JP2014518275A5 - - Google Patents
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- Publication number
- JP2014518275A5 JP2014518275A5 JP2014519145A JP2014519145A JP2014518275A5 JP 2014518275 A5 JP2014518275 A5 JP 2014518275A5 JP 2014519145 A JP2014519145 A JP 2014519145A JP 2014519145 A JP2014519145 A JP 2014519145A JP 2014518275 A5 JP2014518275 A5 JP 2014518275A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- meibomian gland
- glucocorticoid
- weight
- azalide antibiotic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims description 57
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 39
- 210000004175 meibomian gland Anatomy 0.000 claims description 37
- 230000003115 biocidal effect Effects 0.000 claims description 33
- 239000003862 glucocorticoid Substances 0.000 claims description 33
- 230000000306 recurrent effect Effects 0.000 claims description 22
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims description 17
- 229960004099 azithromycin Drugs 0.000 claims description 17
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 17
- 229960003957 dexamethasone Drugs 0.000 claims description 17
- 229920000642 polymer Polymers 0.000 claims description 14
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
- 238000002560 therapeutic procedure Methods 0.000 claims description 7
- 208000010217 blepharitis Diseases 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 239000004971 Cross linker Substances 0.000 claims description 5
- 239000003431 cross linking reagent Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000013268 sustained release Methods 0.000 claims description 2
- 239000012730 sustained-release form Substances 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims 2
- 208000005494 xerophthalmia Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 description 9
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161502490P | 2011-06-29 | 2011-06-29 | |
| US61/502,490 | 2011-06-29 | ||
| PCT/US2012/044949 WO2013003731A2 (en) | 2011-06-29 | 2012-06-29 | Methods of treating recurrent meibomian glands disorder and thereby decreasing the frequency of recurrence |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014518275A JP2014518275A (ja) | 2014-07-28 |
| JP2014518275A5 true JP2014518275A5 (enExample) | 2015-08-06 |
Family
ID=47424819
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519145A Pending JP2014518275A (ja) | 2011-06-29 | 2012-06-29 | 再発性マイボーム腺障害の処置方法およびそれによる再発頻度の減少方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20140142055A1 (enExample) |
| EP (1) | EP2726081A4 (enExample) |
| JP (1) | JP2014518275A (enExample) |
| KR (1) | KR20140054002A (enExample) |
| CA (1) | CA2840626A1 (enExample) |
| WO (1) | WO2013003731A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7981145B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience Inc. | Treatment of meibomian glands |
| US8950405B2 (en) | 2006-05-15 | 2015-02-10 | Tearscience, Inc. | Treatment of obstructive disorders of the eye or eyelid |
| US8915253B2 (en) | 2005-07-18 | 2014-12-23 | Tearscience, Inc. | Method and apparatus for treating gland dysfunction employing heated medium |
| US20090043365A1 (en) | 2005-07-18 | 2009-02-12 | Kolis Scientific, Inc. | Methods, apparatuses, and systems for reducing intraocular pressure as a means of preventing or treating open-angle glaucoma |
| US7981095B2 (en) | 2005-07-18 | 2011-07-19 | Tearscience, Inc. | Methods for treating meibomian gland dysfunction employing fluid jet |
| US20080114423A1 (en) | 2006-05-15 | 2008-05-15 | Grenon Stephen M | Apparatus for inner eyelid treatment of meibomian gland dysfunction |
| US20070060988A1 (en) | 2005-07-18 | 2007-03-15 | Grenon Stephen M | Melting meibomian gland obstructions |
| WO2013003594A2 (en) | 2011-06-28 | 2013-01-03 | Tearscience, Inc. | Methods and systems for treating meibomian gland dysfunction using radio-frequency energy |
| US8128674B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for outer eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| US9314369B2 (en) | 2006-05-15 | 2016-04-19 | Tearscience, Inc. | System for inner eyelid treatment of meibomian gland dysfunction |
