-08-09 | Merck & Co., Inc. | Melanin-concentrating hormone analogs |
| EP1504111A4 (en) * | 2002-04-19 | 2005-11-23 | California Inst Of Techn | LIBRARY OF MOLECULES OF NUCLEIC ACIDS AND PEPTIDES IN WHICH THE PEPTIDES CONTAIN NON-NATURAL AMINO ACID RESIDUES AND METHODS FOR THEIR PRODUCTION |
| WO2004110964A2 (en) | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
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| WO2006003183A1 (de) * | 2004-07-02 | 2006-01-12 | Alois Jungbauer | Peptide zur blockierung von fviii-inhibitoren |
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| WO2007097923A2 (en) | 2006-02-20 | 2007-08-30 | Phylogica Limited | Method of constructing and screening libraries of peptide structures |
| EP2141175B1 (en) * | 2007-03-26 | 2016-07-27 | The University of Tokyo | Process for synthesizing cyclic peptide compound |
| US8404445B2 (en) | 2008-09-30 | 2013-03-26 | Abbvie Inc. | Antibody libraries |
| JP5818237B2 (ja) | 2010-09-09 | 2015-11-18 | 国立大学法人 東京大学 | Ｎ−メチルアミノ酸およびその他の特殊アミノ酸を含む特殊ペプチド化合物ライブラリーの翻訳構築と活性種探索法 |
| JP6206943B2 (ja) * | 2010-12-03 | 2017-10-04 | 国立大学法人 東京大学 | ペプチドライブラリーの製造方法、ペプチドライブラリー、及びスクリーニング方法 |
| EP3143050A4 (en) | 2014-05-14 | 2017-10-25 | Evorx Technologies, Inc. | Barcoded peptides |
| US10323067B2 (en) | 2014-05-14 | 2019-06-18 | Evorx Technologies, Inc. | Methods and compositions for controlling gene expression and treating cancer |
| US20180327453A1 (en) * | 2015-11-06 | 2018-11-15 | Evorx Technologies, Inc. | Her-2-specific cyclized supr peptides |
-
2012
- 2012-08-31 JP JP2014528669A patent/JP2014527801A/ja active Pending
- 2012-08-31 EP EP12828021.1A patent/EP2751291B1/en not_active Not-in-force
- 2012-08-31 WO PCT/US2012/053526 patent/WO2013033636A2/en not_active Ceased
- 2012-08-31 EP EP17156757.1A patent/EP3222720A1/en not_active Withdrawn
- 2012-08-31 US US14/342,347 patent/US9944675B2/en not_active Expired - Fee Related
-
2017
- 2017-11-30 JP JP2017230546A patent/JP2018064573A/ja active Pending
-
2018
- 2018-04-16 US US15/953,989 patent/US20180312539A1/en not_active Abandoned
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