JP2014526548A5 - - Google Patents
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- JP2014526548A5 JP2014526548A5 JP2014531331A JP2014531331A JP2014526548A5 JP 2014526548 A5 JP2014526548 A5 JP 2014526548A5 JP 2014531331 A JP2014531331 A JP 2014531331A JP 2014531331 A JP2014531331 A JP 2014531331A JP 2014526548 A5 JP2014526548 A5 JP 2014526548A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- limbs
- formulated
- antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 208000023275 Autoimmune disease Diseases 0.000 claims 6
- 230000003115 biocidal effect Effects 0.000 claims 5
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 4
- 239000003242 anti bacterial agent Substances 0.000 claims 4
- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 claims 4
- 229960004287 clofazimine Drugs 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 4
- AEUTYOVWOVBAKS-UWVGGRQHSA-N ethambutol Chemical compound CC[C@@H](CO)NCCN[C@@H](CC)CO AEUTYOVWOVBAKS-UWVGGRQHSA-N 0.000 claims 4
- 210000003414 extremity Anatomy 0.000 claims 4
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 claims 4
- 206010003591 Ataxia Diseases 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 3
- ZWBTYMGEBZUQTK-PVLSIAFMSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17,32-tetrahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-1'-(2-methylpropyl)-6,23-dioxospiro[8,33-dioxa-24,27,29-triazapentacyclo[23.6.1.14,7.05,31.026,30]tritriaconta-1(32),2,4,9,19,21,24,26,30-nonaene-28,4'-piperidine]-13-yl] acetate Chemical compound CO[C@H]1\C=C\O[C@@]2(C)Oc3c(C2=O)c2c4NC5(CCN(CC(C)C)CC5)N=c4c(=NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C ZWBTYMGEBZUQTK-PVLSIAFMSA-N 0.000 claims 3
- 229960002626 clarithromycin Drugs 0.000 claims 3
- AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 claims 3
- 210000003141 lower extremity Anatomy 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 229960000885 rifabutin Drugs 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 2
- RXZBMPWDPOLZGW-XMRMVWPWSA-N (E)-roxithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=N/OCOCCOC)/[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 RXZBMPWDPOLZGW-XMRMVWPWSA-N 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 108010013198 Daptomycin Proteins 0.000 claims 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 2
- 229930182566 Gentamicin Natural products 0.000 claims 2
- 229930193140 Neomycin Natural products 0.000 claims 2
- 239000004104 Oleandomycin Substances 0.000 claims 2
- RZPAKFUAFGMUPI-UHFFFAOYSA-N Oleandomycin Natural products O1C(C)C(O)C(OC)CC1OC1C(C)C(=O)OC(C)C(C)C(O)C(C)C(=O)C2(OC2)CC(C)C(OC2C(C(CC(C)O2)N(C)C)O)C1C RZPAKFUAFGMUPI-UHFFFAOYSA-N 0.000 claims 2
- 208000003435 Optic Neuritis Diseases 0.000 claims 2
- 206010033799 Paralysis Diseases 0.000 claims 2
- UOZODPSAJZTQNH-UHFFFAOYSA-N Paromomycin II Natural products NC1C(O)C(O)C(CN)OC1OC1C(O)C(OC2C(C(N)CC(N)C2O)OC2C(C(O)C(O)C(CO)O2)N)OC1CO UOZODPSAJZTQNH-UHFFFAOYSA-N 0.000 claims 2
- 239000004098 Tetracycline Substances 0.000 claims 2
- 206010047700 Vomiting Diseases 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 229960004099 azithromycin Drugs 0.000 claims 2
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims 2
- 229960002227 clindamycin Drugs 0.000 claims 2
- KDLRVYVGXIQJDK-AWPVFWJPSA-N clindamycin Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](O)[C@@H](SC)O1 KDLRVYVGXIQJDK-AWPVFWJPSA-N 0.000 claims 2