| US8137390B2 (en) | 2006-05-15 | 2012-03-20 | Tearscience, Inc. | System for providing heat treatment and heat loss reduction for treating meibomian gland dysfunction |
| US8128673B2 (en) | 2006-05-15 | 2012-03-06 | Tearscience, Inc. | System for inner eyelid heat and pressure treatment for treating meibomian gland dysfunction |
| CN104011073B (zh) | 2011-10-18 | 2017-08-25 | 科荣生生物科学公司 | 使用氨基酸稳定的依那西普制剂 |
| US10842670B2 (en) | 2012-08-22 | 2020-11-24 | Johnson & Johnson Vision Care, Inc. | Apparatuses and methods for diagnosing and/or treating lipid transport deficiency in ocular tear films, and related components and devices |
| US10130507B2 (en) | 2013-08-03 | 2018-11-20 | Michael C. Whitehurst | Dry eye treatment device |
| US9463201B2 (en) | 2014-10-19 | 2016-10-11 | M.G. Therapeutics Ltd | Compositions and methods for the treatment of meibomian gland dysfunction |
| CN108472312A (zh) * | 2015-09-28 | 2018-08-31 | 阿祖拉眼科有限公司 | 用于增加睑板腺脂质分泌物的含硫醇及二硫化物的药剂 |
| MA44676A (fr) | 2016-04-14 | 2019-02-20 | Azura Ophthalmics Ltd | Compositions de disulfure de sélénium destinées à être utilisées dans le traitement du dysfonctionnement de la glande de meibomius |
| WO2018178769A1 (en) * | 2017-03-29 | 2018-10-04 | M.G. Therapeutics Ltd. | Agents for increasing meibomian gland lipid secretion |
| KR101895321B1 (ko) | 2017-04-24 | 2018-09-05 | 주식회사 이루다 | 눈꺼풀의 분비샘 이상에 대한 치료장치 |
| US11759472B2 (en) * | 2017-11-21 | 2023-09-19 | Cs Pharmaceuticals Limited | Compositions and methods of use for treating aberrant inflammation in peri-ocular secretory glands or at the ocular surface |
| EP3955937A4 (en) | 2019-04-18 | 2023-01-18 | Azura Ophthalmics Ltd. | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF EYE DISEASES |
| EP4087655A4 (en) | 2020-01-10 | 2024-02-21 | Azura Ophthalmics Ltd | INSTRUCTIONS FOR COMPOSITION AND SENSITIVITY |
| CN116940570A (zh) * | 2020-10-21 | 2023-10-24 | 阿祖拉眼科有限公司 | 用于治疗眼部病症的化合物和方法 |
| IL302173A (en) * | 2020-10-21 | 2023-06-01 | Azura Ophthalmics Ltd | Compounds and methods for the treatment of ocular disorders |
| EP4247367A4 (en) | 2020-11-23 | 2024-10-16 | Sight Sciences, Inc. | Formulations and methods for treating conditions of the eye |
| WO2022180568A1 (en) * | 2021-02-25 | 2022-09-01 | Sun Pharmaceutical Industries Limited | Dexamethasone for treatment of blepharitis |
| US20250275916A1 (en) * | 2024-03-04 | 2025-09-04 | Ocusoft, Inc. | Medicated eyelid cleansing compositions |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6239113B1 (en) * | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
| US8372814B2 (en) * | 2004-06-07 | 2013-02-12 | Ista Pharmaceuticals, Inc. | Ophthalmic formulations and uses thereof |
| EP2089035A1 (en) * | 2006-11-02 | 2009-08-19 | Riolan Technologies, Inc. | Method for treating blepharitis |
| US10105441B2 (en) * | 2007-08-16 | 2018-10-23 | The Schepens Eye Research Institute, Inc. | Method for inhibiting or reducing dry eye disease by IL-1Ra |
| US7795231B2 (en) * | 2007-10-04 | 2010-09-14 | Insite Vision Incorporated | Concentrated aqueous azalide formulations |
| EP2313103B1 (en) * | 2008-07-10 | 2014-06-18 | Inspire Pharmaceuticals, Inc. | Method of treating blepharitis |
| US10201548B2 (en) * | 2009-03-06 | 2019-02-12 | Sun Pharma Global Fze | Methods for treating ocular inflammatory diseases |
| PL2493474T3 (pl) * | 2009-10-30 | 2020-03-31 | Intratus, Inc. | Sposoby i kompozycje do podtrzymywanego dostarczania leków |
-
2012
- 2012-06-29 CA CA2840626A patent/CA2840626A1/en not_active Abandoned
- 2012-06-29 WO PCT/US2012/044949 patent/WO2013003731A2/en not_active Ceased
- 2012-06-29 KR KR1020147002457A patent/KR20140054002A/ko not_active Withdrawn
- 2012-06-29 US US14/233,152 patent/US20140142055A1/en not_active Abandoned
- 2012-06-29 EP EP12803892.4A patent/EP2726081A4/en not_active Withdrawn
- 2012-06-29 JP JP2014519145A patent/JP2014518275A/ja active Pending
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