JP2014524929A - プラスグレルの調製方法 - Google Patents

プラスグレルの調製方法 Download PDF

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Publication number
JP2014524929A
JP2014524929A JP2014522117A JP2014522117A JP2014524929A JP 2014524929 A JP2014524929 A JP 2014524929A JP 2014522117 A JP2014522117 A JP 2014522117A JP 2014522117 A JP2014522117 A JP 2014522117A JP 2014524929 A JP2014524929 A JP 2014524929A
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JP
Japan
Prior art keywords
prasugrel
base
solvent
acid
acetate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014522117A
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English (en)
Japanese (ja)
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JP2014524929A5 (OSRAM
Inventor
ビシュヌ ネワドカール，ラビンドラナス
ジョシ，アニル プルショッタム
ベンドレ，サミール ラグナス
ジェレ，ディーパック へマント
バルジョアン，ペレ ダルマセス
ムニョス イザベル ナヴァーロ
クロテット，フアン ヒュゲット
Original Assignee
ラボラトリオス レスヴィ，エス．エル．
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Application filed by ラボラトリオス レスヴィ，エス．エル． filed Critical ラボラトリオス レスヴィ，エス．エル．
Publication of JP2014524929A publication Critical patent/JP2014524929A/ja
Publication of JP2014524929A5 publication Critical patent/JP2014524929A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Epidemiology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2014522117A 2011-07-28 2012-07-30 プラスグレルの調製方法 Pending JP2014524929A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP11175721.7 2011-07-28
EP11175721 2011-07-28
US201161574248P 2011-07-29 2011-07-29
US61/574,248 2011-07-29
EP12150675 2012-01-10
EP12150675.2 2012-01-10
PCT/EP2012/064852 WO2013014295A1 (en) 2011-07-28 2012-07-30 Process for preparing prasugrel

Publications (2)

Publication Number Publication Date
JP2014524929A true JP2014524929A (ja) 2014-09-25
JP2014524929A5 JP2014524929A5 (OSRAM) 2015-05-21

Family

ID=47600543

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014522117A Pending JP2014524929A (ja) 2011-07-28 2012-07-30 プラスグレルの調製方法

Country Status (4)

Country Link
EP (2) EP2736509B1 (OSRAM)
JP (1) JP2014524929A (OSRAM)
ES (1) ES2557199T3 (OSRAM)
WO (1) WO2013014295A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105085541A (zh) * 2014-05-07 2015-11-25 江苏先声药业有限公司 一种普拉格雷类似物的制备方法
CN104592250B (zh) * 2015-01-15 2016-05-11 新发药业有限公司 一种低成本的普拉格雷的环保制备方法
CN106117240A (zh) * 2016-06-09 2016-11-16 青岛辰达生物科技有限公司 一种制备抗血栓药物普拉格雷的方法
HU231079B1 (hu) 2016-06-23 2020-06-29 Richter Gedeon Nyrt. Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával
EP3528790A1 (en) 2016-10-21 2019-08-28 Laboratorios Lesvi S.L. Pharmaceutical formulations of prasugrel and processes for the preparation thereof

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002145883A (ja) * 2000-07-06 2002-05-22 Sankyo Co Ltd ヒドロピリジン誘導体酸付加塩
WO2007114526A1 (ja) * 2006-04-06 2007-10-11 Daiichi Sankyo Company, Limited 高純度のプラスグレル及びその酸付加塩の製造方法
CN101177430A (zh) * 2007-12-11 2008-05-14 鲁南制药集团股份有限公司 氢化吡啶衍生物及其盐的制备方法
WO2009062044A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs
WO2009130289A1 (en) * 2008-04-25 2009-10-29 Sandoz Ag HYDROGENSULFATE SALT OF 2-ACETOXY-5-(a-CYCLOPROPYLCARBONYL-2-FLUOROBENZYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-c]PYRIDINE AND ITS PREPARATION
WO2011057592A1 (en) * 2009-11-16 2011-05-19 Zentiva, K.S. Method of producing highly pure prasugrel and pharmaceutically acceptable salts thereof
WO2012105594A1 (ja) * 2011-02-01 2012-08-09 協和発酵キリン株式会社 縮環複素環誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI101150B (fi) 1991-09-09 1998-04-30 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
HU227746B1 (en) 2000-07-06 2012-02-28 Ube Industries Hydropyridine derivative acid addition salts, process for their preparation, pharmaceutical compositions containing them and their use

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002145883A (ja) * 2000-07-06 2002-05-22 Sankyo Co Ltd ヒドロピリジン誘導体酸付加塩
WO2007114526A1 (ja) * 2006-04-06 2007-10-11 Daiichi Sankyo Company, Limited 高純度のプラスグレル及びその酸付加塩の製造方法
WO2009062044A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for the preparation of prasugrel, and its salts and polymorphs
CN101177430A (zh) * 2007-12-11 2008-05-14 鲁南制药集团股份有限公司 氢化吡啶衍生物及其盐的制备方法
WO2009130289A1 (en) * 2008-04-25 2009-10-29 Sandoz Ag HYDROGENSULFATE SALT OF 2-ACETOXY-5-(a-CYCLOPROPYLCARBONYL-2-FLUOROBENZYL)-4,5,6,7-TETRAHYDROTHIENO[3,2-c]PYRIDINE AND ITS PREPARATION
WO2011057592A1 (en) * 2009-11-16 2011-05-19 Zentiva, K.S. Method of producing highly pure prasugrel and pharmaceutically acceptable salts thereof
WO2012105594A1 (ja) * 2011-02-01 2012-08-09 協和発酵キリン株式会社 縮環複素環誘導体

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ANON.: "Process for the preparation of 5-(2-cyclopropyl-1-(2-fluorophenyl)-2- oxoethyl)-4,5,6,7-tetrahydroth", IP.COM JOURNAL, vol. 11(6A), JPN6016031519, 2011, pages 29, ISSN: 0003381197 *
KISHINO H: "DISCOVERY OF IMIDAZO[1,2-A]PHRIDINES AS POTENT MCH1R ANTAGONISTS", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. V19 N16, JPN5014008802, 15 August 2009 (2009-08-15), GB, pages 4589 - 4593, ISSN: 0003381198 *
TEITEI, TSUTOMU: "The synthesis of 2-(5-phenylthiazol-4-yl)benzoic acids", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 33(3), JPN6016031520, 1980, pages 605 - 11, ISSN: 0003381199 *

Also Published As

Publication number Publication date
ES2557199T3 (es) 2016-01-22
EP2736509B1 (en) 2015-09-23
EP2985023A1 (en) 2016-02-17
WO2013014295A1 (en) 2013-01-31
EP2736509A1 (en) 2014-06-04

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