- 102000003675 cytokine receptors Human genes 0.000 claims 2
- 108010057085 cytokine receptors Proteins 0.000 claims 2
- 229960005484 daptomycin Drugs 0.000 claims 2
- DOAKLVKFURWEDJ-QCMAZARJSA-N daptomycin Chemical compound C([C@H]1C(=O)O[C@H](C)[C@@H](C(NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@H](C(=O)N1)[C@H](C)CC(O)=O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)CCCCCCCCC)C(=O)C1=CC=CC=C1N DOAKLVKFURWEDJ-QCMAZARJSA-N 0.000 claims 2
- 230000001934 delay Effects 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 229960003276 erythromycin Drugs 0.000 claims 2
- 229960000285 ethambutol Drugs 0.000 claims 2
- 229960002518 gentamicin Drugs 0.000 claims 2
- 229960003350 isoniazid Drugs 0.000 claims 2
- QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims 2
- 229960000318 kanamycin Drugs 0.000 claims 2
- 229930027917 kanamycin Natural products 0.000 claims 2
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 claims 2
- 229930182823 kanamycin A Natural products 0.000 claims 2
- 229960004023 minocycline Drugs 0.000 claims 2
- 229960004927 neomycin Drugs 0.000 claims 2
- 229960002351 oleandomycin Drugs 0.000 claims 2
- RZPAKFUAFGMUPI-KGIGTXTPSA-N oleandomycin Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C RZPAKFUAFGMUPI-KGIGTXTPSA-N 0.000 claims 2
- 235000019367 oleandomycin Nutrition 0.000 claims 2
- 208000021090 palsy Diseases 0.000 claims 2
- UOZODPSAJZTQNH-LSWIJEOBSA-N paromomycin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)N)O[C@@H]1CO UOZODPSAJZTQNH-LSWIJEOBSA-N 0.000 claims 2
- 229960001914 paromomycin Drugs 0.000 claims 2
- 230000011514 reflex Effects 0.000 claims 2
- 229960001225 rifampicin Drugs 0.000 claims 2
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 2
- 229960005224 roxithromycin Drugs 0.000 claims 2
- 230000035807 sensation Effects 0.000 claims 2
- 229960005322 streptomycin Drugs 0.000 claims 2
- 208000011580 syndromic disease Diseases 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 229960002180 tetracycline Drugs 0.000 claims 2
- 229930101283 tetracycline Natural products 0.000 claims 2
- 235000019364 tetracycline Nutrition 0.000 claims 2
- 150000003522 tetracyclines Chemical class 0.000 claims 2
- 229960000707 tobramycin Drugs 0.000 claims 2
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 claims 2
- 206010044652 trigeminal neuralgia Diseases 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- 206010069632 Bladder dysfunction Diseases 0.000 claims 1
- 206010051290 Central nervous system lesion Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 206010010904 Convulsion Diseases 0.000 claims 1
- 206010011878 Deafness Diseases 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 206010012305 Demyelination Diseases 0.000 claims 1
- 208000003164 Diplopia Diseases 0.000 claims 1
- 206010013887 Dysarthria Diseases 0.000 claims 1
- 208000014094 Dystonic disease Diseases 0.000 claims 1
- 241001539473 Euphoria Species 0.000 claims 1
- 206010015535 Euphoric mood Diseases 0.000 claims 1
- 206010017577 Gait disturbance Diseases 0.000 claims 1
- 208000004547 Hallucinations Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 206010019468 Hemiplegia Diseases 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 206010040021 Sensory abnormalities Diseases 0.000 claims 1
- 208000009205 Tinnitus Diseases 0.000 claims 1
- 206010043994 Tonic convulsion Diseases 0.000 claims 1
- 210000003815 abdominal wall Anatomy 0.000 claims 1
- 238000001467 acupuncture Methods 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 230000001977 ataxic effect Effects 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 230000002146 bilateral effect Effects 0.000 claims 1
- 208000015114 central nervous system disease Diseases 0.000 claims 1
- 230000002920 convulsive effect Effects 0.000 claims 1
- 231100000895 deafness Toxicity 0.000 claims 1
- 230000008034 disappearance Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000002173 dizziness Diseases 0.000 claims 1
- 208000029444 double vision Diseases 0.000 claims 1
- 208000010118 dystonia Diseases 0.000 claims 1
- 206010013990 dysuria Diseases 0.000 claims 1
- 210000001513 elbow Anatomy 0.000 claims 1
- 230000001815 facial effect Effects 0.000 claims 1
- 210000004247 hand Anatomy 0.000 claims 1
- 208000016354 hearing loss disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 claims 1
- 229960004963 mesalazine Drugs 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 201000001119 neuropathy Diseases 0.000 claims 1
- 230000007823 neuropathy Effects 0.000 claims 1
- 231100000862 numbness Toxicity 0.000 claims 1
- 206010029864 nystagmus Diseases 0.000 claims 1
- 208000035824 paresthesia Diseases 0.000 claims 1
- 230000001314 paroxysmal effect Effects 0.000 claims 1
- 208000033808 peripheral neuropathy Diseases 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 231100000886 tinnitus Toxicity 0.000 claims 1
- 230000001052 transient effect Effects 0.000 claims 1
- 210000000707 wrist Anatomy 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161536824P | 2011-09-20 | 2011-09-20 | |
| US61/536,824 | 2011-09-20 | ||
| US201161537229P | 2011-09-21 | 2011-09-21 | |
| US61/537,229 | 2011-09-21 | ||
| PCT/IB2012/002252 WO2013041963A2 (en) | 2011-09-20 | 2012-09-19 | A composition and method for treating an autoimmune disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014526548A JP2014526548A (ja) | 2014-10-06 |
| JP2014526548A5 true JP2014526548A5 (enExample) | 2015-11-05 |
| JP6035340B2 JP6035340B2 (ja) | 2016-11-30 |
Family
ID=47914967
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014531331A Active JP6035340B2 (ja) | 2011-09-20 | 2012-09-19 | 自己免疫疾患を処置するための組成物および方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9901638B2 (enExample) |
| EP (1) | EP2758061B1 (enExample) |
| JP (1) | JP6035340B2 (enExample) |
| KR (1) | KR101987512B1 (enExample) |
| CN (1) | CN103813797B (enExample) |
| AU (1) | AU2012311235B2 (enExample) |
| BR (1) | BR112014006473A2 (enExample) |
| CA (1) | CA2849255C (enExample) |
| CL (1) | CL2014000671A1 (enExample) |
| DK (1) | DK2758061T3 (enExample) |
| ES (1) | ES2614923T3 (enExample) |
| HU (1) | HUE032959T2 (enExample) |
| IL (1) | IL231489A (enExample) |
| IN (1) | IN2014CN02908A (enExample) |
| MX (1) | MX347660B (enExample) |
| PL (1) | PL2758061T3 (enExample) |
| PT (1) | PT2758061T (enExample) |
| RU (1) | RU2621129C2 (enExample) |
| SG (1) | SG11201400386RA (enExample) |
| TW (1) | TWI573590B (enExample) |
| WO (1) | WO2013041963A2 (enExample) |
| ZA (1) | ZA201401954B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105307654B (zh) * | 2013-04-30 | 2022-06-07 | 托马斯·朱利叶斯·波洛迪 | 用于治疗微生物区系相关的精神病况和疾病的组合物和方法 |
| EP3145510B8 (en) * | 2014-05-22 | 2021-10-27 | Kuenstner, John, Todd | Treatment of diseases using combination of ultraviolet blood irradiation and antibiotics |
| BR112017008220A2 (pt) * | 2014-10-24 | 2018-01-09 | Redhill Biopharma Ltd. | terapia para inibição de replicação do vírus de rna de filamento único |
| AU2016336133B2 (en) * | 2015-10-06 | 2021-02-25 | Redhill Biopharma Ltd. | Combination therapies for treating cancer |
| CA3022515A1 (en) | 2016-05-02 | 2017-11-09 | Prothena Biosciences Limited | Antibodies recognizing tau |
| CN111148531A (zh) | 2017-09-08 | 2020-05-12 | 伊夫罗生物科学公司 | 细菌胞外囊泡 |
| CA3187031A1 (en) * | 2020-06-30 | 2022-01-06 | Redhill Biopharma Ltd. | Triple antibiotic fixed-dose combination products, dosing regimen, methods, and kits for treating pulmonary non-tuberculosis mycobacterial infections |
| EP4497437A4 (en) * | 2022-03-22 | 2025-03-12 | Kyoto University | MEDICINES FOR THE TREATMENT OR PREVENTION OF CHARCOT-MARIE-TOOTH DISEASE |
| CN116649295A (zh) * | 2023-03-20 | 2023-08-29 | 广西医科大学第一附属医院 | GluN1359-378多肽主动免疫PTZ诱发癫痫及认知障碍的动物模型、建立方法及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI0971735T1 (sl) * | 1997-04-01 | 2008-08-31 | Borody Thomas J | Postopek in sestavina za zdravljenje bolezni vnetja debelega äśrevesa |
| US7488580B1 (en) | 2005-03-10 | 2009-02-10 | University Of Central Florida Research Foundation, Inc. | Protocol for detection of Mycobacterium avium subspecies paratuberculosis in blood |
| US20090054380A1 (en) * | 2005-12-20 | 2009-02-26 | Greenstein Robert J | Methods for diagnosing and treating a mycobacterium avium subspecies paratuberculosis infection |
| US20080275063A1 (en) | 2007-04-24 | 2008-11-06 | Heike Schauerte | Inhibitors of protein kinases |
| WO2009042114A2 (en) * | 2007-09-21 | 2009-04-02 | The Johns Hopkins University | Phenazine derivatives and uses thereof |
| CA2714043C (en) | 2008-02-08 | 2016-11-08 | Giaconda Limited | Methods and compositions for treating inflammatory bowel disease |
| WO2011011706A2 (en) * | 2009-07-24 | 2011-01-27 | The Johns Hopkins University | Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents |
-
2012
- 2012-09-18 TW TW101134166A patent/TWI573590B/zh not_active IP Right Cessation
- 2012-09-19 JP JP2014531331A patent/JP6035340B2/ja active Active
- 2012-09-19 HU HUE12834382A patent/HUE032959T2/hu unknown
- 2012-09-19 SG SG11201400386RA patent/SG11201400386RA/en unknown
- 2012-09-19 RU RU2014115807A patent/RU2621129C2/ru active
- 2012-09-19 PT PT128343829T patent/PT2758061T/pt unknown
- 2012-09-19 DK DK12834382.9T patent/DK2758061T3/en active
- 2012-09-19 CA CA2849255A patent/CA2849255C/en active Active
- 2012-09-19 MX MX2014003430A patent/MX347660B/es active IP Right Grant
- 2012-09-19 KR KR1020147010372A patent/KR101987512B1/ko not_active Expired - Fee Related
- 2012-09-19 IN IN2908CHN2014 patent/IN2014CN02908A/en unknown
- 2012-09-19 WO PCT/IB2012/002252 patent/WO2013041963A2/en not_active Ceased
- 2012-09-19 BR BR112014006473A patent/BR112014006473A2/pt not_active Application Discontinuation
- 2012-09-19 ES ES12834382.9T patent/ES2614923T3/es active Active
- 2012-09-19 AU AU2012311235A patent/AU2012311235B2/en not_active Ceased
- 2012-09-19 PL PL12834382T patent/PL2758061T3/pl unknown
- 2012-09-19 CN CN201280045735.5A patent/CN103813797B/zh active Active
- 2012-09-19 EP EP12834382.9A patent/EP2758061B1/en active Active
- 2012-09-19 US US14/345,839 patent/US9901638B2/en active Active
-
2014
- 2014-03-12 IL IL231489A patent/IL231489A/en active IP Right Grant
- 2014-03-17 ZA ZA2014/01954A patent/ZA201401954B/en unknown
- 2014-03-19 CL CL2014000671A patent/CL2014000671A1/es unknown
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